{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:35:14Z","timestamp":1777664114431,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.lfs.2021.119706","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T11:01:37Z","timestamp":1622890897000},"page":"119706","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Pioglitazone and\/or irbesartan ameliorate COPD-induced endothelial dysfunction in side stream cigarette smoke-exposed mice model"],"prefix":"10.1016","volume":"280","author":[{"given":"Alaa T.","family":"Abdelhafez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa M.S.","family":"Gomaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa M.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manal M.","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa A.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2021.119706_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0195724","article-title":"Imbalance between endothelial damage and repair capacity in chronic obstructive pulmonary disease","volume":"13","author":"Garc\u00eda-Lucio","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2021.119706_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2019.00079","article-title":"Karma of cardiovascular disease risk factors for prevention and management of major cardiovascular events in the context of acute exacerbations of chronic obstructive pulmonary disease","volume":"6","author":"Crisan","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.lfs.2021.119706_bb0015","doi-asserted-by":"crossref","DOI":"10.1289\/EHP2452","article-title":"House dust endotoxin association with chronic bronchitis and emphysema","volume":"126","author":"Mendy","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.lfs.2021.119706_bb0020","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S2213-2600(15)00241-6","article-title":"Risk of cardiovascular comorbidity in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis","volume":"3","author":"Chen","year":"2015","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.lfs.2021.119706_bb0025","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.4103\/jfmpc.jfmpc_477_19","article-title":"COPD from an everyday primary care point of view","volume":"8","author":"Aguilar-Shea","year":"2019","journal-title":"J. Fam. Med. Prim. Care"},{"key":"10.1016\/j.lfs.2021.119706_bb0030","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.18632\/aging.103000","article-title":"Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis","volume":"12","author":"Wang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.lfs.2021.119706_bb0035","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1165\/rcmb.2017-0114TR","article-title":"Hydrogen sulfide: a novel player in airway development, pathophysiology of respiratory diseases, and antiviral defenses","volume":"57","author":"Bazhanov","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.lfs.2021.119706_bb0040","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41390-019-0396-6","article-title":"Cystathionine \u03b3-lyase deficiency enhances airway reactivity and viral-induced disease in mice exposed to side-stream tobacco smoke","volume":"86","author":"Ivanciuc","year":"2019","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.lfs.2021.119706_bb0045","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0057-2018","article-title":"Cardiovascular disease and COPD: dangerous liaisons?","volume":"27","author":"Rabe","year":"2018","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.lfs.2021.119706_bb0050","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3390\/ijerph16010096","article-title":"Environmental tobacco smoke and cardiovascular disease","volume":"16","author":"DiGiacomo","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.lfs.2021.119706_bb0055","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12931-017-0505-1","article-title":"The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)","volume":"18","author":"Green","year":"2017","journal-title":"Respir. Res."},{"key":"10.1016\/j.lfs.2021.119706_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116745","article-title":"LncRNA AK094457 promotes AngII-mediated hypertension and endothelial dysfunction through suppressing of activation of PPAR\u03b3","volume":"233","author":"Zhuo","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2021.119706_bb0065","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/387842","article-title":"Proinflammatory cytokines increase vascular endothelial growth factor expression in alveolar epithelial cells","volume":"2015","author":"Maloney","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.lfs.2021.119706_bb0070","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1161\/HYPERTENSIONAHA.117.09358","article-title":"Genetic interference with endothelial PPAR-\u03b3 (peroxisome proliferator\u2013activated receptor-\u03b3) augments effects of angiotensin II while impairing responses to angiotensin 1\u20137","volume":"70","author":"De Silva","year":"2017","journal-title":"Hypertension (Dallas, Tex.: 1979)"},{"key":"10.1016\/j.lfs.2021.119706_bb0075","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.7150\/ijbs.29741","article-title":"The nuclear export and ubiquitin-proteasome-dependent degradation of PPAR\u03b3 induced by angiotensin II","volume":"15","author":"Sun","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.lfs.2021.119706_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00515","article-title":"Inactivation of FOXA2 by respiratory bacterial pathogens and dysregulation of pulmonary mucus homeostasis","volume":"11","author":"Choi","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2021.119706_bb0085","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10741-017-9667-7","article-title":"Heart failure risk and major cardiovascular events in diabetes: an overview of within-group differences in non-insulin antidiabetic treatment","volume":"23","author":"Terlizzese","year":"2018","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.lfs.2021.119706_bb0090","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4103\/0971-5916.195022","article-title":"Angiotensin receptor blockers & endothelial dysfunction: possible correlation & therapeutic implications","volume":"144","author":"Radenkovi\u0107","year":"2016","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.lfs.2021.119706_bb0095","doi-asserted-by":"crossref","DOI":"10.1177\/2045894018758528","article-title":"COPD as an endothelial disorder: endothelial injury linking lesions in the lungs and other organs? (2017 Grover Conference Series)","volume":"8","author":"Polverino","year":"2018","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.lfs.2021.119706_bb0100","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/hr.2013.3","article-title":"Irbesartan, an angiotensin receptor blocker, exhibits metabolic, anti-inflammatory and antioxidative effects in patients with high-risk hypertension","volume":"36","author":"Taguchi","year":"2013","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.lfs.2021.119706_bb0105","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/978-1-4939-7568-6_5","article-title":"Protocols to evaluate cigarette smoke-induced lung inflammation and pathology in mice","volume":"1725","author":"Vlahos","year":"2018","journal-title":"Methods Mol. Biol. (Clifton, N.J.)"},{"key":"10.1016\/j.lfs.2021.119706_bb0110","doi-asserted-by":"crossref","first-page":"e13251","DOI":"10.1371\/journal.pone.0013251","article-title":"Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection","volume":"5","author":"Bauer","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2021.119706_bb0115","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.pupt.2010.12.006","article-title":"Local and systemic effects of angiotensin receptor blockade in an emphysema mouse model","volume":"24","author":"Raupach","year":"2011","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2021.119706_bb0120","first-page":"365","article-title":"Non invasive measurement of systolic blood pressure in rats: a simple technique","volume":"4","author":"Pauline","year":"2011","journal-title":"Al Ameen J. Med. Sci."},{"key":"10.1016\/j.lfs.2021.119706_bb0125","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/laban0803-48","article-title":"Collection of mouse urine for bioassays","volume":"32","author":"Chew","year":"2003","journal-title":"Lab. Anim."},{"key":"10.1016\/j.lfs.2021.119706_bb0130","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1046\/j.1467-2995.2003.13335.x","article-title":"Urethane anesthesia in adult female rats: preliminary observations","volume":"30","author":"Golder","year":"2003","journal-title":"Vet. Anaesth. Analg."},{"key":"10.1016\/j.lfs.2021.119706_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13020-016-0094-9","article-title":"Loki zupa (Luooukezupa) decoction reduced airway inflammation in an OVA-induced asthma mouse model","volume":"11","author":"Wei","year":"2016","journal-title":"Chin. Med."},{"key":"10.1016\/j.lfs.2021.119706_bb0140","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1006\/niox.2000.0319","article-title":"A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite","volume":"5","author":"Miranda","year":"2001","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.lfs.2021.119706_bb0145","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0003-2697(71)90116-3","article-title":"Direct spectrophotometric determination of inorganic sulfide in biological materials and in other complex mixtures","volume":"43","author":"Gilboa-Garber","year":"1971","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.lfs.2021.119706_bb0150","doi-asserted-by":"crossref","first-page":"360","DOI":"10.4236\/abc.2012.24044","article-title":"Measuring free tissue sulfide","volume":"2","author":"Ang","year":"2012","journal-title":"Adv. Biol. Chem."},{"key":"10.1016\/j.lfs.2021.119706_bb0155","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fphys.2018.00058","article-title":"Establishment and evaluation of a rat model of sidestream cigarette smoke-induced chronic obstructive pulmonary disease","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lfs.2021.119706_bb0160","first-page":"356","article-title":"Effects of cigarette smoking on histology of trachea and lungs of albino rat","volume":"3","author":"Shraideh","year":"2013","journal-title":"Res. Opin. Anim. Vet. Sci."},{"key":"10.1016\/j.lfs.2021.119706_bb0165","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.21037\/tlcr.2019.03.02","article-title":"Smoking, immunity, and DNA damage","volume":"8","author":"Yamaguchi","year":"2019","journal-title":"Transl. Lung Cancer Res."},{"key":"10.1016\/j.lfs.2021.119706_bb0170","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2147\/COPD.S113625","article-title":"Gender differences in the T-cell profiles of the airways in COPD patients associated with clinical phenotypes","volume":"12","author":"Forsslund","year":"2017","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.lfs.2021.119706_bb0175","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/thoraxjnl-2012-202212","article-title":"Critical role of fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium","volume":"68","author":"Rius","year":"2013","journal-title":"Thorax"},{"key":"10.1016\/j.lfs.2021.119706_bb0180","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3389\/fimmu.2018.00294","article-title":"Endothelial to mesenchymal transition represents a key link in the interaction between inflammation and endothelial dysfunction","volume":"9","author":"Cho","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2021.119706_bb0185","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1164\/rccm.201803-0402OC","article-title":"Albuminuria, lung function decline, and risk of incident chronic obstructive pulmonary disease. The NHLBI Pooled Cohorts Study","volume":"199","author":"Oelsner","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.lfs.2021.119706_bb0190","first-page":"195","article-title":"C74 advances in translational COPD: renal and pulmonary endothelial dysfunction in COPD is ameliorated by enalapril therapy","author":"Polverino","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.lfs.2021.119706_bb0195","first-page":"H639","article-title":"Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension","volume":"316","author":"Dikalov","year":"2019","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.lfs.2021.119706_bb0200","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000343345","article-title":"Short-term systemic effects of nose-only cigarette smoke exposure in mice: role of oxidative stress","volume":"31","author":"Nemmar","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.lfs.2021.119706_bb0205","first-page":"H388","article-title":"Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice","volume":"300","author":"Talukder","year":"2011","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.lfs.2021.119706_bb0210","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1089\/ars.2018.7632","article-title":"Crosstalk between mitochondrial hyperacetylation and oxidative stress in vascular dysfunction and hypertension","volume":"31","author":"Dikalov","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.lfs.2021.119706_bb0215","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.3389\/fimmu.2018.01724","article-title":"Cigarette smoke-induced pulmonary inflammation becomes systemic by circulating extracellular vesicles containing Wnt5a and inflammatory cytokines","volume":"9","author":"Feller","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2021.119706_bb0220","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1080\/15412555.2018.1432034","article-title":"Angiotensin converting enzyme inhibitors and angiotensin receptor blockers: a promising medication for chronic obstructive pulmonary disease?","volume":"15","author":"Vasileiadis","year":"2018","journal-title":"COPD: J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.lfs.2021.119706_bb0225","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2147\/VHRM.S1958","article-title":"Endothelial effects of antihypertensive treatment: focus on irbesartan","volume":"4","author":"Negro","year":"2008","journal-title":"Vasc. Health Risk Manag."},{"key":"10.1016\/j.lfs.2021.119706_bb0230","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/15376516.2018.1544681","article-title":"Incense smoke exposure augments systemic oxidative stress, inflammation and endothelial dysfunction in male albino rats","volume":"29","author":"Hussain","year":"2019","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.lfs.2021.119706_bb0235","first-page":"L743","article-title":"Effects of cigarette smoke on pulmonary endothelial cells","volume":"314","author":"Lu","year":"2018","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.lfs.2021.119706_bb0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-52839-6","article-title":"Pioglitazone modulates the vascular contractility in hypertension by interference with ET-1 pathway","volume":"9","author":"Palacios-Ram\u00edrez","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2021.119706_bb0245","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/rr44","article-title":"Role of endothelin-1 in lung disease","volume":"2","author":"Fagan","year":"2001","journal-title":"Respir. Res."},{"key":"10.1016\/j.lfs.2021.119706_bb0250","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bcp.2016.07.008","article-title":"TNF\u03b1-induced airway smooth muscle cell proliferation depends on endothelin receptor signaling, GM-CSF and IL-6","volume":"116","author":"Knobloch","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119706_bb0255","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/ATVBAHA.113.300156","article-title":"Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis","volume":"34","author":"Messner","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.lfs.2021.119706_bb0260","first-page":"10","article-title":"Role of endothelial dysfunction in cardiovascular diseases: the link between inflammation and hydrogen sulfide","author":"Sun","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119706_bb0265","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4579140","article-title":"An update on hydrogen sulfide and nitric oxide interactions in the cardiovascular system","volume":"2018","author":"Wu","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2021.119706_bb0270","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1073\/pnas.1321871111","article-title":"Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent","volume":"111","author":"King","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.lfs.2021.119706_bb0275","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/jcmm.12077","article-title":"Crosstalk between hydrogen sulfide and nitric oxide in endothelial cells","volume":"17","author":"Altaany","year":"2013","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.lfs.2021.119706_bb0280","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.3390\/ijms20184329","article-title":"Molecular characteristics and treatment of endothelial dysfunction in patients with COPD: a review article","volume":"20","author":"Szucs","year":"2019","journal-title":"Int. J. Mol. Sci."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521006925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521006925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:47:23Z","timestamp":1758401243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521006925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":56,"alternative-id":["S0024320521006925"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119706","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pioglitazone and\/or irbesartan ameliorate COPD-induced endothelial dysfunction in side stream cigarette smoke-exposed mice model","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119706","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119706"}}