{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T16:43:03Z","timestamp":1772383383180,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016714","name":"University of Sharjah","doi-asserted-by":"publisher","award":["2001090281"],"award-info":[{"award-number":["2001090281"]}],"id":[{"id":"10.13039\/100016714","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.lfs.2021.119731","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T22:39:38Z","timestamp":1623796778000},"page":"119731","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Canagliflozin ameliorates aortic and hepatic dysfunction in dietary-induced hypercholesterolemia in the rabbit"],"prefix":"10.1016","volume":"280","author":[{"given":"Nora A.","family":"Ashry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania R.","family":"Abd\u0435laziz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada M.","family":"Suddek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2021.119731_bb0005","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pop.2012.11.003","article-title":"Hyperlipidemia as a risk factor for cardiovascular disease","volume":"40","author":"Nelson","year":"2013","journal-title":"Prim Care"},{"key":"10.1016\/j.lfs.2021.119731_bb0010","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/hep.22904","article-title":"Nutritional model of steatohepatitis and metabolic syndrome in the Ossabaw miniature swine","volume":"50","author":"Lee","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2021.119731_bb0015","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0002-9343(99)00271-5","article-title":"Association of nonalcoholic fatty liver disease with insulin resistance","volume":"107","author":"Marchesini","year":"1999","journal-title":"Am. J. Med."},{"key":"10.1016\/j.lfs.2021.119731_bb0020","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/cr.2009.73","article-title":"Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells","volume":"19","author":"Wobser","year":"2009","journal-title":"Cell Res."},{"key":"10.1016\/j.lfs.2021.119731_bb0025","doi-asserted-by":"crossref","first-page":"III27","DOI":"10.1161\/01.CIR.0000131515.03336.f8","article-title":"Role of endothelial dysfunction in atherosclerosis","volume":"109","author":"Davignon","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2021.119731_bb0030","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1463-1326.2011.01406.x","article-title":"Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects","volume":"13","author":"Sha","year":"2011","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.lfs.2021.119731_bb0035","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1007\/s00125-019-4859-4","article-title":"Canagliflozin reduces inflammation and fibrosis biomarkers: a potential mechanism of action for beneficial effects of SGLT2 inhibitors in diabetic kidney disease","volume":"62","author":"Heerspink","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.lfs.2021.119731_bb0040","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-019-0816-2","article-title":"SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart","volume":"18","author":"Li","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.lfs.2021.119731_bb0045","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.lfs.2018.01.032","article-title":"The anti-diabetic drug dapagliflozin induces vasodilation via activation of PKG and Kv channels","volume":"197","author":"Li","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2021.119731_bb0050","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ebiom.2017.05.028","article-title":"SGLT2 inhibition by empagliflozin promotes fat utilization and browning and attenuates inflammation and insulin resistance by polarizing M2 macrophages in diet-induced obese mice","volume":"20","author":"Xu","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.lfs.2021.119731_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117275","article-title":"The potential effect of imatinib against hypercholesterolemia induced atherosclerosis, endothelial dysfunction and hepatic injury in rabbits","volume":"243","author":"Ashry","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2021.119731_bb0060","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1007\/s00210-015-1168-4","article-title":"Antioxidant and anti-inflammatory effects of flavocoxid in high-cholesterol-fed rabbits","volume":"388","author":"El-Sheakh","year":"2015","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119731_bb0065","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bbrc.2017.08.031","article-title":"Canagliflozin potentiates GLP-1 secretion and lowers the peak of GIP secretion in rats fed a high-fat high-sucrose diet","volume":"492","author":"Hira","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2021.119731_bb0070","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-018-0749-1","article-title":"Canagliflozin attenuates the progression of atherosclerosis and inflammation process in APOE knockout mice","volume":"17","author":"Nasiri-Ansari","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.lfs.2021.119731_bb0075","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1056\/NEJM196702022760507","article-title":"Fat transport in lipoproteins\u2014an integrated approach to mechanisms and disorders","volume":"276","author":"Fredrickson","year":"1967","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2021.119731_bb0080","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/clinchem\/20.4.470","article-title":"Enzymatic determination of total serum cholesterol","volume":"20","author":"Allain","year":"1974","journal-title":"Clin. Chem."},{"key":"10.1016\/j.lfs.2021.119731_bb0085","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/clinchem\/24.6.931","article-title":"Cholesterol in high-density lipoprotein: use of Mg2+\/dextran sulfate in its enzymic measurement","volume":"24","author":"Finley","year":"1978","journal-title":"Clin. Chem."},{"key":"10.1016\/j.lfs.2021.119731_bb0090","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin. Chem."},{"key":"10.1016\/j.lfs.2021.119731_bb0095","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/00001432-199706000-00007","article-title":"L. C-reactive protein: its role in the diagnosis and follow-up of infectious diseases","volume":"10","author":"Hansson","year":"1997","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.lfs.2021.119731_bb0100","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.lfs.2021.119731_bb0105","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.lfs.2021.119731_bb0110","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.lfs.2021.119731_bb0115","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.lfs.2021.119731_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103577","article-title":"Protocatechuic acid improves hepatic insulin resistance and restores vascular oxidative status in type-2 diabetic rats","volume":"83","author":"Abdelmageed","year":"2021","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119731_bb0125","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.cccn.2004.12.007","article-title":"Atheroprotective effect of exogenous heparin-derivative treatment on the aortic disturbances and lipoprotein oxidation in hypercholesterolemic diet fed rats","volume":"355","author":"Deepa","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.lfs.2021.119731_bb0130","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1089\/jmf.2006.291","article-title":"Hypoglycemic and hypocholesterolemic potential of Persea americana leaf extracts","volume":"10","author":"Brai","year":"2007","journal-title":"J. Med. Food"},{"key":"10.1016\/j.lfs.2021.119731_bb0135","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.atherosclerosis.2005.10.023","article-title":"Selective iNOS inhibitor, ONO1714 successfully retards the development of high-cholesterol diet induced atherosclerosis by novel mechanism","volume":"187","author":"Hayashi","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.lfs.2021.119731_bb0140","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.clnu.2004.01.006","article-title":"Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits","volume":"23","author":"Jeon","year":"2004","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.lfs.2021.119731_bb0145","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/hc3401.093153","article-title":"Immunopathogenesis of atherosclerosis: endotoxin accelerates atherosclerosis in rabbits on hypercholesterolemic diet","volume":"104","author":"Lehr","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2021.119731_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179960","article-title":"Effects of canagliflozin on weight loss in high-fat diet-induced obese mice","volume":"12","author":"Ji","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2021.119731_bb0155","doi-asserted-by":"crossref","first-page":"222","DOI":"10.18433\/jpps29831","article-title":"Effects of canagliflozin on fatty liver indexes in patients with type 2 diabetes: a meta-analysis of randomized controlled trials","volume":"21","author":"Li","year":"2018","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.lfs.2021.119731_bb0160","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1172\/JCI115499","article-title":"Role of oxidized low density lipoprotein in atherogenesis","volume":"88","author":"Witztum","year":"1991","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2021.119731_bb0165","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1054-8807(04)00004-3","article-title":"The vulnerable atherosclerotic plaque: pathogenesis and therapeutic approach","volume":"13","author":"Aikawa","year":"2004","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.lfs.2021.119731_bb0170","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.nut.2007.01.013","article-title":"A diet rich in dietary fiber from cocoa improves lipid profile and reduces malondialdehyde in hypercholesterolemic rats","volume":"23","author":"Lecumberri","year":"2007","journal-title":"Nutrition"},{"key":"10.1016\/j.lfs.2021.119731_bb0175","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1089\/ars.2005.7.425","article-title":"Essential roles of lipoxygenases in LDL oxidation and development of atherosclerosis","volume":"7","author":"Takahashi","year":"2005","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.lfs.2021.119731_bb0180","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/sj.bjp.0703127","article-title":"Decreased aortic glutathione levels may contribute to impaired nitric oxide-induced relaxation in hypercholesterolaemia","volume":"129","author":"Adachi","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119731_bb0185","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1111\/j.1582-4934.2009.00965.x","article-title":"Functional alterations of myeloid cell subsets in hyperlipidaemia: relevance for atherosclerosis","volume":"13","author":"Soehnlein","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.lfs.2021.119731_bb0190","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.clinbiochem.2009.01.010","article-title":"Association between ischemia-modified albumin, lipids and inflammation biomarkers in patients with hypercholesterolemia","volume":"42","author":"Duarte","year":"2009","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.lfs.2021.119731_bb0195","first-page":"27","article-title":"Hypoglycemic agents and potential anti-inflammatory activity","volume":"9","author":"Kothari","year":"2016","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.lfs.2021.119731_bb0200","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/jphp.12223","article-title":"Effects of sodium-glucose cotransporter 2 selective inhibitor ipragliflozin on hyperglycaemia, oxidative stress, inflammation and liver injury in streptozotocin-induced type 1 diabetic rats","volume":"66","author":"Tahara","year":"2014","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119731_bb0205","first-page":"2018","article-title":"Melatonin modulation of Sirtuin-1 attenuates liver injury in a hypercholesterolemic mouse model","volume":"7968452","author":"Bonomini","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.lfs.2021.119731_bb0210","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.atherosclerosis.2011.01.047","article-title":"Olmesartan severely weakened the development of NASH in an animal model of hypercholesterolemia","volume":"216","author":"Sturzeneker","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.lfs.2021.119731_bb0215","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.intimp.2015.01.027","article-title":"Beneficial effects of neomangiferin on high fat diet-induced nonalcoholic fatty liver disease in rats","volume":"25","author":"Zhou","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2021.119731_bb0220","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1872-034X.2008.00401.x","article-title":"Hepatic oxidant\/antioxidant status in cholesterol-fed rabbits: effects of garlic extract","volume":"39","author":"Arhan","year":"2009","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.lfs.2021.119731_bb0225","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1007\/s00125-013-3039-1","article-title":"Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trial","volume":"56","author":"Lavalle-Gonzalez","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.lfs.2021.119731_bb0230","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00535-017-1364-8","article-title":"Effects of canagliflozin, an SGLT2 inhibitor, on hepatic function in Japanese patients with type 2 diabetes mellitus: pooled and subgroup analyses of clinical trials","volume":"53","author":"Seko","year":"2018","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.lfs.2021.119731_bb0235","doi-asserted-by":"crossref","first-page":"16365","DOI":"10.1073\/pnas.1411086111","article-title":"C-Abl tyrosine kinase promotes adipocyte differentiation by targeting PPAR-gamma 2","volume":"111","author":"Keshet","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2021.119731_bb0240","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3748\/wjg.v10.i9.1329","article-title":"Peroxisome proliferator activated receptor-gamma in pathogenesis of experimental fatty liver disease","volume":"10","author":"Zhao","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2021.119731_bb0245","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/cvr\/21.1.34","article-title":"Effect of lipid feeding on endothelium dependent relaxation in rabbit aortic preparations","volume":"21","author":"Chappell","year":"1987","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2021.119731_bb0250","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1161\/01.CIR.94.3.498","article-title":"Effects of dietary L-arginine on atherosclerosis and endothelium-dependent vasodilatation in the hypercholesterolemic rabbit. Response according to treatment duration, anatomic site, and sex","volume":"94","author":"Jeremy","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2021.119731_bb0255","first-page":"C628","article-title":"Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells","volume":"266","author":"Kuchan","year":"1994","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.lfs.2021.119731_bb0260","doi-asserted-by":"crossref","first-page":"8745","DOI":"10.1073\/pnas.93.16.8745","article-title":"Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits","volume":"93","author":"White","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2021.119731_bb0265","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1161\/01.ATV.21.1.122","article-title":"Simvastatin preserves coronary endothelial function in hypercholesterolemia in the absence of lipid lowering","volume":"21","author":"Wilson","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.lfs.2021.119731_bb0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9150(96)05953-9","article-title":"The L-arginine-nitric oxide pathway: role in atherosclerosis and therapeutic implications","volume":"127","author":"Boger","year":"1996","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.lfs.2021.119731_bb0275","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1291\/hypres.26.273","article-title":"Effects of cholesterol-lowering therapy on pressor hyperreactivity to stress in hypercholesterolemic patients","volume":"26","author":"Minami","year":"2003","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.lfs.2021.119731_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2016.09.009","article-title":"Nitric oxide levels in patients with diabetes mellitus: a systematic review and meta-analysis","volume":"61","author":"Assmann","year":"2016","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.lfs.2021.119731_bb0285","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1161\/01.CIR.99.10.1355","article-title":"Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed","volume":"99","author":"Prasad","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2021.119731_bb0290","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/107424849700200409","article-title":"Prevention of hypercholesterolemic atherosclerosis by garlic, an antixoidant","volume":"2","author":"Prasad","year":"1997","journal-title":"J. Cardiovasc. Pharmacol. Ther."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521007177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521007177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:48:26Z","timestamp":1758401306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521007177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":58,"alternative-id":["S0024320521007177"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119731","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Canagliflozin ameliorates aortic and hepatic dysfunction in dietary-induced hypercholesterolemia in the rabbit","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119731","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119731"}}