{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:19:53Z","timestamp":1792217993561,"version":"4.4.0"},"reference-count":96,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"am","delay-in-days":304,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.lfs.2021.119765","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T10:48:56Z","timestamp":1624704536000},"page":"119765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Epigenetic histone acetylation and Bdnf dysregulation in the hippocampus of rats exposed to repeated, low-dose diisopropylfluorophosphate"],"prefix":"10.1016","volume":"281","author":[{"given":"Ana C.R.","family":"Ribeiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fay M.","family":"Jahr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad M.","family":"Kronfol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabha M.","family":"Younis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L.","family":"McClay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laxmikant S.","family":"Deshpande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2021.119765_bb0005","series-title":"Gulf War and Health: Volume 10: Update of Health Effects of Serving in the Gulf War","year":"2016"},{"issue":"1","key":"10.1016\/j.lfs.2021.119765_bb0010","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1038\/s41598-021-82535-3","article-title":"Resolving whether inhalation of depleted uranium contributed to Gulf War Illness using high-sensitivity mass spectrometry","volume":"11","author":"Parrish","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2021.119765_bb0015","first-page":"107716","article-title":"Gulf War illness: mechanisms underlying brain dysfunction and promising therapeutic strategies","author":"Dickey","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2021.119765_bb0020","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbi.2017.08.003","article-title":"Corticosterone potentiates DFP-induced neuroinflammation and affects high-order diffusion imaging in a rat model of Gulf War Illness","volume":"67","author":"Koo","year":"2018","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.lfs.2021.119765_bb0025","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/jnc.13088","article-title":"Corticosterone primes the neuroinflammatory response to DFP in mice: potential animal model of Gulf War illness","volume":"133","author":"O'Callaghan","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.lfs.2021.119765_bb0030","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neuro.2015.04.005","article-title":"Effects of low-level sarin and cyclosarin exposure on white matter integrity in Gulf War Veterans","volume":"48","author":"Chao","year":"2015","journal-title":"Neurotoxicology"},{"issue":"2","key":"10.1016\/j.lfs.2021.119765_bb0035","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/neup.12061","article-title":"Exposure to an organophosphate pesticide, individually or in combination with other Gulf War agents, impairs synaptic integrity and neuronal differentiation, and is accompanied by subtle microvascular injury in a mouse model of Gulf War agent exposure","volume":"34","author":"Ojo","year":"2014","journal-title":"Neuropathology"},{"issue":"2","key":"10.1016\/j.lfs.2021.119765_bb0040","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1471-4159.2011.07428.x","article-title":"Organophosphates dysregulate dopamine signaling, glutamatergic neurotransmission, and induce neuronal injury markers in striatum","volume":"119","author":"Torres-Altoro","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.lfs.2021.119765_bb0045","doi-asserted-by":"crossref","DOI":"10.1177\/2633105520979841","article-title":"Calcium hypothesis of Gulf War Illness: role of calcium ions in neurological morbidities in a DFP-based rat model for Gulf War illness","volume":"15","author":"Phillips","year":"2020","journal-title":"Neurosci Insights"},{"key":"10.1016\/j.lfs.2021.119765_bb0050","doi-asserted-by":"crossref","first-page":"704","DOI":"10.3389\/fpsyt.2020.00704","article-title":"The innate immune system and inflammatory priming: potential mechanistic factors in mood disorders and Gulf War illness","volume":"11","author":"Trageser","year":"2020","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.lfs.2021.119765_bb0055","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neuro.2020.06.008","article-title":"Neurotoxicity in Gulf War Illness and the potential role of glutamate","volume":"80","author":"Joyce","year":"2020","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.lfs.2021.119765_bb0060","doi-asserted-by":"crossref","first-page":"108073","DOI":"10.1016\/j.neuropharm.2020.108073","article-title":"Acetylcholinesterase inhibitor exposures as an initiating factor in the development of Gulf War Illness, a chronic neuroimmune disorder in deployed veterans","volume":"171","author":"Michalovicz","year":"2020","journal-title":"Neuropharmacology"},{"issue":"19","key":"10.1016\/j.lfs.2021.119765_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16193751","article-title":"The Gut-Microbiome in Gulf War Veterans: a preliminary report","volume":"16","author":"Janulewicz","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"2","key":"10.1016\/j.lfs.2021.119765_bb0070","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/MOP.0b013e32832925cc","article-title":"Epigenetics and environmental chemicals","volume":"21","author":"Baccarelli","year":"2009","journal-title":"Curr. Opin. Pediatr."},{"issue":"1","key":"10.1016\/j.lfs.2021.119765_bb0075","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/jech.2010.130690","article-title":"Epigenetics and environmental exposures","volume":"66","author":"Stein","year":"2012","journal-title":"J. Epidemiol. Community Health"},{"issue":"10","key":"10.1016\/j.lfs.2021.119765_bb0080","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1007\/s00439-012-1189-8","article-title":"Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships","volume":"131","author":"Cortessis","year":"2012","journal-title":"Hum. Genet."},{"issue":"7143","key":"10.1016\/j.lfs.2021.119765_bb0085","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature05919","article-title":"Phenotypic plasticity and the epigenetics of human disease","volume":"447","author":"Feinberg","year":"2007","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.lfs.2021.119765_bb0090","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.arr.2009.03.004","article-title":"The role of epigenetics in aging and age-related diseases","volume":"8","author":"Calvanese","year":"2009","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.lfs.2021.119765_bb0095","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev-pharmtox-061008-103102","article-title":"Epigenetics, DNA methylation, and chromatin modifying drugs","volume":"49","author":"Szyf","year":"2009","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"2","key":"10.1016\/j.lfs.2021.119765_bb0100","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1152\/physrev.00012.2010","article-title":"Epigenetic regulation of gene expression in physiological and pathological brain processes","volume":"91","author":"Graff","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.lfs.2021.119765_bb0105","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neuro.2016.05.007","article-title":"Long-term epigenetic alterations in a rat model of Gulf War illness","volume":"55","author":"Pierce","year":"2016","journal-title":"Neurotoxicology"},{"issue":"1","key":"10.1016\/j.lfs.2021.119765_bb0110","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12974-018-1113-9","article-title":"Epigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illness","volume":"15","author":"Ashbrook","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"6","key":"10.1016\/j.lfs.2021.119765_bb0115","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1089\/dna.2018.4469","article-title":"Alterations in DNA Methylation Status Associated with Gulf War illness","volume":"38","author":"Trivedi","year":"2019","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.lfs.2021.119765_bb0120","first-page":"58","article-title":"Epigenetic mechanisms in neurological and neurodegenerative diseases","volume":"9","author":"Landgrave-Gomez","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"11","key":"10.1016\/j.lfs.2021.119765_bb0125","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.tins.2009.06.002","article-title":"Multiple roles of HDAC inhibition in neurodegenerative conditions","volume":"32","author":"Chuang","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.lfs.2021.119765_bb0130","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fncel.2020.00082","article-title":"The role of BDNF on neural plasticity in depression","volume":"14","author":"Yang","year":"2020","journal-title":"Front. Cell. Neurosci."},{"issue":"Pt C","key":"10.1016\/j.lfs.2021.119765_bb0135","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.neuropharm.2013.04.002","article-title":"Role of BDNF epigenetics in activity-dependent neuronal plasticity","volume":"76","author":"Karpova","year":"2014","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.lfs.2021.119765_bb0140","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainresrev.2008.07.007","article-title":"New insights into brain BDNF function in normal aging and Alzheimer disease","volume":"59","author":"Tapia-Arancibia","year":"2008","journal-title":"Brain Res. Rev."},{"issue":"3","key":"10.1016\/j.lfs.2021.119765_bb0145","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.pneurobio.2011.05.003","article-title":"Mechanisms of specificity in neuronal activity-regulated gene transcription","volume":"94","author":"Lyons","year":"2011","journal-title":"Prog. Neurobiol."},{"issue":"7","key":"10.1016\/j.lfs.2021.119765_bb0150","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/j.1601-183X.2010.00605.x","article-title":"Lack of promoter IV-driven BDNF transcription results in depression-like behavior","volume":"9","author":"Sakata","year":"2010","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.lfs.2021.119765_bb0155","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.neuroscience.2013.12.013","article-title":"Lack of BDNF expression through promoter IV disturbs expression of monoamine genes in the frontal cortex and hippocampus","volume":"260","author":"Sakata","year":"2014","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.lfs.2021.119765_bb0160","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4161\/epi.27558","article-title":"Prenatal stress decreases Bdnf expression and increases methylation of Bdnf exon IV in rats","volume":"9","author":"Boersma","year":"2014","journal-title":"Epigenetics"},{"key":"10.1016\/j.lfs.2021.119765_bb0165","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neuro.2020.06.011","article-title":"Molecular mechanisms for the antidepressant-like effects of a low-dose ketamine treatment in a DFP-based rat model for Gulf War illness","volume":"80","author":"Ribeiro","year":"2020","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.lfs.2021.119765_bb0170","doi-asserted-by":"crossref","DOI":"10.1177\/2633105520942480","article-title":"Host Akkermansia muciniphila abundance correlates with Gulf War illness symptom persistence via NLRP3-mediated neuroinflammation and decreased brain-derived neurotrophic factor","volume":"15","author":"Kimono","year":"2020","journal-title":"Neurosci. Insights"},{"issue":"suppl_1","key":"10.1016\/j.lfs.2021.119765_bb0175","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/milmed\/usx148","article-title":"Chronic neurological morbidities and elevated hippocampal calcium levels in a DFP-based rat model of Gulf War illness","volume":"183","author":"Phillips","year":"2018","journal-title":"Mil. Med."},{"key":"10.1016\/j.lfs.2021.119765_bb0180","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neuro.2015.11.014","article-title":"Repeated low-dose organophosphate DFP exposure leads to the development of depression and cognitive impairment in a rat model of Gulf War Illness","volume":"52","author":"Phillips","year":"2016","journal-title":"Neurotoxicology"},{"issue":"2","key":"10.1016\/j.lfs.2021.119765_bb0185","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/toxsci\/kfz070","article-title":"Targeting intracellular calcium stores alleviates neurological morbidities in a DFP-based rat model of Gulf War illness","volume":"169","author":"Phillips","year":"2019","journal-title":"Toxicol. Sci."},{"issue":"13","key":"10.1016\/j.lfs.2021.119765_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17134710","article-title":"Assessment of ketamine and its enantiomers in an organophosphate-based rat model for features of Gulf War illness","volume":"17","author":"Zhu","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"16","key":"10.1016\/j.lfs.2021.119765_bb0195","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2217\/pgs-2016-0113","article-title":"Pharmacogenomics and histone deacetylase inhibitors","volume":"17","author":"Goey","year":"2016","journal-title":"Pharmacogenomics"},{"issue":"39","key":"10.1016\/j.lfs.2021.119765_bb0200","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.lfs.2021.119765_bb0205","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2174\/138920007780655397","article-title":"Histone deacetylase inhibitors: molecular and biological activity as a premise to clinical application","volume":"8","author":"Santini","year":"2007","journal-title":"Curr. Drug Metab."},{"issue":"2","key":"10.1016\/j.lfs.2021.119765_bb0210","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1042\/BST20130233","article-title":"HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand?","volume":"42","author":"Whittle","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.lfs.2021.119765_bb0215","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.neuropharm.2016.02.009","article-title":"Early life stress increases stress vulnerability through BDNF gene epigenetic changes in the rat hippocampus","volume":"105","author":"Seo","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lfs.2021.119765_bb0220","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-1-4939-7380-4_3","article-title":"How to combine ChIP with qPCR","volume":"1689","author":"Asp","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"2","key":"10.1016\/j.lfs.2021.119765_bb0225","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in rodents","volume":"2","author":"Walf","year":"2007","journal-title":"Nat. Protocols"},{"issue":"6","key":"10.1016\/j.lfs.2021.119765_bb0230","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nprot.2012.044","article-title":"Using the rat forced swim test to assess antidepressant-like activity in rodents","volume":"7","author":"Slattery","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.lfs.2021.119765_bb0235","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-1-61779-458-2_7","article-title":"Modeling depression in animal models","volume":"829","author":"Overstreet","year":"2012","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.lfs.2021.119765_bb0240","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/sj.mp.4002099","article-title":"The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons","volume":"14","author":"Yasuda","year":"2009","journal-title":"Mol. Psychiatry"},{"issue":"11","key":"10.1016\/j.lfs.2021.119765_bb0245","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrm3890","article-title":"Histone core modifications regulating nucleosome structure and dynamics","volume":"15","author":"Tessarz","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.lfs.2021.119765_bb0250","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.tox.2013.01.017","article-title":"Epigenetics and pesticides","volume":"307","author":"Collotta","year":"2013","journal-title":"Toxicology"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2021.119765_bb0255","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1515\/reveh-2016-0032","article-title":"Future of environmental research in the age of epigenomics and exposomics","volume":"32","author":"Holland","year":"2017","journal-title":"Rev. Environ. Health"},{"issue":"Pt 1","key":"10.1016\/j.lfs.2021.119765_bb0260","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1242\/jeb.106971","article-title":"Influence of environmental exposure on human epigenetic regulation","volume":"218","author":"Marsit","year":"2015","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.lfs.2021.119765_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2013.10.028","article-title":"Epigenetics and depression: return of the repressed","volume":"155","author":"Dalton","year":"2014","journal-title":"J. Affect. Disord."},{"issue":"5","key":"10.1016\/j.lfs.2021.119765_bb0270","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrn2132","article-title":"Epigenetic regulation in psychiatric disorders","volume":"8","author":"Tsankova","year":"2007","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"10.1016\/j.lfs.2021.119765_bb0275","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/cpt.345","article-title":"Epigenetics and addiction","volume":"99","author":"Cadet","year":"2016","journal-title":"Clin. Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.lfs.2021.119765_bb0280","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/clpt.2011.282","article-title":"The epigenetic code in depression: implications for treatment","volume":"91","author":"Schroeder","year":"2012","journal-title":"Clin. Pharmacol. Ther."},{"issue":"12","key":"10.1016\/j.lfs.2021.119765_bb0285","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.molmed.2013.08.006","article-title":"Common non-epigenetic drugs as epigenetic modulators","volume":"19","author":"Lotsch","year":"2013","journal-title":"Trends Mol. Med."},{"issue":"3","key":"10.1016\/j.lfs.2021.119765_bb0290","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00441-014-1835-7","article-title":"Crafting the brain - role of histone acetyltransferases in neural development and disease","volume":"356","author":"Sheikh","year":"2014","journal-title":"Cell Tissue Res."},{"issue":"2\u20133","key":"10.1016\/j.lfs.2021.119765_bb0295","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1387\/ijdb.082649rb","article-title":"Histone deacetylase HDAC1\/HDAC2-controlled embryonic development and cell differentiation","volume":"53","author":"Brunmeir","year":"2009","journal-title":"Int J Dev Biol"},{"issue":"4\u20136","key":"10.1016\/j.lfs.2021.119765_bb0300","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1387\/ijdb.150071tz","article-title":"Histone deacetylases 1 and 2 are required for brain development","volume":"59","author":"Jaworska","year":"2015","journal-title":"Int J Dev Biol"},{"issue":"3","key":"10.1016\/j.lfs.2021.119765_bb0305","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1042\/BST20130010","article-title":"The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts","volume":"41","author":"Kelly","year":"2013","journal-title":"Biochem. Soc. Trans."},{"issue":"2","key":"10.1016\/j.lfs.2021.119765_bb0310","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1080\/15592294.2016.1146850","article-title":"Gestational stress induces depressive-like and anxiety-like phenotypes through epigenetic regulation of BDNF expression in offspring hippocampus","volume":"11","author":"Zheng","year":"2016","journal-title":"Epigenetics"},{"issue":"6","key":"10.1016\/j.lfs.2021.119765_bb0315","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1073\/pnas.1914655117","article-title":"Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression","volume":"117","author":"Dudek","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.lfs.2021.119765_bb0320","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12974-021-02091-5","article-title":"Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression","volume":"18","author":"Li","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"16","key":"10.1016\/j.lfs.2021.119765_bb0325","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1097\/WNR.0000000000000879","article-title":"Abnormal modification of histone acetylation involved in depression-like behaviors of rats induced by chronically unpredicted stress","volume":"28","author":"Li","year":"2017","journal-title":"Neuroreport"},{"issue":"11","key":"10.1016\/j.lfs.2021.119765_bb0330","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1016\/j.euroneuro.2015.08.016","article-title":"Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity","volume":"25","author":"Erburu","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"51","key":"10.1016\/j.lfs.2021.119765_bb0335","doi-asserted-by":"crossref","first-page":"15755","DOI":"10.1073\/pnas.1513913112","article-title":"Ketamine produces antidepressant-like effects through phosphorylation-dependent nuclear export of histone deacetylase 5 (HDAC5) in rats","volume":"112","author":"Choi","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.lfs.2021.119765_bb0340","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neulet.2011.02.022","article-title":"Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition","volume":"493","author":"Covington","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.lfs.2021.119765_bb0345","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nn1659","article-title":"Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action","volume":"9","author":"Tsankova","year":"2006","journal-title":"Nat. Neurosci."},{"issue":"5","key":"10.1016\/j.lfs.2021.119765_bb0350","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jpsychires.2009.08.015","article-title":"Altered gene expression of histone deacetylases in mood disorder patients","volume":"44","author":"Hobara","year":"2010","journal-title":"J. Psychiatr. Res."},{"issue":"4","key":"10.1016\/j.lfs.2021.119765_bb0355","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/jcb.20591","article-title":"Histone acetylase inhibitor trichostatin a induces acetylcholinesterase expression and protects against organophosphate exposure","volume":"96","author":"Curtin","year":"2005","journal-title":"J. Cell. Biochem."},{"issue":"7","key":"10.1016\/j.lfs.2021.119765_bb0360","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/tra.12489","article-title":"Pharmacologically increasing microtubule acetylation corrects stress-exacerbated effects of organophosphates on neurons","volume":"18","author":"Rao","year":"2017","journal-title":"Traffic"},{"issue":"6","key":"10.1016\/j.lfs.2021.119765_bb0365","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/s41593-020-0634-6","article-title":"Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression","volume":"23","author":"Beagan","year":"2020","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.lfs.2021.119765_bb0370","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/aps.2010.184","article-title":"The role of BDNF in depression on the basis of its location in the neural circuitry","volume":"32","author":"Yu","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"issue":"4","key":"10.1016\/j.lfs.2021.119765_bb0375","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000319946","article-title":"Associations between brain-derived neurotrophic factor plasma levels and severity of the illness, recurrence and symptoms in depressed patients","volume":"62","author":"Dell'Osso","year":"2010","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.lfs.2021.119765_bb0380","doi-asserted-by":"crossref","first-page":"107136","DOI":"10.1016\/j.nlm.2019.107136","article-title":"Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain-derived neurotrophic factor (BDNF) expression level in the hippocampus","volume":"167","author":"Wu","year":"2020","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.lfs.2021.119765_bb0385","doi-asserted-by":"crossref","first-page":"7260130","DOI":"10.1155\/2017\/7260130","article-title":"Brain-derived neurotrophic factor, depression, and physical activity: making the neuroplastic connection","volume":"2017","author":"Phillips","year":"2017","journal-title":"Neural Plast."},{"key":"10.1016\/j.lfs.2021.119765_bb0390","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jad.2014.11.044","article-title":"BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis","volume":"174","author":"Polyakova","year":"2015","journal-title":"J. Affect. Disord."},{"issue":"3","key":"10.1016\/j.lfs.2021.119765_bb0395","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/S1461145710000738","article-title":"Blood BDNF concentrations reflect brain-tissue BDNF levels across species","volume":"14","author":"Klein","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"15","key":"10.1016\/j.lfs.2021.119765_bb0400","doi-asserted-by":"crossref","first-page":"5368","DOI":"10.1523\/JNEUROSCI.6251-09.2010","article-title":"Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume","volume":"30","author":"Erickson","year":"2010","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.lfs.2021.119765_bb0405","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.cell.2021.01.034","article-title":"Antidepressant drugs act by directly binding to TRKB neurotrophin receptors","volume":"184","author":"Casarotto","year":"2021","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.lfs.2021.119765_bb0410","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1089\/rej.2012.1312","article-title":"Epigenetic-mediated decline in synaptic plasticity during aging","volume":"15","author":"Mendelsohn","year":"2012","journal-title":"Rejuvenation Res."},{"issue":"7","key":"10.1016\/j.lfs.2021.119765_bb0415","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1002\/hipo.20990","article-title":"HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons","volume":"22","author":"Calfa","year":"2012","journal-title":"Hippocampus"},{"issue":"42","key":"10.1016\/j.lfs.2021.119765_bb0420","doi-asserted-by":"crossref","first-page":"10576","DOI":"10.1523\/JNEUROSCI.1786-08.2008","article-title":"Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory","volume":"28","author":"Lubin","year":"2008","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.lfs.2021.119765_bb0425","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/toxsci\/kfr253","article-title":"Delayed reduction of hippocampal synaptic transmission and spines following exposure to repeated subclinical doses of organophosphorus pesticide in adult mice","volume":"125","author":"Speed","year":"2012","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.lfs.2021.119765_bb0430","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1527-3458.2003.tb00249.x","article-title":"Valproate: past, present, and future","volume":"9","author":"Johannessen","year":"2003","journal-title":"CNS Drug Rev"},{"issue":"16","key":"10.1016\/j.lfs.2021.119765_bb0435","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1007\/s00018-007-7079-x","article-title":"The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees?","volume":"64","author":"Rosenberg","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"issue":"Suppl 2","key":"10.1016\/j.lfs.2021.119765_bb0440","first-page":"17","article-title":"Pharmacology of valproate","volume":"37","author":"Owens","year":"2003","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.lfs.2021.119765_bb0445","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbr.2017.04.015","article-title":"Antidepressant-like effect of valproic acid-possible involvement of PI3K\/Akt\/mTOR pathway","volume":"329","author":"Lima","year":"2017","journal-title":"Behav. Brain Res."},{"issue":"7","key":"10.1016\/j.lfs.2021.119765_bb0450","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.pnpbp.2007.06.014","article-title":"Cytoskeleton of hippocampal neurons as a target for valproic acid in an experimental model of depression","volume":"31","author":"Ferrero","year":"2007","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"6","key":"10.1016\/j.lfs.2021.119765_bb0455","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1089\/jwh.2019.7705","article-title":"Prevalence and patterns of symptoms among female veterans of the 1991 Gulf War Era: 25 years later","volume":"29","author":"Sullivan","year":"2020","journal-title":"J. Women's Health (Larchmt)"},{"key":"10.1016\/j.lfs.2021.119765_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119623","article-title":"Neurotoxicant exposures and rates of chronic multisymptom illness and Kansas Gulf War illness criteria in gulf war deployed women veterans","author":"Krengel","year":"2021","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.lfs.2021.119765_bb0465","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1148\/radiol.11101715","article-title":"Hippocampal dysfunction in Gulf War veterans: investigation with ASL perfusion MR imaging and physostigmine challenge","volume":"261","author":"Li","year":"2011","journal-title":"Radiology"},{"issue":"5","key":"10.1016\/j.lfs.2021.119765_bb0470","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.neuro.2010.05.006","article-title":"Effects of low-level exposure to sarin and cyclosarin during the 1991 Gulf War on brain function and brain structure in US veterans","volume":"31","author":"Chao","year":"2010","journal-title":"Neurotoxicology"},{"issue":"19","key":"10.1016\/j.lfs.2021.119765_bb0475","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17197081","article-title":"Assessing the beneficial effects of the immunomodulatory glycan LNFPIII on gut microbiota and health in a mouse model of Gulf War illness","volume":"17","author":"Mote","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"3","key":"10.1016\/j.lfs.2021.119765_bb0480","doi-asserted-by":"crossref","first-page":"e0172914","DOI":"10.1371\/journal.pone.0172914","article-title":"Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation","volume":"12","author":"Alhasson","year":"2017","journal-title":"PLoS One"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521007517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521007517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:50:40Z","timestamp":1758401440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521007517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":96,"alternative-id":["S0024320521007517"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119765","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic histone acetylation and Bdnf dysregulation in the hippocampus of rats exposed to repeated, low-dose diisopropylfluorophosphate","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119765","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119765"}}