{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:14:40Z","timestamp":1791346480306,"version":"4.3.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"am","delay-in-days":300,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K16797"],"award-info":[{"award-number":["17K16797"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K09673"],"award-info":[{"award-number":["19K09673"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.lfs.2021.119855","type":"journal-article","created":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T10:26:49Z","timestamp":1627122409000},"page":"119855","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Aging-related severe hypertension induces detrusor underactivity in rats"],"prefix":"10.1016","volume":"283","author":[{"given":"Shogo","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kurabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youichirou","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Karashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoaki","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1016\/j.lfs.2021.119855_bb0005","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1007\/s11255-014-0808-9","article-title":"Pathophysiology and animal modeling of underactive bladder","volume":"46","author":"Tyagi","year":"2014","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.lfs.2021.119855_bb0010","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.4111\/icu.2017.58.S2.S82","article-title":"Pathophysiology of the underactive bladder","volume":"58","author":"Aizawa","year":"2017","journal-title":"Investig. Clin. Urol."},{"key":"10.1016\/j.lfs.2021.119855_bb0015","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ajur.2017.02.003","article-title":"Underactive bladder: pathophysiology and clinical significance","volume":"5","author":"Aldamanhori","year":"2018","journal-title":"Asian J. Urol."},{"key":"10.1016\/j.lfs.2021.119855_bb0020","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.eururo.2013.10.015","article-title":"Detrusor underactivity and the underactive bladder: a new clinical entity? A review of current terminology, definitions, epidemiology, aetiology, and diagnosis","volume":"65","author":"Osman","year":"2014","journal-title":"Eur. Urol."},{"key":"10.1016\/j.lfs.2021.119855_bb0025","doi-asserted-by":"crossref","first-page":"401","DOI":"10.5152\/tud.2019.37659","article-title":"Underactive bladder: a review of the current treatment concepts","volume":"45","author":"Bayrak","year":"2019","journal-title":"Turk. J. Urol."},{"key":"10.1016\/j.lfs.2021.119855_bb0030","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/nau.21213","article-title":"Nicorandil ameliorates hypertension-related bladder dysfunction in the rat","volume":"31","author":"Saito","year":"2012","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.lfs.2021.119855_bb0035","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1002\/nau.23550","article-title":"Bladder overdistension with polyuria in a hypertensive rat model","volume":"37","author":"Velasquez Flores","year":"2018","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.lfs.2021.119855_bb0040","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.arr.2009.07.002","article-title":"Endothelial dysfunction and aging: an update","volume":"9","author":"Herrera","year":"2010","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.lfs.2021.119855_bb0045","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1046\/j.1523-1755.2002.00516.x","article-title":"Association of renal injury with nitric oxide deficiency in aged SHR: prevention by hypertension control with AT1 blockade","volume":"62","author":"Zhou","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2021.119855_bb0050","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jphs.2016.09.002","article-title":"Effect of naftopidil on brain noradrenaline-induced decrease in arginine-vasopressin secretion in rats","volume":"132","author":"Yamamoto","year":"2016","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.lfs.2021.119855_bb0055","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/nau.22405","article-title":"Olmesartan ameliorates urinary dysfunction in the spontaneously hypertensive rat via recovering bladder blood flow and decreasing oxidative stress","volume":"33","author":"Shimizu","year":"2014","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.lfs.2021.119855_bb0060","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1111\/bph.14439","article-title":"Angiotensin II, a stress-related neuropeptide in the CNS, facilitates micturition reflex in rats","volume":"175","author":"Shimizu","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119855_bb0065","doi-asserted-by":"crossref","first-page":"E86","DOI":"10.1111\/bju.14649","article-title":"Functional and molecular characterisation of the bilateral pelvic nerve crush injury rat model for neurogenic detrusor underactivity","volume":"123","author":"Dewulf","year":"2019","journal-title":"BJU Int."},{"key":"10.1016\/j.lfs.2021.119855_bb0070","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1476-5381.2011.01231.x","article-title":"Nicorandil ameliorates ischaemia-reperfusion injury in the rat kidney","volume":"163","author":"Shimizu","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119855_bb0075","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2217\/bmm.13.106","article-title":"Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats","volume":"8","author":"Zhang","year":"2014","journal-title":"Biomark. Med"},{"key":"10.1016\/j.lfs.2021.119855_bb0080","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1681\/ASN.V125900","article-title":"Role of the increase in p21 in cisplatin-induced acute renal failure in rats","volume":"12","author":"Miyaji","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.lfs.2021.119855_bb0085","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1161\/01.CIR.91.1.161","article-title":"Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat","volume":"91","author":"Conrad","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2021.119855_bb0090","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1161\/01.CIR.98.19.2074","article-title":"Postinfarction survival and inducibility of ventricular arrhythmias in the spontaneously hypertensive rat : effects of ramipril and hydralazine","volume":"98","author":"Nguyen","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2021.119855_bb0095","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/S0022-5347(05)68236-5","article-title":"Overactivity and structural changes in the chronically ischemic bladder","volume":"162","author":"Azadzoi","year":"1999","journal-title":"J. Urol."},{"key":"10.1016\/j.lfs.2021.119855_bb0100","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.juro.2013.10.097","article-title":"Progressive vascular damage may lead to bladder underactivity in rats","volume":"191","author":"Nomiya","year":"2014","journal-title":"J. Urol."},{"key":"10.1016\/j.lfs.2021.119855_bb0105","doi-asserted-by":"crossref","first-page":"16328","DOI":"10.1038\/s41598-019-52811-4","article-title":"Induction of detrusor underactivity by extensive vascular endothelial damages of iliac arteries in a rat model and its pathophysiology in the genetic levels","volume":"9","author":"Kim","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2021.119855_bb0110","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4111\/icu.2016.57.4.249","article-title":"Progressive changes in detrusor function and micturition patterns with chronic bladder ischemia","volume":"57","author":"Zhao","year":"2016","journal-title":"Investig. Clin. Urol."},{"key":"10.1016\/j.lfs.2021.119855_bb0115","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1002\/nau.20843","article-title":"The effects of chronic hyperlipidemia on bladder function in myocardial infarction-prone watanabe heritable hyperlipidemic (WHHLMI) rabbits","volume":"29","author":"Yoshida","year":"2010","journal-title":"Neurourol. Urodyn."},{"issue":"Suppl 1","key":"10.1016\/j.lfs.2021.119855_bb0120","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1757-5672.2011.00138.x","article-title":"Effects of chronic hyperlipidemia on lower urinary tract function-bladder dysfunction in myocardial infarction-prone watanabe heritable hyperlipidemic rabbits","volume":"4","author":"Yoshida","year":"2012","journal-title":"Low Urin Tract Symptoms."},{"key":"10.1016\/j.lfs.2021.119855_bb0125","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.lfs.2014.10.016","article-title":"The urinary bladder of spontaneously hypertensive rat demonstrates bladder hypertrophy, inflammation, and fibrosis but not hyperplasia","volume":"121","author":"Shen","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2021.119855_bb0130","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.juro.2012.08.222","article-title":"Roles of polyuria and hyperglycemia in bladder dysfunction in diabetes","volume":"189","author":"Xiao","year":"2013","journal-title":"J. Urol."},{"key":"10.1016\/j.lfs.2021.119855_bb0135","doi-asserted-by":"crossref","first-page":"F665","DOI":"10.1152\/ajprenal.00226.2004","article-title":"Glomerular and tubular damage in normotensive and hypertensive rats","volume":"288","author":"Ofstad","year":"2005","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.lfs.2021.119855_bb0140","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1530\/EJE-20-0114","article-title":"GENETICS IN ENDOCRINOLOGY pathophysiology, diagnosis and treatment of familial nephrogenic diabetes insipidus","volume":"183","author":"Bichet","year":"2020","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.lfs.2021.119855_bb0145","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s002400000135","article-title":"Altered neural control of micturition in the aged F344 rat","volume":"28","author":"Chai","year":"2000","journal-title":"Urol. Res."},{"key":"10.1016\/j.lfs.2021.119855_bb0150","doi-asserted-by":"crossref","first-page":"R1287","DOI":"10.1152\/ajpregu.00499.2001","article-title":"Age-related changes in urethrovesical coordination in male rats: relationship with bladder instability?","volume":"284","author":"Lluel","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.lfs.2021.119855_bb0155","doi-asserted-by":"crossref","first-page":"F390","DOI":"10.1152\/ajprenal.00574.2012","article-title":"Effects of urethane on reflex activity of lower urinary tract in decerebrate unanesthetized rats","volume":"304","author":"Yoshiyama","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521008420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521008420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:48:50Z","timestamp":1758401330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521008420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":31,"alternative-id":["S0024320521008420"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119855","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aging-related severe hypertension induces detrusor underactivity in rats","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119855","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119855"}}