{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:08:37Z","timestamp":1786993717453,"version":"build-2736575974"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT170100431"],"award-info":[{"award-number":["FT170100431"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1066916"],"award-info":[{"award-number":["APP1066916"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-148712"],"award-info":[{"award-number":["PJT-148712"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.lfs.2021.120016","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T12:28:42Z","timestamp":1633350522000},"page":"120016","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Intrauterine growth restriction alters the activity of drug metabolising enzymes in the maternal-placental-fetal unit"],"prefix":"10.1016","volume":"285","author":[{"given":"Grace M.","family":"McBride","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley S.","family":"Meakin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Yin","family":"Soo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack R.T.","family":"Darby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara J.","family":"Varcoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L.","family":"Bradshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell C.","family":"Lock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey L.","family":"Holman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brahmdeep S.","family":"Saini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K.","family":"Macgowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Seed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary J.","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Wiese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janna L.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.lfs.2021.120016_bb0005","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-004365","article-title":"Medication use in pregnancy: a cross-sectional, multinational web-based study","volume":"4","author":"Lupattelli","year":"2014","journal-title":"BMJ Open"},{"issue":"7","key":"10.1016\/j.lfs.2021.120016_bb0010","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1053\/j.semperi.2015.08.002","article-title":"Epidemiology of medications use in pregnancy","volume":"39","author":"Ayad","year":"2015","journal-title":"Semin. Perinatol."},{"issue":"3","key":"10.1016\/j.lfs.2021.120016_bb0015","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/ajmg.c.30309","article-title":"We don't know what we don't study: the case for research on medication effects in pregnancy","volume":"157C","author":"Parisi","year":"2011","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.lfs.2021.120016_bb0020","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.phrs.2018.02.001","article-title":"Does poor fetal growth influence the extent of fetal exposure to maternal medications?","volume":"130","author":"Soo","year":"2018","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.lfs.2021.120016_bb0025","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1113\/JP271402","article-title":"The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome","volume":"594","author":"Miller","year":"2016","journal-title":"J. Physiol."},{"issue":"5","key":"10.1016\/j.lfs.2021.120016_bb0030","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11892-016-0732-8","article-title":"Diagnosis and management of IUGR in pregnancy complicated by type 1 diabetes mellitus","volume":"16","author":"Gutaj","year":"2016","journal-title":"Curr. Diabetes Rep."},{"issue":"9","key":"10.1016\/j.lfs.2021.120016_bb0035","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.placenta.2014.06.375","article-title":"Placental pathology in early intrauterine growth restriction associated with maternal hypertension","volume":"35","author":"Veerbeek","year":"2014","journal-title":"Placenta"},{"issue":"8663","key":"10.1016\/j.lfs.2021.120016_bb0040","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0140-6736(89)90710-1","article-title":"Weight in infancy and death from ischaemic heart disease","volume":"2","author":"Barker","year":"1989","journal-title":"Lancet (London, England)"},{"issue":"6","key":"10.1016\/j.lfs.2021.120016_bb0045","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1471-0528.2000.tb13336.x","article-title":"The relationship between intrauterine growth restriction and preterm delivery: an empirical approach using data from a european case-control study","volume":"107","author":"Zeitlin","year":"2000","journal-title":"Brit J Obstet Gynaec"},{"issue":"6","key":"10.1016\/j.lfs.2021.120016_bb0050","first-page":"158","volume":"41","author":"Calkins","year":"2011","journal-title":"Curr Probl Pediatr AdolescHealth Care"},{"key":"10.1016\/j.lfs.2021.120016_bb0055","first-page":"67","article-title":"Intrauterine growth restriction: antenatal and postnatal aspects, clinical medicine insights","volume":"10","author":"Sharma","year":"2016","journal-title":"Pediatrics"},{"issue":"12","key":"10.1016\/j.lfs.2021.120016_bb0060","doi-asserted-by":"crossref","first-page":"e552","DOI":"10.1111\/apa.13220","article-title":"Impact of intrauterine growth restriction on preterm lung disease","volume":"104","author":"Sasi","year":"2015","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.lfs.2021.120016_bb0065","series-title":"Clinical Practice Guidelines","first-page":"1","article-title":"Antenatal corticosteroids given to women prior to birth to improve fetal, infant, child and adult health","author":"Antenatal Corticosteroid Clinical Practice Guidelines Panel","year":"2015"},{"key":"10.1016\/j.lfs.2021.120016_bb0070","series-title":"Standards of Maternity Care in Australia and New Zealand, RANZCOG Publications, Victoria, Australia","year":"2016"},{"issue":"15","key":"10.1016\/j.lfs.2021.120016_bb0075","doi-asserted-by":"crossref","first-page":"5055","DOI":"10.1113\/JP274444","article-title":"Stress during pregnancy and its life-long consequences for the infant","volume":"595","author":"Fowden","year":"2017","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.lfs.2021.120016_bb0080","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJMra0708473","article-title":"Effect of in utero and early-life conditions on adult health and disease","volume":"359","author":"Gluckman","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.lfs.2021.120016_bb0085","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1152\/physrev.00053.2003","article-title":"Developmental origins of the metabolic syndrome: prediction, plasticity, and programming","volume":"85","author":"McMillen","year":"2005","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.lfs.2021.120016_bb0090","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","article-title":"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation","volume":"138","author":"Zanger","year":"2013","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.lfs.2021.120016_bb0095","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2174\/138920006776359329","article-title":"A literature review of enzyme kinetic parameters for CYP3A4-mediated metabolic reactions of 113 drugs in human liver microsomes: structure- kinetics relationship assessment","volume":"7","author":"Bu","year":"2006","journal-title":"Curr. Drug Metab."},{"issue":"4","key":"10.1016\/j.lfs.2021.120016_bb0100","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1080\/03602530701690374","article-title":"Drugs as CYP3A probes, inducers, and inhibitors","volume":"39","author":"Liu","year":"2007","journal-title":"Drug Metab. Rev."},{"issue":"6","key":"10.1016\/j.lfs.2021.120016_bb0105","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s00216-008-2291-6","article-title":"Functional pharmacogenetics\/genomics of human cytochromes P450 involved in drug biotransformation","volume":"392","author":"Zanger","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"issue":"6","key":"10.1016\/j.lfs.2021.120016_bb0110","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1517\/17425255.2.6.947","article-title":"Using pharmacokinetics to predict the effects of pregnancy and maternal-infant transfer of drugs during lactation","volume":"2","author":"Anderson","year":"2006","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"6","key":"10.1016\/j.lfs.2021.120016_bb0115","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1517\/17425251003677755","article-title":"Altered drug metabolism during pregnancy: hormonal regulation of drug-metabolizing enzymes","volume":"6","author":"Jeong","year":"2010","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"7","key":"10.1016\/j.lfs.2021.120016_bb0120","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1053\/j.semperi.2015.08.003","article-title":"Pharmacokinetics of drugs in pregnancy","volume":"39","author":"Feghali","year":"2015","journal-title":"Semin. Perinatol."},{"issue":"5","key":"10.1016\/j.lfs.2021.120016_bb0125","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/FTD.0b013e318261c372","article-title":"Therapeutic drug monitoring in pregnancy","volume":"34","author":"Matsui","year":"2012","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.lfs.2021.120016_bb0130","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.reprotox.2016.04.008","article-title":"Limited fetal metabolism of rosiglitazone: elimination via the maternal compartment in the pregnant ewe","volume":"61","author":"Bazargan","year":"2016","journal-title":"Reprod. Toxicol."},{"issue":"4","key":"10.1016\/j.lfs.2021.120016_bb0135","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/jbt.20179","article-title":"Ontogeny of human hepatic cytochromes P450","volume":"21","author":"Hines","year":"2007","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"6","key":"10.1016\/j.lfs.2021.120016_bb0140","doi-asserted-by":"crossref","first-page":"R1123","DOI":"10.1152\/ajpregu.00391.2017","article-title":"Improving pregnancy outcomes in humans through studies in sheep","volume":"315","author":"Morrison","year":"2018","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"7","key":"10.1016\/j.lfs.2021.120016_bb0145","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1440-1681.2008.04975.x","article-title":"Sheep models of intrauterine growth restriction: fetal adaptations and consequences","volume":"35","author":"Morrison","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"6","key":"10.1016\/j.lfs.2021.120016_bb0150","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1517\/17425255.3.6.819","article-title":"Drug transport across the placenta, role of the ABC drug efflux transporters","volume":"3","author":"Behravan","year":"2007","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"134","key":"10.1016\/j.lfs.2021.120016_bb0155","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.phrs.2018.06.003","article-title":"Intrauterine growth restriction may reduce hepatic drug metabolism in the early neonatal period","volume":"134","author":"Soo","year":"2018","journal-title":"Pharmacol. Res."},{"issue":"6","key":"10.1016\/j.lfs.2021.120016_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol."},{"issue":"2","key":"10.1016\/j.lfs.2021.120016_bb0165","first-page":"120","article-title":"Russell and Burch's 3Rs then and now: the need for clarity in definition and purpose","volume":"54","author":"Tannenbaum","year":"2015","journal-title":"J. Am. Assoc. Lab. Anim."},{"key":"10.1016\/j.lfs.2021.120016_bb0170","series-title":"Australian code for the care and use of animals for scientific purposes, Canberra","year":"2013"},{"key":"10.1016\/j.lfs.2021.120016_bb0175","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1530\/jrf.0.0070289","article-title":"Studies on the placenta of the sheep (Ovis Aries L.)","volume":"7","author":"Alexander","year":"1964","journal-title":"J. Reprod. Fertil."},{"issue":"1","key":"10.1016\/j.lfs.2021.120016_bb0180","doi-asserted-by":"crossref","first-page":"R306","DOI":"10.1152\/ajpregu.00798.2006","article-title":"Restriction of placental function alters heart development in the sheep fetus","volume":"293","author":"Morrison","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"Pt 2","key":"10.1016\/j.lfs.2021.120016_bb0185","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1113\/jphysiol.2004.080523","article-title":"Restriction of placental growth results in greater hypotensive response to alpha-adrenergic blockade in fetal sheep during late gestation","volume":"563","author":"Danielson","year":"2005","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.lfs.2021.120016_bb0190","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/af\/vfz019","article-title":"Considerations in selecting postoperative analgesia for pregnant sheep following fetal instrumentation surgery","volume":"9","author":"Varcoe","year":"2019","journal-title":"Anim. Front."},{"key":"10.1016\/j.lfs.2021.120016_bb0195","doi-asserted-by":"crossref","first-page":"R780","DOI":"10.1152\/ajpregu.00273.2017","article-title":"Feasibility of phase-contrast cine magnetic resonance imaging for measuring blood flow in the sheep fetus","volume":"317","author":"Duan","year":"2019","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"1","key":"10.1016\/j.lfs.2021.120016_bb0200","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12968-017-0383-1","article-title":"Feasibility of detecting myocardial infarction in the sheep fetus using late gadolinium enhancement CMR imaging","volume":"19","author":"Duan","year":"2017","journal-title":"J. Cardiovasc. Magn. Reson."},{"issue":"1","key":"10.1016\/j.lfs.2021.120016_bb0205","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12968-018-0512-5","article-title":"Fetal hemodynamics and cardiac streaming assessed by 4D flow cardiovascular magnetic resonance in fetal sheep","volume":"21","author":"Schrauben","year":"2019","journal-title":"J. Cardiovasc. Magn. Reson."},{"issue":"13","key":"10.1016\/j.lfs.2021.120016_bb0210","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1113\/JP279054","article-title":"Feasibility of ventricular volumetry by cardiovascular MRI to assess cardiac function in the fetal sheep","volume":"598","author":"Cho","year":"2020","journal-title":"J. Physiol."},{"issue":"15","key":"10.1016\/j.lfs.2021.120016_bb0215","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1113\/JP279725","article-title":"Normal human and sheep fetal vessel oxygen saturations by T2 magnetic resonance imaging","volume":"598","author":"Saini","year":"2020","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.lfs.2021.120016_bb0220","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.neuroimage.2006.01.015","article-title":"User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability","volume":"31","author":"Yushkevich","year":"2006","journal-title":"NeuroImage"},{"key":"10.1016\/j.lfs.2021.120016_bb0225","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0140-6736(94)92638-7","article-title":"Fetal weight estimation by echo-planar magnetic resonance imaging","volume":"343","author":"Baker","year":"1994","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.lfs.2021.120016_bb0230","doi-asserted-by":"crossref","first-page":"R151","DOI":"10.1152\/ajpregu.00036.2014","article-title":"Impact of chronic hypoxemia on blood flow to the brain, heart, and adrenal gland in the late-gestation IUGR sheep fetus","volume":"308","author":"Poudel","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"3","key":"10.1016\/j.lfs.2021.120016_bb0235","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/bcp.12207","article-title":"Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19","volume":"77","author":"Ke","year":"2014","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"2","key":"10.1016\/j.lfs.2021.120016_bb0240","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4155\/bio.13.289","article-title":"Simultaneous LC-MS\/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasma","volume":"6","author":"Bosilkovska","year":"2014","journal-title":"Bioanalysis"},{"issue":"5","key":"10.1016\/j.lfs.2021.120016_bb0245","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/bcpt.12231","article-title":"Incorporation of flurbiprofen in a 4-drug cytochrome p450 phenotyping cocktail","volume":"115","author":"Bosilkovska","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"8","key":"10.1016\/j.lfs.2021.120016_bb0250","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1124\/dmd.112.045245","article-title":"Down-regulation of hepatic CYP3A and CYP2C mediated metabolism in rats with moderate chronic kidney disease","volume":"40","author":"Velenosi","year":"2012","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.lfs.2021.120016_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2020.106934","article-title":"Development of a method to determine cytochrome P450 1A2, 2C9, 2D6 and 3A4 activity sheep hepatic microsomes","volume":"106","author":"McBride","year":"2020","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.lfs.2021.120016_bb0260","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jpba.2018.01.034","article-title":"Analysis by LC-MS\/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue","volume":"152","author":"Hakkinen","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"3","key":"10.1016\/j.lfs.2021.120016_bb0265","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.reprotox.2012.01.013","article-title":"Maternal undernutrition reduces P-glycoprotein in Guinea pig placenta and developing brain in late gestation","volume":"33","author":"Soo","year":"2012","journal-title":"Reprod. Toxicol."},{"issue":"2","key":"10.1016\/j.lfs.2021.120016_bb0270","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/00003081-200606000-00008","article-title":"Perinatal outcome and later implications of intrauterine growth restriction","volume":"49","author":"Pallotto","year":"2006","journal-title":"Clin. Obstet. Gynecol."},{"key":"10.1016\/j.lfs.2021.120016_bb0275","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.placenta.2020.07.009","article-title":"Differences in cytochrome p450 enzyme expression and activity in fetal and adult tissues","volume":"100","author":"Robinson","year":"2020","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.lfs.2021.120016_bb0280","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.siny.2004.11.001","article-title":"Ontogeny of drug metabolizing enzymes in the neonate","volume":"10","author":"Blake","year":"2005","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.lfs.2021.120016_bb0285","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cbi.2014.12.025","article-title":"Monepantel induces hepatic cytochromes p450 in sheep in vitro and in vivo","volume":"227","author":"Stuchl\u00edkov\u00e1","year":"2015","journal-title":"Chem. Biol. Interact."},{"issue":"8","key":"10.1016\/j.lfs.2021.120016_bb0290","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1124\/dmd.30.8.883","article-title":"Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7","volume":"30","author":"Williams","year":"2002","journal-title":"Drug Metab. Dispos."},{"issue":"4","key":"10.1016\/j.lfs.2021.120016_bb0295","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/bcpt.12392","article-title":"Expression of CYP3A4 and CYP3A7 in human foetal tissues and its correlation with nuclear receptors","volume":"117","author":"Betts","year":"2015","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"2","key":"10.1016\/j.lfs.2021.120016_bb0300","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1248\/bpb.33.249","article-title":"Cytochrome P450 3As gene expression and testosterone 6&beta;-hydroxylase activity in human fetal membranes and placenta at full term","volume":"33","author":"Maezawa","year":"2010","journal-title":"Biol. Pharm. Bull."},{"issue":"11","key":"10.1016\/j.lfs.2021.120016_bb0305","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1093\/aje\/kwj125","article-title":"Caffeine metabolites in umbilical cord blood, cytochrome P-450 1A2 activity, and intrauterine growth restriction","volume":"163","author":"Grosso","year":"2006","journal-title":"Am. J. Epidemiol."},{"issue":"3","key":"10.1016\/j.lfs.2021.120016_bb0310","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1208\/s12248-019-0316-z","article-title":"Mechanisms of CYP3A induction during pregnancy: studies in HepaRG cells","volume":"21","author":"Sachar","year":"2019","journal-title":"AAPS J."},{"issue":"8","key":"10.1016\/j.lfs.2021.120016_bb0315","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1124\/dmd.119.086769","article-title":"Activation of pregnane X receptor-cytochrome P450s axis: a possible reason for the enhanced accelerated blood clearance phenomenon of PEGylated liposomes in vivo","volume":"47","author":"Wang","year":"2019","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.lfs.2021.120016_bb0320","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.placenta.2017.01.123","article-title":"Review: placental adaptations to the presence of maternal asthma during pregnancy","volume":"54","author":"Meakin","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.lfs.2021.120016_bb0325","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.6368","article-title":"Intrauterine growth and the maturation process of adrenal function","volume":"7","author":"Iwata","year":"2019","journal-title":"PeerJ"},{"issue":"12","key":"10.1016\/j.lfs.2021.120016_bb0330","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.placenta.2011.09.009","article-title":"Sex specific changes in placental growth and MAPK following short term maternal dexamethasone exposure in the mouse","volume":"32","author":"Cuffe","year":"2011","journal-title":"Placenta"},{"issue":"12","key":"10.1016\/j.lfs.2021.120016_bb0335","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.1210\/en.2006-0825","article-title":"Glucocorticoids prevent the normal increase in placental vascular endothelial growth factor expression and placental vascularity during late pregnancy in the rat","volume":"147","author":"Hewitt","year":"2006","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.lfs.2021.120016_bb0340","doi-asserted-by":"crossref","first-page":"F166","DOI":"10.1136\/adc.2004.049320","article-title":"Fetal plasma testosterone correlates positively with cortisol","volume":"90","author":"Gitau","year":"2005","journal-title":"Arch. Dis. Child Fetal Neonatal. Ed."},{"issue":"5","key":"10.1016\/j.lfs.2021.120016_bb0345","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19051496","article-title":"Oxidative Stress in Preeclampsia and Placental Diseases","volume":"19","author":"Aouache","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.lfs.2021.120016_bb0350","first-page":"1174","article-title":"Elevated levels of umbilical cord plasma corticotropin-releasing hormone in growth-retarded fetuses","volume":"77","author":"Goland","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.lfs.2021.120016_bb0355","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1071\/RD9951227","article-title":"Concentrations of corticotrophin-releasing hormone in the umbilical-cord blood of pregnancies complicated by pre-eclampsia","volume":"7","author":"Goland","year":"1995","journal-title":"Reprod. Fertil. Dev."},{"issue":"3","key":"10.1016\/j.lfs.2021.120016_bb0360","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.placenta.2009.12.002","article-title":"Differences in gene expression dependent on sampling site in placental tissue of fetuses with intrauterine growth restriction","volume":"31","author":"Tzschoppe","year":"2010","journal-title":"Placenta"},{"issue":"6","key":"10.1016\/j.lfs.2021.120016_bb0365","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1203\/00006450-199612000-00014","article-title":"Placental restriction alters the functional development of the pituitary-adrenal axis in the sheep fetus during late gestation","volume":"40","author":"Phillips","year":"1996","journal-title":"Pediatr. Res."},{"issue":"6","key":"10.1016\/j.lfs.2021.120016_bb0370","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1172\/JCI0215563","article-title":"Differential effects of the early and late intrauterine environment on corticotrophic cell development","volume":"110","author":"Butler","year":"2002","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.lfs.2021.120016_bb0375","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/CS20060339","article-title":"Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches","volume":"113","author":"Jansson","year":"2007","journal-title":"Clin. Sci. (Lond.)"},{"issue":"3","key":"10.1016\/j.lfs.2021.120016_bb0380","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/ajmg.c.30313","article-title":"Evolving knowledge of the teratogenicity of medications in human pregnancy","volume":"157C","author":"Adam","year":"2011","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"issue":"5","key":"10.1016\/j.lfs.2021.120016_bb0385","first-page":"459","article-title":"Exposed or not exposed?Exploring exposure classification in studies using administrative data to investigate outcomes following medication use during pregnancy","volume":"68","author":"Grzeskowiak","year":"2012"},{"issue":"5","key":"10.1016\/j.lfs.2021.120016_bb0390","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/AOG.0000000000002579","article-title":"Prescription and other medication use in pregnancy","volume":"131","author":"Haas","year":"2018","journal-title":"Obstet. Gynecol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521010031?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521010031?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T17:46:48Z","timestamp":1770400008000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521010031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":78,"alternative-id":["S0024320521010031"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.120016","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intrauterine growth restriction alters the activity of drug metabolising enzymes in the maternal-placental-fetal unit","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.120016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120016"}}