{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:08:42Z","timestamp":1786993722007,"version":"build-2736575974"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006261","name":"Taif University","doi-asserted-by":"publisher","award":["TURSP-2020\/52"],"award-info":[{"award-number":["TURSP-2020\/52"]}],"id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.lfs.2021.120121","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T23:13:04Z","timestamp":1635981184000},"page":"120121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Arctigenin alleviates cadmium-induced nephrotoxicity: Targeting endoplasmic reticulum stress, Nrf2 signaling, and the associated inflammatory response"],"prefix":"10.1016","volume":"287","author":[{"given":"Samir A.","family":"Salama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Mohamadin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Abdel-Bakky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.lfs.2021.120121_bb0005","first-page":"135","article-title":"Cadmium toxicity and treatment: an update","volume":"8","author":"Rafati Rahimzadeh","year":"2017","journal-title":"Caspian J. Intern. Med."},{"issue":"4","key":"10.1016\/j.lfs.2021.120121_bb0010","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1039\/C6FO01580H","article-title":"Toxicity of cadmium and its health risks from leafy vegetable consumption","volume":"8","author":"Huang","year":"2017","journal-title":"Food Funct."},{"key":"10.1016\/j.lfs.2021.120121_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106646","article-title":"Urinary metabolic characterization with nephrotoxicity for residents under cadmium exposure","volume":"154","author":"Zeng","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.lfs.2021.120121_bb0020","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/394652","article-title":"Cadmium toxicity and treatment","volume":"2013","author":"Bernhoft","year":"2013","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.lfs.2021.120121_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144646","article-title":"Cadmium toxicity: a role in bone cell function and teeth development","volume":"769","author":"Ma","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.lfs.2021.120121_bb0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jinorgbio.2018.04.001","article-title":"Alpha lipoic acid attenuates cadmium-induced nephrotoxicity via the mitochondrial apoptotic pathways in rat","volume":"184","author":"Chen","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.lfs.2021.120121_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117324","article-title":"Oleic acid protects against cadmium induced cardiac and hepatic tissue injury in male wistar rats: a mechanistic study","volume":"244","author":"Bhattacharjee","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2021.120121_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.etap.2017.11.002","article-title":"Protective effects of proanthocyanidins against cadmium-induced testicular injury through the modification of Nrf2-Keap1 signal path in rats","volume":"57","author":"He","year":"2018","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.lfs.2021.120121_bb0045","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0013-9351(75)90071-7","article-title":"Cadmium accumulation in mouse organs during the sequential injections of cadmium-109","volume":"10","author":"Matsubara-Khan","year":"1975","journal-title":"Environ. Res."},{"issue":"9","key":"10.1016\/j.lfs.2021.120121_bb0050","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0278-6915(97)00068-9","article-title":"Cadmium accumulation in liver and kidney of mice exposed to the same weekly cadmium dose continuously or once a week","volume":"35","author":"Lind","year":"1997","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.lfs.2021.120121_bb0055","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s10534-021-00333-w","article-title":"Nephroprotective and anti-inflammatory potential of aqueous extract from Persea Americana seeds against cadmium-induced nephrotoxicity in wistar rats","volume":"34","author":"Osukoya","year":"2021","journal-title":"Biometals"},{"key":"10.1016\/j.lfs.2021.120121_bb0060","doi-asserted-by":"crossref","first-page":"e12014","DOI":"10.7717\/peerj.12014","article-title":"Prevalence of abnormal urinary cadmium and risk of albuminuria as a primary bioindicator for kidney problems among a healthy population","volume":"9","author":"Madrim","year":"2021","journal-title":"PeerJ"},{"issue":"2","key":"10.1016\/j.lfs.2021.120121_bb0065","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/abbi.1997.0197","article-title":"Enzyme activity alteration by cadmium administration to rats: the possibility of iron involvement in lipid peroxidation","volume":"346","author":"Casalino","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.lfs.2021.120121_bb0070","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.fct.2015.02.011","article-title":"Insight into the oxidative stress induced by lead and\/or cadmium in blood, liver and kidneys","volume":"78","author":"Matovic","year":"2015","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.lfs.2021.120121_bb0075","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.crvi.2008.03.009","article-title":"Cadmium-induced oxidative stress and DNA damage in kidney of pregnant female rats","volume":"331","author":"Chater","year":"2008","journal-title":"C. R. Biol."},{"issue":"2\u20133","key":"10.1016\/j.lfs.2021.120121_bb0080","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0378-4274(82)90064-9","article-title":"Enhancement of rat and human phagocyte superoxide anion radical production by cadmium in vitro","volume":"10","author":"Amoruso","year":"1982","journal-title":"Toxicol. Lett."},{"issue":"3","key":"10.1016\/j.lfs.2021.120121_bb0085","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.taap.2009.01.029","article-title":"Role of oxidative stress in cadmium toxicity and carcinogenesis","volume":"238","author":"Liu","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.lfs.2021.120121_bb0090","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.freeradbiomed.2008.04.041","article-title":"Cadmium generates reactive oxygen- and carbon-centered radical species in rats: insights from in vivo spin-trapping studies","volume":"45","author":"Liu","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"2\u20133","key":"10.1016\/j.lfs.2021.120121_bb0095","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tox.2011.03.001","article-title":"Advances in metal-induced oxidative stress and human disease","volume":"283","author":"Jomova","year":"2011","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.lfs.2021.120121_bb0100","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.3390\/ijms14036116","article-title":"Cadmium-induced pathologies: where is the oxidative balance lost (or not)?","volume":"14","author":"Nair","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.lfs.2021.120121_bb0105","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s12011-008-8128-5","article-title":"Zinc or magnesium supplementation modulates cd intoxication in blood, kidney, spleen, and bone of rabbits","volume":"124","author":"Bulat","year":"2008","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.lfs.2021.120121_bb0110","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jtemb.2011.10.002","article-title":"Effect of zinc supplementation on glutathione peroxidase activity and selenium concentration in the serum, liver and kidney of rats chronically exposed to cadmium","volume":"26","author":"Galazyn-Sidorczuk","year":"2012","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"1","key":"10.1016\/j.lfs.2021.120121_bb0115","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2478\/10004-1254-62-2011-2075","article-title":"Cadmium toxicity revisited: focus on oxidative stress induction and interactions with zinc and magnesium","volume":"62","author":"Matovic","year":"2011","journal-title":"Arh. Hig. Rada Toksikol."},{"issue":"6","key":"10.1016\/j.lfs.2021.120121_bb0120","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/009841099157601","article-title":"Cadmium-induced renal lipid peroxidation in rats and protection by selenium","volume":"57","author":"Yiin","year":"1999","journal-title":"J. Toxic. Environ. Health A"},{"issue":"1","key":"10.1016\/j.lfs.2021.120121_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0895-3988(10)60024-4","article-title":"Induction of endoplasmic reticulum stress by cadmium and its regulation on Nrf2 signaling pathway in kidneys of rats","volume":"32","author":"Chen","year":"2019","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.lfs.2021.120121_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111862","article-title":"Quercetin alleviates cadmium chloride-induced renal damage in rats by suppressing endoplasmic reticulum stress through SIRT1-dependent deacetylation of xbp-1s and eIF2\u03b1","volume":"141","author":"Alshammari","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.lfs.2021.120121_bb0135","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s12011-015-0314-7","article-title":"Ameliorative effects of selenium on cadmium-induced oxidative stress and endoplasmic reticulum stress in the chicken kidney","volume":"167","author":"Liu","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"issue":"5","key":"10.1016\/j.lfs.2021.120121_bb0140","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s10534-010-9296-2","article-title":"The oxidative stress: endoplasmic reticulum stress axis in cadmium toxicity","volume":"23","author":"Kitamura","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.lfs.2021.120121_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111229","article-title":"Natural antioxidants' effects on endoplasmic reticulum stress-related diseases","volume":"138","author":"Reyes-Fermin","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.lfs.2021.120121_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112620","article-title":"The epigenetic regulator BRD4 is involved in cadmium-triggered inflammatory response in rat kidney","volume":"224","author":"Gong","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.lfs.2021.120121_bb0155","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.3390\/molecules26051252","article-title":"Protective effect of Thymus serrulatus essential oil on cadmium-induced nephrotoxicity in rats, through suppression of oxidative stress and downregulation of NF-\u03baB, iNOS, and Smad2 mRNA expression","volume":"26","author":"Ansari","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.lfs.2021.120121_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115919","article-title":"Inhibition of ROS\/NLRP3\/Caspase-1 mediated pyroptosis attenuates cadmium-induced apoptosis in duck renal tubular epithelial cells","volume":"273","author":"Wei","year":"2021","journal-title":"Environ. Pollut."},{"issue":"9","key":"10.1016\/j.lfs.2021.120121_bb0165","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1177\/0960327119842635","article-title":"Nephroprotective effect of wogonin against cadmium-induced nephrotoxicity via inhibition of oxidative stress\u2013induced MAPK and NF-kB pathway in Sprague dawley rats","volume":"38","author":"Jiao","year":"2019","journal-title":"Hum. Exp. Toxicol."},{"issue":"2","key":"10.1016\/j.lfs.2021.120121_bb0170","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jep.2007.11.030","article-title":"Anti-inflammatory activity of arctigenin from forsythiae fructus","volume":"116","author":"Kang","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.lfs.2021.120121_bb0175","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.lfs.2019.03.037","article-title":"Arctigenin ameliorates renal impairment and inhibits endoplasmic reticulum stress in diabetic db\/db mice","volume":"223","author":"Zhang","year":"2019","journal-title":"Life Sci."},{"issue":"10","key":"10.1016\/j.lfs.2021.120121_bb0180","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/aps.2014.70","article-title":"Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways","volume":"35","author":"Wu","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"issue":"6","key":"10.1016\/j.lfs.2021.120121_bb0185","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.3892\/mmr.2020.11539","article-title":"Arctigenin suppresses fibroblast activity and extracellular matrix deposition in hypertrophic scarring by reducing inflammation and oxidative stress","volume":"22","author":"Jiang","year":"2020","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.lfs.2021.120121_bb0190","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1159\/000493038","article-title":"Arctigenin attenuates Ischemia\/Reperfusion induced ventricular arrhythmias by decreasing oxidative stress in rats","volume":"49","author":"Yang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.lfs.2021.120121_bb0195","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cbi.2018.01.005","article-title":"Arctigenin protects against ultraviolet-A-induced damage to stemness through inhibition of the NF-kappaB\/MAPK pathway","volume":"282","author":"Park","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.lfs.2021.120121_bb0200","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.phymed.2017.03.003","article-title":"Arctigenin suppresses renal interstitial fibrosis in a rat model of obstructive nephropathy","volume":"30","author":"Li","year":"2017","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2021.120121_bb0205","first-page":"10","article-title":"Protective effect of arctigenin on organ damage of rotenone-induced parkinson rats","author":"Wen","year":"2017","journal-title":"J. Shenyang Pharm. Univ."},{"issue":"6","key":"10.1016\/j.lfs.2021.120121_bb0210","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4062\/biomolther.2014.121","article-title":"Arctigenin increases Hemeoxygenase-1 gene expression by modulating PI3K\/AKT signaling pathway in rat primary astrocytes","volume":"22","author":"Jeong","year":"2014","journal-title":"Biomol. Ther. (Seoul)"},{"issue":"25","key":"10.1016\/j.lfs.2021.120121_bb0215","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1016\/j.lfs.2005.11.004","article-title":"Structure\u2013radical scavenging activity relationships of phenolic compounds from traditional chinese medicinal plants","volume":"78","author":"Cai","year":"2006","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.lfs.2021.120121_bb0220","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/aps.2018.32","article-title":"Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L","volume":"39","author":"Gao","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.lfs.2021.120121_bb0225","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fphar.2016.00182","article-title":"Arctigenin treatment protects against brain damage through an anti-inflammatory and anti-apoptotic mechanism after needle insertion","volume":"7","author":"Song","year":"2016","journal-title":"Front. Pharmacol."},{"issue":"1\u20133","key":"10.1016\/j.lfs.2021.120121_bb0230","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejphar.2013.01.014","article-title":"Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K\/AKT pathway and polarizing M1 macrophages to M2-like macrophages","volume":"708","author":"Hyam","year":"2013","journal-title":"Eur. J. Pharmacol."},{"issue":"10\u201311","key":"10.1016\/j.lfs.2021.120121_bb0235","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.intimp.2004.06.011","article-title":"Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition","volume":"4","author":"Cho","year":"2004","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2021.120121_bb0240","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.canlet.2020.08.033","article-title":"Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages via downregulating fatty acid oxidation to prevent colitis-associated cancer","volume":"491","author":"Qiao","year":"2020","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.lfs.2021.120121_bb0245","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1055\/s-0030-1250179","article-title":"Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells","volume":"77","author":"Sun","year":"2011","journal-title":"Planta Med."},{"key":"10.1016\/j.lfs.2021.120121_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119610","article-title":"Modulatory effects of carvacrol against cadmium-induced hepatotoxicity and nephrotoxicity by molecular targeting regulation","volume":"277","author":"Kandemir","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2021.120121_bb0255","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cbi.2018.02.034","article-title":"L-carnitine mitigates UVA-induced skin tissue injury in rats through downregulation of oxidative stress, p38\/c-fos signaling, and the proinflammatory cytokines","volume":"285","author":"Salama","year":"2018","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.lfs.2021.120121_bb0260","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s12011-016-0624-4","article-title":"Gamma-glutamyl cysteine attenuates tissue damage and enhances tissue regeneration in a rat model of Lead-induced nephrotoxicity","volume":"173","author":"Salama","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"issue":"12","key":"10.1016\/j.lfs.2021.120121_bb0265","doi-asserted-by":"crossref","first-page":"6632","DOI":"10.1039\/C8FO01086B","article-title":"Troxerutin down-regulates KIM-1, modulates p38 MAPK signaling, and enhances renal regenerative capacity in a rat model of gentamycin-induced acute kidney injury","volume":"9","author":"Salama","year":"2018","journal-title":"Food Funct."},{"issue":"20","key":"10.1016\/j.lfs.2021.120121_bb0270","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1056\/NEJM199811123392007","article-title":"Pathophysiology of progressive nephropathies","volume":"339","author":"Remuzzi","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2021.120121_bb0275","doi-asserted-by":"crossref","first-page":"22424","DOI":"10.1002\/jcp.28807","article-title":"Targeting MAPKs, NF-kappaB, and PI3K\/AKT pathways by methyl palmitate ameliorates ethanol-induced gastric mucosal injury in rats","volume":"234","author":"Arab","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.lfs.2021.120121_bb0280","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s10753-013-9797-6","article-title":"Nicotine mediates hypochlorous acid-induced nuclear protein damage in mammalian cells","volume":"37","author":"Salama","year":"2014","journal-title":"Inflammation"},{"issue":"4","key":"10.1016\/j.lfs.2021.120121_bb0285","first-page":"501","article-title":"Amino acid chloramine damage to proliferating cell nuclear antigen in mammalian cells","volume":"26","author":"Salama","year":"2012","journal-title":"In Vivo"},{"key":"10.1016\/j.lfs.2021.120121_bb0290","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.biochem.73.011303.073723","article-title":"Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints","volume":"73","author":"Sancar","year":"2004","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.lfs.2021.120121_bb0295","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.lfs.2021.120121_bb0300","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.fct.2014.04.032","article-title":"Camel's milk ameliorates TNBS-induced colitis in rats via downregulation of inflammatory cytokines and oxidative stress","volume":"69","author":"Arab","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"12","key":"10.1016\/j.lfs.2021.120121_bb0305","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/jbt.21732","article-title":"Chronic cadmium exposure Lead to inhibition of serum and hepatic alkaline phosphatase activity in wistar rats","volume":"29","author":"Trevino","year":"2015","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.lfs.2021.120121_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119572","article-title":"Ergothioneine mitigates cisplatin-evoked nephrotoxicity via targeting Nrf2, NF-kappaB, and apoptotic signaling and inhibiting gamma-glutamyl transpeptidase","volume":"278","author":"Salama","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2021.120121_bb0315","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.biochi.2015.06.006","article-title":"Glutamyl cysteine dipeptide suppresses ferritin expression and alleviates liver injury in iron-overload rat model","volume":"115","author":"Salama","year":"2015","journal-title":"Biochimie"},{"issue":"8","key":"10.1016\/j.lfs.2021.120121_bb0320","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.3390\/ijms20082027","article-title":"Rosmarinic acid attenuates cadmium-induced nephrotoxicity via inhibition of oxidative stress, apoptosis, inflammation and fibrosis","volume":"20","author":"Joardar","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2021.120121_bb0325","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s12011-015-0453-x","article-title":"Thymoquinone ameliorates cadmium-induced nephrotoxicity, apoptosis, and oxidative stress in rats is based on its anti-apoptotic and anti-oxidant properties","volume":"170","author":"Erboga","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"issue":"2","key":"10.1016\/j.lfs.2021.120121_bb0330","first-page":"139","article-title":"An important role of Nrf2-ARE pathway in the cellular defense mechanism","volume":"37","author":"Lee","year":"2004","journal-title":"J. Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.lfs.2021.120121_bb0335","doi-asserted-by":"crossref","first-page":"H701","DOI":"10.1152\/ajpheart.00024.2005","article-title":"Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes","volume":"289","author":"Turkseven","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.lfs.2021.120121_bb0340","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cotox.2017.10.005","article-title":"NQO1 in protection against oxidative stress","volume":"7","author":"Ross","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"issue":"22","key":"10.1016\/j.lfs.2021.120121_bb0345","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.3390\/molecules25225474","article-title":"An overview of Nrf2 signaling pathway and its role in inflammation","volume":"25","author":"Saha","year":"2020","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.lfs.2021.120121_bb0350","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/sj.cdd.4402154","article-title":"Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response","volume":"14","author":"Yokouchi","year":"2007","journal-title":"Cell Death Differ."},{"issue":"5","key":"10.1016\/j.lfs.2021.120121_bb0355","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S1097-2765(00)00108-8","article-title":"Regulated translation initiation controls stress-induced gene expression in mammalian cells","volume":"6","author":"Harding","year":"2000","journal-title":"Mol. Cell"},{"issue":"14","key":"10.1016\/j.lfs.2021.120121_bb0360","doi-asserted-by":"crossref","first-page":"12343","DOI":"10.1074\/jbc.M107988200","article-title":"Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP","volume":"277","author":"Gotoh","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.lfs.2021.120121_bb0365","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1074\/jbc.M705951200","article-title":"Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response","volume":"283","author":"Yokouchi","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.lfs.2021.120121_bb0370","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/febs.14608","article-title":"Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications","volume":"286","author":"Almanza","year":"2019","journal-title":"FEBS J."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521011085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521011085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:53:16Z","timestamp":1758401596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521011085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":74,"alternative-id":["S0024320521011085"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.120121","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arctigenin alleviates cadmium-induced nephrotoxicity: Targeting endoplasmic reticulum stress, Nrf2 signaling, and the associated inflammatory response","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.120121","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120121"}}