{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:02:01Z","timestamp":1775890921176,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002378","name":"Faculty of Veterinary Medicine, Cairo University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002378","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.lfs.2021.120154","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T11:25:00Z","timestamp":1637148300000},"page":"120154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Impact of the ACE2 activator xanthenone on tacrolimus nephrotoxicity: Modulation of uric acid\/ERK\/p38 MAPK and Nrf2\/SOD3\/GCLC signaling pathways"],"prefix":"10.1016","volume":"288","author":[{"given":"Amany A.","family":"Azouz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hany A.","family":"Omar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatema","family":"Hersi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fares E.M.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa Mohammed M.","family":"Hussein Elkelawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.lfs.2021.120154_bb0005","doi-asserted-by":"crossref","first-page":"167","DOI":"10.33549\/physiolres.933332","article-title":"Pathophysiological mechanisms of calcineurin inhibitor-induced nephrotoxicity and arterial hypertension","volume":"66","author":"Ho\u0161kov\u00e1","year":"2017","journal-title":"Physiol. Res."},{"issue":"9","key":"10.1016\/j.lfs.2021.120154_bb0010","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1016\/j.transproceed.2018.03.031","article-title":"Tetrahydrocurcumin ameliorates tacrolimus-induced nephrotoxicity via inhibiting apoptosis","volume":"50","author":"Park","year":"2018","journal-title":"Transplant. Proc."},{"issue":"4","key":"10.1016\/j.lfs.2021.120154_bb0015","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00125480-199707000-00032","article-title":"Tacrolimus (FK506)-associated renal pathology","volume":"4","author":"Randhawa","year":"1997","journal-title":"Adv. Anat. Pathol."},{"issue":"1","key":"10.1016\/j.lfs.2021.120154_bb0020","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000449289","article-title":"The protective effect of febuxostat on chronic tacrolimus-induced nephrotoxicity in rats","volume":"135","author":"Kim","year":"2017","journal-title":"Nephron"},{"key":"10.1016\/j.lfs.2021.120154_bb0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijcard.2015.08.109","article-title":"Regulation of uric acid metabolism and excretion","volume":"213","author":"Maiuolo","year":"2016","journal-title":"Int. J. Cardiol."},{"issue":"4","key":"10.1016\/j.lfs.2021.120154_bb0030","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3109\/0886022X.2011.653753","article-title":"New insights into uric acid effects on the progression and prognosis of chronic kidney disease","volume":"34","author":"Filiopoulos","year":"2012","journal-title":"Ren. Fail."},{"key":"10.1016\/j.lfs.2021.120154_bb0035","doi-asserted-by":"crossref","first-page":"5817348","DOI":"10.1155\/2020\/5817348","article-title":"Research advances in the mechanisms of hyperuricemia-induced renal injury","volume":"2020","author":"Su","year":"2020","journal-title":"Biomed. Res. Int."},{"issue":"6","key":"10.1016\/j.lfs.2021.120154_bb0040","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.3904\/kjim.2020.340","article-title":"The role of asymptomatic hyperuricemia in the progression of chronic kidney disease CKD and cardiovascular diseases CVD","volume":"36","author":"Waheed","year":"2021","journal-title":"KoreanJ. Intern. Med."},{"issue":"9","key":"10.1016\/j.lfs.2021.120154_bb0045","first-page":"2749","article-title":"Roles of hyperuricemia in metabolic syndrome and cardiac-kidney-vascular system diseases","volume":"10","author":"Wang","year":"2018","journal-title":"Am. J. Transl. Res."},{"issue":"4","key":"10.1016\/j.lfs.2021.120154_bb0050","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1159\/000324847","article-title":"Serum uric acid level and endothelial dysfunction in patients with nondiabetic chronic kidney disease","volume":"33","author":"Kanbay","year":"2011","journal-title":"Am. J. Nephrol."},{"issue":"1","key":"10.1016\/j.lfs.2021.120154_bb0055","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1080\/0886022X.2019.1633350","article-title":"The role of oxidative stress-mediated apoptosis in the pathogenesis of uric acid nephropathy","volume":"41","author":"Yang","year":"2019","journal-title":"Ren. Fail."},{"issue":"6","key":"10.1016\/j.lfs.2021.120154_bb0060","doi-asserted-by":"crossref","first-page":"F1327","DOI":"10.1152\/ajprenal.00272.2019","article-title":"Uric acid and inflammation in kidney disease","volume":"318","author":"Jung","year":"2020","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"2","key":"10.1016\/j.lfs.2021.120154_bb0065","first-page":"153","article-title":"Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions","volume":"22","author":"Pearson","year":"2001","journal-title":"Endocr. Rev."},{"issue":"12","key":"10.1016\/j.lfs.2021.120154_bb0070","first-page":"1547","article-title":"ERK kinases modulate the activation of PI3 kinase related kinases (PIKKs) in DNA damage response","volume":"28","author":"Lin","year":"2013","journal-title":"Histol. Histopathol."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2021.120154_bb0075","first-page":"109","article-title":"Kidney injury molecule-1 (KIM-1) mediates renal epithelial cell repair via ERK MAPK signaling pathway","volume":"416","author":"Zhang","year":"2016","journal-title":"Mol. Cell. Biochem."},{"issue":"6","key":"10.1016\/j.lfs.2021.120154_bb0080","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1161\/01.HYP.0000072820.07472.3B","article-title":"Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2","volume":"41","author":"Kanellis","year":"2003","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.lfs.2021.120154_bb0085","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1016\/j.joca.2016.07.001","article-title":"Intra-articular basic calcium phosphate and monosodium urate crystals inhibit anti-osteoclastogenic cytokine signalling","volume":"24","author":"Cunningham","year":"2016","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.lfs.2021.120154_bb0090","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.reprotox.2014.08.006","article-title":"ACE2 activation by xanthenone prevents leptin-induced increases in blood pressure and proteinuria during pregnancy in Sprague-dawley rats","volume":"49","author":"Ibrahim","year":"2014","journal-title":"Reprod. Toxicol."},{"issue":"9","key":"10.1016\/j.lfs.2021.120154_bb0095","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00210-018-1523-3","article-title":"Modulation of brain ACE and ACE2 may be a promising protective strategy against cerebral ischemia\/reperfusion injury: an experimental trial in rats","volume":"391","author":"Abdel-Fattah","year":"2018","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"issue":"5","key":"10.1016\/j.lfs.2021.120154_bb0100","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1161\/HYPERTENSIONAHA.107.108944","article-title":"Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents","volume":"51","author":"Hern\u00e1ndez Prada","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2021.120154_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104833","article-title":"Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor","volume":"157","author":"Li","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.lfs.2021.120154_bb0110","first-page":"1","article-title":"Molecular mechanisms of the modulatory effect of vitamin E on tacrolimus (FK506)-induced renal injury in rats","volume":"9","author":"Afify","year":"2016","journal-title":"J. Pharm. Res. Int."},{"key":"10.1016\/j.lfs.2021.120154_bb0115","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.fct.2018.07.027","article-title":"Hepatoprotective effects of diosmin and\/or sildenafil against cholestatic liver cirrhosis: the role of Keap-1\/Nrf-2 and P38-MAPK\/NF-\u03baB\/iNOS signaling pathway","volume":"120","author":"Ali","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.lfs.2021.120154_bb0120","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"methods"},{"key":"10.1016\/j.lfs.2021.120154_bb0125","series-title":"Theory and Practice of Histological Techniques","author":"Bancroft","year":"2008"},{"issue":"2","key":"10.1016\/j.lfs.2021.120154_bb0130","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/aor.13551","article-title":"Tacrolimus: 20 years of use in adult kidney transplantation. What we should know about its nephrotoxicity","volume":"44","author":"Bentata","year":"2020","journal-title":"Artif. Organs"},{"issue":"2","key":"10.1016\/j.lfs.2021.120154_bb0135","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s13105-015-0451-7","article-title":"Protective effect of mycophenolate mofetil against nephrotoxicity and hepatotoxicity induced by tacrolimus in wistar rats","volume":"72","author":"Ferjani","year":"2016","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.lfs.2021.120154_bb0140","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.toxrep.2018.06.003","article-title":"Immunosuppressant drug tacrolimus induced mitochondrial nephrotoxicity, modified PCNA and Bcl-2 expression attenuated by Ocimum basilicum L. In CD1 mice","volume":"5","author":"Oyouni","year":"2018","journal-title":"Toxicol. Rep."},{"issue":"1","key":"10.1016\/j.lfs.2021.120154_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12882-019-1399-6","article-title":"Cilastatin protects against tacrolimus-induced nephrotoxicity via anti-oxidative and anti-apoptotic properties","volume":"20","author":"Luo","year":"2019","journal-title":"BMC Nephrol."},{"issue":"7","key":"10.1016\/j.lfs.2021.120154_bb0150","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1016\/j.transproceed.2005.08.042","article-title":"Influence of cyclosporine and tacrolimus on serum uric acid levels in stable kidney transplant recipients","volume":"37","author":"Kanbay","year":"2005","journal-title":"Transplant. Proc."},{"issue":"8","key":"10.1016\/j.lfs.2021.120154_bb0155","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/hr.2014.79","article-title":"Tacrolimus-induced hypertension and nephrotoxicity in fawn-hooded rats are attenuated by dual inhibition of renin\u2013angiotensin system","volume":"37","author":"Ho\u0161kov\u00e1","year":"2014","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.lfs.2021.120154_bb0160","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/607246","article-title":"Olmesartan attenuates tacrolimus-induced biochemical and ultrastructural changes in rat kidney tissue","volume":"2014","author":"Al-Harbi","year":"2014","journal-title":"Biomed. Res. Int."},{"issue":"5","key":"10.1016\/j.lfs.2021.120154_bb0165","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1055\/a-1369-8651","article-title":"Evaluation of the effect of captopril and losartan on tacrolimus-induced nephrotoxicity in rats","volume":"71","author":"Poormoosavi","year":"2021","journal-title":"Drug Res."},{"issue":"1","key":"10.1016\/j.lfs.2021.120154_bb0170","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2169\/internalmedicine.54.2931","article-title":"Effects of combined enalapril and folic acid therapy on the serum uric acid levels in hypertensive patients: a multicenter, randomized, double-blind, parallel-controlled clinical trial","volume":"54","author":"Li","year":"2015","journal-title":"Intern. Med."},{"key":"10.1016\/j.lfs.2021.120154_bb0175","series-title":"An Open Label Prospective Study on Uricosuric Effects of Losartan in Hypertensive Patients with Hyperuricaemia","author":"Banupriya","year":"2017"},{"issue":"3","key":"10.1016\/j.lfs.2021.120154_bb0180","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/ejhf.1056","article-title":"Sacubitril\/valsartan reduces serum uric acid concentration, an independent predictor of adverse outcomes in PARADIGM-HF","volume":"20","author":"Mogensen","year":"2018","journal-title":"Eur. J. Heart Fail."},{"issue":"2","key":"10.1016\/j.lfs.2021.120154_bb0185","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.bcp.2011.11.001","article-title":"Cyclosporin a and tacrolimus induce renal Erk1\/2 pathway via ROS-induced and metalloproteinase-dependent EGF-receptor signaling","volume":"83","author":"Akool","year":"2012","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.lfs.2021.120154_bb0190","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jgr.2016.12.013","article-title":"Protective effect of ginsenoside Rb1 against tacrolimus-induced apoptosis in renal proximal tubular LLC-PK1 cells","volume":"42","author":"Lee","year":"2018","journal-title":"J. Ginseng Res."},{"issue":"2","key":"10.1016\/j.lfs.2021.120154_bb0195","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/eji.201747135","article-title":"Calcineurin inhibitor-induced complement system activation via ERK1\/2 signalling is inhibited by SOCS-3 in human renal tubule cells","volume":"48","author":"Loeschenberger","year":"2018","journal-title":"Europ. J. Immun."},{"issue":"2","key":"10.1016\/j.lfs.2021.120154_bb0200","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/10799893.2016.1203941","article-title":"Uric acid stimulates proliferative pathways in vascular smooth muscle cells through the activation of p38 MAPK, p44\/42 MAPK and PDGFR\u03b2","volume":"37","author":"K\u0131r\u00e7a","year":"2017","journal-title":"J. Recept. Signal Transduct. Res."},{"issue":"5","key":"10.1016\/j.lfs.2021.120154_bb0205","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.3892\/mmr.2016.5083","article-title":"Nox4 has a crucial role in uric acid-induced oxidative stress and apoptosis in renal tubular cells","volume":"13","author":"Li","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.lfs.2021.120154_bb0210","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.2353\/ajpath.2008.070762","article-title":"Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK\/p38 MAP kinase pathway","volume":"172","author":"Koka","year":"2008","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.lfs.2021.120154_bb0215","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41569-020-0387-7","article-title":"Mechanisms by which angiotensin-receptor blockers increase ACE2 levels","volume":"17","author":"Ferrario","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"issue":"7","key":"10.1016\/j.lfs.2021.120154_bb0220","doi-asserted-by":"crossref","first-page":"10868","DOI":"10.1002\/jcp.27929","article-title":"Uric acid and angiotensin II additively promote inflammation and oxidative stress in human proximal tubule cells by activation of toll-like receptor 4","volume":"234","author":"Milanesi","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"11","key":"10.1016\/j.lfs.2021.120154_bb0225","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.2174\/1389450117666160727142401","article-title":"The anti-inflammatory potential of ACE2\/angiotensin-(1\u20137)\/Mas receptor axis: evidence from basic and clinical research","volume":"18","author":"Rodrigues Prestes","year":"2017","journal-title":"Curr. Drug Targets"},{"issue":"3","key":"10.1016\/j.lfs.2021.120154_bb0230","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/bph.12159","article-title":"ACE2, angiotensin-(1-7) and M as receptor axis in inflammation and fibrosis","volume":"169","author":"Sim\u00f5es e Silva","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2021.120154_bb0235","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.phrs.2016.03.018","article-title":"ACE inhibition, ACE2 and angiotensin-(1\u2fff 7) axis in kidney and cardiac inflammation and fibrosis","volume":"107","author":"Teixeira","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.lfs.2021.120154_bb0240","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12974-016-0489-7","article-title":"Angiotensin-converting enzyme 2 activator diminazene aceturate prevents lipopolysaccharide-induced inflammation by inhibiting MAPK and NF-\u03baB pathways in human retinal pigment epithelium","volume":"13","author":"Tao","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.lfs.2021.120154_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117749","article-title":"Diminazene aceturate extenuate the renal deleterious consequences of angiotensin-II induced by \u03b3-irradiation through boosting ACE2 signaling cascade","volume":"253","author":"Hasan","year":"2020","journal-title":"Life Sci."},{"issue":"23","key":"10.1016\/j.lfs.2021.120154_bb0250","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1042\/CS20201022","article-title":"ACE2 activator diminazene aceturate exerts renoprotective effects in gentamicin-induced acute renal injury in rats","volume":"134","author":"Silva de Almeida","year":"2020","journal-title":"Clin. Sci."},{"issue":"31","key":"10.1016\/j.lfs.2021.120154_bb0255","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000021492","article-title":"Alteration and association between serum ACE2\/angiotensin (1\u20137)\/Mas axis and oxidative stress in chronic kidney disease: a pilot study","volume":"99","author":"Shi","year":"2020","journal-title":"Medicine"},{"key":"10.1016\/j.lfs.2021.120154_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116796","article-title":"Angiotensin II type 2 receptor and angiotensin-converting enzyme 2 mediate ischemic renal injury in diabetic and non-diabetic rats","volume":"235","author":"Sharma","year":"2019","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.lfs.2021.120154_bb0265","doi-asserted-by":"crossref","DOI":"10.1002\/phy2.264","article-title":"ACE 2 deficiency increases NADPH-mediated oxidative stress in the kidney","volume":"2","author":"Wysocki","year":"2014","journal-title":"Physiol. Rep."},{"issue":"5","key":"10.1016\/j.lfs.2021.120154_bb0270","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1161\/HYPERTENSIONAHA.120.15681","article-title":"Overexpression of central ACE2 (Angiotensin-converting enzyme 2) attenuates the pressor response to chronic central infusion of ang II (Angiotensin II) a potential role for Nrf2 (Nuclear factor [Erythroid-derived 2]-like 2)","volume":"76","author":"Ma","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2021.120154_bb0275","series-title":"The Role of Central ACE2 and Nrf2 in Sympatho-Excitation: Responses to Central Angiotensin II","author":"Ma","year":"2020"},{"key":"10.1016\/j.lfs.2021.120154_bb0280","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.scitotenv.2018.09.211","article-title":"Di (2-ethylhexyl) phthalate induced hepatotoxicity in quail (Coturnix japonica) via modulating the mitochondrial unfolded protein response and NRF2 mediated antioxidant defense","volume":"651","author":"Zhang","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"12","key":"10.1016\/j.lfs.2021.120154_bb0285","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1089\/ars.2007.2019","article-title":"Nrf2-mediated transcriptional induction of antioxidant response in mouse embryos exposed to ethanol in vivo: implications for the prevention of fetal alcohol spectrum disorders","volume":"10","author":"Dong","year":"2008","journal-title":"Antioxid. Redox Signal."},{"issue":"17","key":"10.1016\/j.lfs.2021.120154_bb0290","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell. Mol. Life Sci."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521011413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521011413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T10:31:01Z","timestamp":1717237861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521011413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":58,"alternative-id":["S0024320521011413"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.120154","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of the ACE2 activator xanthenone on tacrolimus nephrotoxicity: Modulation of uric acid\/ERK\/p38 MAPK and Nrf2\/SOD3\/GCLC signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.120154","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120154"}}