{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:09:06Z","timestamp":1793261346861,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U19A2001"],"award-info":[{"award-number":["U19A2001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.lfs.2021.120180","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T16:22:45Z","timestamp":1637943765000},"page":"120180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Interleukin-9 attenuates inflammatory response and hepatocyte apoptosis in alcoholic liver injury"],"prefix":"10.1016","volume":"288","author":[{"given":"Hongwu","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruowen","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2021.120180_bb0005","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/gutjnl-2019-319720","article-title":"Recent advances in alcohol-related liver disease (ALD): summary of a gut round table meeting","volume":"69","author":"Avila","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2021.120180_bb0010","first-page":"113","article-title":"Current management of alcoholic hepatitis and future therapies","volume":"4","author":"Saberi","year":"2016","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.lfs.2021.120180_bb0015","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1053\/j.gastro.2014.10.042","article-title":"Gut-liver axis in alcoholic liver disease","volume":"148","author":"Szabo","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2021.120180_bb0020","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s00204-012-0814-6","article-title":"Cytokines in alcoholic liver disease","volume":"86","author":"An","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.lfs.2021.120180_bb0025","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.cell.2019.12.034","article-title":"Bacteriophage prevents alcoholic liver disease","volume":"180","author":"Colakoglu","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2021.120180_bb0030","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41586-019-1742-x","article-title":"Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease","volume":"575","author":"Duan","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2021.120180_bb0035","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1146\/annurev-nutr-072610-145138","article-title":"Inflammation in alcoholic liver disease","volume":"32","author":"Wang","year":"2012","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.lfs.2021.120180_bb0040","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nm.4373","article-title":"Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells","volume":"23","author":"Rauber","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2021.120180_bb0045","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3389\/fimmu.2018.01139","article-title":"A decade of Th9 cells: role of Th9 cells in inflammatory bowel disease","volume":"9","author":"Vyas","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2021.120180_bb0050","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.3389\/fimmu.2019.02844","article-title":"To be or not to be a pathogen: Candida albicans and celiac disease","volume":"10","author":"Renga","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2021.120180_bb0055","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41419-017-0071-y","article-title":"Ethanol sensitizes hepatocytes for TGF-beta-triggered apoptosis","volume":"9","author":"Gaitantzi","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2021.120180_bb0060","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.omtn.2019.06.018","article-title":"LINC01093 upregulation protects against alcoholic hepatitis through inhibition of NF-kappaB signaling pathway","volume":"17","author":"Shi","year":"2019","journal-title":"Mol. Ther.\u2013Nucleic Acids"},{"key":"10.1016\/j.lfs.2021.120180_bb0065","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.3389\/fphar.2018.01031","article-title":"Beta-arrestin 2 promotes hepatocyte apoptosis by inhibiting akt pathway in alcoholic liver disease","volume":"9","author":"Sun","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2021.120180_bb0070","doi-asserted-by":"crossref","first-page":"7566","DOI":"10.7150\/thno.36942","article-title":"The hepatocyte-specifically expressed lnc-HSER alleviates hepatic fibrosis by inhibiting hepatocyte apoptosis and epithelial-mesenchymal transition","volume":"9","author":"Zhang","year":"2019","journal-title":"Theranostics."},{"key":"10.1016\/j.lfs.2021.120180_bb0075","doi-asserted-by":"crossref","first-page":"25855","DOI":"10.1074\/jbc.274.36.25855","article-title":"Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9","volume":"274","author":"Demoulin","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2021.120180_bb0080","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1038\/cdd.2008.79","article-title":"IL-9\/IL-9 receptor signaling selectively protects cortical neurons against developmental apoptosis","volume":"15","author":"Fontaine","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.lfs.2021.120180_bb0085","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1158\/1940-6207.CAPR-10-0340","article-title":"Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis","volume":"4","author":"Prasad","year":"2011","journal-title":"Cancer Prev. Res. (Phila.)"},{"key":"10.1016\/j.lfs.2021.120180_bb0090","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ydbio.2007.10.001","article-title":"Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling","volume":"312","author":"Suemoto","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.lfs.2021.120180_bb0095","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1006\/taap.2001.9360","article-title":"Regulation of cell proliferation, apoptosis, and transcription factor activities during the promotion of liver carcinogenesis by polychlorinated biphenyls","volume":"179","author":"Tharappel","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.lfs.2021.120180_bb0100","first-page":"2451","article-title":"MicroRNA-543 suppresses liver cancer growth and induces apoptosis via the JAK2\/STAT3 signaling pathway","volume":"17","author":"Xiu","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.lfs.2021.120180_bb0105","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cytogfr.2019.12.001","article-title":"Role of extracellular vesicles in cell-cell communication and inflammation following exposure to pulmonary toxicants","volume":"51","author":"Andres","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.lfs.2021.120180_bb0110","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.cmet.2019.10.010","article-title":"The crosstalk between hepatocytes, hepatic macrophages, and hepatic stellate cells facilitates alcoholic liver disease","volume":"30","author":"Kisseleva","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2021.120180_bb0115","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nprot.2013.032","article-title":"Mouse model of chronic and binge ethanol feeding (the NIAAA model)","volume":"8","author":"Bertola","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.lfs.2021.120180_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1020660303855","article-title":"The physiological scavenger receptor function of hepatic sinusoidal endothelial and kupffer cells is independent of scavenger receptor class a type I and II","volume":"240","author":"Hansen","year":"2002","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.lfs.2021.120180_bb0125","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1189\/jlb.0308173","article-title":"Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury","volume":"84","author":"Holt","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.lfs.2021.120180_bb0130","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/jlb.38.2.213","article-title":"Preparation of pure hepatocytes and reticuloendothelial cells in high yield from a single rat liver by means of percoll centrifugation and selective adherence","volume":"38","author":"Smedsrod","year":"1985","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.lfs.2021.120180_bb0135","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ymeth.2017.12.009","article-title":"Alternatives to current flow cytometry data analysis for clinical and research studies","volume":"134\u2013135","author":"Gondhalekar","year":"2018","journal-title":"Methods"},{"key":"10.1016\/j.lfs.2021.120180_bb0140","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.tox.2019.04.004","article-title":"4-methylcoumarin-[5,6-g]-hesperetin attenuates inflammatory responses in alcoholic hepatitis through PPAR-gamma activation","volume":"421","author":"Meng","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.lfs.2021.120180_bb0145","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/hep.23837","article-title":"Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3","volume":"52","author":"Ki","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2021.120180_bb0150","doi-asserted-by":"crossref","first-page":"C305","DOI":"10.1152\/ajpcell.00005.2017","article-title":"Lipopolysaccharide downregulates macrophage-derived IL-22 to modulate alcohol-induced hepatocyte cell death","volume":"313","author":"Liu","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.lfs.2021.120180_bb0155","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1172\/JCI104574","article-title":"Ethanol metabolism and production of free acetate in the human liver","volume":"41","author":"Lundquist","year":"1962","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2021.120180_bb0160","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2021.120180_bb0165","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1055\/s-0030-1255354","article-title":"Macrophages: master regulators of inflammation and fibrosis","volume":"30","author":"Wynn","year":"2010","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.lfs.2021.120180_bb0170","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1080\/13880209.2017.1357737","article-title":"Anti-inflammatory effect of pomegranate flower in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages","volume":"55","author":"Xu","year":"2017","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.lfs.2021.120180_bb0175","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0091-6749(00)90185-4","article-title":"IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma","volume":"105","author":"Shimbara","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.lfs.2021.120180_bb0180","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/ni.2133","article-title":"An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation","volume":"12","author":"Wilhelm","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.lfs.2021.120180_bb0185","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4137\/JCD.S39824","article-title":"Mechanism of hepatocyte apoptosis","volume":"9","author":"Cao","year":"2016","journal-title":"J. Cell Death"},{"key":"10.1016\/j.lfs.2021.120180_bb0190","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","article-title":"Targeting hepatic macrophages to treat liver diseases","volume":"66","author":"Tacke","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2021.120180_bb0195","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cyto.2017.03.018","article-title":"STAT3 in cancer: a double edged sword","volume":"98","author":"Avalle","year":"2017","journal-title":"Cytokine"},{"key":"10.1016\/j.lfs.2021.120180_bb0200","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.pharmthera.2015.10.004","article-title":"Targeting transcription factor STAT3 for cancer prevention and therapy","volume":"162","author":"Chai","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2021.120180_bb0205","first-page":"7940","article-title":"IL-9 promotes proliferation and metastasis of hepatocellular cancer cells by activating JAK2\/STAT3 pathway","volume":"10","author":"Lei","year":"2017","journal-title":"Int. J. Clin. Exp. Pathol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052101167X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052101167X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T10:32:30Z","timestamp":1717237950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002432052101167X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":41,"alternative-id":["S002432052101167X"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.120180","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interleukin-9 attenuates inflammatory response and hepatocyte apoptosis in alcoholic liver injury","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.120180","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120180"}}