{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:41:42Z","timestamp":1781660502142,"version":"3.54.5"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001502","name":"Department of Atomic Energy, Government of India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001502","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013306","name":"National Institute of Science Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013306","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.lfs.2021.120201","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T03:45:12Z","timestamp":1638503112000},"page":"120201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Microbiota transplantation from younger to older mice could restore lost immunity to effectively clear salmonella infection in Th2-biased BALB\/c mice"],"prefix":"10.1016","volume":"288","author":[{"given":"Salila","family":"Pradhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratikshya","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palok","family":"Aich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2021.120201_bb0005","article-title":"Gut microbiota density influences host physiology and is shaped by host and microbial factors","volume":"8","author":"Contijoch","year":"2018","journal-title":"elife"},{"key":"10.1016\/j.lfs.2021.120201_bb0010","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/femsre\/fuw007","article-title":"Lipopolysaccharide modification in gram-negative bacteria during chronic infection","volume":"40","author":"Maldonado","year":"2016","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.lfs.2021.120201_bb0015","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.lfs.2021.120201_bb0020","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3390\/nu3060637","article-title":"Gut microbiota and inflammation","volume":"3","author":"Hakansson","year":"2011","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2021.120201_bb0025","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fmicb.2016.00455","article-title":"Gut microbiota diversity and human diseases: should we reintroduce key predators in our ecosystem?","volume":"7","author":"Mosca","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.lfs.2021.120201_bb0030","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3389\/fcimb.2019.00444","article-title":"Age-related changes in the gut microbiota modify brain lipid composition","volume":"9","author":"Albouery","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.lfs.2021.120201_bb0035","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00558-19","article-title":"Age-related variation of bacterial and fungal communities in different body habitats across the young, elderly, and centenarians in Sardinia","volume":"5","author":"Wu","year":"2020","journal-title":"MSphere"},{"key":"10.1016\/j.lfs.2021.120201_bb0040","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1177\/1756283X12453637","article-title":"Fecal microbiota transplantation in relapsing Clostridium difficile infection","volume":"5","author":"Rohlke","year":"2012","journal-title":"Ther. Adv. Gastroenterol."},{"key":"10.1016\/j.lfs.2021.120201_bb0045","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4037\/aacnacc2016703","article-title":"Clostridium difficile infection and fecal microbiota transplant","volume":"27","author":"Liubakka","year":"2016","journal-title":"AACN Adv. Crit. Care"},{"key":"10.1016\/j.lfs.2021.120201_bb0050","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.7502","article-title":"Factors affecting the composition of the gut microbiota, and its modulation","volume":"7","author":"Hasan","year":"2019","journal-title":"PeerJ"},{"key":"10.1016\/j.lfs.2021.120201_bb0055","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.27014","article-title":"Regulation of life span by the gut microbiota in the short-lived african turquoise killifish","volume":"6","author":"Smith","year":"2017","journal-title":"elife"},{"key":"10.1016\/j.lfs.2021.120201_bb0060","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4161\/gmic.28403","article-title":"Broad scope method for creating humanized animal models for animal health and disease research through antibiotic treatment and human fecal transfer","volume":"5","author":"Hintze","year":"2014","journal-title":"Gut Microbes"},{"key":"10.1016\/j.lfs.2021.120201_bb0065","series-title":"Comparative Analysis of the Effects of Two Probiotic Bacterial Strains on Metabolism and Innate Immunity in the RAW 264.7 Murine Macrophage Cell Line, Probiotics and Antimicrobial Proteins","first-page":"73","volume":"8","author":"Pradhan","year":"2016"},{"key":"10.1016\/j.lfs.2021.120201_bb0070","series-title":"Probiotics L. acidophilus and B. clausii Modulate Gut Microbiota in Th1- and Th2-Biased Mice to Ameliorate Salmonella Typhimurium-Induced Diarrhea, Probiotics and Antimicrobial Proteins","volume":"11","author":"Pradhan","year":"2019"},{"key":"10.1016\/j.lfs.2021.120201_bb0075","doi-asserted-by":"crossref","DOI":"10.1039\/C9TX00006B","article-title":"Lactobacillus rhamnosus GG reverses mortality of neonatal mice against salmonella challenge","volume":"8","author":"Naik","year":"2019","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.lfs.2021.120201_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2018.01948","article-title":"Structural and functional alterations in the microbial community and immunological consequences in a mouse model of antibiotic-induced dysbiosis","volume":"9","author":"Shi","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.lfs.2021.120201_bb0085","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkl244","article-title":"NAST: a multiple sequence alignment server for comparative analysis of 16S rRNA genes","volume":"34","author":"DeSantis","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.lfs.2021.120201_bb0090","first-page":"10","article-title":"Metabolomic data processing, analysis, and interpretation using MetaboAnalyst","author":"Xia","year":"2011","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"10.1016\/j.lfs.2021.120201_bb0095","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1039\/C9TX00006B","article-title":"Lactobacillus rhamnosus GG reverses mortality of neonatal mice against Salmonella challenge","volume":"8","author":"Naik","year":"2019","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.lfs.2021.120201_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/cti.2017.2","article-title":"Roles of the intestinal microbiota in pathogen protection","volume":"6","author":"Ubeda","year":"2017","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.lfs.2021.120201_bb0105","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/imr.12567","article-title":"Gut microbiota: role in pathogen colonization, immune responses, and inflammatory disease","volume":"279","author":"Pickard","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.lfs.2021.120201_bb0110","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.4049\/jimmunol.174.3.1675","article-title":"The salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms","volume":"174","author":"Hapfelmeier","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2021.120201_bb0115","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiota shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.lfs.2021.120201_bb0120","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cmet.2016.06.016","article-title":"Effects of gut microbiota manipulation by antibiotics on host metabolism in obese humans: a randomized double-blind placebo-controlled trial","volume":"24","author":"Reijnders","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2021.120201_bb0125","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fcimb.2019.00099","article-title":"Antibiotic-induced disruption of gut microbiota alters local metabolomes and immune responses","volume":"9","author":"Sun","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.lfs.2021.120201_bb0130","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.2174\/138161209788168164","article-title":"The role of the gut microbiota in energy metabolism and metabolic disease","volume":"15","author":"Cani","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.lfs.2021.120201_bb0135","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/j.ajpath.2013.09.001","article-title":"TNF-\u03b1 modulation of intestinal epithelial tight junction barrier is regulated by ERK1\/2 activation of Elk-1","volume":"183","author":"Al-Sadi","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.lfs.2021.120201_bb0140","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1179\/joc.2001.13.Supplement-2.159","article-title":"Antibiotic induced endotoxin release and clinical sepsis: a review","author":"Holzheimer","year":"2001","journal-title":"J. Chemother."},{"key":"10.1016\/j.lfs.2021.120201_bb0145","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1080\/19490976.2015.1121364","article-title":"The Intersection of TNF, IBD and the microbiome","volume":"7","author":"Jones-Hall","year":"2016","journal-title":"Gut Microbes"},{"key":"10.1016\/j.lfs.2021.120201_bb0150","doi-asserted-by":"crossref","first-page":"858","DOI":"10.3390\/nu3100858","article-title":"Regulation of inflammation by short chain fatty acids","volume":"3","author":"Vinolo","year":"2011","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2021.120201_bb0155","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","article-title":"Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism","volume":"7","author":"Morrison","year":"2016","journal-title":"Gut Microbes"},{"key":"10.1016\/j.lfs.2021.120201_bb0160","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.3390\/nu7042930","article-title":"The role of microbial amino acid metabolism in host metabolism","volume":"7","author":"Neis","year":"2015","journal-title":"Nutrients"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521011887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521011887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T10:33:35Z","timestamp":1717238015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521011887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":32,"alternative-id":["S0024320521011887"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.120201","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbiota transplantation from younger to older mice could restore lost immunity to effectively clear salmonella infection in Th2-biased BALB\/c mice","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.120201","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120201"}}