{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T03:11:01Z","timestamp":1794107461957,"version":"4.8.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1R01HD094380"],"award-info":[{"award-number":["1R01HD094380"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.lfs.2021.120238","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T20:07:25Z","timestamp":1640030845000},"page":"120238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Differential response to hypoxia in leiomyoma and myometrial cells"],"prefix":"10.1016","volume":"290","author":[{"given":"Mariko","family":"Miyashita-Ishiwata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malak","family":"El Sabeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren D.","family":"Reschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia","family":"Afrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa A.","family":"Borahay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2021.120238_bb0005","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1067\/mob.2003.99","article-title":"High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence","volume":"188","author":"Baird","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.lfs.2021.120238_bb0010","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/humupd\/dmt042","article-title":"The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapy","volume":"20","author":"Tal","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.lfs.2021.120238_bb0015","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.bpobgyn.2008.01.005","article-title":"Pathophysiology of fibroid disease: angiogenesis and regulation of smooth muscle proliferation","volume":"22","author":"Fleischer","year":"2008","journal-title":"Best. Pract. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.lfs.2021.120238_bb0020","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","article-title":"Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1","volume":"16","author":"Forsythe","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.lfs.2021.120238_bb0025","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1177\/1933719118776793","article-title":"Hypoxia induces hypoxia-inducible factor 1\u03b1 and potential HIF-responsive gene expression in uterine leiomyoma","volume":"26","author":"Ishikawa","year":"2019","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.lfs.2021.120238_bb0030","doi-asserted-by":"crossref","first-page":"18700","DOI":"10.1073\/pnas.0704472104","article-title":"Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells","volume":"104","author":"Ono","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2021.120238_bb0035","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.mehy.2011.08.026","article-title":"Hypoxia: the driving force of uterine myometrial stem cells differentiation into leiomyoma cells","volume":"77","author":"Zhou","year":"2011","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.lfs.2021.120238_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105856","article-title":"Simvastatin modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradation","volume":"172","author":"Afrin","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2021.120238_bb0045","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.ajog.2020.05.012","article-title":"Simvastatin ameliorates altered mechanotransduction in uterine leiomyoma cells","volume":"223","author":"Afrin","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.lfs.2021.120238_bb0050","doi-asserted-by":"crossref","first-page":"35075","DOI":"10.1074\/jbc.M114.583575","article-title":"Simvastatin potently induces calcium-dependent apoptosis of human leiomyoma cells","volume":"289","author":"Borahay","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.lfs.2021.120238_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/endocr\/bqab211","article-title":"Simvastatin inhibits Wnt\/beta-catenin pathway in uterine leiomyoma","volume":"162","author":"El Sabeh","year":"2021","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2021.120238_bb0060","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/01.LAB.0000017499.51216.3E","article-title":"Immortalization of human uterine leiomyoma and myometrial cell lines after induction of telomerase activity: molecular and phenotypic characteristics","volume":"82","author":"Carney","year":"2002","journal-title":"Lab. Investig."},{"key":"10.1016\/j.lfs.2021.120238_bb0065","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1309\/AJCPVJDS28KNYZLD","article-title":"Immunohistochemical reevaluation of carbonic anhydrase IX (CA IX) expression in tumors and normal tissues","volume":"141","author":"Luong-Player","year":"2014","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.lfs.2021.120238_bb0070","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fcell.2018.00100","article-title":"The Warburg effect in endothelial cells and its potential as an anti-angiogenic target in cancer","volume":"6","author":"Fitzgerald","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.lfs.2021.120238_bb0075","doi-asserted-by":"crossref","first-page":"6128","DOI":"10.1158\/1078-0432.CCR-08-3180","article-title":"Identification of a novel small molecule HIF-1alpha translation inhibitor","volume":"15","author":"Narita","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.lfs.2021.120238_bb0080","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0301-5629(92)90079-P","article-title":"The assessment of benign uterine tumor vascularization by transvaginal color doppler","volume":"18","author":"Kurjak","year":"1992","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.lfs.2021.120238_bb0085","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/0029-7844(96)00073-7","article-title":"Intratumoral blood flow in uterine myoma correlated with a lower tumor size and volume, but not correlated with cell proliferation or angiogenesis","volume":"87","author":"Huang","year":"1996","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.lfs.2021.120238_bb0090","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1172\/JCI67230","article-title":"HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations","volume":"123","author":"Semenza","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2021.120238_bb0095","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/cvr\/cvq045","article-title":"Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling","volume":"86","author":"Rey","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2021.120238_bb0100","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1039\/b701676j","article-title":"The human oxygen sensing machinery and its manipulation","volume":"37","author":"Chowdhury","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.lfs.2021.120238_bb0105","doi-asserted-by":"crossref","first-page":"L549","DOI":"10.1152\/ajplung.00081.2012","article-title":"Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1","volume":"304","author":"Pisarcik","year":"2013","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"10.1016\/j.lfs.2021.120238_bb0110","doi-asserted-by":"crossref","first-page":"40524","DOI":"10.1038\/srep40524","article-title":"Adrenomedullin promotes angiogenesis in epithelial ovarian cancer through upregulating hypoxia-inducible factor-1\u03b1 and vascular endothelial growth factor","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"issue":"Suppl. 1","key":"10.1016\/j.lfs.2021.120238_bb0115","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1634\/theoncologist.9-suppl_1-2","article-title":"Vascular endothelial growth factor as a target for anticancer therapy","volume":"9","author":"Ferrara","year":"2004","journal-title":"Oncologist"},{"key":"10.1016\/j.lfs.2021.120238_bb0120","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1042\/cs1010691","article-title":"Quantification of vascular endothelial growth factor-a in leiomyomas and adjacent myometrium","volume":"101","author":"Gentry","year":"2001","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.lfs.2021.120238_bb0125","first-page":"2808","article-title":"Expression of the hypoxically regulated angiogenic factor adrenomedullin correlates with uterine leiomyoma vascular density","volume":"6","author":"Hague","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.lfs.2021.120238_bb0130","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3109\/09513591003632159","article-title":"Expression of vascular endothelial growth factor mRNA in human leiomyomas","volume":"26","author":"Lewicka","year":"2010","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.lfs.2021.120238_bb0135","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.fertnstert.2005.07.1294","article-title":"Spatial differences in biologic activity of large uterine leiomyomata","volume":"85","author":"Wei","year":"2006","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.lfs.2021.120238_bb0140","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1038\/sj.onc.1205374","article-title":"Adrenomedullin promotes formation of xenografted endometrial tumors by stimulation of autocrine growth and angiogenesis","volume":"21","author":"Oehler","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2021.120238_bb0145","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.1038\/sj.onc.1206789","article-title":"Vinblastine inhibits the angiogenic response induced by adrenomedullin in vitro and in vivo","volume":"22","author":"Ribatti","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2021.120238_bb0150","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/sj.onc.1201768","article-title":"PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non estrogenic mechanism in the human endometrium","volume":"16","author":"Zhao","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2021.120238_bb0155","doi-asserted-by":"crossref","first-page":"23345","DOI":"10.1074\/jbc.271.38.23345","article-title":"Adrenomedullin expression in human tumor cell lines. Its potential role as an autocrine growth factor","volume":"271","author":"Miller","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2021.120238_bb0160","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/molehr\/6.9.811","article-title":"Adrenomedullin is an autocrine regulator of endothelial growth in human endometrium","volume":"6","author":"Nikitenko","year":"2000","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.lfs.2021.120238_bb0165","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1177\/1933719114542018","article-title":"Enodthelin 1 is elevated in plasma and explants from patients having uterine leiomyomas","volume":"21","author":"Wallace","year":"2014","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.lfs.2021.120238_bb0170","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2174\/157016105774329462","article-title":"Endothelin-1 and angiogenesis in cancer","volume":"3","author":"Knowles","year":"2005","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.lfs.2021.120238_bb0175","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1210\/en.2006-0291","article-title":"Endothelin-1 inhibits apoptosis through a sphingosine kinase 1-dependent mechanism in uterine leiomyoma ELT3 cells","volume":"147","author":"Raymond","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2021.120238_bb0180","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1530\/ERC-12-0007","article-title":"miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5","volume":"19","author":"Chuang","year":"2012","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.lfs.2021.120238_bb0185","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1007\/s10815-019-01582-y","article-title":"SATB2 and NGR1: potential upstream regulatory factors in uterine leiomyomas","volume":"36","author":"Sato","year":"2019","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.lfs.2021.120238_bb0190","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1158\/0008-5472.CAN-07-6339","article-title":"Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia","volume":"68","author":"Mayer","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2021.120238_bb0195","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nature04483","article-title":"Angiogenesis as a therapeutic target","volume":"438","author":"Ferrara","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2021.120238_bb0200","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1055\/s-0037-1606303","article-title":"New and emerging therapies for uterine fibroids","volume":"35","author":"Fritton","year":"2017","journal-title":"Semin. Reprod. Med."},{"issue":"1","key":"10.1016\/j.lfs.2021.120238_bb0205","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2119\/molmed.2014.00053","article-title":"Signaling pathways in leiomyoma: understanding pathobiology and implications for therapy","volume":"21","author":"Borahay","year":"2015","journal-title":"Mol. Med."},{"issue":"9","key":"10.1016\/j.lfs.2021.120238_bb0210","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1177\/1933719116678686","article-title":"Estrogen receptors and signaling in fibroids: role in pathobiology and therapeutic implications","volume":"24","author":"Borahay","year":"2016","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.lfs.2021.120238_bb0215","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1007\/s11010-021-04174-6","article-title":"Wnt\/beta-catenin signaling pathway in uterine leiomyoma: role in tumor biology and targeting opportunities","volume":"476","author":"El Sabeh","year":"2021","journal-title":"Mol. Cell. Biochem."},{"issue":"3, supplement","key":"10.1016\/j.lfs.2021.120238_bb5000","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1016\/j.fertnstert.2021.07.041","article-title":"Hypoxia induces angiogenesis and proliferation in uterine fibroid cells","volume":"116","author":"Miyashita-Ishiwata","year":"2021","journal-title":"Fertil. Steril."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052101225X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052101225X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:52:36Z","timestamp":1758401556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002432052101225X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":44,"alternative-id":["S002432052101225X"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.120238","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.741371360.793592501","asserted-by":"object"}]},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential response to hypoxia in leiomyoma and myometrial cells","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.120238","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120238"}}