{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:52:03Z","timestamp":1761709923680,"version":"3.44.0"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016136","name":"Fundacion Araucaria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.lfs.2022.120303","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T01:43:33Z","timestamp":1642383813000},"page":"120303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Sulfasalazine exposure during pregnancy and lactation induces alterations in reproductive behavior in adult female rat offspring"],"prefix":"10.1016","volume":"293","author":[{"given":"Simone","family":"Forcato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Beatriz","family":"de Oliveira Aquino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaly","family":"de Moura Camparoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah Hamada Mendon\u00e7a","family":"Lens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Alessandra","family":"Guarnier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina Inhasz","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Cristina Ceccatto","family":"Gerardin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2022.120303_bb0005","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.autrev.2016.07.014","article-title":"Critical review of the current recommendations for the treatment of systemic inflammatory rheumatic diseases during pregnancy and lactation","volume":"15","author":"Levy","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.lfs.2022.120303_bb0010","first-page":"917","article-title":"The effect of sulfasalazine and 5-aminosalicylic acid on the secretion of interleukin 8 by human colon myofibroblasts","volume":"72","author":"Lodowska","year":"2015","journal-title":"acta pol. Pharm. -Drug Res."},{"key":"10.1016\/j.lfs.2022.120303_bb0015","doi-asserted-by":"crossref","first-page":"10018","DOI":"10.1002\/jcp.27860","article-title":"Strategies toward rheumatoid arthritis therapy; the old and the new","volume":"234","author":"Abbasi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.lfs.2022.120303_bb0020","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/BOR.0000000000000710","article-title":"Antirheumatic medications in pregnancy and breastfeeding","volume":"32","author":"Birru Talabi","year":"2020","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.lfs.2022.120303_bb0025","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3109\/03009742.2011.626442","article-title":"Outcomes after anti-rheumatic drug use before and during pregnancy: a cohort study among 150 000 pregnant women and expectant fathers","volume":"41","author":"Viktil","year":"2012","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.lfs.2022.120303_bb0030","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1111\/j.1572-0241.2007.01216.x","article-title":"Therapeutic drug use in women with crohn\u2019s disease and birth outcomes: a danish nationwide cohort study","volume":"102","author":"N\u00f8rg\u00e5rd","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.lfs.2022.120303_bb0035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1651-2227.1987.tb10430.x","article-title":"Sulphasalazine and sulphapyridine serum levels in children to mothers treated with sulphasalazine during pregnancy and lactation","volume":"76","author":"Esbjorner","year":"1987","journal-title":"Acta Paediatr. Scand."},{"key":"10.1016\/j.lfs.2022.120303_bb0040","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3109\/00365528109182032","article-title":"Placental transfer of sulphasalazine and sulphapyridine and some of its metabolites","volume":"16","author":"J\u00e4rnerot","year":"1981","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.lfs.2022.120303_bb0045","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000455519","article-title":"Disposition of salicylazosulfapyridine ( Azulfidine) and metabolites in human breast milk","volume":"1","author":"Berlin","year":"1980","journal-title":"Dev. Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2022.120303_bb0050","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1136\/bmj.2.6204.1553","article-title":"Placental and mammary transfer of sulphasalazine","volume":"2","author":"Khan","year":"1979","journal-title":"Br. Med. J."},{"year":"2011","series-title":"The Pharmacological Basis of Therapeutics","key":"10.1016\/j.lfs.2022.120303_bb0055"},{"key":"10.1016\/j.lfs.2022.120303_bb0060","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0016-5085(73)80035-6","article-title":"Distribution studies of salicylazosulfapyridine and its metabolites","volume":"64","author":"Peppercorn","year":"1973","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2022.120303_bb0065","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1517\/13543784.2012.670634","article-title":"Sulfasalazine for brain cancer fits","volume":"21","author":"Sontheimer","year":"2012","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.lfs.2022.120303_bb0070","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ijpharm.2016.01.024","article-title":"Diclofenac- \u03b2 -cyclodextrin for colonic drug targeting : in vivo performance in rats","volume":"500","author":"Vieira","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.lfs.2022.120303_bb0075","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/bdd.2510160502","article-title":"Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals","volume":"16","author":"Kararli","year":"1995","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.lfs.2022.120303_bb0080","series-title":"Effect of Sulfasalazine on Basal and Bacteria-stimulated Interleukin-8 Production by Endocervical Epithelial Cells","first-page":"190","volume":"61","author":"Peltier","year":"2009"},{"key":"10.1016\/j.lfs.2022.120303_bb0085","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1095\/biolreprod67.2.668","article-title":"Nuclear factor kappa B regulation of proinflammatory cytokines in human gestational tissues in vitro","volume":"67","author":"Lappas","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.lfs.2022.120303_bb0090","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1172\/JCI992","article-title":"Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B","volume":"101","author":"Wahl","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2022.120303_bb0095","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1440-1746.2005.03862.x","article-title":"Sulfasalazine inhibits activation of nuclear factor-\u03baB in patients with ulcerative colitis","volume":"20","author":"Gan","year":"2005","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2022.120303_bb0100","doi-asserted-by":"crossref","DOI":"10.1111\/and.12981","article-title":"Quercetin and rutin ameliorates sulphasalazine-induced spermiotoxicity, alterations in reproductive hormones and steroidogenic enzyme imbalance in rats","volume":"50","author":"Osawe","year":"2018","journal-title":"Andrologia"},{"key":"10.1016\/j.lfs.2022.120303_bb0105","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1439-0272.1984.tb00258.x","article-title":"Abnormal semen quality and low serum testosterone in men with inflammatory bowel disease treated for a long time with Sulfasalazine\"","volume":"16","author":"Ragni","year":"1984","journal-title":"Andrologia"},{"key":"10.1016\/j.lfs.2022.120303_bb0110","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.reprotox.2016.07.011","article-title":"Environmental factors, epigenetics, and developmental origin of reproductive disorders","volume":"68","author":"Ho","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.lfs.2022.120303_bb0115","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1071\/RD20007","article-title":"Effect of paracetamol treatment on maternal care and reproductive outcomes in female rat offspring","volume":"32","author":"Aleixo","year":"2012","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.lfs.2022.120303_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2017.08.023","article-title":"In utero and lactational exposure to metformin induces reproductive alterations in male rat offspring","volume":"74","author":"Forcato","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.lfs.2022.120303_bb0125","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.reprotox.2012.07.006","article-title":"Could maternal exposure to the antidepressants fluoxetine and St. John\u2019s Wort induce long-term reproductive effects on male rats?","volume":"35","author":"Vieira","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.lfs.2022.120303_bb0130","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.tox.2018.10.005","article-title":"Investigation of the potential e ff ects of triclosan as an endocrine disruptor in female rats : uterotrophic assay and two-generation study","volume":"410","author":"Montagnini","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.lfs.2022.120303_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2016.04.006","article-title":"In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring","volume":"62","author":"dos Santos","year":"2016","journal-title":"Reprod. Toxicol."},{"year":"2015","series-title":"Knobil and Neill\u2019s Physiology of Reproduction","author":"Levine","key":"10.1016\/j.lfs.2022.120303_bb0140"},{"key":"10.1016\/j.lfs.2022.120303_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.115.133652","article-title":"How is the number of primordial follicles in the ovarian reserve established?","volume":"93","author":"Findlay","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.lfs.2022.120303_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep41382","article-title":"Behavioural effects of using sulfasalazine to inhibit glutamate released by cancer cells: a novel target for cancer-induced depression","volume":"7","author":"Nashed","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2022.120303_bb0155","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1007\/s00213-014-3612-4","article-title":"Behavioral assessment of acute inhibition of system xc- in rats","volume":"231","author":"Lutgen","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.lfs.2022.120303_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnsys.2017.00042","article-title":"Integrating neural circuits controlling female sexual behavior","volume":"11","author":"Micevych","year":"2017","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.lfs.2022.120303_bb0165","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/j.1365-2826.2011.02200.x","article-title":"Functional mapping of the neural circuitry of rat maternal motivation: effects of site-specific transient neural inactivation","volume":"23","author":"Pereira","year":"2011","journal-title":"J. Neuroendocrionol."},{"key":"10.1016\/j.lfs.2022.120303_bb0170","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.crohns.2012.04.009","article-title":"Management of inflammatory bowel disease in pregnancy","volume":"6","author":"Vermeire","year":"2012","journal-title":"J. Crohn's Colitis"},{"key":"10.1016\/j.lfs.2022.120303_bb0175","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1002\/art.20375","article-title":"Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis","volume":"50","author":"Jansen","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.lfs.2022.120303_bb0180","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJM200011303432204","article-title":"Folic acid antagonists during pregnancy and the risk of birth defects","volume":"343","author":"Hern\u00e1ndez-D\u00edaz","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2022.120303_bb0185","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1136\/annrheumdis-2015-208840","article-title":"The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation","volume":"75","author":"Skorpen","year":"2016","journal-title":"Ann. Rheum. Dis."},{"first-page":"1","year":"2011","series-title":"Office of the Science Advisor Risk Assessment Forum, Recommended Use of Body Weight 3\/4 as the Default Method in Derivation of the Oral Reference Dose, Epa\/100\/R11\/0001","key":"10.1016\/j.lfs.2022.120303_bb0190"},{"key":"10.1016\/j.lfs.2022.120303_bb0195","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.toxlet.2017.11.034","article-title":"Dual effects of sulfasalazine on rat sperm characteristics, spermatogenesis, and steroidogenesis in two experimental models","volume":"284","author":"Ommati","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.lfs.2022.120303_bb0200","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1538\/expanim.18-0029","article-title":"Sulfasalazine treatment can cause a positive effecon lps-induced endotoxic rats","volume":"67","author":"Dik","year":"2018","journal-title":"Exp. Anim."},{"key":"10.1016\/j.lfs.2022.120303_bb0205","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.reprotox.2008.10.007","article-title":"Sulfasalazine induced oxidative stress: a possible mechanism of male infertility","volume":"27","author":"Alonso","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.lfs.2022.120303_bb0210","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0890-6238(99)00061-1","article-title":"Rat epididymal sperm motion changes induced by ethylene glycol monoethyl ether, sulfasalazine, and 2,5-hexandione","volume":"14","author":"Horimoto","year":"2000","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.lfs.2022.120303_bb0215","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.lfs.2016.03.042","article-title":"Does fish oil or folic acid prevent vascular changes in female progeny caused by maternal exposure to fluoxetine?","volume":"152","author":"Higashi","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2022.120303_bb0220","series-title":"BSR and BHPR guideline on prescribing drugs in pregnancy and breastfeeding \u2014 part I\u00a0: standard and biologic disease modifying anti-rheumatic drugs and corticosteroids","first-page":"1","author":"Flint","year":"2016"},{"key":"10.1016\/j.lfs.2022.120303_bb0225","doi-asserted-by":"crossref","first-page":"e534","DOI":"10.1097\/SCS.0000000000004488","article-title":"Maternal folic acid supplementation and the risk of oral clefts in offspring","volume":"29","author":"Jahanbin","year":"2018","journal-title":"J. Craniofac. Surg."},{"key":"10.1016\/j.lfs.2022.120303_bb0230","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.3390\/nu5114760","article-title":"Folate deficiency and folic acid supplementation: the prevention of neural-tube defects and congenital heart defects","volume":"5","author":"Czeizel","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2022.120303_bb0235","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.physbeh.2012.08.001","article-title":"Impact of maternal mild hyperglycemia on maternal care and offspring development and behavior of wistar rats","volume":"107","author":"Kiss","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.lfs.2022.120303_bb0240","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.physbeh.2016.08.017","article-title":"Reproductive parameters of female wistar rats treated with methylphenidate during development","volume":"167","author":"Montagnini","year":"2016","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.lfs.2022.120303_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.ntt.2019.106841","article-title":"Statistical modeling with litter as a random effect in mixed models to manage \u201cintralitter likeness\u201d","volume":"77","author":"Golub","year":"2020","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.lfs.2022.120303_bb0250","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0890-6238(99)00036-2","article-title":"Interpreting the toxicologic significance of alterations in anogenital distance: potential for confounding effects of progeny body weights","volume":"13","author":"Gallavan","year":"1999","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.lfs.2022.120303_bb0255","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1530\/jrf.0.0170555","article-title":"Proposal for a classification of oocytes and follicles in the mouse ovary","volume":"17","author":"Pedersen","year":"1968","journal-title":"Reproduction"},{"key":"10.1016\/j.lfs.2022.120303_bb0260","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1002\/mus.21798","article-title":"Time course of skeletal muscle loss and oxidative stress in rats with Walker 256 solid tumor","volume":"42","author":"Guarnier","year":"2010","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.lfs.2022.120303_bb0265","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1645\/0022-3395(2000)086[1067:OSOLIH]2.0.CO;2","article-title":"Oxidative stress of liver in hamsters infected with Leishmania ( L .) Chagasi","volume":"86","author":"Cecchini","year":"2000","journal-title":"J Parasitol."},{"key":"10.1016\/j.lfs.2022.120303_bb0270","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0891-5849(91)90002-K","article-title":"Hydroperoxide-initiated chemiluminescence: an assay for oxidative stress in biopsies of heart, liver, and muscle","volume":"10","author":"Gonzalez Flecha","year":"1991","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2022.120303_bb0275","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0003-2697(69)90064-5","article-title":"Enzymic method for quantitative nanogram amounts of Total glutathione : determination and oxidized","volume":"27","author":"Tietze","year":"1969","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.lfs.2022.120303_bb0280","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1590\/S1519-69842002000400008","article-title":"Determination of the estrous cycle phases of rats: some helpful considerations","volume":"62","author":"Marcondes","year":"2002","journal-title":"Braz. J. Biol."},{"key":"10.1016\/j.lfs.2022.120303_bb0285","first-page":"1382","article-title":"Effect of plastoquinone derivative 10-(60 -plastoquinonyl) decyltriphenylphosphonium (SkQ1) on estrous cycle and 17b-estradiol level in rats","volume":"77","author":"Chistyakov","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.lfs.2022.120303_bb0290","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.physbeh.2014.12.047","article-title":"Effects of maternal exposure to the galactagogue sulpiride on reproductive parameters in female rats","volume":"140","author":"De Azevedo Camin","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.lfs.2022.120303_bb0295","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/0091-3057(79)90250-8","article-title":"Prenatal amphetamine exposure: ovulation, sexual behavior and hypothalamic monoamine content in rats","volume":"11","author":"Ramirez","year":"1979","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.lfs.2022.120303_bb0300","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0031-9384(76)90254-7","article-title":"Prolonged hormone deprivation and pretest cage adaptation as factors affecting the display of lordosis by female rats","volume":"16","author":"Beach","year":"1976","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.lfs.2022.120303_bb0305","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0031-9384(71)90120-X","article-title":"Effects of mounts without intromission upon the behavior of female rats during the onset of estrogen-induced heat","volume":"7","author":"Fitzroy Hardy","year":"1971","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.lfs.2022.120303_bb0310","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1172\/JCI34241","article-title":"Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism","volume":"118","author":"Welsh","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2022.120303_bb0315","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.yhbeh.2008.07.004","article-title":"The role of neonatal NMDA receptor activation in defeminization and masculinization of sex behavior in the rat","volume":"54","author":"Schwarz","year":"2008","journal-title":"Horm Behav."},{"key":"10.1016\/j.lfs.2022.120303_bb0320","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1126\/science.6163211","article-title":"Sexual differentiation of the central nervous system","volume":"211","author":"Maclusky","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.lfs.2022.120303_bb0325","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.reprotox.2009.10.005","article-title":"Reproductive development and function of female rats exposed to di-\u03b7-butyl-phthalate (DBP) in utero and during lactation","volume":"29","author":"Guerra","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.lfs.2022.120303_bb0330","first-page":"15","article-title":"Practical recommendations for statistical analysis and data presentation in biochemia medica journal","volume":"22","author":"Simundic","year":"2012","journal-title":"biochemMedica."},{"key":"10.1016\/j.lfs.2022.120303_bb0335","doi-asserted-by":"crossref","unstructured":"F.B. Brasil M.R. De Oliveira , Maternal folic acid consumption during gestation and its long-term effects on offspring \u2019 s liver: a systematic review, 17 (n.d.) 7\u201315.","DOI":"10.1590\/1806-93042017000100002"},{"key":"10.1016\/j.lfs.2022.120303_bb0340","series-title":"Life Stages: Pregnancy and Lactation","volume":"30","author":"Angelo","year":"2016"},{"key":"10.1016\/j.lfs.2022.120303_bb0345","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/sj.leu.2402238","article-title":"Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x-ccystine transporter: a new action for an old drug","volume":"15","author":"Gout","year":"2001","journal-title":"Leukemia"},{"key":"10.1016\/j.lfs.2022.120303_bb0350","article-title":"Corticostriatal dysfunction and social interaction deficits in mice lacking the cystine\/glutamate antiporter","author":"Bentea","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.lfs.2022.120303_bb0355","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.1523\/JNEUROSCI.5465-10.2011","article-title":"Loss of system xc- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility","volume":"31","author":"de Bundel","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2022.120303_bb0360","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1096\/fj.10-177212","article-title":"Dopaminergic neurons of system x c \u2013 -deficient mice are highly protected against 6-hydroxydopamine-induced toxicity","volume":"25","author":"Massie","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2022.120303_bb0365","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/jnr.490250321","article-title":"The Alzheimer\u2019s amyloid precursor protein is produced by type I astrocytes in primary cultures of rat neuroglia","volume":"25","author":"Berkenbosch","year":"1990","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.lfs.2022.120303_bb0370","first-page":"161","article-title":"Neuroendocrinology and adaptive physiology of maternal care, curr top","volume":"43","author":"Smiley","year":"2019","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.lfs.2022.120303_bb0375","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.neubiorev.2013.04.004","article-title":"Flexibility and adaptation of the neural substrate that supports maternal behavior in mammals","volume":"37","author":"Olaz\u00e1bal","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.lfs.2022.120303_bb0380","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/dev.20198","article-title":"Motivational systems and the neural circuitry of maternal behavior in the rat","volume":"49","author":"Numan","year":"2007","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.lfs.2022.120303_bb0385","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.yfrne.2014.11.007","article-title":"Neuroendocrine regulation of maternal behavior","volume":"36","author":"Bridges","year":"2015","journal-title":"Front Neuroendocr."},{"key":"10.1016\/j.lfs.2022.120303_bb0390","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.niox.2005.07.002","article-title":"Nitric oxide mediated oxidative stress injury in rat skeletal muscle subjected to ischemia \/ reperfusion as evaluated by chemiluminescence","volume":"13","author":"Zimiani","year":"2005","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.lfs.2022.120303_bb0395","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0899-9007(03)00162-X","article-title":"Decreased oxidative stress in patients with ulcerative colitis supplemented with fish oil \u03c9-3 fatty acids","volume":"19","author":"Barbosa","year":"2003","journal-title":"Nutrition"},{"year":"2015","series-title":"Free Radicals in Biology and Medicine","author":"Halliwell","key":"10.1016\/j.lfs.2022.120303_bb0400"},{"key":"10.1016\/j.lfs.2022.120303_bb0405","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0149-7634(79)90013-7","article-title":"Differentiation of coital behavior in mammals: a comparative analysis","volume":"3","author":"Baum","year":"1979","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.lfs.2022.120303_bb0410","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1523\/JNEUROSCI.03-05-00933.1983","article-title":"A regional analysis of estrogen binding to hypothalamic cell nuclei in relation to masculinization and defeminization","volume":"3","author":"Nordeen","year":"1983","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2022.120303_bb0415","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0896-6273(91)90077-D","article-title":"Two genes encode distinct glutamate decarboxylases","volume":"7","author":"Erlander","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/j.lfs.2022.120303_bb0420","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0006-8993(90)90519-H","article-title":"Increased GABAergic transmission in medial hypothalamus facilitates lordosis but has the opposite effect in preoptic area","volume":"507","author":"McCarthy","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.lfs.2022.120303_bb0425","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0031-9384(86)90009-0","article-title":"Effect of bicuculline on sexual activity in castrated male rats","volume":"36","author":"Fernandez-Guasti","year":"1986","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.lfs.2022.120303_bb0430","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/0091-3057(86)90456-9","article-title":"GABAergic control of masculine sexual behavior","volume":"24","author":"Fern\u00e1ndez-Guasti","year":"1986","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.lfs.2022.120303_bb0435","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0736-5748(90)90080-L","article-title":"Ben ari, GABA mediated excitation in immature rat CA3 hippocampal neurons","volume":"8","author":"Cherubini","year":"1990","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.lfs.2022.120303_bb0440","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1937-6448(08)02002-9","article-title":"Hypothalamic neural systems controlling the female reproductive life cycle: gonadotropin-releasing hormone, glutamate, and GABA","volume":"274","author":"Maffucci","year":"2009","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.lfs.2022.120303_bb0445","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.conb.2010.04.004","article-title":"Sexual differentiation and development of forebrain reproductive circuits","volume":"20","author":"Semaan","year":"2010","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.lfs.2022.120303_bb0450","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.yfrne.2011.06.002","article-title":"Sexual differentiation of the gonadotropin surge release mechanism: a new role for the canonical Nf\u03baB signaling pathway","volume":"33","author":"Petersen","year":"2012","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.lfs.2022.120303_bb0455","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1210\/en.2006-1540","article-title":"Sexual differentiation of Kiss1 gene expression in the brain of the rat","volume":"148","author":"Kauffman","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2022.120303_bb0460","doi-asserted-by":"crossref","first-page":"8097","DOI":"10.1523\/JNEUROSCI.2267-04.2004","article-title":"Dual-phenotype GABA\/glutamate neurons in adult preoptic area: sexual dimorphism and function","volume":"24","author":"Ottem","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2022.120303_bb0465","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0166-4328(97)00191-5","article-title":"Organization and regulation of sexually dimorphic neuroendocrine pathways","volume":"92","author":"Simerly","year":"1998","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.lfs.2022.120303_bb0470","doi-asserted-by":"crossref","first-page":"0","DOI":"10.1111\/jne.12642","article-title":"The glutamine-glutamate cycle regulates synaptic glutamate release in the ventrolateral ventromedial nucleus of the hypothalamus of perinatal female rats","volume":"30","author":"Liang","year":"2018","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.lfs.2022.120303_bb0475","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2013.04.017","article-title":"Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males","volume":"153","author":"Yang","year":"2013","journal-title":"Cell"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522000030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522000030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:53:28Z","timestamp":1758401608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320522000030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":95,"alternative-id":["S0024320522000030"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120303","relation":{},"ISSN":["0024-3205"],"issn-type":[{"type":"print","value":"0024-3205"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sulfasalazine exposure during pregnancy and lactation induces alterations in reproductive behavior in adult female rat offspring","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120303","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120303"}}