{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:09:23Z","timestamp":1792069763769,"version":"4.4.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.lfs.2022.120304","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T02:22:25Z","timestamp":1641781345000},"page":"120304","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Mitigation of dexamethasone-induced nephrotoxicity by modulating the activity of adrenergic receptors: Implication of Wnt\/\u03b2-arrestin2\/\u03b2-catenin pathway"],"prefix":"10.1016","volume":"293","author":[{"given":"Rasha M.S.M.","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enssaf Ahmad","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bothina H.F.","family":"Omran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr T.","family":"Sakr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islam A.A.E.-H.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona F.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa E.","family":"El-Naggar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.lfs.2022.120304_bb0005","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1523-1755.2003.00840.x","article-title":"Pathophysiology of proteinuria","volume":"63","author":"D'amico","year":"2003","journal-title":"Kidney Int."},{"issue":"103","key":"10.1016\/j.lfs.2022.120304_bb0010","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.urology.2017.02.011","article-title":"Prevalence of proteinuria and other abnormalities in urinalysis performed in the urology clinic","volume":"1","author":"Bezinque","year":"2017","journal-title":"Urology"},{"issue":"10","key":"10.1016\/j.lfs.2022.120304_bb0015","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.4049\/jimmunol.158.10.5007","article-title":"Corticosteroids inhibit lymphocyte binding to endothelium and intercellular adhesion: an additional mechanism for their anti-inflammatory and immunosuppressive effect","volume":"158","author":"Pitzalis","year":"1997","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.lfs.2022.120304_bb0020","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF00172664","article-title":"High incidence of serious side effects of high-dose dexamethasone treatment in patients with epidural spinal cord compression","volume":"12","author":"Heimdal","year":"1992","journal-title":"J. Neuro-Oncol."},{"issue":"6","key":"10.1016\/j.lfs.2022.120304_bb0025","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/ki.1988.126","article-title":"Prednisolone can increase glomerular permeability to proteins in nephrotic syndrome","volume":"33","author":"Wetzels","year":"1988","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.lfs.2022.120304_bb0030","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1053\/ajkd.1998.v31.pm9506681","article-title":"Administration of dexamethasone induces proteinuria of glomerular origin in mice","volume":"31","author":"Chen","year":"1998","journal-title":"Am. J. Kidney Dis."},{"issue":"2\u20133","key":"10.1016\/j.lfs.2022.120304_bb0035","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0306-4522(91)90304-7","article-title":"Differential role of mineralocorticoid and glucocorticoid receptors in the genesis of dexamphetamine-induced sensitization of mesolimbic, \u03b11 adrenergic receptors in the ventral striatum","volume":"43","author":"Cools","year":"1991","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.lfs.2022.120304_bb0040","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1476-5381.1985.tb16154.x","article-title":"The role of \u03b1-adrenoceptors in the regulation of renal tubular sodium reabsorption and renin secretion in the rabbit","volume":"84","author":"Hesse","year":"1985","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.lfs.2022.120304_bb0045","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/nep.13584","article-title":"Beta2-adrenergic receptor in kidney biology: a current prospective","volume":"24","author":"Arif","year":"2019","journal-title":"Nephrology"},{"issue":"6","key":"10.1016\/j.lfs.2022.120304_bb0050","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1159\/000485931","article-title":"The role of \u03b2-adrenergic overstimulation in the early stages of renal injury","volume":"42","author":"de Ponte","year":"2017","journal-title":"Kidney Blood Press. Res."},{"issue":"5","key":"10.1016\/j.lfs.2022.120304_bb0055","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/ki.1980.186","article-title":"Renal effects of beta-adrenoceptor blockade","volume":"18","author":"Weber","year":"1980","journal-title":"Kidney Int."},{"issue":"333","key":"10.1016\/j.lfs.2022.120304_bb0060","article-title":"Quercetin and lithium chloride potentiate the protective effects of carvedilol against renal ischemia-reperfusion injury in high-fructose, high-fat diet-fed swiss albino mice independent of renal lipid signaling","volume":"5","author":"Rezk","year":"2021","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.lfs.2022.120304_bb0065","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/kisup.2014.16","article-title":"Wnt\/\u03b2-catenin signaling and kidney fibrosis","volume":"4","author":"Tan","year":"2014","journal-title":"Kidney Int. Suppl."},{"issue":"16","key":"10.1016\/j.lfs.2022.120304_bb0070","doi-asserted-by":"crossref","first-page":"6690","DOI":"10.1073\/pnas.0611356104","article-title":"\u03b2-arrestin is a necessary component of Wnt\/\u03b2-catenin signaling in vitro and in vivo","volume":"104","author":"Bryja","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"10","key":"10.1016\/j.lfs.2022.120304_bb0075","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1007\/s00210-020-01883-5","article-title":"Effect of omega-3 fatty acids on glucose homeostasis: role of free fatty acid receptor 1","volume":"393","author":"El-Fayoumi","year":"2020","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"issue":"3","key":"10.1016\/j.lfs.2022.120304_bb0080","first-page":"345","article-title":"Effect of garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats","volume":"45","author":"Mahendran","year":"2001","journal-title":"Indian J. Physiol. Pharmacol."},{"issue":"3","key":"10.1016\/j.lfs.2022.120304_bb0085","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1177\/2192568217699189","article-title":"Corticosteroid treatment for metastatic spinal cord compression: a review","volume":"7","author":"Skeoch","year":"2017","journal-title":"Glob. Spine J."},{"issue":"4","key":"10.1016\/j.lfs.2022.120304_bb0090","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1177\/1074248420905683","article-title":"Carvedilol diminishes cardiac remodeling induced by high-fructose\/high-fat diet in mice via enhancing cardiac \u03b2-Arrestin2 signaling","volume":"25","author":"Ibrahim","year":"2020","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.lfs.2022.120304_bb0095","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ijcard.2012.11.051","article-title":"Minimal dose for effective clinical outcome and predictive factors for responsiveness to carvedilol: japanese chronic heart failure (J-CHF) study","volume":"164","author":"Okamoto","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.lfs.2022.120304_bb0100","first-page":"A630","article-title":"Dose-dependent cardiac morphologic changes following intraperitoneal phenylephrine in rats","volume":"107","author":"Hu","year":"2007","journal-title":"Anesthesiology"},{"issue":"6","key":"10.1016\/j.lfs.2022.120304_bb0105","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.clinthera.2007.05.021","article-title":"Meta-analysis of the efficacy of a single dose of phenylephrine 10 mg compared with placebo in adults with acute nasal congestion due to the common cold","volume":"29","author":"Kollar","year":"2007","journal-title":"Clin. Ther."},{"issue":"5","key":"10.1016\/j.lfs.2022.120304_bb0110","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1111\/jgh.13207","article-title":"Combined administration of propranolol+ AG490 offers better effects on portal hypertensive rats with cirrhosis","volume":"31","author":"Wang","year":"2016","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"19","key":"10.1016\/j.lfs.2022.120304_bb0115","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1097\/00005344-199219001-00009","article-title":"Blood pressure lowering and cerebral blood flow: a comparison of the effects of carvedilol and propranolol on the cerebral circulation in hypertensive patients","volume":"1","author":"James","year":"1992","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"4","key":"10.1016\/j.lfs.2022.120304_bb0120","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1161\/01.HYP.28.4.627","article-title":"Role of angiotensin-converting enzyme, adrenergic receptors, and blood pressure in cardiac gene expression of spontaneously hypertensive rats during development","volume":"28","author":"Ohta","year":"1996","journal-title":"Hypertension"},{"issue":"S1","key":"10.1016\/j.lfs.2022.120304_bb0125","doi-asserted-by":"crossref","first-page":"83S","DOI":"10.1111\/j.1365-2125.1986.tb02858.x","article-title":"The antihypertensive effects of doxazosin: a clinical overview","volume":"21","author":"Cox","year":"1986","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"5","key":"10.1016\/j.lfs.2022.120304_bb0130","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1365-3016.2008.00956.x","article-title":"To pool or not to pool, from whether to when: applications of pooling to biospecimens subject to a limit of detection","volume":"22","author":"Schisterman","year":"2008","journal-title":"Paediatr. Perinat. Epidemiol."},{"issue":"824","key":"10.1016\/j.lfs.2022.120304_bb0135","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ejphar.2018.02.001","article-title":"Ameliorative effects of clonidine on ethanol induced kidney injury in rats: potential role for imidazoline-1 receptor","volume":"5","author":"Elkomy","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.lfs.2022.120304_bb0140","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/1440-1681.13232","article-title":"Effect of imidazoline-1 receptor agonists on renal dysfunction in rats associated with chronic, sequential fructose and ethanol administration","volume":"47","author":"Elkomy","year":"2020","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"5","key":"10.1016\/j.lfs.2022.120304_bb0145","first-page":"179","article-title":"Role of protein kinase C in podocytes and development of glomerular damage in diabetic nephropathy","volume":"5","author":"Teng","year":"2014","journal-title":"Front. Endocrinol."},{"issue":"47","key":"10.1016\/j.lfs.2022.120304_bb0150","doi-asserted-by":"crossref","first-page":"7043","DOI":"10.1038\/sj.onc.1208870","article-title":"RAS and TGF-\u03b2 exert antagonistic effects on extracellular matrix gene expression and fibroblast transformation","volume":"24","author":"Wisdom","year":"2005","journal-title":"Oncogene"},{"issue":"42","key":"10.1016\/j.lfs.2022.120304_bb0155","doi-asserted-by":"crossref","first-page":"27268","DOI":"10.1074\/jbc.273.42.27268","article-title":"Distinct mechanisms mediate the initial and sustained phases of integrin-mediated activation of the Raf\/MEK\/mitogen-activated protein kinase cascade","volume":"273","author":"Howe","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.lfs.2022.120304_bb0160","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1016\/j.bbamcr.2013.07.008","article-title":"The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts","volume":"1833","author":"Fuentes-Calvo","year":"2013","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"issue":"3\u20134","key":"10.1016\/j.lfs.2022.120304_bb0165","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1089\/ars.2005.7.308","article-title":"Expression and localization of NOX2 and NOX4 in primary human endothelial cells","volume":"7","author":"Buul","year":"2005","journal-title":"Antioxid. Redox Signal."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2022.120304_bb0170","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0027-5107(99)00010-X","article-title":"Lipid peroxidation\u2014DNA damage by malondialdehyde","volume":"424","author":"Marnett","year":"1999","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.lfs.2022.120304_bb0175","series-title":"Renal Fibrosis: Mechanisms and Therapies","first-page":"585","article-title":"Oxidative stress and renal fibrosis: mechanisms and therapies","author":"Su","year":"2019"},{"issue":"2","key":"10.1016\/j.lfs.2022.120304_bb0180","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/labinvest.2015.153","article-title":"Wnt\/\u03b2-catenin signaling in kidney injury and repair: a double-edged sword","volume":"96","author":"Zhou","year":"2016","journal-title":"Lab. Investig."},{"issue":"4","key":"10.1016\/j.lfs.2022.120304_bb0185","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.89","article-title":"\u03b2-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy","volume":"7","author":"Liu","year":"2016","journal-title":"Cell Death Dis."},{"issue":"42","key":"10.1016\/j.lfs.2022.120304_bb0190","doi-asserted-by":"crossref","first-page":"16657","DOI":"10.1073\/pnas.0707936104","article-title":"A unique mechanism of \u03b2-blocker action: carvedilol stimulates \u03b2-arrestin signaling","volume":"104","author":"Wisler","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.lfs.2022.120304_bb0195","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1097\/HJH.0b013e3280127948","article-title":"Antioxidant activity of carvedilol in cardiovascular disease","volume":"25","author":"Dandona","year":"2007","journal-title":"J. Hypertens."},{"issue":"6","key":"10.1016\/j.lfs.2022.120304_bb0200","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1472-8206.2004.00279.x","article-title":"Carvedilol attenuates ischemia\u2013reperfusion-induced oxidative renal injury in rats","volume":"18","author":"Singh","year":"2004","journal-title":"Fundam. Clin. Pharmacol."},{"issue":"5","key":"10.1016\/j.lfs.2022.120304_bb0205","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/sj.bjp.0704329","article-title":"Renoprotective effects of carvedilol in hypertensive-stroke prone rats may involve inhibition of TGF\u03b2 expression","volume":"134","author":"Wong","year":"2001","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.lfs.2022.120304_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-32309-1","article-title":"Anti-fibrotic impact of carvedilol in a CCl-4 model of liver fibrosis via serum microRNA-200a\/SMAD7 enhancement to bridle TGF-\u03b21\/EMT track","volume":"8","author":"El-Wakeel","year":"2018","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.lfs.2022.120304_bb0215","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.yjmcc.2010.11.014","article-title":"Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure","volume":"51","author":"Jensen","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"3","key":"10.1016\/j.lfs.2022.120304_bb0220","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/1053-0770(92)90144-V","article-title":"Renal function and cardiopulmonary bypass: effect of perfusion pressure","volume":"6","author":"Urzua","year":"1992","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"issue":"6","key":"10.1016\/j.lfs.2022.120304_bb0225","doi-asserted-by":"crossref","DOI":"10.1186\/cc7121","article-title":"Phenylephrine versus norepinephrine for initial hemodynamic support of patients with septic shock: a randomized, controlled trial","volume":"12","author":"Morelli","year":"2008","journal-title":"Crit. Care"},{"issue":"6","key":"10.1016\/j.lfs.2022.120304_bb0230","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.jamcollsurg.2014.01.058","article-title":"Efficacy and safety of phenylephrine in the management of low systolic blood pressure after renal transplantation","volume":"218","author":"Day","year":"2014","journal-title":"J. Am. Coll. Surg."},{"issue":"1","key":"10.1016\/j.lfs.2022.120304_bb0235","article-title":"Effects of epinephrine, norepinephrine and phenylephrine on regional and microcirculatory blood flow during sepsis","volume":"5","author":"Krejci","year":"2001","journal-title":"Crit. Care"},{"issue":"1","key":"10.1016\/j.lfs.2022.120304_bb0240","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/01.HYP.34.1.151","article-title":"Renal injury and salt-sensitive hypertension after exposure to catecholamines","volume":"34","author":"Johnson","year":"1999","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.lfs.2022.120304_bb0245","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S0022-5223(99)70379-X","article-title":"Delayed myocardial preconditioning by \u03b11-adrenoceptors involves inhibition of apoptosis","volume":"117","author":"Baghelai","year":"1999","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"3","key":"10.1016\/j.lfs.2022.120304_bb0250","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3892\/etm.2012.867","article-title":"Mechanism of the protective effect of phenylephrine pretreatment against irradiation-induced damage in the submandibular gland","volume":"5","author":"Xiang","year":"2013","journal-title":"Exp. Ther. Med."},{"issue":"4","key":"10.1016\/j.lfs.2022.120304_bb0255","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000445302","article-title":"Beta-blocker use is associated with higher renal tissue oxygenation in hypertensive patients suspected of renal artery stenosis","volume":"6","author":"Hall","year":"2016","journal-title":"Cardiorenal Med."},{"issue":"2","key":"10.1016\/j.lfs.2022.120304_bb0260","first-page":"265","article-title":"Protective effect of propranolol in the treatment of ischemically damaged canine kidneys prior to transplantation","volume":"84","author":"Stowe","year":"1978","journal-title":"Surgery"},{"issue":"5","key":"10.1016\/j.lfs.2022.120304_bb0265","first-page":"401","article-title":"Propranolol protection in acute renal failure","volume":"15","author":"Klein","year":"1978","journal-title":"Investig. Urol."},{"issue":"7926","key":"10.1016\/j.lfs.2022.120304_bb0270","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(75)90060-4","article-title":"Reduction in severity of acute renal failure in rats by beta-adrenergic blockade","volume":"306","author":"Iaina","year":"1975","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.lfs.2022.120304_bb0275","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0895-7061(99)00005-9","article-title":"\u03b2-adrenergic receptor blockade as a therapeutic approach for suppressing the renin-angiotensin-aldosterone system in normotensive and hypertensive subjects","volume":"12","author":"Blumenfeld","year":"1999","journal-title":"Am. J. Hypertens."},{"issue":"25","key":"10.1016\/j.lfs.2022.120304_bb0280","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1056\/NEJMoa030656","article-title":"The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia","volume":"349","author":"McConnell","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.lfs.2022.120304_bb0285","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1517\/14656566.9.4.625","article-title":"Doxazosin in the current treatment of hypertension","volume":"9","author":"Wykretowicz","year":"2008","journal-title":"Expert. Opin. Pharmacother."},{"issue":"5","key":"10.1016\/j.lfs.2022.120304_bb0290","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1161\/01.HYP.27.5.1108","article-title":"Doxazosin prevents proteinuria and glomerular loss of heparan sulfate in diabetic rats","volume":"27","author":"Jyothirmayi","year":"1996","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.lfs.2022.120304_bb0295","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/bcpt.13371","article-title":"Doxazosin down-regulates sodium-glucose cotransporter-2 and exerts a renoprotective effect in rat models of acute renal injury","volume":"126","author":"Rezq","year":"2020","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"2","key":"10.1016\/j.lfs.2022.120304_bb0300","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1527-3466.1994.tb00285.x","article-title":"Carvedilol: a novel multiple action antihypertensive drug that provides major organ protection","volume":"12","author":"Feuerstein","year":"1994","journal-title":"Cardiovasc. Drug Rev."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522000042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522000042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:55:13Z","timestamp":1758401713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320522000042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":60,"alternative-id":["S0024320522000042"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120304","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitigation of dexamethasone-induced nephrotoxicity by modulating the activity of adrenergic receptors: Implication of Wnt\/\u03b2-arrestin2\/\u03b2-catenin pathway","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120304","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120304"}}