{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:12:36Z","timestamp":1778703156038,"version":"3.51.4"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DBT\/IC-2\/Indo-Brazil\/2016-19\/01"],"award-info":[{"award-number":["DBT\/IC-2\/Indo-Brazil\/2016-19\/01"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["MAP\/2015\/58"],"award-info":[{"award-number":["MAP\/2015\/58"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.lfs.2022.120372","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T12:03:44Z","timestamp":1644235424000},"page":"120372","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Co-treatment of Nimbolide augmented the anti-arthritic effects of methotrexate while protecting against organ toxicities"],"prefix":"10.1016","volume":"295","author":[{"given":"Pratibha","family":"Anchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biswajit","family":"Panda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindra Bapu","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandraiah","family":"Godugu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2022.120372_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114350","article-title":"Fears and beliefs in rheumatoid arthritis and spondyloarthritis: a qualitative study","volume":"9","author":"Berenbaum","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2022.120372_bb0010","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1084\/jem.191.2.313","article-title":"Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist\u2013deficient mice","volume":"191","author":"Horai","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.lfs.2022.120372_bb0015","doi-asserted-by":"crossref","DOI":"10.1093\/rheumatology\/keh618","article-title":"B cells as a therapeutic target in autoimmune diseases other than rheumatoid arthritis","volume":"44","author":"Looney","year":"2005","journal-title":"Rheumatology"},{"key":"10.1016\/j.lfs.2022.120372_bb0020","doi-asserted-by":"crossref","first-page":"A288","DOI":"10.1016\/j.autrev.2009.11.019","article-title":"The environment, geo-epidemiology, and autoimmune disease: rheumatoid arthritis","volume":"9","author":"Tob\u00f3n","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.lfs.2022.120372_bb0025","first-page":"161","article-title":"Rheumatoid arthritis: early diagnosis and treatment outcomes","volume":"2","author":"Heidari","year":"2011","journal-title":"Caspian J. Intern. Med."},{"key":"10.1016\/j.lfs.2022.120372_bb0030","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and management of rheumatoid arthritis: a review","volume":"320","author":"Aletaha","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.lfs.2022.120372_bb0035","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1016\/S0140-6736(17)31491-5","article-title":"Novel treatment strategies in rheumatoid arthritis","volume":"389","author":"Burmester","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2022.120372_bb0040","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/039463201302600132","article-title":"Overuse of prescription and OTC non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis and osteoarthritis","volume":"26","author":"Cavagna","year":"2013","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.lfs.2022.120372_bb0045","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/clpt.2011.278","article-title":"Biologics-based therapy for the treatment of rheumatoid arthritis","volume":"91","author":"Scott","year":"2012","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2022.120372_bb0050","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00296-016-3621-1","article-title":"Oral to subcutaneous methotrexate dose-conversion strategy in the treatment of rheumatoid arthritis","volume":"37","author":"Schiff","year":"2017","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.lfs.2022.120372_bb0055","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1136\/annrheumdis-2016-210715","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update","volume":"76","author":"Smolen","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.lfs.2022.120372_bb0060","article-title":"Mechanisms of action of methotrexate","volume":"71","author":"Chan","year":"2013","journal-title":"Bull. Hosp. Jt Dis."},{"key":"10.1016\/j.lfs.2022.120372_bb0065","first-page":"S21","article-title":"How does methotrexate suppress inflammation","volume":"28","author":"Cronstein","year":"2010","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.lfs.2022.120372_bb0070","doi-asserted-by":"crossref","first-page":"10018","DOI":"10.1002\/jcp.27860","article-title":"Strategies toward rheumatoid arthritis therapy; the old and the new","volume":"234","author":"Abbasi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.lfs.2022.120372_bb0075","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41584-020-0373-9","article-title":"Methotrexate and its mechanisms of action in inflammatory arthritis","volume":"16","author":"Cronstein","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.lfs.2022.120372_bb0080","first-page":"1","article-title":"Side effects and management of side effects of methotrexate in rheumatoid arthritis","volume":"13","author":"Albrecht","year":"2010","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.lfs.2022.120372_bb0085","doi-asserted-by":"crossref","first-page":"909","DOI":"10.15537\/1658-3175.5101","article-title":"Adverse effects of low dose methotrexate in rheumatoid arthritis patients","volume":"31","author":"Attar","year":"2010","journal-title":"Saudi Med. J."},{"key":"10.1016\/j.lfs.2022.120372_bb0090","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/859383","article-title":"Mechanisms of thymoquinone hepatorenal protection in methotrexate-induced toxicity in rats","volume":"2015","author":"El-Sheikh","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.lfs.2022.120372_bb0095","article-title":"Molecular toxicity of methotrexate in rheumatoid arthritis treatment: a novel perspective and therapeutic implications","volume":"152909","author":"Katturajan","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.lfs.2022.120372_bb0100","first-page":"S27","article-title":"Methotrexate bioavailability","volume":"28","author":"Van Roon","year":"2010","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.lfs.2022.120372_bb0105","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ejmech.2018.09.027","article-title":"Side effects of methotrexate therapy for rheumatoid arthritis: a systematic review","volume":"158","author":"Wang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.lfs.2022.120372_bb0110","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jbspin.2009.05.011","article-title":"New insights in synovial angiogenesis","volume":"77","author":"Szekanecz","year":"2010","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.lfs.2022.120372_bb0115","article-title":"Angiogenesis as a potential treatment strategy for rheumatoid arthritis","volume":"174500","author":"Wang","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2022.120372_bb0120","first-page":"1","article-title":"Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis: a network meta-analysis","volume":"8","author":"Hazlewood","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.lfs.2022.120372_bb0125","series-title":"Cochrane Database Syst. Rev.","article-title":"Methotrexate monotherapy versus methotrexate combination therapy with non-biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis","author":"Katchamart","year":"2010"},{"key":"10.1016\/j.lfs.2022.120372_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118911","article-title":"Nimbolide exerts protective effects in complete Freund's adjuvant induced inflammatory arthritis via abrogation of STAT-3\/NF-\u03baB\/Notch-1 signaling","volume":"266","author":"Anchi","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2022.120372_bb0135","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1080\/21691401.2019.1649269","article-title":"Evaluation of antiarthritic activity of nimbolide against Freund\u2019s adjuvant induced arthritis in rats","volume":"47","author":"Cui","year":"2019","journal-title":"Artif. Cells Nanomedicine Biotechnol."},{"key":"10.1016\/j.lfs.2022.120372_bb0140","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10787-018-0527-4","article-title":"Nimbolide ameliorates fibrosis and inflammation in experimental murine model of bleomycin-induced scleroderma","volume":"27","author":"Diddi","year":"2019","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.lfs.2022.120372_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-018-1247-9","article-title":"Nimbolide protects against endotoxin-induced acute respiratory distress syndrome by inhibiting TNF-\u03b1 mediated NF-\u03baB and HDAC-3 nuclear translocation","volume":"10","author":"Pooladanda","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2022.120372_bb0150","article-title":"iRGD conjugated nimbolide liposomes protect against endotoxin induced acute respiratory distress syndrome","volume":"33","author":"Pooladanda","year":"2021","journal-title":"Nanomedicine"},{"key":"10.1016\/j.lfs.2022.120372_bb0155","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s11033-017-4132-1","article-title":"Nimbolide attenuate the lipid accumulation, oxidative stress and antioxidant in primary hepatocytes","volume":"44","author":"Alshammari","year":"2017","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.lfs.2022.120372_bb0160","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.molimm.2019.06.003","article-title":"Nimbolide ameliorates unilateral ureteral obstruction-induced renal fibrosis by inhibition of TGF-\u03b2 and EMT\/Slug signalling","volume":"112","author":"Annaldas","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.lfs.2022.120372_bb0165","first-page":"3455","article-title":"Evaluation of acute toxicity of neem active constituent, nimbolide and its hepatoprotective activity against acute dose of carbon tetrachloride treated albino rats","volume":"5","author":"Baligar","year":"2014","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"10.1016\/j.lfs.2022.120372_bb0170","doi-asserted-by":"crossref","first-page":"7131","DOI":"10.3748\/wjg.v26.i45.7131","article-title":"Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis","volume":"26","author":"Ram","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2022.120372_bb0175","doi-asserted-by":"crossref","first-page":"77","DOI":"10.21608\/ejb.2017.10184","article-title":"Anti-hepatotoxic and synergistic effects of sesame oil with methotrexate in adjuvant induced arthritis","volume":"35","author":"Ali","year":"2017","journal-title":"Egypt. J. Biochem. Mol. Biol."},{"key":"10.1016\/j.lfs.2022.120372_bb0180","article-title":"Therapeutic effect of matrine on collagen-induced arthritis rats and its regulatory effect on RANKL and OPG expression","volume":"2021","author":"Li","year":"2021","journal-title":"Int. J. Immunol. Res."},{"key":"10.1016\/j.lfs.2022.120372_bb0185","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jep.2018.08.011","article-title":"Therapeutic effects of Caesalpinia minax hance on complete Freund's adjuvant (CFA)-induced arthritis and the anti-inflammatory activity of cassane diterpenes as main active components","volume":"226","author":"Tong","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.lfs.2022.120372_bb0190","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ejps.2019.02.002","article-title":"Dramatic improvement in pharmacokinetic and pharmacodynamic effects of sustain release curcumin microparticles demonstrated in experimental type 1 diabetes model","volume":"130","author":"Anchi","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.lfs.2022.120372_bb0195","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/biof.1534","article-title":"Withaferin a ameliorates renal injury due to its potent effect on inflammatory signaling","volume":"45","author":"Peddakkulappagari","year":"2019","journal-title":"Biofactors"},{"key":"10.1016\/j.lfs.2022.120372_bb0200","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/rb\/rbz039","article-title":"Platelet-rich plasma combined with injectable hyaluronic acid hydrogel for porcine cartilage regeneration: a 6-month follow-up","volume":"7","author":"Yan","year":"2020","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.lfs.2022.120372_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106909","article-title":"Piperlongumine attenuates bile duct ligation-induced liver fibrosis in mice via inhibition of TGF-\u03b21\/Smad and EMT pathways","volume":"88","author":"Chilvery","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2022.120372_bb0210","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.2217\/nnm-2018-0085","article-title":"Nanoceria suppresses multiple low doses of streptozotocin-induced type 1 diabetes by inhibition of Nrf2\/NF-\u03baB pathway and reduction of apoptosis","volume":"13","author":"Khurana","year":"2018","journal-title":"Nanomedicine"},{"key":"10.1016\/j.lfs.2022.120372_bb0215","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/excr.2000.5118","article-title":"MT1-MMP initiates activation of pro-MMP-2 and integrin \u03b1v\u03b23 promotes maturation of MMP-2 in breast carcinoma cells","volume":"263","author":"Deryugina","year":"2001","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.lfs.2022.120372_bb0220","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fphar.2018.00248","article-title":"An adaptogen: withaferin a ameliorates in vitro and in vivo pulmonary fibrosis by modulating the interplay of fibrotic, matricelluar proteins, and cytokines","volume":"9","author":"Bale","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2022.120372_bb0225","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3109\/15360288.2014.959238","article-title":"Methotrexate: a gold standard for treatment of rheumatoid arthritis","volume":"28","author":"Shinde","year":"2014","journal-title":"J. Pain Palliat. Care Pharmacother."},{"key":"10.1016\/j.lfs.2022.120372_bb0230","first-page":"16","article-title":"Methotrexate in rheumatoid arthritis: a quarter century of development","volume":"124","author":"Weinblatt","year":"2013","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"10.1016\/j.lfs.2022.120372_bb0235","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3390\/jcm8040515","article-title":"How to get the most from methotrexate (MTX) treatment for your rheumatoid arthritis patient?\u2014MTX in the treat-to-target strategy","volume":"8","author":"Taylor","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.lfs.2022.120372_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107246","article-title":"Nimbolide ameliorates pancreatic inflammation and apoptosis by modulating NF-\u03baB\/SIRT1 and apoptosis signaling in acute pancreatitis model","volume":"90","author":"Bansod","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"5.4","key":"10.1016\/j.lfs.2022.120372_bb0245","article-title":"Models of inflammation: carrageenan-or complete freund\u2019s adjuvant (CFA)\u2013induced edema and hypersensitivity in the rat","volume":"56","author":"Fehrenbacher","year":"2012","journal-title":"Curr. Protoc. Pharmacol."},{"key":"10.1016\/j.lfs.2022.120372_bb0250","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1007\/s10753-018-0841-4","article-title":"Novel anti-arthritic mechanisms of polydatin in complete Freund\u2019s adjuvant-induced arthritis in rats: involvement of IL-6, STAT-3, IL-17, and NF-\u043aB","volume":"41","author":"Kamel","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.lfs.2022.120372_bb0255","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.biopha.2017.05.055","article-title":"Rheumatoid arthritis: recent advances on its etiology, role of cytokines and pharmacotherapy","volume":"92","author":"Alam","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2022.120372_bb0260","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/jir.2019.0085","article-title":"Constitutive inflammatory cytokine storm: a major threat to human health","volume":"40","author":"Gupta","year":"2020","journal-title":"J. Interf. Cytokine Res."},{"key":"10.1016\/j.lfs.2022.120372_bb0265","first-page":"101","article-title":"Adverse effects of low dose methotrexate in rheumatoid arthritis patients","volume":"22","author":"Gilani","year":"2012","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"10.1016\/j.lfs.2022.120372_bb0270","article-title":"Methotrexate-induced organ toxicity in patients with rheumatoid arthritis: a review article","volume":"14","author":"Sah","year":"2020","journal-title":"Drug Invent. Today"},{"key":"10.1016\/j.lfs.2022.120372_bb0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2157-7609.1000125","article-title":"Methotrexate side effects: review article","volume":"3","author":"Gaies","year":"2012","journal-title":"J. Drug Metab. Toxicol."},{"key":"10.1016\/j.lfs.2022.120372_bb0280","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.3899\/jrheum.090153","article-title":"Methotrexate drug interactions in the treatment of rheumatoid arthritis: a systematic review","volume":"37","author":"Bourr\u00e9-Tessier","year":"2010","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.lfs.2022.120372_bb0285","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4103\/WKMP-0110.170764","article-title":"Acute methotrexate toxicity","volume":"1","author":"Madke","year":"2015","journal-title":"Indian J. Drugs Dermatol."},{"key":"10.1016\/j.lfs.2022.120372_bb0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079284","article-title":"Targeting TNF-\u03b1 and NF-\u03baB activation by bee venom: role in suppressing adjuvant induced arthritis and methotrexate hepatotoxicity in rats","volume":"8","author":"Darwish","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2022.120372_bb0295","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.biopha.2018.07.001","article-title":"Evaluation of the effect of andrographolide and methotrexate combined therapy in complete Freund\u02bcs adjuvant induced arthritis with reduced hepatotoxicity","volume":"106","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2022.120372_bb0300","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/ard.2008.101378","article-title":"Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and\/or leflunomide","volume":"69","author":"Curtis","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.lfs.2022.120372_bb0305","doi-asserted-by":"crossref","first-page":"99","DOI":"10.14218\/JCTH.2015.00007","article-title":"Drug induced liver injury: review with a focus on genetic factors, tissue diagnosis, and treatment options","volume":"3","author":"Khoury","year":"2015","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.lfs.2022.120372_bb0310","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2147\/TCRM.S194921","article-title":"Drug-related problems in patients with rheumatoid arthritis","volume":"15","author":"Ma","year":"2019","journal-title":"Ther. Clin. Risk Manag."},{"key":"10.1016\/j.lfs.2022.120372_bb0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-018-2408-1","article-title":"Therapeutic benefits of Indole-3-carbinol in adjuvant-induced arthritis and its protective effect against methotrexate induced-hepatic toxicity","volume":"18","author":"Hasan","year":"2018","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.lfs.2022.120372_bb0320","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ejphar.2012.10.024","article-title":"Evaluation of the effect of losartan and methotrexate combined therapy in adjuvant-induced arthritis in rats","volume":"698","author":"Refaat","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2022.120372_bb0325","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/mc.20812","article-title":"Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2\/9 expression via inhibiting ERK1\/2 and reducing DNA-binding activity of NF-\u03baB in colon cancer cells","volume":"51","author":"Babykutty","year":"2012","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.lfs.2022.120372_bb0330","doi-asserted-by":"crossref","first-page":"156","DOI":"10.5808\/GI.2014.12.4.156","article-title":"Review on molecular and chemopreventive potential of nimbolide in cancer","volume":"12","author":"Elumalai","year":"2014","journal-title":"Genomics Inform."},{"key":"10.1016\/j.lfs.2022.120372_bb0335","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/ptr.5657","article-title":"Nimbolide inhibits nuclear factor-\u041aB pathway in intestinal epithelial cells and macrophages and alleviates experimental colitis in mice","volume":"30","author":"Seo","year":"2016","journal-title":"Phytother. Res."},{"key":"10.1016\/j.lfs.2022.120372_bb0340","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.3390\/ijms19072012","article-title":"Implications of angiogenesis involvement in arthritis","volume":"19","author":"MacDonald","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2022.120372_bb0345","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/BOR.0b013e328337c95a","article-title":"Angiogenesis and vasculogenesis in rheumatoid arthritis","volume":"22","author":"Szekanecz","year":"2010","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.lfs.2022.120372_bb0350","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00296-010-1592-1","article-title":"Expression levels and association of gelatinases MMP-2 and MMP-9 and collagenases MMP-1 and MMP-13 with VEGF in synovial fluid of patients with arthritis","volume":"31","author":"Kim","year":"2011","journal-title":"Rheumatol. Int."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522000728?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522000728?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:07:02Z","timestamp":1778702822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320522000728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":70,"alternative-id":["S0024320522000728"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120372","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Co-treatment of Nimbolide augmented the anti-arthritic effects of methotrexate while protecting against organ toxicities","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120372","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120372"}}