{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:03:24Z","timestamp":1788930204448,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.lfs.2022.120480","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T02:13:04Z","timestamp":1646878384000},"page":"120480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Telmisartan neuroprotective effects in 3-nitropropionic acid Huntington's disease model in rats: Cross talk between PPAR-\u03b3 and PI3K\/Akt\/GSK-3\u03b2 pathway"],"prefix":"10.1016","volume":"297","author":[{"given":"Nora O.","family":"Abdel Rasheed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weam W.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.lfs.2022.120480_bb0005","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1007\/s12035-015-9303-2","article-title":"Role of rho kinase inhibition in the protective effect of fasudil and simvastatin against 3-nitropropionic acid-induced striatal neurodegeneration and mitochondrial dysfunction in rats","volume":"53","author":"Ahmed","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.lfs.2022.120480_bb0010","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/toxsci\/kfq036","article-title":"A possible neuroprotective action of a vinylic telluride against mn-induced neurotoxicity","volume":"115","author":"Avila","year":"2010","journal-title":"Toxicol. Sci."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2022.120480_bb0015","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.lfs.2022.120480_bb0020","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.phymed.2016.12.017","article-title":"Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson\u2019s disease: involvement of PI3K\/Akt and MEK\/ERK signaling pathways","volume":"25","author":"Chen","year":"2017","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2022.120480_bb0025","series-title":"Handbook of Histopathological and Histochemical Techniques","author":"Culling","year":"2013"},{"key":"10.1016\/j.lfs.2022.120480_bb0030","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fendo.2017.00108","article-title":"Angiotensins and Huntington's disease: a study on immortalized progenitor striatal cell lines","volume":"8","author":"De Mello","year":"2017","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.lfs.2022.120480_bb0035","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.3389\/fneur.2020.588516","article-title":"The protective effects of peroxisome proliferator-activated receptor gamma in cerebral ischemia-reperfusion injury","volume":"11","author":"Ding","year":"2020","journal-title":"Front. Neurol."},{"issue":"9","key":"10.1016\/j.lfs.2022.120480_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203837","article-title":"Cilostazol disrupts TLR-4, Akt\/GSK-3\u03b2\/CREB, and IL-6\/JAK-2\/STAT-3\/SOCS-3 crosstalk in a rat model of Huntington's disease","volume":"13","author":"El-Abhar","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2022.120480_bb0045","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.taap.2018.05.035","article-title":"Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: a pivotal role of AMPK\/SIRT1 and JAK2\/STAT3\/NF-\u041aB signalling pathway modulation","volume":"352","author":"Elbaz","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.lfs.2022.120480_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118076","article-title":"Dapagliflozin improves behavioral dysfunction of Huntington's disease in rats via inhibiting apoptosis-related glycolysis","volume":"257","author":"El-Sahar","year":"2020","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.lfs.2022.120480_bb0055","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/acps.12799","article-title":"The effect of adjunctive telmisartan treatment on psychopathology and cognition in patients with schizophrenia","volume":"136","author":"Fan","year":"2017","journal-title":"Acta Psychiatr. Scand."},{"issue":"11","key":"10.1016\/j.lfs.2022.120480_bb0060","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.3390\/ijms22115444","article-title":"C60 fullerene reduces 3-nitropropionic acid-induced oxidative stress disorders and mitochondrial dysfunction in rats by modulation of p53, Bcl-2 and Nrf2 targeted proteins","volume":"22","author":"Gonchar","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2022.120480_bb0065","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neuro.2014.10.004","article-title":"Potential of protease inhibitor in 3-nitropropionic acid induced Huntington's disease like symptoms: mitochondrial dysfunction and neurodegeneration","volume":"45","author":"Hariharan","year":"2014","journal-title":"Neurotoxicology"},{"issue":"1","key":"10.1016\/j.lfs.2022.120480_bb0070","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.yexcr.2004.09.032","article-title":"Peroxisome proliferator-activated receptor \u03b4 is expressed in hippocampal neurons and its activation prevents \u03b2-amyloid neurodegeneration: role of wnt signaling","volume":"304","author":"Inestrosa","year":"2005","journal-title":"Exp. Cell Res."},{"issue":"4","key":"10.1016\/j.lfs.2022.120480_bb0075","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1007\/s12035-015-9260-9","article-title":"Angiotensin-(1\u20137) is reduced and inversely correlates with tau hyperphosphorylation in animal models of Alzheimer's disease","volume":"53","author":"Jiang","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.lfs.2022.120480_bb0080","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/jnc.12190","article-title":"Neuroprotective effects of PPAR-\u03b3 agonist rosiglitazone in N171\u201382Q mouse model of Huntington's disease","volume":"125","author":"Jin","year":"2013","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.lfs.2022.120480_bb0085","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s12640-019-00085-z","article-title":"Telmisartan protects against aluminum-induced alzheimer-like pathological changes in rats","volume":"37","author":"Khalifa","year":"2020","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.lfs.2022.120480_bb0090","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3389\/fphar.2017.00673","article-title":"Schisandra chinensis stem ameliorates 3-nitropropionic acid-induced striatal toxicity via activation of the Nrf2 pathway and inhibition of the MAPKs and NF-\u041aB pathways","volume":"8","author":"Kim","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.lfs.2022.120480_bb0095","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/00001756-200302100-00020","article-title":"Glycogen. Synthase kinase-3\u03b2-mediated tau phosphorylation in cultured cell lines","volume":"14","author":"Lee","year":"2003","journal-title":"Neuroreport"},{"issue":"4","key":"10.1016\/j.lfs.2022.120480_bb0100","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.lfs.2022.120480_bb0105","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.lfs.2022.120480_bb0110","doi-asserted-by":"crossref","first-page":"456","DOI":"10.2174\/0929866527666200110154523","article-title":"The renin-angiotensin system in Huntington's disease: villain or hero?","volume":"27","author":"Machado","year":"2020","journal-title":"Protein Pept. Lett."},{"issue":"5","key":"10.1016\/j.lfs.2022.120480_bb0120","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1161\/HYPERTENSIONAHA.112.192401","article-title":"Peroxisome proliferator-activated receptor-\u03b4 activation with angiotensin II type 1 receptor blockade is pivotal for the prevention of blood-brain barrier impairment and cognitive decline in type 2 diabetic mice","volume":"59","author":"Min","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2022.120480_bb0125","series-title":"Reactive Oxygen Species in Neurodegenerative Diseases: Implications in Pathogenesis and Treatment Strategies","author":"Oladele","year":"2021"},{"issue":"s3","key":"10.1016\/j.lfs.2022.120480_bb0130","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.3233\/JAD-132738","article-title":"Apoptosis and oxidative stress in neurodegenerative diseases","volume":"42","author":"Radi","year":"2014","journal-title":"J. Alzheimers Dis."},{"issue":"5","key":"10.1016\/j.lfs.2022.120480_bb0135","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s11011-018-0252-0","article-title":"Thymoquinone loaded solid lipid nanoparticles counteracts 3-nitropropionic acid induced motor impairments and neuro-inflammation in rat model of Huntington'\u0622s disease","volume":"33","author":"Ramachandran","year":"2018","journal-title":"Metab. Brain Dis."},{"issue":"4","key":"10.1016\/j.lfs.2022.120480_bb0140","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/ilar.48.4.356","article-title":"Animal models of Huntington's disease","volume":"48","author":"Ramaswamy","year":"2007","journal-title":"ILAR J."},{"key":"10.1016\/j.lfs.2022.120480_bb0145","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1172-5-40","article-title":"Huntington's disease: a clinical review","volume":"5","author":"Roos","year":"2010","journal-title":"Orphanet J. Rare Dis."},{"issue":"4","key":"10.1016\/j.lfs.2022.120480_bb0150","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrneurol.2014.24","article-title":"Huntington disease: natural history, biomarkers and prospects for therapeutics","volume":"10","author":"Ross","year":"2014","journal-title":"Nat. Rev. Neurol."},{"issue":"10","key":"10.1016\/j.lfs.2022.120480_bb0155","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1042\/CS20120078","article-title":"Angiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders","volume":"123","author":"Saavedra","year":"2012","journal-title":"Clin. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2022.120480_bb0160","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s13311-019-00805-5","article-title":"Vildagliptin attenuates Huntington's disease through activation of GLP-1 receptor\/PI3K\/Akt\/BDNF pathway in 3-nitropropionic acid rat model","volume":"17","author":"Sayed","year":"2020","journal-title":"Neurotherapeutics"},{"issue":"3","key":"10.1016\/j.lfs.2022.120480_bb0165","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s12640-018-9921-3","article-title":"Telmisartan ameliorates astroglial and dopaminergic functions in a mouse model of chronic parkinsonism","volume":"34","author":"Sekar","year":"2018","journal-title":"Neurotox. Res."},{"issue":"2","key":"10.1016\/j.lfs.2022.120480_bb0170","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1177\/1470320312459977","article-title":"Attenuating effect of lisinopril and telmisartan in intracerebroventricular streptozotocin induced experimental dementia of Alzheimer's disease type: possible involvement of PPAR-\u03b4 agonistic property","volume":"14","author":"Singh","year":"2013","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"issue":"2","key":"10.1016\/j.lfs.2022.120480_bb0175","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00210-011-0654-6","article-title":"Neuroprotective mechanisms of peroxisome proliferator-activated receptor agonists in Alzheimer's disease","volume":"384","author":"Sodhi","year":"2011","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"issue":"13","key":"10.1016\/j.lfs.2022.120480_bb0180","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1038\/npp.2012.152","article-title":"Candesartan, an angiotensin II AT 1-receptor blocker and PPAR-\u03b3 agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice","volume":"37","author":"Villapol","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.lfs.2022.120480_bb0185","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.neuropharm.2013.11.022","article-title":"Telmisartan ameliorates glutamate-induced neurotoxicity: roles of AT1 receptor blockade and PPAR-\u03b3 activation","volume":"79","author":"Wang","year":"2014","journal-title":"Neuropharmacology"},{"issue":"9","key":"10.1016\/j.lfs.2022.120480_bb0190","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/s41401-020-00558-4","article-title":"Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington's disease via suppressing MAPKs and NF-\u041aB pathways in the striatum","volume":"42","author":"Yang","year":"2021","journal-title":"Acta Pharmacol. Sin."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522001801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522001801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:57:11Z","timestamp":1758401831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320522001801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":37,"alternative-id":["S0024320522001801"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120480","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Telmisartan neuroprotective effects in 3-nitropropionic acid Huntington's disease model in rats: Cross talk between PPAR-\u03b3 and PI3K\/Akt\/GSK-3\u03b2 pathway","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120480","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120480"}}