{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:11:06Z","timestamp":1792512666947,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.lfs.2022.120622","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T10:52:52Z","timestamp":1651920772000},"page":"120622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Melatonin relieves liver fibrosis induced by Txnrd3 knockdown and nickel exposure via IRE1\/NF-kB\/NLRP3 and PERK\/TGF-\u03b21 axis activation"],"prefix":"10.1016","volume":"301","author":[{"given":"Qi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senqiu","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzeng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"242","key":"10.1016\/j.lfs.2022.120622_bb0005","first-page":"115","article-title":"Nickel - role in human organism and toxic effects","volume":"41","author":"Zdrojewicz","year":"2016","journal-title":"Pol. Merkur. Lekarski"},{"issue":"9","key":"10.1016\/j.lfs.2022.120622_bb0010","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1039\/C5MT00072F","article-title":"Nickel-responsive transcriptional regulators","volume":"7","author":"Musiani","year":"2015","journal-title":"Metallomics"},{"issue":"12","key":"10.1016\/j.lfs.2022.120622_bb0015","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.bbapap.2016.09.008","article-title":"Nickel impact on human health: an intrinsic disorder perspective","volume":"1864","author":"Zambelli","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.lfs.2022.120622_bb0020","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/cod.13327","article-title":"Nickel allergy and allergic contact dermatitis: a clinical review of immunology, epidemiology, exposure, and treatment","volume":"81","author":"Ahlstr\u00f6m","year":"2019","journal-title":"Contact Dermatitis"},{"issue":"2","key":"10.1016\/j.lfs.2022.120622_bb0025","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1515\/reveh.2011.012","article-title":"Exploring the molecular mechanisms of nickel-induced genotoxicity and carcinogenicity: a literature review","volume":"26","author":"Cameron","year":"2011","journal-title":"Rev. Environ. Health"},{"issue":"2","key":"10.1016\/j.lfs.2022.120622_bb0030","first-page":"3133","article-title":"Role of oxidative stress in liver toxicity induced by nickel oxide nanoparticles in rats","volume":"17","author":"Yu","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.lfs.2022.120622_bb0035","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1021\/jf304562b","article-title":"Sesamin protects mouse liver against nickel-induced oxidative DNA damage and apoptosis by the PI3K-akt pathway","volume":"61","author":"Liu","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.lfs.2022.120622_bb0040","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fct.2015.05.001","article-title":"Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2\/HO-1 and p38\/STAT1\/NF-\u03baB pathway","volume":"82","author":"Liu","year":"2015","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.lfs.2022.120622_bb0045","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1039\/C9FO02861G","article-title":"The proteomic profiling of multiple tissue damage in chickens for a selenium deficiency biomarker discovery","volume":"11","author":"Zhang","year":"2020","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.lfs.2022.120622_bb0050","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jcp.29831","article-title":"Zhang ZA-O: LncRNA 0003250 accelerates heart autophagy and binds to miR-17-5p as a competitive endogenous RNA in chicken induced by selenium deficiency","volume":"236","author":"Yang","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.lfs.2022.120622_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102003","article-title":"Roles of selenoprotein S in reactive oxygen species-dependent neutrophil extracellular trap formation induced by selenium-deficient arteritis","volume":"44","author":"Chi","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2022.120622_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125794","article-title":"Antagonistic effect of selenium on lead-induced neutrophil apoptosis in chickens via miR-16-5p targeting of PiK3R1 and IGF1R","volume":"246","author":"Yin","year":"2020","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.lfs.2022.120622_bb0065","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/s41418-019-0399-1","article-title":"SLC27A5 deficiency activates NRF2\/TXNRD1 pathway by increased lipid peroxidation in HCC","volume":"27","author":"Gao","year":"2020","journal-title":"Cell Death Differ."},{"issue":"19","key":"10.1016\/j.lfs.2022.120622_bb0070","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12935-019-0919-6","article-title":"Lu LA-O: miR-125b-5p inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma via targeting TXNRD1","volume":"30","author":"Hua","year":"2019","journal-title":"Cancer Cell Int."},{"issue":"7","key":"10.1016\/j.lfs.2022.120622_bb0075","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002278","article-title":"Thioredoxin reductase 2 (Txnrd2) regulates mitochondrial integrity in the progression of age-related heart failure","volume":"4","author":"Yoshioka","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.lfs.2022.120622_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101652","article-title":"Mitochondrial TXNRD3 confers drug resistance via redox-mediated mechanism and is a potential therapeutic target in vivo","volume":"36","author":"Liu","year":"2020","journal-title":"Redox Biol."},{"issue":"2-3","key":"10.1016\/j.lfs.2022.120622_bb0085","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuchi.2015.03.002","article-title":"Melatonin: physiological effects in humans","volume":"61","author":"Claustrat","year":"2015","journal-title":"Neurochirurgie"},{"issue":"4","key":"10.1016\/j.lfs.2022.120622_bb0090","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3390\/ijms18040673","article-title":"Effects of melatonin on liver injuries and diseases","volume":"18","author":"Zhang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"24","key":"10.1016\/j.lfs.2022.120622_bb0095","doi-asserted-by":"crossref","first-page":"7427","DOI":"10.3748\/wjg.v21.i24.7427","article-title":"Liver fibrosis markers of nonalcoholic steatohepatitis","volume":"21","author":"Enomoto","year":"2015","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.lfs.2022.120622_bb0100","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5152\/tjg.2018.17330","article-title":"Liver fibrosis","volume":"29","author":"Bataller","year":"2018","journal-title":"Turk. J. Gastroenterol."},{"key":"10.1016\/j.lfs.2022.120622_bb0105","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-med-090514-013832","article-title":"Liver cancer: connections with obesity, fatty liver, and cirrhosis","volume":"67","author":"Marengo","year":"2016","journal-title":"Annu. Rev. Med."},{"issue":"1","key":"10.1016\/j.lfs.2022.120622_bb0110","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s42000-019-00127-3","article-title":"Selenium and selenoprotein P in nonalcoholic fatty liver disease","volume":"19","author":"Polyzos","year":"2020","journal-title":"Hormones (Athens)"},{"issue":"2","key":"10.1016\/j.lfs.2022.120622_bb0115","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3390\/nu13020619","article-title":"Serum selenium status as a diagnostic marker for the prognosis of liver transplantation","volume":"13","author":"G\u00fcl-Klein","year":"2021","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.lfs.2022.120622_bb0120","first-page":"2433","article-title":"Assessment of the selenoprotein M (SELM) over-expression on human hepatocellular carcinoma tissues by immunohistochemistry","volume":"58","author":"Guerriero","year":"2014","journal-title":"Eur. J. Histochem."},{"key":"10.1016\/j.lfs.2022.120622_bb0125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mam.2018.09.002","article-title":"Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues","volume":"65","author":"Parola","year":"2019","journal-title":"Mol. Asp. Med."},{"issue":"5","key":"10.1016\/j.lfs.2022.120622_bb0130","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1039\/C6TX00197A","article-title":"Oxidative stress and inflammatory responses involved in dietary nickel chloride (NiCl(2))-induced pulmonary toxicity in broiler chickens","volume":"5","author":"Deng","year":"2016","journal-title":"Toxicol. Res. (Camb.)"},{"issue":"19","key":"10.1016\/j.lfs.2022.120622_bb0135","first-page":"4690","article-title":"Nickel carcinogenesis mechanism: dna damage","volume":"20","author":"Guo","year":"2019","journal-title":"[doi] LID - 4690. Int J Mol Sci."},{"key":"10.1016\/j.lfs.2022.120622_bb0140","series-title":"Solar and Ultraviolet Radiation","year":"1992"},{"issue":"7","key":"10.1016\/j.lfs.2022.120622_bb0145","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1002\/tox.22414","article-title":"Nickel sulfate induced apoptosis via activating ROS-dependent mitochondria and endoplasmic reticulum stress pathways in rat Leydig cells","volume":"32","author":"Zou","year":"2017","journal-title":"Environ. Toxicol."},{"issue":"676","key":"10.1016\/j.lfs.2022.120622_bb0150","article-title":"Nickel-refining fumes induce NLRP3 activation dependent on mitochondrial damage and ROS production in Beas-2B cells","volume":"15","author":"Xin","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"issue":"6","key":"10.1016\/j.lfs.2022.120622_bb0155","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1515\/BC.2002.102","article-title":"Molecular mechanisms of nickel carcinogenesis","volume":"383","author":"Costa","year":"2002","journal-title":"Biol. Chem."},{"issue":"4","key":"10.1016\/j.lfs.2022.120622_bb0160","first-page":"412","article-title":"Nickel, its adverse health effects & oxidative stress","volume":"128","author":"Das","year":"2008","journal-title":"Indian J Med Res."},{"issue":"8","key":"10.1016\/j.lfs.2022.120622_bb0165","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1177\/0960327116666650","article-title":"Nickel oxide nanoparticles induced pulmonary fibrosis via TGF- \u03b21 activation in rats","volume":"36","author":"Chang","year":"2017","journal-title":"Hum. Exp. Toxicol."},{"issue":"6","key":"10.1016\/j.lfs.2022.120622_bb0170","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/j.1939-4640.2004.tb03173.x","article-title":"Nickel-induced oxidative stress in testis of mice: evidence of DNA damage and genotoxic effects","volume":"25","author":"Doreswamy","year":"2004","journal-title":"J. Androl."},{"issue":"12","key":"10.1016\/j.lfs.2022.120622_bb0175","doi-asserted-by":"crossref","first-page":"7310","DOI":"10.3390\/ijerph10127310","article-title":"The association between splenocyte apoptosis and alterations of Bax, Bcl-2 and caspase-3 mRNA expression, and oxidative stress induced by dietary nickel chloride in broilers","volume":"10","author":"Huang","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"2","key":"10.1016\/j.lfs.2022.120622_bb0180","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3390\/molecules23020509","article-title":"Mitochondria: central organelles for melatonin's antioxidant and anti-aging actions","volume":"23","author":"Reiter","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.lfs.2022.120622_bb0185","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/978-3-030-34521-1_30","article-title":"Involvement of heparanase in endothelial cell-cardiomyocyte crosstalk","volume":"1221","author":"Shang","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.lfs.2022.120622_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138686","article-title":"Environmental contaminant ammonia triggers epithelial-to-mesenchymal transition-mediated jejunal fibrosis with the disassembly of epithelial cell-cell contacts in chicken","volume":"726","author":"Jing","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.lfs.2022.120622_bb0195","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3390\/ijms18040843","article-title":"Melatonin, a full service anti-cancer agent: inhibition of initiation, progression and metastasis","volume":"18","author":"Reiter","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.lfs.2022.120622_bb0200","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.3390\/biom10091211","article-title":"Melatonin's impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease","volume":"10","author":"Chitimus","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.lfs.2022.120622_bb0205","article-title":"Puerarin reverses cadmium-induced lysosomal dysfunction in primary rat proximal tubular cells via inhibiting Nrf2 pathway","volume":"162","author":"Wang","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"466","key":"10.1016\/j.lfs.2022.120622_bb0210","article-title":"Mitochondria damage and ferroptosis involved in Ni-induced hepatotoxicity in mice","volume":"30","author":"Wei","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.lfs.2022.120622_bb0215","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.rvsc.2021.10.017","article-title":"Selenium deficiency induced apoptosis via mitochondrial pathway caused by oxidative stress in porcine gastric tissues","volume":"144","author":"Li","year":"2022","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.lfs.2022.120622_bb0220","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.fsi.2021.12.017","article-title":"Exposure to imidacloprid induce oxidative stress, mitochondrial dysfunction, inflammation, apoptosis and mitophagy via NF-kappaB\/JNK pathway in grass carp hepatocytes","volume":"120","author":"Miao","year":"2022","journal-title":"Fish Shellfish Immunol."},{"issue":"230","key":"10.1016\/j.lfs.2022.120622_bb0225","article-title":"TMT induces apoptosis and necroptosis in mouse kidneys through oxidative stress-induced activation of the NLRP3 inflammasome","volume":"5","author":"Liu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"159","key":"10.1016\/j.lfs.2022.120622_bb0230","article-title":"Glyphosate damages blood-testis barrier via NOX1-triggered oxidative stress in rats: Long-term exposure as a potential risk for male reproductive health","volume":"15","author":"Liu","year":"2022","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.lfs.2022.120622_bb0235","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5152\/tjg.2018.17330","article-title":"Liver fibrosis","volume":"29","author":"Ayd\u0131n","year":"2018","journal-title":"Turk. J. Gastroenterol."},{"key":"10.1016\/j.lfs.2022.120622_bb0240","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.biopha.2018.11.030","article-title":"Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway","volume":"109","author":"Kong","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.lfs.2022.120622_bb0245","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/tox.22878","article-title":"TGF-\u03b21 mediated Smad signaling pathway and EMT in hepatic fibrosis induced by Nano NiO in vivo and in vitro","volume":"35","author":"Zhang","year":"2020","journal-title":"Environ. Toxicol."},{"issue":"6","key":"10.1016\/j.lfs.2022.120622_bb0250","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.jhep.2015.07.033","article-title":"Activation of Slit2-Robo1 signaling promotes liver fibrosis","volume":"63","author":"Chang","year":"2015","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.lfs.2022.120622_bb0255","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.emboj.7601974","article-title":"Protein quality control in the early secretory pathway","volume":"27","author":"Anelli","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.lfs.2022.120622_bb0260","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-012513-104649","article-title":"The role of endoplasmic reticulum stress in human pathology","volume":"10","author":"Oakes","year":"2015","journal-title":"Annu. Rev. Pathol."},{"issue":"2","key":"10.1016\/j.lfs.2022.120622_bb0265","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00018-022-04155-y","article-title":"Thioredoxin reductase 3 suppression promotes colitis and carcinogenesis via activating pyroptosis and necrosis","volume":"79","author":"Liu","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.lfs.2022.120622_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.125901","article-title":"MicroRNA profiling identifies biomarkers in head kidneys of common carp exposed to cadmium","volume":"247","author":"Liu","year":"2020","journal-title":"Chemosphere"},{"issue":"7","key":"10.1016\/j.lfs.2022.120622_bb0275","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7","key":"10.1016\/j.lfs.2022.120622_bb0280","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.201110131","article-title":"The impact of the unfolded protein response on human disease","volume":"197","author":"Wang","year":"2012","journal-title":"J. Cell Biol."},{"issue":"418","key":"10.1016\/j.lfs.2022.120622_bb0285","article-title":"Hydrogen sulfide exposure induces pyroptosis in the trachea of broilers via the regulatory effect of circRNA-17828\/miR-6631-5p\/DUSP6 crosstalk on ROS production","volume":"15","author":"Song","year":"2021","journal-title":"J. Hazard. Mater."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522003228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522003228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:05:21Z","timestamp":1758402321000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320522003228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":57,"alternative-id":["S0024320522003228"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120622","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melatonin relieves liver fibrosis induced by Txnrd3 knockdown and nickel exposure via IRE1\/NF-kB\/NLRP3 and PERK\/TGF-\u03b21 axis activation","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120622","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120622"}}