{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:18:41Z","timestamp":1777886321879,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.lfs.2022.120653","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T13:08:38Z","timestamp":1652965718000},"page":"120653","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Epimedin A ameliorates DNFB-induced allergic contact dermatitis in mice: Role of NF-\u03baB\/NLRP3-driven pyroptosis, Nrf2\/HO-1 pathway, and inflammation modulation"],"prefix":"10.1016","volume":"302","author":[{"given":"Mohamed F.","family":"Balaha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nehad J.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyad S.","family":"Almalki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah K.","family":"Alahmari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.","family":"Alshehri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamal A.","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abubaker M.","family":"Hamad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2022.120653_bb0005","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3390\/ph13110411","article-title":"Atopic dermatitis as a multifactorial skin disorder. Can the analysis of pathophysiological targets represent the winning therapeutic strategy?","volume":"13","author":"Magnifico","year":"2020","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.lfs.2022.120653_bb0010","doi-asserted-by":"crossref","first-page":"320","DOI":"10.2340\/00015555-3510","article-title":"Prevalence and incidence of atopic dermatitis: a systematic review","volume":"100","author":"Bylund","year":"2020","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.lfs.2022.120653_bb0015","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/08923973.2021.1889583","article-title":"Atopic dermatitis: new insight into the etiology, pathogenesis, diagnosis and novel treatment strategies","volume":"43","author":"Mandlik","year":"2021","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.lfs.2022.120653_bb0020","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.3390\/ijms22094677","article-title":"Nod-like receptors in host defence and disease at the epidermal barrier","volume":"22","author":"Danis","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2022.120653_bb0025","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/JLB.3MIR0120-625R","article-title":"Pyroptosis: the missing puzzle among innate and adaptive immunity crosstalk","volume":"108","author":"Hachim","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.lfs.2022.120653_bb0030","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.celrep.2018.07.027","article-title":"Interleukin-1\u03b2 maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and-independent secretion","volume":"24","author":"Monteleone","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.lfs.2022.120653_bb0035","series-title":"Topical Inflammasome Inhibition With Disulfiram Prevents Irritant Contact Dermatitis","author":"Bonnekoh","year":"2021"},{"key":"10.1016\/j.lfs.2022.120653_bb0040","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3390\/antiox11020227","article-title":"AHR and NRF2 in skin homeostasis and atopic dermatitis","volume":"11","author":"Edamitsu","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.lfs.2022.120653_bb0045","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.3390\/cells10123559","article-title":"Role of aryl hydrocarbon receptor activation in inflammatory chronic skin diseases","volume":"10","author":"Napolitano","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2022.120653_bb0050","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.3390\/molecules25225474","article-title":"An overview of Nrf2 signaling pathway and its role in inflammation","volume":"25","author":"Saha","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.lfs.2022.120653_bb0055","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-021-03384-1","article-title":"Khan, anti-allergic activities of umbelliferone against histamine- and picryl chloride-induced ear edema by targeting Nrf2\/iNOS signaling in mice","volume":"21","author":"Younas","year":"2021","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.lfs.2022.120653_bb0060","doi-asserted-by":"crossref","DOI":"10.1007\/s10856-020-06472-9","article-title":"Development of epimedin a complex drugs for treating the osteoporosis","volume":"32","author":"Liu","year":"2021","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.lfs.2022.120653_bb0065","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ultsonch.2007.09.002","article-title":"Simultaneous extraction of epimedin A, B, C and icariin from Herba Epimedii by ultrasonic technique","volume":"15","author":"Zhang","year":"2008","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.lfs.2022.120653_bb0070","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.jgr.2020.02.003","article-title":"A novel herbal formulation consisting of red ginseng extract and Epimedium koreanum Nakai-attenuated dextran sulfate sodium-induced colitis in mice","volume":"44","author":"Saba","year":"2020","journal-title":"J.Ginseng Res."},{"key":"10.1016\/j.lfs.2022.120653_bb0075","doi-asserted-by":"crossref","first-page":"AB177","DOI":"10.1016\/j.jaci.2019.12.373","article-title":"Epimedin officinalis inhibits NFkB, ERK and JNK signaling and enhances nuclear translocation of the glucocorticoid receptor: implications for reversing steroid-resistance","volume":"145","author":"Li","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.lfs.2022.120653_bb0080","author":"Lan"},{"key":"10.1016\/j.lfs.2022.120653_bb0085","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4103\/pm.pm_152_17","article-title":"Anti-inflammatory effects of Brassica oleracea var. capitata L. (cabbage) methanol extract in mice with contact dermatitis","volume":"14","author":"Lee","year":"2018","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.lfs.2022.120653_bb0090","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.intimp.2014.12.026","article-title":"Total glucosides of paeony inhibit the inflammatory responses of mice with allergic contact dermatitis by restoring the balanced secretion of pro-\/anti-inflammatory cytokines","volume":"24","author":"Wang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2022.120653_bb0095","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1186\/s13287-021-02671-5","article-title":"Multilineage-differentiating stress-enduring cells alleviate atopic dermatitis-associated behaviors in mice","volume":"12","author":"Fei","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.lfs.2022.120653_bb0100","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8878153","article-title":"Cicadidae periostracum attenuates atopic dermatitis symptoms and pathology via the regulation of NLRP3 inflammasome activation","volume":"2021","author":"Park","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2022.120653_bb0105","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0021-9258(18)57021-6","article-title":"Determination of serum proteins by means of the biuret reaction","volume":"177","author":"Gornall","year":"1949","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2022.120653_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/S0091-6749(97)70003-4","article-title":"Immunoglobulin E production in mice by means of contact sensitization with a simple chemical, hapten","volume":"100","author":"Nagai","year":"1997","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.lfs.2022.120653_bb0115","series-title":"Bancroft's Theory and Practice of Histological Techniques E-Book","author":"Suvarna","year":"2018"},{"key":"10.1016\/j.lfs.2022.120653_bb0120","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.3390\/ijerph17093326","article-title":"Hand sanitizers: a review on formulation aspects, adverse effects, and regulations","volume":"17","author":"Jing","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.lfs.2022.120653_bb0125","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jaci.2010.12.006","article-title":"Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes","volume":"127","author":"Dai","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.lfs.2022.120653_bb0130","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/cei.13575","article-title":"Keratinocytes: innate immune cells in atopic dermatitis","volume":"204","author":"Chieosilapatham","year":"2021","journal-title":"Clinical & Experimental Immunology."},{"key":"10.1016\/j.lfs.2022.120653_bb0135","doi-asserted-by":"crossref","DOI":"10.1186\/s12989-021-00443-w","article-title":"Skin damage induced by zinc oxide nanoparticles combined with UVB is mediated by activating cell pyroptosis via the NLRP3 inflammasome\u2013autophagy\u2013exosomal pathway","volume":"19","author":"Chen","year":"2022","journal-title":"Particle Fibre Toxicol."},{"key":"10.1016\/j.lfs.2022.120653_bb0140","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1111\/exd.14412","article-title":"Mdivi-1 alleviates atopic dermatitis through the inhibition of NLRP3 inflammasome","volume":"30","author":"Li","year":"2021","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.lfs.2022.120653_bb0145","series-title":"Caspases in Cell Death, Inflammation, and Pyroptosis","first-page":"567","volume":"38","author":"Kesavardhana","year":"2020"},{"key":"10.1016\/j.lfs.2022.120653_bb0150","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ceb.2020.02.004","article-title":"New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8","volume":"63","author":"Schwarzer","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.lfs.2022.120653_bb0155","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3390\/ijms22010426","article-title":"Switching from apoptosis to pyroptosis: gasdermin-elicited inflammation and antitumor immunity","volume":"22","author":"Tsuchiya","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2022.120653_bb0160","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1126\/sciadv.abc3465","article-title":"Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality","volume":"6","author":"Demarco","year":"2020","journal-title":"Sci.Adv."},{"key":"10.1016\/j.lfs.2022.120653_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113167","article-title":"TMT induces apoptosis and necroptosis in mouse kidneys through oxidative stress-induced activation of the NLRP3 inflammasome","volume":"230","author":"Liu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.lfs.2022.120653_bb0170","doi-asserted-by":"crossref","first-page":"10799","DOI":"10.3390\/ijms221910799","article-title":"What are reactive oxygen species, free radicals, and oxidative stress in skin Diseases?","volume":"22","author":"Nakai","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2022.120653_bb0175","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mad.2017.08.005","article-title":"The senescent bystander effect is caused by ROS-activated NF-\u03baB signalling","volume":"170","author":"Nelson","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.lfs.2022.120653_bb0180","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/emmm.201200219","article-title":"Nrf2 links epidermal barrier function with antioxidant defense","volume":"4","author":"Sch\u00e4fer","year":"2012","journal-title":"EMBO Mol Med."},{"key":"10.1016\/j.lfs.2022.120653_bb0185","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/toxsci\/kft075","article-title":"Reactivity of chemical sensitizers toward amino acids in cellulo plays a role in the activation of the Nrf2-ARE pathway in human monocyte dendritic cells and the THP-1 cell line","volume":"133","author":"Migdal","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.lfs.2022.120653_bb0190","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/j.tiv.2013.09.009","article-title":"Gene expression changes induced by skin sensitizers in the KeratinoSensTM cell line: discriminating Nrf2-dependent and Nrf2-independent events","volume":"27","author":"Emter","year":"2013","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.lfs.2022.120653_bb0195","first-page":"1761","article-title":"Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2\/HO-1 axis","volume":"20","author":"Wu","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.lfs.2022.120653_bb0200","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.phymed.2014.04.011","article-title":"Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-\u03baB and STAT1 and activation of Nrf2\/ARE-mediated heme oxygenase-1","volume":"21","author":"Choi","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2022.120653_bb0205","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ejphar.2006.07.019","article-title":"Inhibition of scratching behavior associated with allergic dermatitis in mice by tacrolimus, but not by dexamethasone","volume":"546","author":"Inagaki","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2022.120653_bb0210","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3389\/fimmu.2019.01004","article-title":"Nrf2 involvement in chemical-induced skin innate immunity","volume":"10","author":"Helou","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2022.120653_bb0215","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.fct.2013.02.038","article-title":"Role of oxidative stress in chemical allergens induced skin cells activation","volume":"61","author":"Corsini","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.lfs.2022.120653_bb0220","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/j.1398-9995.2011.02652.x","article-title":"Mechanisms of chemical-induced innate immunity in allergic contact dermatitis","volume":"66","author":"Martin","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.lfs.2022.120653_bb0225","article-title":"Contact dermatitis (primer)","volume":"7","author":"Scheinman","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.lfs.2022.120653_bb0230","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-36335-2_59","article-title":"Mechanisms of irritant and allergic contact dermatitis","volume":"95\u2013120","author":"Martin","year":"2021","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.lfs.2022.120653_bb0235","doi-asserted-by":"crossref","first-page":"867","DOI":"10.3390\/pharmaceutics12090867","article-title":"NLRP3 inflammasome and allergic contact dermatitis: a connection to demystify","volume":"12","author":"Sebasti\u00e3o","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.lfs.2022.120653_bb0240","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3390\/cells11010083","article-title":"In vitro monitoring of human T cell responses to skin sensitizing chemicals\u2014a systematic review","volume":"11","author":"Aparicio-Soto","year":"2022","journal-title":"Cells."},{"key":"10.1016\/j.lfs.2022.120653_bb0245","series-title":"The Role of il-6Ra in Irritant Contact Dermatitis","author":"Frempah","year":"2019"},{"key":"10.1016\/j.lfs.2022.120653_bb0250","article-title":"Oral administration of p-hydroxycinnamic acid attenuates atopic dermatitis by downregulating Th1 and Th2 cytokine production and keratinocyte activation","volume":"11","author":"Lee","year":"2016","journal-title":"PLoS ONE"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522003538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522003538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:59:49Z","timestamp":1758401989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320522003538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":50,"alternative-id":["S0024320522003538"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120653","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epimedin A ameliorates DNFB-induced allergic contact dermatitis in mice: Role of NF-\u03baB\/NLRP3-driven pyroptosis, Nrf2\/HO-1 pathway, and inflammation modulation","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120653","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120653"}}