{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T07:51:41Z","timestamp":1780645901850,"version":"3.54.1"},"reference-count":104,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"am","delay-in-days":293,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.lfs.2022.120718","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T21:42:56Z","timestamp":1655242976000},"page":"120718","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Early life stress exacerbates obesity in adult female mice via mineralocorticoid receptor-dependent increases in adipocyte triglyceride and glycerol content"],"prefix":"10.1016","volume":"304","author":[{"given":"Jacqueline R.","family":"Leachman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cole","family":"Cincinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermin","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Dalmasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gatineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara S.","family":"Nikolajczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederique","family":"Yiannikouris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Terry D.","family":"Hinds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Analia S.","family":"Loria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2022.120718_bb0005","first-page":"1","article-title":"Prevalence of obesity and severe obesity among adults: United States, 2017\u20132018","volume":"360","author":"Hales","year":"2020","journal-title":"NCHS Data Brief."},{"issue":"6","key":"10.1016\/j.lfs.2022.120718_bb0010","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3810\/pgm.2009.11.2074","article-title":"The medical risks of obesity","volume":"121","author":"Pi-Sunyer","year":"2009","journal-title":"Postgrad. Med."},{"issue":"4","key":"10.1016\/j.lfs.2022.120718_bb0015","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.3892\/etm.2016.3667","article-title":"Obesity and hypertension","volume":"12","author":"Jiang","year":"2016","journal-title":"Exp. Ther. Med."},{"issue":"4","key":"10.1016\/j.lfs.2022.120718_bb0020","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","article-title":"Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The adverse childhood experiences (ACE) study","volume":"14","author":"Felitti","year":"1998","journal-title":"Am. J. Prev. Med."},{"issue":"9","key":"10.1016\/j.lfs.2022.120718_bb0025","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.117.004391","article-title":"Examining the prevalence of adverse childhood experiences and associated cardiovascular disease risk factors among low-income uninsured adults","volume":"12","author":"Allen","year":"2019","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"issue":"4","key":"10.1016\/j.lfs.2022.120718_bb0030","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/ije\/30.4.668","article-title":"Theories for social epidemiology in the 21st century: an ecosocial perspective","volume":"30","author":"Krieger","year":"2001","journal-title":"Int. J. Epidemiol."},{"issue":"4","key":"10.1016\/j.lfs.2022.120718_bb0035","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/jts.20421","article-title":"Adverse childhood events are associated with obesity and disordered eating: results from a U.S. Population-based survey of young adults","volume":"22","author":"Fuemmeler","year":"2009","journal-title":"J. Trauma. Stress."},{"key":"10.1016\/j.lfs.2022.120718_bb0040","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ypmed.2019.03.032","article-title":"Adverse childhood experiences and the onset of chronic disease in young adulthood","volume":"123","author":"Sonu","year":"2019","journal-title":"Prev. Med."},{"issue":"12","key":"10.1016\/j.lfs.2022.120718_bb0045","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1001\/archpediatrics.2009.214","article-title":"Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers","volume":"163","author":"Danese","year":"2009","journal-title":"Arch. Pediatr. Adolesc. Med."},{"issue":"5","key":"10.1016\/j.lfs.2022.120718_bb0050","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/mp.2013.54","article-title":"Childhood maltreatment and obesity: systematic review and meta-analysis","volume":"19","author":"Danese","year":"2014","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.lfs.2022.120718_bb0055","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/HYPERTENSIONAHA.113.02755","article-title":"Adverse childhood experiences are associated with detrimental hemodynamics and elevated circulating endothelin-1 in adolescents and young adults","volume":"64","author":"Su","year":"2014","journal-title":"Hypertension (Dallas, Tex : 1979)"},{"issue":"19","key":"10.1016\/j.lfs.2022.120718_bb0060","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1161\/CIRCULATIONAHA.114.013104","article-title":"Adverse childhood experiences and blood pressure trajectories from childhood to young adulthood: the Georgia stress and heart study","volume":"131","author":"Su","year":"2015","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.lfs.2022.120718_bb0065","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1037\/tra0000313","article-title":"Adverse childhood experiences and obesity: systematic review of behavioral interventions for women","volume":"10","author":"McDonnell","year":"2018","journal-title":"Psychol. Trauma Theory Res. Pract. Policy"},{"key":"10.1016\/j.lfs.2022.120718_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.chiabu.2019.104175","article-title":"Impact of adverse childhood experiences on cardiovascular disease risk factors in adulthood among Mexican women","volume":"99","author":"Flores-Torres","year":"2020","journal-title":"Child Abuse Negl."},{"issue":"8","key":"10.1016\/j.lfs.2022.120718_bb0075","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/CIRCULATIONAHA.111.076877","article-title":"Physical and sexual abuse in childhood as predictors of early-onset cardiovascular events in women","volume":"126","author":"Rich-Edwards","year":"2012","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.lfs.2022.120718_bb0080","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1353\/hpu.2016.0027","article-title":"Adult cancer risk behaviors associated with adverse childhood experiences in a low income population in the southeastern United States","volume":"27","author":"Mouton","year":"2016","journal-title":"J. Health Care Poor Underserved"},{"issue":"4","key":"10.1016\/j.lfs.2022.120718_bb0085","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/s41390-019-0414-8","article-title":"Adverse childhood experiences are associated with an increased risk of obesity in early adolescence: a population-based prospective cohort study","volume":"86","author":"Gardner","year":"2019","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.lfs.2022.120718_bb0090","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.comppsych.2016.08.002","article-title":"The impact of adverse childhood experiences on obesity and unhealthy weight control behaviors among adolescents","volume":"71","author":"Isohookana","year":"2016","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.lfs.2022.120718_bb0095","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2202-11-123","article-title":"Maternal separation with early weaning: a novel mouse model of early life neglect","volume":"11","author":"George","year":"2010","journal-title":"BMC Neurosci."},{"issue":"4","key":"10.1016\/j.lfs.2022.120718_bb0100","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1017\/S095457941200079X","article-title":"Maternal separation with early weaning: a rodent model providing novel insights into neglect associated developmental deficits","volume":"24","author":"Carlyle","year":"2012","journal-title":"Dev. Psychopathol."},{"issue":"5","key":"10.1016\/j.lfs.2022.120718_bb0105","doi-asserted-by":"crossref","first-page":"E852","DOI":"10.1152\/ajpendo.00243.2020","article-title":"Exacerbated obesogenic response in female mice exposed to early life stress is linked to fat depot-specific upregulation of leptin protein expression","volume":"319","author":"Leachman","year":"2020","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.lfs.2022.120718_bb0110","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1038\/s41366-018-0035-z","article-title":"A model of neglect during postnatal life heightens obesity-induced hypertension and is linked to a greater metabolic compromise in female mice","volume":"42","author":"Murphy","year":"2018","journal-title":"Int. J. Obes."},{"issue":"10","key":"10.1016\/j.lfs.2022.120718_bb0115","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1161\/CIRCULATIONAHA.111.067264","article-title":"Body fat distribution and risk of cardiovascular disease: an update","volume":"126","author":"Despr\u00e9s","year":"2012","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.lfs.2022.120718_bb0120","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s12944-018-0856-8","article-title":"Localization of fat depots and cardiovascular risk","volume":"17","author":"Gruzdeva","year":"2018","journal-title":"Lipids Health Dis."},{"issue":"2","key":"10.1016\/j.lfs.2022.120718_bb0125","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/HPC.0b013e318057d4c9","article-title":"Cardiovascular disease under the influence of excess visceral fat","volume":"6","author":"Despr\u00e9s","year":"2007","journal-title":"Crit. Pathw. Cardiol."},{"key":"10.1016\/j.lfs.2022.120718_bb0130","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.bbi.2020.12.018","article-title":"Linking the hemodynamic consequences of adverse childhood experiences to an altered HPA axis and acute stress response","volume":"93","author":"Dempster","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.lfs.2022.120718_bb0135","doi-asserted-by":"crossref","first-page":"E98","DOI":"10.1152\/ajpendo.00308.2016","article-title":"Postnatal treatment with metyrapone attenuates the effects of diet-induced obesity in female rats exposed to early-life stress","volume":"312","author":"Murphy","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2022.120718_bb0140","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000264406","article-title":"Metabolic imprinting in obesity","volume":"63","author":"Sullivan","year":"2010","journal-title":"Forum Nutr."},{"issue":"4","key":"10.1016\/j.lfs.2022.120718_bb0145","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41580-018-0093-z","article-title":"Adipogenesis and metabolic health","volume":"20","author":"Ghaben","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.lfs.2022.120718_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/nu10101383","article-title":"Regulation and metabolic significance of De novo lipogenesis in adipose tissues","volume":"10","author":"Song","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2022.120718_bb0155","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev.nutr.27.061406.093734","article-title":"Regulation of lipolysis in adipocytes","volume":"27","author":"Duncan","year":"2007","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.lfs.2022.120718_bb0160","article-title":"The glucocorticoid receptor: cause or cure for obesity?","volume":"2015","author":"John","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.lfs.2022.120718_bb0165","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.metabol.2011.06.012","article-title":"The effects of glucocorticoids on adipose tissue lipid metabolism","volume":"60","author":"Peckett","year":"2011","journal-title":"Metab. Clin. Exp."},{"issue":"7","key":"10.1016\/j.lfs.2022.120718_bb0170","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1210\/endo.140.7.6868","article-title":"Differentiation of adipose stromal cells: the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase","volume":"140","author":"Bujalska","year":"1999","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.lfs.2022.120718_bb0175","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1172\/JCI114345","article-title":"Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium","volume":"84","author":"Hauner","year":"1989","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.lfs.2022.120718_bb0180","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1091\/mbc.e08-04-0420","article-title":"Glucocorticoid signaling defines a novel commitment state during adipogenesis in vitro","volume":"19","author":"Pantoja","year":"2008","journal-title":"Mol. Biol. Cell"},{"issue":"10","key":"10.1016\/j.lfs.2022.120718_bb0185","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1096\/fasebj.3.10.2666232","article-title":"Role of glucocorticoids in the regulation of lipogenesis","volume":"3","author":"Berdanier","year":"1989","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.lfs.2022.120718_bb0190","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1093\/jn\/134.5.1032","article-title":"The human fatty acid synthase gene and de novo lipogenesis are coordinately regulated in human adipose tissue","volume":"134","author":"Wang","year":"2004","journal-title":"J. Nutr."},{"issue":"5","key":"10.1016\/j.lfs.2022.120718_bb0195","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0026-0495(76)90007-X","article-title":"Glucocorticoids and triglyceride transport: effects on triglyceride secretion rates, lipoprotein lipase, and plasma lipoproteins in the rat","volume":"25","author":"Bagdade","year":"1976","journal-title":"Metab. Clin. Exp."},{"issue":"8","key":"10.1016\/j.lfs.2022.120718_bb0200","first-page":"2542","article-title":"Glucocorticoid regulation of leptin synthesis and secretion in humans: elevated plasma leptin levels in Cushing's syndrome1","volume":"82","author":"Masuzaki","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.lfs.2022.120718_bb0205","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1210\/jc.2004-0395","article-title":"Adipose tissue as an endocrine organ","volume":"89","author":"Kershaw","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.lfs.2022.120718_bb0210","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1083\/jcb.101.4.1227","article-title":"Glucocorticoid regulation of adipocyte differentiation: hormonal triggering of the developmental program and induction of a differentiation-dependent gene","volume":"101","author":"Chapman","year":"1985","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.lfs.2022.120718_bb0215","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1210\/jcem-64-4-832","article-title":"Glucocorticoids and insulin promote the differentiation of human adipocyte precursor cells into fat cells","volume":"64","author":"Hauner","year":"1987","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"8","key":"10.1016\/j.lfs.2022.120718_bb0220","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1073\/pnas.0607378104","article-title":"Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C\/EBPbeta by GCN5","volume":"104","author":"Wiper-Bergeron","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.lfs.2022.120718_bb0225","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.1210\/en.2006-0267","article-title":"Modulation of early human preadipocyte differentiation by glucocorticoids","volume":"147","author":"Tomlinson","year":"2006","journal-title":"Endocrinology"},{"issue":"21","key":"10.1016\/j.lfs.2022.120718_bb0230","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1042\/CS20190679","article-title":"Lack of adipose-specific hexose-6-phosphate dehydrogenase causes inactivation of adipose glucocorticoids and improves metabolic phenotype in mice","volume":"133","author":"Wang","year":"2019","journal-title":"Clin. Sci. (London, England: 1979)"},{"key":"10.1016\/j.lfs.2022.120718_bb0235","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijdevneu.2017.10.005","article-title":"Early emergence of altered 5-HT2A receptor-evoked behavior, neural activation and gene expression following maternal separation","volume":"65","author":"Sood","year":"2018","journal-title":"Int. J. Dev. Neurosci."},{"issue":"2","key":"10.1016\/j.lfs.2022.120718_bb0240","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bbrc.2012.01.139","article-title":"Contribution of glucocorticoid-mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction","volume":"419","author":"Hirata","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4812","key":"10.1016\/j.lfs.2022.120718_bb0245","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.3037703","article-title":"Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor","volume":"237","author":"Arriza","year":"1987","journal-title":"Science (New York, N.Y.)"},{"issue":"4812","key":"10.1016\/j.lfs.2022.120718_bb0250","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.3037703","article-title":"Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor","volume":"237","author":"Arriza","year":"1987","journal-title":"Science (New York, N.Y.)"},{"issue":"11","key":"10.1016\/j.lfs.2022.120718_bb0255","doi-asserted-by":"crossref","first-page":"5470","DOI":"10.1210\/en.2007-0585","article-title":"Proteasome-dependent down-regulation of activated nuclear hippocampal glucocorticoid receptors determines dynamic responses to corticosterone","volume":"148","author":"Conway-Campbell","year":"2007","journal-title":"Endocrinology"},{"issue":"40","key":"10.1016\/j.lfs.2022.120718_bb0260","doi-asserted-by":"crossref","first-page":"11336","DOI":"10.1073\/pnas.1605246113","article-title":"Acute stress enhances heterodimerization and binding of corticosteroid receptors at glucocorticoid target genes in the hippocampus","volume":"113","author":"Mifsud","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5549","key":"10.1016\/j.lfs.2022.120718_bb0265","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1126\/science.1066285","article-title":"A transgenic model of visceral obesity and the metabolic syndrome","volume":"294","author":"Masuzaki","year":"2001","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.lfs.2022.120718_bb0270","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.2337\/diabetes.54.4.1023","article-title":"Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity","volume":"54","author":"Kershaw","year":"2005","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.lfs.2022.120718_bb0275","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1210\/en.2010-0674","article-title":"Antiadipogenic effects of the mineralocorticoid receptor antagonist drospirenone: potential implications for the treatment of metabolic syndrome","volume":"152","author":"Caprio","year":"2011","journal-title":"Endocrinology"},{"issue":"9","key":"10.1016\/j.lfs.2022.120718_bb0280","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1096\/fj.06-7970com","article-title":"Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis","volume":"21","author":"Caprio","year":"2007","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.lfs.2022.120718_bb0285","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/cvr\/cvp191","article-title":"Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice","volume":"84","author":"Hirata","year":"2009","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.lfs.2022.120718_bb0290","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1210\/en.2010-0674","article-title":"Antiadipogenic effects of the mineralocorticoid receptor antagonist drospirenone: potential implications for the treatment of metabolic syndrome","volume":"152","author":"Caprio","year":"2011","journal-title":"Endocrinology"},{"issue":"9","key":"10.1016\/j.lfs.2022.120718_bb0295","first-page":"2791","article-title":"Estimation of body fat and lean tissue distribution by dual energy X-ray absorptiometry and abdominal body fat evaluation by computed tomography in Cushing's disease","volume":"80","author":"Wajchenberg","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.lfs.2022.120718_bb0300","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1530\/eje.0.1490561","article-title":"Computed tomography assessment of fat distribution in male and female patients with Cushing's syndrome","volume":"149","author":"Rockall","year":"2003","journal-title":"Eur. J. Endocrinol."},{"issue":"2","key":"10.1016\/j.lfs.2022.120718_bb0305","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bbrc.2012.01.139","article-title":"Contribution of glucocorticoid\u2013mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction","volume":"419","author":"Hirata","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.lfs.2022.120718_bb0310","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.bbadis.2013.05.029","article-title":"Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity","volume":"1842","author":"Lee","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.lfs.2022.120718_bb0315","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/HYPERTENSIONAHA.117.09980","article-title":"Sex differences in mechanisms of hypertension associated with obesity","volume":"71","author":"Faulkner","year":"2018","journal-title":"Hypertension (Dallas, Tex : 1979)"},{"issue":"23","key":"10.1016\/j.lfs.2022.120718_bb0320","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012309","article-title":"Female mice exposed to postnatal neglect display angiotensin II-dependent obesity-induced hypertension","volume":"8","author":"Dalmasso","year":"2019","journal-title":"J. Am. Heart Assoc."},{"issue":"5","key":"10.1016\/j.lfs.2022.120718_bb0325","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1161\/HYPERTENSIONAHA.121.17298","article-title":"Epididymal fat-derived sympathoexcitatory signals exacerbate neurogenic hypertension in obese male mice exposed to early life stress","volume":"78","author":"Dalmasso","year":"2021","journal-title":"Hypertension (Dallas, Tex\u202f: 1979)"},{"issue":"3","key":"10.1016\/j.lfs.2022.120718_bb0330","doi-asserted-by":"crossref","first-page":"E609","DOI":"10.1152\/ajpendo.00135.2020","article-title":"The prorenin receptor and its soluble form contribute to lipid homeostasis","volume":"320","author":"Gatineau","year":"2021","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.lfs.2022.120718_bb0335","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1161\/ATVBAHA.119.313056","article-title":"Coronary artery disease risk-associated Plpp3 gene and its product lipid phosphate phosphatase 3 regulate experimental atherosclerosis","volume":"39","author":"Mueller","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"11","key":"10.1016\/j.lfs.2022.120718_bb0340","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1194\/jlr.M093096","article-title":"Effects of diet and hyperlipidemia on levels and distribution of circulating lysophosphatidic acid","volume":"60","author":"Kraemer","year":"2019","journal-title":"J. Lipid Res."},{"issue":"22","key":"10.1016\/j.lfs.2022.120718_bb0345","doi-asserted-by":"crossref","DOI":"10.1002\/rcm.8911","article-title":"Evaluating a targeted multiple reaction monitoring approach to global untargeted lipidomic analyses of human plasma","volume":"34","author":"Khan","year":"2020","journal-title":"Rapid Commun. Mass Spectrom."},{"issue":"5","key":"10.1016\/j.lfs.2022.120718_bb0350","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1161\/HYPERTENSIONAHA.121.17298","article-title":"Epididymal fat-derived sympathoexcitatory signals exacerbate neurogenic hypertension in obese male mice exposed to early life stress","volume":"78","author":"Dalmasso","year":"2021","journal-title":"Hypertension"},{"issue":"10","key":"10.1016\/j.lfs.2022.120718_bb0355","doi-asserted-by":"crossref","first-page":"158788","DOI":"10.1016\/j.bbalip.2020.158788","article-title":"Lipidomics of brown and white adipose tissue: implications for energy metabolism","volume":"1865","author":"Leiria","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"4","key":"10.1016\/j.lfs.2022.120718_bb0360","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/biot.200600012","article-title":"Essential fatty acids: biochemistry, physiology and pathology","volume":"1","author":"Das","year":"2006","journal-title":"Biotechnol. J."},{"issue":"3","key":"10.1016\/j.lfs.2022.120718_bb0365","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/nu8030128","article-title":"An increase in the Omega-6\/Omega-3 fatty acid ratio increases the risk for obesity","volume":"8","author":"Simopoulos","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2022.120718_bb0370","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.prostaglandins.2016.06.003","article-title":"Linoleic acid and the pathogenesis of obesity","volume":"125","author":"Naughton","year":"2016","journal-title":"Prostaglandins Other Lipid Mediat."},{"issue":"3\u20135","key":"10.1016\/j.lfs.2022.120718_bb0375","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.plefa.2008.09.019","article-title":"Too much linoleic acid promotes inflammation-doesn't it?","volume":"79","author":"Fritsche","year":"2008","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.lfs.2022.120718_bb0380","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1146\/annurev.immunol.25.022106.141647","article-title":"Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways","volume":"25","author":"Serhan","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.lfs.2022.120718_bb0385","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plefa.2018.05.004","article-title":"Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease","volume":"135","author":"Burns","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"issue":"12","key":"10.1016\/j.lfs.2022.120718_bb0390","doi-asserted-by":"crossref","first-page":"G927","DOI":"10.1152\/ajpgi.00206.2015","article-title":"Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications","volume":"309","author":"Pohl","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"1","key":"10.1016\/j.lfs.2022.120718_bb0395","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1038\/s41467-019-09744-3","article-title":"Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling","volume":"10","author":"Wong","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.lfs.2022.120718_bb0400","doi-asserted-by":"crossref","first-page":"135","DOI":"10.5056\/jnm16105","article-title":"Chronic early-life stress in rat pups alters basal corticosterone, intestinal permeability, and fecal microbiota at weaning: influence of sex","volume":"23","author":"Moussaoui","year":"2017","journal-title":"J. Neurogastroenterol. Motil."},{"issue":"9","key":"10.1016\/j.lfs.2022.120718_bb0405","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nrm1469","article-title":"From structure to disease: the evolving tale of aquaporin biology","volume":"5","author":"King","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.lfs.2022.120718_bb0410","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0014-5793(03)01083-4","article-title":"Aquaporin water channels: molecular mechanisms for human diseases","volume":"555","author":"Agre","year":"2003","journal-title":"FEBS Lett."},{"issue":"5\u20136","key":"10.1016\/j.lfs.2022.120718_bb0415","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.mam.2012.02.004","article-title":"Implications of aquaglyceroporins 7 and 9 in glycerol metabolism and metabolic syndrome","volume":"33","author":"Maeda","year":"2012","journal-title":"Mol. Asp. Med."},{"issue":"4","key":"10.1016\/j.lfs.2022.120718_bb0420","doi-asserted-by":"crossref","first-page":"E586","DOI":"10.1210\/jc.2010-1408","article-title":"Insulin- and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K\/Akt\/mTOR signaling cascade","volume":"96","author":"Rodr\u00edguez","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.lfs.2022.120718_bb0425","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.4161\/cc.10.10.15672","article-title":"Aquaglyceroporins serve as metabolic gateways in adiposity and insulin resistance control","volume":"10","author":"Rodr\u00edguez","year":"2011","journal-title":"Cell Cycle (Georgetown, Tex)"},{"issue":"5","key":"10.1016\/j.lfs.2022.120718_bb0430","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1042\/BCJ20190468","article-title":"Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics","volume":"477","author":"Yang","year":"2020","journal-title":"Biochem. J."},{"issue":"31","key":"10.1016\/j.lfs.2022.120718_bb0435","doi-asserted-by":"crossref","first-page":"10993","DOI":"10.1073\/pnas.0503291102","article-title":"Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase","volume":"102","author":"Hibuse","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.lfs.2022.120718_bb0440","doi-asserted-by":"crossref","first-page":"F1403","DOI":"10.1152\/ajprenal.00059.2002","article-title":"Regulation of collecting duct AQP3 expression: response to mineralocorticoid","volume":"283","author":"Kwon","year":"2002","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"1","key":"10.1016\/j.lfs.2022.120718_bb0445","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000098435","article-title":"Increased renal expression of aquaporin-3 in rats inhibited type 2 11beta-hydroxysteroid dehydrogenase","volume":"30","author":"Ma","year":"2007","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.lfs.2022.120718_bb0450","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/bs.vh.2018.09.003","article-title":"Belin de Chantem\u00e8le EJ","volume":"109","author":"Faulkner","year":"2019","journal-title":"Leptin and aldosterone. Vitam. Horm."},{"issue":"12","key":"10.1016\/j.lfs.2022.120718_bb0455","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11906-020-01113-6","article-title":"Female sex, a major risk factor for salt-sensitive hypertension","volume":"22","author":"Faulkner","year":"2020","journal-title":"Curr. Hypertens. Rep."},{"issue":"2","key":"10.1016\/j.lfs.2022.120718_bb0460","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/MNH.0000000000000384","article-title":"The regulation of aldosterone secretion by leptin: implications in obesity-related cardiovascular disease","volume":"27","author":"Faulkner","year":"2018","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"3","key":"10.1016\/j.lfs.2022.120718_bb0465","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1161\/HYPERTENSIONAHA.119.12802","article-title":"Progesterone predisposes females to obesity-associated leptin-mediated endothelial dysfunction via upregulating endothelial MR (mineralocorticoid receptor) expression","volume":"74","author":"Faulkner","year":"2019","journal-title":"Hypertension (Dallas, Tex : 1979)"},{"issue":"22","key":"10.1016\/j.lfs.2022.120718_bb0470","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1161\/CIRCULATIONAHA.115.018226","article-title":"Adipocyte-derived hormone leptin is a direct regulator of aldosterone secretion, which promotes endothelial dysfunction and cardiac fibrosis","volume":"132","author":"Huby","year":"2015","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.lfs.2022.120718_bb0475","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1161\/HYPERTENSIONAHA.115.06642","article-title":"Leptin induces hypertension and endothelial dysfunction via aldosterone-dependent mechanisms in obese female mice","volume":"67","author":"Huby","year":"2016","journal-title":"Hypertension (Dallas, Tex : 1979)"},{"issue":"3","key":"10.1016\/j.lfs.2022.120718_bb0480","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11906-016-0626-9","article-title":"Aldosterone production and signaling dysregulation in obesity","volume":"18","author":"Vecchiola","year":"2016","journal-title":"Curr. Hypertens. Rep."},{"issue":"8","key":"10.1016\/j.lfs.2022.120718_bb0485","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.2337\/db15-1627","article-title":"Adipocyte-specific mineralocorticoid receptor overexpression in mice is associated with metabolic syndrome and vascular dysfunction: role of redox-sensitive PKG-1 and rho kinase","volume":"65","author":"Nguyen Dinh Cat","year":"2016","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.lfs.2022.120718_bb0490","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1161\/HYPERTENSIONAHA.114.04981","article-title":"Adipocyte mineralocorticoid receptor activation leads to metabolic syndrome and induction of prostaglandin D2 synthase","volume":"66","author":"Urbanet","year":"2015","journal-title":"Hypertension (Dallas, Tex : 1979)"},{"issue":"8","key":"10.1016\/j.lfs.2022.120718_bb0495","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1096\/fj.13-245415","article-title":"Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice","volume":"28","author":"Armani","year":"2014","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.lfs.2022.120718_bb0500","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1210\/en.2009-0869","article-title":"Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet","volume":"151","author":"Wada","year":"2010","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.lfs.2022.120718_bb0505","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ejim.2012.11.007","article-title":"Evolving strategies for the use of spironolactone in cardiovascular disease","volume":"24","author":"Jolobe","year":"2013","journal-title":"Eur. J. Intern. Med."},{"issue":"3","key":"10.1016\/j.lfs.2022.120718_bb0510","first-page":"257","article-title":"Addition of spironolactone in patients with resistant hypertension: a meta-analysis of randomized controlled trials","volume":"39","author":"Liu","year":"2017","journal-title":"Clin. Exp. Hypertens. (New York, NY: 1993)"},{"issue":"1","key":"10.1016\/j.lfs.2022.120718_bb0515","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/pde.14391","article-title":"Use of spironolactone to treat acne in adolescent females","volume":"38","author":"Roberts","year":"2021","journal-title":"Pediatr. Dermatol."},{"issue":"1","key":"10.1016\/j.lfs.2022.120718_bb0520","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1001\/jama.1973.03220280028007","article-title":"Adverse reactions to spironolactone. A report from the Boston collaborative drug surveillance program","volume":"225","author":"Greenblatt","year":"1973","journal-title":"JAMA"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522004180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522004180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:01:47Z","timestamp":1758402107000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320522004180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":104,"alternative-id":["S0024320522004180"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120718","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early life stress exacerbates obesity in adult female mice via mineralocorticoid receptor-dependent increases in adipocyte triglyceride and glycerol content","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120718","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120718"}}