{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T05:53:11Z","timestamp":1792389191257,"version":"4.4.0"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":325,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.lfs.2022.120962","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T11:58:06Z","timestamp":1663070286000},"page":"120962","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Reactive oxygen species-dependent-NLRP3 inflammasome activation in human neutrophils induced by l-amino acid oxidase derived from Calloselasma rhodostoma venom"],"prefix":"10.1016","volume":"308","author":[{"given":"Mauro Valentino","family":"Paloschi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Nunes","family":"Boeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Amaral","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Matiele Alves","family":"Rego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Daniela Souza","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hallison Mota","family":"Santana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne Nery","family":"Serrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoda Janaina","family":"Ikenohuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braz Junior Campos","family":"Farias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1tia Paula","family":"Felipin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neriane Monteiro","family":"Nery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdison Pereira","family":"dos Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb Torres","family":"de Lima Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaina Rodrigues","family":"Evangelista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulamita","family":"da Silva Set\u00fabal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreimar Martins","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Pavan","family":"Zuliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.lfs.2022.120962_bb0005","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0041-0101(02)00102-2","article-title":"Snake venom l-amino acid oxidases","volume":"40","author":"Du","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.lfs.2022.120962_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/196754","article-title":"Snake venom L-amino acid oxidases: trends in pharmacology and biochemistry","volume":"2014","author":"Izidoro","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.lfs.2022.120962_bb0015","doi-asserted-by":"crossref","first-page":"908","DOI":"10.2174\/092986609788923347","article-title":"Snake venom L-amino acid oxidases: some consideration about their functional characterization","volume":"16","author":"Zuliani","year":"2009","journal-title":"Protein Pept Lett."},{"key":"10.1016\/j.lfs.2022.120962_bb0020","series-title":"Handbook of Venoms And Toxins of Reptiles","first-page":"413","article-title":"Reptile venom L-amino acid oxidases \u2013 structure and function","volume":"2","author":"Zuliani","year":"2021"},{"issue":"4","key":"10.1016\/j.lfs.2022.120962_bb0025","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.biochi.2008.12.004","article-title":"Structural and functional properties of Bp-LAAO, a new L-amino acid oxidase isolated from Bothrops pauloensis snake venom","volume":"91","author":"Rodrigues","year":"2009","journal-title":"Biochimie"},{"key":"10.1016\/j.lfs.2022.120962_bb0030","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.toxicon.2018.02.046","article-title":"Role of l-amino acid oxidase isolated from Calloselasma rhodostoma venom on neutrophil NADPH oxidase complex activation","volume":"145","author":"Paloschi","year":"2018","journal-title":"Toxicon"},{"issue":"21","key":"10.1016\/j.lfs.2022.120962_bb0035","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.2174\/0929867324666171109114125","article-title":"An update on potential molecular mechanisms underlying the actions of snake venom L-amino acid oxidases (LAAOs)","volume":"25","author":"Paloschi","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.lfs.2022.120962_bb0040","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.toxicon.2013.12.013","article-title":"Effect of l-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils","volume":"80","author":"Pontes","year":"2014","journal-title":"Toxicon"},{"key":"10.1016\/j.lfs.2022.120962_bb0045","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.toxicon.2016.05.013","article-title":"p38 MAPK is involved in human neutrophil chemotaxis induced by L-amino acid oxidase from Calloselasma rhodosthoma","volume":"119","author":"Pontes","year":"2016","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.lfs.2022.120962_bb0050","doi-asserted-by":"crossref","first-page":"10976","DOI":"10.1038\/s41598-020-67345-3","article-title":"Cytosolic phospholipase A2-\u03b1 participates in lipid body formation and PGE2 release in human neutrophils stimulated with an l-amino acid oxidase from Calloselasma rhodostoma venom","volume":"10","author":"Paloschi","year":"2020","journal-title":"Sci.Rep."},{"issue":"1","key":"10.1016\/j.lfs.2022.120962_bb0055","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nri.2015.8","article-title":"Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease","volume":"16","author":"Cao","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.lfs.2022.120962_bb0060","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","article-title":"DAMP-sensing receptors in sterile inflammation and inflammatory diseases","volume":"20","author":"Gong","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.lfs.2022.120962_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.metabol.2017.06.002","article-title":"Current role of the NLRP3 inflammasome on obesity and insulin resistance: a systematic review","volume":"74","author":"Rheinheimer","year":"2017","journal-title":"Metab. Clin. Exp."},{"issue":"10","key":"10.1016\/j.lfs.2022.120962_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.470","article-title":"NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension","volume":"8","author":"Sun","year":"2017","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.lfs.2022.120962_bb0075","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12974-020-1728-5","article-title":"A novel role of NLRP3-generated IL-1\u03b2 in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration","volume":"17","author":"Zhao","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.lfs.2022.120962_bb0080","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1038\/s41467-020-16043-9","article-title":"N-GSDMD trafficking to neutrophil organelles facilitates IL-1\u03b2 release independently of plasma membrane pores and pyroptosis","volume":"11","author":"Karmakar","year":"2020","journal-title":"Nat. Commun."},{"issue":"7610","key":"10.1016\/j.lfs.2022.120962_bb0085","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2022.120962_bb0090","series-title":"Detection of pyroptosis by measuring released lactate dehydrogenase activity","first-page":"85","author":"Rayamajhi","year":"2013"},{"issue":"13","key":"10.1016\/j.lfs.2022.120962_bb0095","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/ars.2014.5994","article-title":"Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?","volume":"22","author":"Abais","year":"2015","journal-title":"Antioxid. Redox Signal."},{"issue":"13","key":"10.1016\/j.lfs.2022.120962_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 inflammasome: an overview of mechanisms of activation and regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.lfs.2022.120962_bb0105","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41419-019-1413-8","article-title":"Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors","volume":"10","author":"Yang","year":"2019","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.lfs.2022.120962_bb0110","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nri3859","article-title":"Eicosanoid storm in infection and inflammation","volume":"15","author":"Dennis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"35","key":"10.1016\/j.lfs.2022.120962_bb0115","doi-asserted-by":"crossref","first-page":"12746","DOI":"10.1073\/pnas.1404372111","article-title":"Phospholipase A2 regulates eicosanoid class switching during inflammasome activation","volume":"111","author":"Norris","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.lfs.2022.120962_bb0120","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/jcp.24815","article-title":"Cyclooxygenase-2 regulates NLRP3 inflammasome-derived IL-1\u03b2 production","volume":"230","author":"Hua","year":"2015","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.lfs.2022.120962_bb0125","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/mi.2017.51","article-title":"Elevated prostaglandin E2 post-bone marrow transplant mediates interleukin-1\u03b2-related lung injury","volume":"11","author":"Mart\u00ednez-Col\u00f3n","year":"2018","journal-title":"Mucosal Immunol."},{"issue":"9","key":"10.1016\/j.lfs.2022.120962_bb0130","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.4049\/jimmunol.1602072","article-title":"The induction of Pro-IL-1\u03b2 by lipopolysaccharide requires endogenous prostaglandin E2 production","volume":"198","author":"Zas\u0142ona","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2022.120962_bb0135","doi-asserted-by":"crossref","first-page":"10760","DOI":"10.1038\/ncomms10760","article-title":"Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality","volume":"7","author":"Zoccal","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2022.120962_bb0140","series-title":"Immunofluorescence and confocal microscopy of neutrophils","first-page":"251","author":"Allen","year":"2014"},{"key":"10.1016\/j.lfs.2022.120962_bb0145","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ijbiomac.2022.01.107","article-title":"NLRP3 inflammasome activation in human peripheral blood mononuclear cells induced by venoms secreted PLA2s","volume":"202","author":"Silva","year":"2022","journal-title":"Int.J.Biol.Macromol."},{"issue":"6","key":"10.1016\/j.lfs.2022.120962_bb0150","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.lfs.2022.120962_bb0155","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1165\/ajrcmb.11.1.8018341","article-title":"Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol","volume":"11","author":"Stolk","year":"1994","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"8","key":"10.1016\/j.lfs.2022.120962_bb0160","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.206","article-title":"TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles)","volume":"7","author":"Xing","year":"2016","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.lfs.2022.120962_bb0165","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41589-019-0278-6","article-title":"MCC950 closes the active conformation of NLRP3 to an inactive state","volume":"15","author":"Tapia-Abell\u00e1n","year":"2019","journal-title":"Nat. Chem. Biol."},{"issue":"2","key":"10.1016\/j.lfs.2022.120962_bb0170","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0022-1759(81)90138-1","article-title":"Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader","volume":"46","author":"Pick","year":"1981","journal-title":"J. Immunol. Methods"},{"issue":"10","key":"10.1016\/j.lfs.2022.120962_bb0175","first-page":"1271","article-title":"Superoxide-independent hydrogen peroxide release by activated macrophages","volume":"22","author":"Russo","year":"1989","journal-title":"Braz.J.Med.Biol.Res."},{"issue":"7","key":"10.1016\/j.lfs.2022.120962_bb0180","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1084\/jem.20161512","article-title":"TLR7\/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA","volume":"214","author":"Lood","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.lfs.2022.120962_bb0185","article-title":"Human neutrophils functionality under effect of an Asp49 phospholipase A2 isolated from Bothrops atrox venom","volume":"6","author":"Set\u00fabal","year":"2020","journal-title":"Toxicon: X"},{"key":"10.1016\/j.lfs.2022.120962_bb0190","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.3389\/fimmu.2019.02419","article-title":"NLRX1 is a multifaceted and enigmatic regulator of immune system function","volume":"10","author":"Nagai-Singer","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2022.120962_bb0195","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3389\/fphys.2014.00352","article-title":"Reactive oxygen species at the crossroads of inflammasome and inflammation","volume":"5","author":"Harijith","year":"2014","journal-title":"Front. Physiol."},{"issue":"Suppl 2","key":"10.1016\/j.lfs.2022.120962_bb0200","article-title":"Priming and de-priming of neutrophil responses in vitro and in vivo","volume":"48","author":"Vogt","year":"2018","journal-title":"Eur. J. Clin. Investig."},{"issue":"5","key":"10.1016\/j.lfs.2022.120962_bb0205","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12652","article-title":"Mapping out p38MAPK","volume":"77","author":"Bonney","year":"2017","journal-title":"Am. J. Reprod. Immunol."},{"issue":"3","key":"10.1016\/j.lfs.2022.120962_bb0210","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nri.2016.147","article-title":"Programmed cell death as a defence against infection","volume":"17","author":"Jorgensen","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.lfs.2022.120962_bb0215","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.abb.2012.04.017","article-title":"Role of PKC\u03b1-p(38)MAPK-G(i)\u03b1 axis in NADPH oxidase derived O(2)(\u00b7-)-mediated activation of cPLA(2) under U46619 stimulation in pulmonary artery smooth muscle cells","volume":"523","author":"Chakraborti","year":"2012","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.lfs.2022.120962_bb0220","doi-asserted-by":"crossref","first-page":"11304","DOI":"10.1038\/ncomms11304","article-title":"Real-time quantification of protein expression at the single-cell level via dynamic protein synthesis translocation reporters","volume":"7","author":"Aymoz","year":"2016","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.lfs.2022.120962_bb0225","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1042\/cs0940461","article-title":"Neutrophil priming: pathophysiological consequences and underlying mechanisms","volume":"94","author":"Condliffe","year":"1998","journal-title":"Clin. Sci."},{"issue":"3","key":"10.1016\/j.lfs.2022.120962_bb0230","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00281-008-0118-3","article-title":"Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane","volume":"30","author":"El-Benna","year":"2008","journal-title":"Semin. Immunopathol."},{"issue":"1","key":"10.1016\/j.lfs.2022.120962_bb0235","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/imr.12447","article-title":"Priming of the neutrophil respiratory burst: role in host defense and inflammation","volume":"273","author":"El-Benna","year":"2016","journal-title":"Immunol. Rev."},{"issue":"Suppl 2","key":"10.1016\/j.lfs.2022.120962_bb0240","article-title":"NADPH oxidase activation in neutrophils: role of the phosphorylation of its subunits","volume":"48","author":"Belambri","year":"2018","journal-title":"Eur. J. Clin. Investig."},{"issue":"2","key":"10.1016\/j.lfs.2022.120962_bb0245","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/omi.12252","article-title":"The roles of NADPH oxidase in modulating neutrophil effector responses","volume":"34","author":"Zeng","year":"2019","journal-title":"Mol. Oral Microbiol."},{"key":"10.1016\/j.lfs.2022.120962_bb0250","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fimmu.2017.00036","article-title":"Canonical and non-canonical activation of NLRP3 inflammasome at the crossroad between immune tolerance and intestinal inflammation","volume":"8","author":"Pellegrini","year":"2017","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.lfs.2022.120962_bb0255","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.lfs.2022.120962_bb0260","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s00018-010-0567-4","article-title":"Inflammasomes: current understanding and open questions","volume":"68","author":"Bauernfeind","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.lfs.2022.120962_bb0265","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/toxins12010022","article-title":"Inflammasome activation induced by a snake venom Lys49-phospholipase A2 homologue","volume":"12","author":"Boeno","year":"2019","journal-title":"Toxins"},{"issue":"5","key":"10.1016\/j.lfs.2022.120962_bb0270","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1042\/CS20201419","article-title":"Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor","volume":"135","author":"Ran\u00e9ia e Silva","year":"2021","journal-title":"Clin.Sci."},{"issue":"1","key":"10.1016\/j.lfs.2022.120962_bb0275","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/bab.1700","article-title":"Role and mechanism of ROS scavengers in alleviating NLRP3-mediated inflammation","volume":"66","author":"Sho","year":"2019","journal-title":"Biotechnol. Appl. Biochem."},{"issue":"8","key":"10.1016\/j.lfs.2022.120962_bb0280","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ni.1631","article-title":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization","volume":"9","author":"Hornung","year":"2008","journal-title":"Nat. Immunol."},{"issue":"26","key":"10.1016\/j.lfs.2022.120962_bb0285","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.1182\/blood-2009-10-250803","article-title":"Human NLRP3 inflammasome activation is Nox1-4 independent","volume":"115","author":"van Bruggen","year":"2010","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.lfs.2022.120962_bb0290","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1074\/jbc.M608083200","article-title":"ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages","volume":"282","author":"Cruz","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"5876","key":"10.1016\/j.lfs.2022.120962_bb0295","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica","volume":"320","author":"Dostert","year":"2008","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.lfs.2022.120962_bb0300","doi-asserted-by":"crossref","first-page":"8410","DOI":"10.4049\/jimmunol.180.12.8410","article-title":"A key role for redox signaling in rapid P2X7 receptor-induced IL-1 beta processing in human monocytes","volume":"180","author":"Hewinson","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2022.120962_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101466","article-title":"A closer look into NADPH oxidase inhibitors: validation and insight into their mechanism of action","volume":"32","author":"Reis","year":"2020","journal-title":"Redox Biol."},{"issue":"44","key":"10.1016\/j.lfs.2022.120962_bb0310","doi-asserted-by":"crossref","first-page":"41507","DOI":"10.1074\/jbc.M205432200","article-title":"Reaction of reduced flavins and flavoproteins with diphenyliodonium chloride","volume":"277","author":"Chakraborty","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.lfs.2022.120962_bb0315","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.bcp.2012.01.022","article-title":"Antiproliferative mechanisms of action of the flavin dehydrogenase inhibitors diphenylene iodonium and di-2-thienyliodonium based on molecular profiling of the NCI-60 human tumor cell panel","volume":"83","author":"Doroshow","year":"2012","journal-title":"Biochem. Pharmacol."},{"issue":"12","key":"10.1016\/j.lfs.2022.120962_bb0320","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1021\/bi9823481","article-title":"The heme component of the neutrophil NADPH oxidase complex is a target for aryliodonium compounds","volume":"38","author":"Doussiere","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.lfs.2022.120962_bb0325","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bcp.2017.07.007","article-title":"Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases","volume":"143","author":"Lu","year":"2017","journal-title":"Biochem. Pharmacol."},{"issue":"Pt 1","key":"10.1016\/j.lfs.2022.120962_bb0330","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1042\/bj2900041","article-title":"Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase","volume":"290","author":"O\u2019Donnell","year":"1993","journal-title":"Biochem. J."},{"issue":"3","key":"10.1016\/j.lfs.2022.120962_bb0335","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.3390\/molecules18032821","article-title":"Apocynin: chemical and biophysical properties of a NADPH oxidase inhibitor","volume":"18","author":"Petr\u00f4nio","year":"2013","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.lfs.2022.120962_bb0340","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1164\/rccm.200710-1602OC","article-title":"Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury","volume":"178","author":"Zmijewski","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.lfs.2022.120962_bb0345","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.sbi.2015.03.014","article-title":"The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines","volume":"31","author":"Hauenstein","year":"2015","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"6","key":"10.1016\/j.lfs.2022.120962_bb0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007795","article-title":"An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS)","volume":"15","author":"Lin","year":"2019","journal-title":"PLoS Pathog."},{"issue":"8","key":"10.1016\/j.lfs.2022.120962_bb0355","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006502","article-title":"Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5\/NLRC4\/ASC inflammasome","volume":"13","author":"Mascarenhas","year":"2017","journal-title":"PLoS Pathog."},{"issue":"5","key":"10.1016\/j.lfs.2022.120962_bb0360","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004887","article-title":"The NLRP3 inflammasome is a pathogen sensor for invasive Entamoeba histolytica via activation of \u03b15\u03b21 integrin at the macrophage-amebae intercellular junction","volume":"11","author":"Mortimer","year":"2015","journal-title":"PLoS Pathog."},{"issue":"3","key":"10.1016\/j.lfs.2022.120962_bb0365","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201707","article-title":"Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients","volume":"218","author":"Rodrigues","year":"2021","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.lfs.2022.120962_bb0370","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s12974-019-1668-0","article-title":"URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion","volume":"16","author":"Su","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.lfs.2022.120962_bb0375","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/978-1-4939-9541-7_16","article-title":"Analysis of inflammasome activation in response to yersinia infection by fluorescence microscopy detection of active Caspase-1 puncta","volume":"2010","author":"Zwack","year":"2019","journal-title":"Methods Mol. Biol."},{"issue":"12","key":"10.1016\/j.lfs.2022.120962_bb0380","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1002\/eji.201243089","article-title":"NADPH oxidase derived reactive oxygen species are involved in human neutrophil IL-1\u03b2 secretion but not in inflammasome activation","volume":"43","author":"Gabelloni","year":"2013","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.lfs.2022.120962_bb0385","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cyto.2015.03.022","article-title":"Mechanisms of unconventional secretion of IL-1 family cytokines","volume":"74","author":"Monteleone","year":"2015","journal-title":"Cytokine"},{"issue":"6","key":"10.1016\/j.lfs.2022.120962_bb0390","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.celrep.2018.07.027","article-title":"Interleukin-1\u03b2 maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretion","volume":"24","author":"Monteleone","year":"2018","journal-title":"Cell Rep."},{"issue":"12","key":"10.1016\/j.lfs.2022.120962_bb0395","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"issue":"7575","key":"10.1016\/j.lfs.2022.120962_bb0400","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.lfs.2022.120962_bb0405","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1042\/BJ20150204","article-title":"Loss of conserved Gsdma3 self-regulation causes autophagy and cell death","volume":"468","author":"Shi","year":"2015","journal-title":"Biochem.J."},{"issue":"28","key":"10.1016\/j.lfs.2022.120962_bb0410","doi-asserted-by":"crossref","first-page":"7858","DOI":"10.1073\/pnas.1607769113","article-title":"GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes","volume":"113","author":"Aglietti","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.lfs.2022.120962_bb0415","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/cr.2016.100","article-title":"Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis","volume":"26","author":"Chen","year":"2016","journal-title":"Cell Res."},{"issue":"7610","key":"10.1016\/j.lfs.2022.120962_bb0420","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.lfs.2022.120962_bb0425","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1016\/j.celrep.2018.02.067","article-title":"Gasdermin D exerts anti-inflammatory effects by promoting neutrophil death","volume":"22","author":"Kambara","year":"2018","journal-title":"Cell Rep."},{"issue":"16","key":"10.1016\/j.lfs.2022.120962_bb0430","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.15252\/embj.201694696","article-title":"GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death","volume":"35","author":"Sborgi","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.lfs.2022.120962_bb0435","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14128","article-title":"Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic\/pyroptotic cell death","volume":"8","author":"Rogers","year":"2017","journal-title":"Nat.Commun."},{"issue":"7661","key":"10.1016\/j.lfs.2022.120962_bb0440","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"issue":"64","key":"10.1016\/j.lfs.2022.120962_bb0445","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abj3859","article-title":"NLRP3 inflammasome activation triggers gasdermin D-independent inflammation","volume":"6","author":"Wang","year":"2021","journal-title":"Sci.Immunol."},{"issue":"3","key":"10.1016\/j.lfs.2022.120962_bb0450","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/sji.12580","article-title":"Complement C5a-induced changes in neutrophil morphology during inflammation","volume":"86","author":"Denk","year":"2017","journal-title":"Scand. J. Immunol."},{"issue":"4","key":"10.1016\/j.lfs.2022.120962_bb0455","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/SHK.0000000000001200","article-title":"A rise in neutrophil cell size precedes organ dysfunction after trauma","volume":"51","author":"Hesselink","year":"2019","journal-title":"Shock"},{"key":"10.1016\/j.lfs.2022.120962_bb0460","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.642867","article-title":"Activation of neutrophil granulocytes by platelet-activating factor is impaired during experimental sepsis","volume":"12","author":"Hug","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2022.120962_bb0465","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.571992","article-title":"Animal-free human whole blood sepsis model to study changes in innate immunity","volume":"11","author":"Messerer","year":"2020","journal-title":"Front. Immunol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522006622?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522006622?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:10:23Z","timestamp":1758402623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320522006622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":93,"alternative-id":["S0024320522006622"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120962","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reactive oxygen species-dependent-NLRP3 inflammasome activation in human neutrophils induced by l-amino acid oxidase derived from Calloselasma rhodostoma venom","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120962","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120962"}}