{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:45:23Z","timestamp":1792226723833,"version":"4.4.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["9613478001"],"award-info":[{"award-number":["9613478001"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.lfs.2022.120966","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T04:32:07Z","timestamp":1663734727000},"page":"120966","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Evaluation of statins as a new therapy to alleviate chronotropic dysfunction in cirrhotic rats"],"prefix":"10.1016","volume":"308","author":[{"given":"Qamar","family":"Niaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohammad","family":"Tavangar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sania","family":"Mehreen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Ghazi-Khansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farahnaz","family":"Jazaeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2022.120966_bb0005","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0140-6736(14)60121-5","article-title":"Liver cirrhosis","volume":"383","author":"Tsochatzis","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2022.120966_bb0010","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0140-6736(08)60383-9","article-title":"Liver cirrhosis","volume":"371","author":"Schuppan","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2022.120966_bb0015","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/872152","article-title":"Liver cirrhosis, evaluation, nutritional status, and prognosis","volume":"2015","author":"Nishikawa","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.lfs.2022.120966_bb0020","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/hep.21673","article-title":"Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA\/Rho-kinase and activation of endothelial nitric oxide synthase","volume":"64","author":"Trebicka","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2022.120966_bb0025","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1136\/gut.2005.081059","article-title":"Intrahepatic upregulation of RhoA and rho-kinase signalling contributes to increased hepatic vascular resistance in rats with secondary biliary cirrhosis","volume":"55","author":"Zhou","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2022.120966_bb0030","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1478-3231.2011.02579.x","article-title":"Endothelial dysfunction in the regulation of cirrhosis and portal hypertension","volume":"32","author":"Iwakiri","year":"2012","journal-title":"Liver Int."},{"key":"10.1016\/j.lfs.2022.120966_bb0035","first-page":"2555","article-title":"Splanchnic vasodilation and hyperdynamic circulatory syndrome in cirrhosis, world","volume":"20","author":"Bolognesi","year":"2014","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.lfs.2022.120966_bb0040","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3748\/wjg.v12.i6.837","article-title":"Cardiac and vascular changes in cirrhosis: pathogenic mechanisms","volume":"12","author":"Liu","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2022.120966_bb0045","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jhep.2017.10.020","article-title":"Clinical states of cirrhosis and competing risks","volume":"68","author":"D'Amico","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2022.120966_bb0050","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.ejim.2014.09.004","article-title":"Clinical implications of the hyperdynamic syndrome in cirrhosis","volume":"25","author":"Licata","year":"2014","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.lfs.2022.120966_bb0055","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.dld.2006.12.014","article-title":"Cirrhotic cardiomyopathy","volume":"39","author":"Milani","year":"2007","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.lfs.2022.120966_bb0060","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3390\/gastroent12010008","article-title":"Cirrhotic cardiomyopathy","volume":"12","author":"Longley","year":"2021","journal-title":"Gastroenterol. Insights"},{"key":"10.1016\/j.lfs.2022.120966_bb0065","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s12072-014-9531-y","article-title":"Cirrhotic cardiomyopathy: review of pathophysiology and treatment","volume":"8","author":"Chayanupatkul","year":"2014","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.lfs.2022.120966_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12876-019-1147-1","article-title":"Comprehensive evaluation of effects and safety of statin on the progression of liver cirrhosis: a systematic review and meta-analysis","volume":"19","author":"Gu","year":"2019","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.lfs.2022.120966_bb0075","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/cld.788","article-title":"Patients with chronic liver disease\/cirrhosis should not take statin medications","volume":"13","author":"Kasia","year":"2019","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.lfs.2022.120966_bb0080","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jhep.2018.07.019","article-title":"Statins: old drugs as new therapy for liver diseases?","volume":"70","author":"Pose","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2022.120966_bb0085","article-title":"Pleiotropic effects of statins in the light of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis","volume":"12","author":"Ahsan","year":"2020","journal-title":"Cureus"},{"key":"10.1016\/j.lfs.2022.120966_bb0090","doi-asserted-by":"crossref","first-page":"354","DOI":"10.4103\/0253-7613.115016","article-title":"Amelioration of cisplatin-induced nephrotoxicity by statins","volume":"45","author":"Maheshwari","year":"2013","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.lfs.2022.120966_bb0095","doi-asserted-by":"crossref","first-page":"3201873","DOI":"10.1155\/2019\/3201873","article-title":"Simvastatin reduces hepatic oxidative stress and endoplasmic reticulum stress in nonalcoholic steatohepatitis experimental model","volume":"2019","author":"Rodrigues","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2022.120966_bb0100","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1159\/000506151","article-title":"Heart failure risk reduction: hydrophilic or lipophilic statins?","volume":"145","author":"Kunutsor","year":"2020","journal-title":"Cardiology"},{"key":"10.1016\/j.lfs.2022.120966_bb0105","first-page":"743","article-title":"Nitrergic and opioidergic systems affect radiographic density and histomorphometric indices in bile-duct-ligated cirrhotic rats","volume":"32","author":"Doustimotlagh","year":"2017","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.lfs.2022.120966_bb0110","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/hep.510240221","article-title":"Inhibition of experimentally induced cirrhosis in rats by hypothyroidism","volume":"24","author":"Oren","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2022.120966_bb0115","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jff.2017.11.020","article-title":"Curcumin, quercetin and atorvastatin protected against the hepatic fibrosis by activating AMP-activated protein kinase","volume":"40","author":"Kabirifar","year":"2018","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.lfs.2022.120966_bb0120","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/liv.12876","article-title":"Bile duct-ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences","volume":"36","author":"O'Brien","year":"2016","journal-title":"Liver Int."},{"key":"10.1016\/j.lfs.2022.120966_bb0125","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.5114\/aoms.2019.86064","article-title":"Histopathological and biochemical assessment of liver damage in albino wister rats treated with cytotoxic platinum compounds in combination with 5-fluorouracil","volume":"15","author":"Bano","year":"2019","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.lfs.2022.120966_bb0130","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/hep.510310136","article-title":"Grading and staging the histopathological lesions of chronic hepatitis: the knodell histology activity index and beyond","volume":"31","author":"Brunt","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2022.120966_bb0135","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.jhep.2011.02.012","article-title":"Histological subclassification of cirrhosis using the laennec fibrosis scoring system correlates with clinical stage and grade of portal hypertension","volume":"55","author":"Kim","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2022.120966_bb0140","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/liv.12039","article-title":"Cirrhosis is associated with development of tolerance to cardiac chronotropic effect of endotoxin in rats","volume":"33","author":"Jazaeri","year":"2013","journal-title":"Liver Int."},{"key":"10.1016\/j.lfs.2022.120966_bb0145","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/10641963.2020.1860077","article-title":"Echocardiographic follow-up to right ventricular modifications in secondary pulmonary hypertension to diabetes in rats","volume":"43","author":"L\u00f3pez","year":"2021","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.lfs.2022.120966_bb0150","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s10238-018-0508-3","article-title":"TNF-R2 in tumor microenvironment as prognostic factor in epithelial ovarian cancer","volume":"18","author":"Nomelini","year":"2018","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.lfs.2022.120966_bb0155","doi-asserted-by":"crossref","DOI":"10.1111\/micc.12651","article-title":"Implication of nuclear factor-erythroid 2-like 2\/heme oxygenase 1 pathway in the protective effects of coenzyme Q10 against preeclampsia-like in a rat model","volume":"27","author":"Li","year":"2020","journal-title":"Microcirculation"},{"key":"10.1016\/j.lfs.2022.120966_bb0160","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","author":"Buege","year":"1978"},{"key":"10.1016\/j.lfs.2022.120966_bb0165","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1053\/j.gastro.2005.11.029","article-title":"Defective RhoA\/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats","volume":"130","author":"Hennenberg","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2022.120966_bb0170","article-title":"Spironolactone lowers portal hypertension by inhibiting liver fibrosis, ROCK-2 activity and activating NO\/PKG pathway in the bile-duct-ligated rat","volume":"7","author":"Luo","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2022.120966_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119261","article-title":"Evaluation of the effect of heat shock protein 70 targeted drugs on cirrhotic cardiomyopathy in biliary cirrhotic rats","volume":"273","author":"Esmaeili","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2022.120966_bb0180","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1478-3231.2012.02803.x","article-title":"Cardiovascular abnormalities in obstructive cholestasis: the possible mechanisms","volume":"33","author":"Moezi","year":"2013","journal-title":"Liver Int."},{"key":"10.1016\/j.lfs.2022.120966_bb0185","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/hep.21115","article-title":"Nitration of cardiac proteins is associated with abnormal cardiac chronotropic responses in rats with biliary cirrhosis","volume":"43","author":"Mani","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2022.120966_bb0190","first-page":"169","article-title":"Physiopathological and diagnostic aspects of cirrhotic cardiomyopathy","volume":"90","author":"Leal-Alvarado","year":"2020","journal-title":"Arch. Cardiol. Mex."},{"key":"10.1016\/j.lfs.2022.120966_bb0195","doi-asserted-by":"crossref","first-page":"e391","DOI":"10.1016\/j.crvasa.2013.06.002","article-title":"Heart failure in patients with liver cirrhosis","volume":"55","author":"Pudil","year":"2013","journal-title":"Cor. Vasa."},{"key":"10.1016\/j.lfs.2022.120966_bb0200","doi-asserted-by":"crossref","first-page":"131","DOI":"10.20517\/2394-5079.2015.58","article-title":"Physiological potential of cytokines and liver damages","volume":"2","author":"Mannaa","year":"2016","journal-title":"Hepatoma Res."},{"key":"10.1016\/j.lfs.2022.120966_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0215752","article-title":"Influence of hepatic fibrosis and inflammation: correlation between histopathological changes and gd-EOB-DTPA-enhanced MR imaging","volume":"14","author":"Verloh","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2022.120966_bb0210","doi-asserted-by":"crossref","first-page":"G147","DOI":"10.1152\/ajpgi.00462.2007","article-title":"Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver","volume":"296","author":"Moreno","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2022.120966_bb0215","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.jhep.2010.04.025","article-title":"Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells","volume":"53","author":"Trebicka","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2022.120966_bb0220","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1007\/s10620-007-0003-2","article-title":"Atorvastatin does not improve liver biochemistries or mayo risk score in primary biliary cirrhosis","volume":"53","author":"Stanca","year":"2008","journal-title":"Dig. Dis. Sci."},{"issue":"2013","key":"10.1016\/j.lfs.2022.120966_bb0225","first-page":"12","article-title":"The influence of atorvastatin on parameters of inflammation left ventricular function, hospitalizations and mortality in patients with dilated cardiomyopathy\u20135-year follow-up","volume":"12","author":"Bielecka-Dabrowa","year":"2013","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.lfs.2022.120966_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166845","article-title":"Atorvastatin improves ventricular remodeling after myocardial infarction by interfering with collagen metabolism","volume":"11","author":"Reichert","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2022.120966_bb0235","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3748\/wjg.v19.i2.241","article-title":"Atorvastatin and rosuvastatin do not prevent thioacetamide induced liver cirrhosis in rats","volume":"19","author":"Shirin","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2022.120966_bb0240","first-page":"485","article-title":"The use of statins in patients with cirrhosis","volume":"14","author":"Kaplan","year":"2018","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2022.120966_bb0245","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.cardfail.2005.06.439","article-title":"Atorvastatin therapy increases heart rate variability, decreases QT variability, and shortens QTc interval duration in patients with advanced chronic heart failure","volume":"11","author":"Vrtovec","year":"2005","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.lfs.2022.120966_bb0250","first-page":"155","article-title":"Prolongation of the QTc interval in patients with cirrhosis","volume":"16","author":"Mimidis","year":"2003","journal-title":"Ann. Gastroenterol."},{"key":"10.1016\/j.lfs.2022.120966_bb0255","first-page":"1345","article-title":"Heart and bile acids\u2013clinical consequences of altered bile acid metabolism","volume":"2018","author":"Vasavan","year":"1864","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.lfs.2022.120966_bb0260","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ijcard.2008.11.030","article-title":"Statin therapy shortens QTc, QTcd, and improves cardiac function in patients with chronic heart failure","volume":"140","author":"Xie","year":"2010","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.lfs.2022.120966_bb0265","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1097\/MEG.0b013e32833e6b2a","article-title":"BNP as marker of heart dysfunction in patients with liver cirrhosis","volume":"22","author":"Padillo","year":"2010","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2022.120966_bb0270","first-page":"564","article-title":"Cirrhotic cardiomyopathy: a new clinical phenotype","volume":"108","author":"Mocarzel","year":"2017","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.lfs.2022.120966_bb0275","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/clc.20273","article-title":"Atorvastatin therapy is associated with reduced levels of N-terminal prohormone brain natriuretic peptide and improved cardiac function in patients with heart failure","volume":"31","author":"Stypmann","year":"2008","journal-title":"Clin. Cardiol."},{"key":"10.1016\/j.lfs.2022.120966_bb0280","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.jhep.2020.09.037","article-title":"Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis","volume":"74","author":"Mohs","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2022.120966_bb0285","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/763257","article-title":"Role of the NRF2-ARE pathway in liver diseases","volume":"2013","author":"Shin","year":"2013","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2022.120966_bb0290","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1124\/pr.117.014753","article-title":"Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach","volume":"70","author":"Cuadrado","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.lfs.2022.120966_bb0295","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.33549\/physiolres.933403","article-title":"Nrf2 as a key player of redox regulation in cardiovascular diseases","volume":"65","author":"Baran\u010d\u00edk","year":"2016","journal-title":"Physiol. Res."},{"key":"10.1016\/j.lfs.2022.120966_bb0300","first-page":"14837","article-title":"Atorvastatin attenuates inflammation and oxidative stress induced by ischemia\/reperfusion in rat heart via the NRF2 transcription factor","volume":"8","author":"Sun","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.lfs.2022.120966_bb0305","series-title":"Lipid Peroxidation","first-page":"483","article-title":"Lipid peroxidation in hepatic fibrosis","author":"Shimizu","year":"2012"},{"key":"10.1016\/j.lfs.2022.120966_bb0310","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4137\/BMI.S639","article-title":"Serum and ascitic fluid superoxide dismutase and malondialdehyde levels in patients with cirrhosis","volume":"3","author":"Ozenirler","year":"2008","journal-title":"Biomark. Insights"},{"key":"10.1016\/j.lfs.2022.120966_bb0315","first-page":"11007","article-title":"Relevance of plasma malondialdehyde level and severity of portal hypertension in cirrhotic patients","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.lfs.2022.120966_bb0320","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ehj.2014.11.003","article-title":"Atorvastatin improves cardiac function and remodeling in chronic non-ischemic heart failure: a clinical and pre-clinical study","volume":"67","author":"Elmadbouh","year":"2015","journal-title":"Egypt. Heart J."},{"key":"10.1016\/j.lfs.2022.120966_bb0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-021-00730-w","article-title":"RhoA: a dubious molecule in cardiac pathophysiology","volume":"28","author":"Kilian","year":"2021","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.lfs.2022.120966_bb0330","doi-asserted-by":"crossref","first-page":"17161","DOI":"10.1073\/pnas.0134112100","article-title":"Distribution of nitric oxide synthase in normal and cirrhotic human liver","volume":"99","author":"McNaughton","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2022.120966_bb0335","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4254\/wjh.v7.i3.443","article-title":"Endothelial dysfunction in cirrhosis: role of inflammation and oxidative stress","volume":"7","author":"Vairappan","year":"2015","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.lfs.2022.120966_bb0340","doi-asserted-by":"crossref","first-page":"00767","DOI":"10.3389\/fphys.2020.00767","article-title":"The emerging role of hepatocellular eNOS in non-alcoholic fatty liver disease development","volume":"11","author":"Cunningham","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lfs.2022.120966_bb0345","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/108155890405200433","article-title":"Statin therapy for cardiac hypertrophy and heart failure","volume":"52","author":"Liao","year":"2004","journal-title":"J. Investig. Med."},{"key":"10.1016\/j.lfs.2022.120966_bb0350","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1002\/hep.28616","article-title":"Statins in cirrhosis: the magic pill?","volume":"63","author":"Malizia","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2022.120966_bb0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14740\/gr1498","article-title":"Statin use in patients with chronic liver disease and cirrhosis","volume":"15","author":"Kreidieh","year":"2022","journal-title":"Gastroenterol. Res."},{"key":"10.1016\/j.lfs.2022.120966_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154226","article-title":"Statin downregulation of mir-652-3p protects endothelium from dyslipidemia by promoting ISL1 expression","volume":"107","author":"Liang","year":"2020","journal-title":"Metabolism"},{"key":"10.1016\/j.lfs.2022.120966_bb0365","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/bja\/ael358","article-title":"Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide","volume":"98","author":"Mcgown","year":"2007","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.lfs.2022.120966_bb0370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12893-017-0235-9","article-title":"Michal heger atorvastatin does not protect against ischemia-reperfusion damage in cholestatic rat livers","volume":"17","author":"Wiggers","year":"2017","journal-title":"BMC Surg."},{"key":"10.1016\/j.lfs.2022.120966_bb0375","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/bja\/aep149","article-title":"Statins for all: the new premed?","volume":"103","author":"Brookes","year":"2009","journal-title":"Br. J. Anesth."},{"key":"10.1016\/j.lfs.2022.120966_bb0380","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/liv.14800","article-title":"Rodent models of cholestatic liver disease: a practical guide for translational research","volume":"41","author":"Gijbels","year":"2021","journal-title":"Liver Int."},{"key":"10.1016\/j.lfs.2022.120966_bb0385","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bpg.2011.02.004","article-title":"Animal models for the study of hepatic fibrosis","volume":"25","author":"Starkel","year":"2011","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.lfs.2022.120966_bb0390","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.4081\/ejh.2017.2803","article-title":"Bile duct ligature in young rats: a revisited animal model for biliary atresia","volume":"61","author":"Garrido","year":"2017","journal-title":"Eur. J. Histochem."},{"key":"10.1016\/j.lfs.2022.120966_bb0395","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1007\/s10620-006-9143-z","article-title":"Diagnosis and measurement of liver fibrosis by MRI in bile duct ligated rats","volume":"52","author":"Aub\u00e9","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.lfs.2022.120966_bb0400","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1755-1536-3-5","article-title":"Procollagen type I N-terminal propeptide (PINP) is a marker for fibrogenesis in bile duct ligation-induced fibrosis in rats","volume":"3","author":"Veidal","year":"2010","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.lfs.2022.120966_bb0405","doi-asserted-by":"crossref","first-page":"G449","DOI":"10.1152\/ajpgi.00199.2012","article-title":"Animal models of chronic liver diseases","volume":"304","author":"Liu","year":"2013","journal-title":"Am. J. Physiol. Gastrointest."},{"key":"10.1016\/j.lfs.2022.120966_bb0410","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jhep.2020.04.011","article-title":"Animal models for liver disease\u2013A practical approach for translational research","volume":"73","author":"Nevzorova","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2022.120966_bb0415","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12876-021-01704-w","article-title":"A systematic review on pharmacokinetics, cardiovascular outcomes and safety profiles of statins in cirrhosis","volume":"21","author":"Sung","year":"2021","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.lfs.2022.120966_bb0420","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/cld.866","article-title":"Use of statins in patients with and without liver disease","volume":"15","author":"Francis","year":"2020","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.lfs.2022.120966_bb0425","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s11938-018-0180-4","article-title":"The use of statins in patients with chronic liver disease and cirrhosis","volume":"16","author":"Moctezuma-Vel\u00e1zquez","year":"2018","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"10.1016\/j.lfs.2022.120966_bb0430","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/flgastro-2014-100500","article-title":"Statin therapy in patients with cirrhosis","volume":"6","author":"Wright","year":"2015","journal-title":"Frontline Gastroenterol."},{"key":"10.1016\/j.lfs.2022.120966_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/S0735-1097(21)04134-6","article-title":"Statins-induced rhabdomyolysis: an important limitation of a common therapeutic","volume":"77","author":"Bhatnagar","year":"2021","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052200666X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052200666X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:10:42Z","timestamp":1758402642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002432052200666X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":87,"alternative-id":["S002432052200666X"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120966","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of statins as a new therapy to alleviate chronotropic dysfunction in cirrhotic rats","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.120966","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"120966"}}