{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:53:15Z","timestamp":1792270395362,"version":"4.4.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.lfs.2022.121040","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T15:14:31Z","timestamp":1664982871000},"page":"121040","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Insights into the role of P2X7R\/DUSP6\/ERK1\/2 and SIRT2\/MDM2 signaling in the nephroprotective effect of berberine against cisplatin-induced renal fibrosis in rats"],"prefix":"10.1016","volume":"309","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8894-9696","authenticated-orcid":false,"given":"Omaima A.","family":"Ahmedy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia M.","family":"El-Tanbouly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa K.","family":"Al-Mokaddem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin A.M.","family":"El-Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2022.121040_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1757-2215-2-2","article-title":"Enhancing the efficacy of cisplatin in ovarian cancer treatment\u2013could arsenic have a role","volume":"2","author":"Helm","year":"2009","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.lfs.2022.121040_bb0010","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0968-0004(00)89095-7","article-title":"Cisplatin and DNA repair in cancer chemotherapy","volume":"20","author":"Zamble","year":"1995","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.lfs.2022.121040_bb0015","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/MAJ.0b013e31812dfe1e","article-title":"Cisplatin nephrotoxicity: a review","volume":"334","author":"Yao","year":"2007","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.lfs.2022.121040_bb0020","doi-asserted-by":"crossref","first-page":"55","DOI":"10.5049\/EBP.2014.12.2.55","article-title":"Cisplatin-induced kidney dysfunction and perspectives on improving treatment strategies","volume":"12","author":"Oh","year":"2014","journal-title":"Electrolytes Blood Press."},{"key":"10.1016\/j.lfs.2022.121040_bb0025","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nrneph.2015.3","article-title":"Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD","volume":"11","author":"Ferenbach","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.lfs.2022.121040_bb0030","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1681\/ASN.2020101455","article-title":"Potential therapeutic targets for cisplatin-induced kidney injury: lessons from other models of AKI and fibrosis","volume":"32","author":"Sears","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.lfs.2022.121040_bb0035","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1517\/13543784.2011.578068","article-title":"A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases","volume":"20","author":"Arulkumaran","year":"2011","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.lfs.2022.121040_bb0040","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1523-1755.2004.00717.x","article-title":"Glomerular expression of the ATP-sensitive P2X7 receptor in diabetic and hypertensive rat models","volume":"66","author":"Vonend","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2022.121040_bb0045","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1038\/sj.ki.5001804","article-title":"The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice","volume":"70","author":"Goncalves","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2022.121040_bb0050","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3389\/fnmol.2017.00448","article-title":"P2X7 nucleotide and EGF receptors exert dual modulation of the dual-specificity phosphatase 6 (MKP-3) in granule neurons and astrocytes, contributing to negative feedback on ERK signaling","volume":"10","author":"Queipo","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.lfs.2022.121040_bb0055","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1089\/ars.2013.5709","article-title":"Dual-specificity phosphatases as molecular targets for inhibition in human disease","volume":"20","author":"Rios","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.lfs.2022.121040_bb0060","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/art.40408","article-title":"Hypomethylation of CYP 2E1 and DUSP 22 promoters associated with disease activity and erosive disease among rheumatoid arthritis patients","volume":"70","author":"Mok","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.lfs.2022.121040_bb0065","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1182\/blood-2008-06-162180","article-title":"Dusp-5 and Snrk-1 coordinately function during vascular development and disease","volume":"113","author":"Pramanik","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2022.121040_bb0070","first-page":"1","article-title":"Dual-specificity phosphatases and kidney diseases","author":"Li","year":"2021","journal-title":"Kidney Dis."},{"key":"10.1016\/j.lfs.2022.121040_bb0075","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.cellsig.2007.12.014","article-title":"DUSP6\/MKP-3 inactivates ERK1\/2 but fails to bind and inactivate ERK5","volume":"20","author":"Arkell","year":"2008","journal-title":"Cell. Signal."},{"key":"10.1016\/j.lfs.2022.121040_bb0080","doi-asserted-by":"crossref","first-page":"37497","DOI":"10.1074\/jbc.M211739200","article-title":"Constitutive induction of p-Erk1\/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence","volume":"278","author":"Kim","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2022.121040_bb0085","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.3892\/mmr.2020.11317","article-title":"DUSP6 protects murine podocytes from high glucose-induced inflammation and apoptosis","volume":"22","author":"Chen","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.lfs.2022.121040_bb0090","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.bbrc.2014.06.135","article-title":"SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages","volume":"450","author":"Lee","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2022.121040_bb0095","doi-asserted-by":"crossref","first-page":"G1155","DOI":"10.1152\/ajpgi.00271.2015","article-title":"Inhibition of SIRT2 suppresses hepatic fibrosis","volume":"310","author":"Arteaga","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2022.121040_bb0100","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1159\/000488613","article-title":"Inhibition of SIRT2 alleviates fibroblast activation and renal tubulointerstitial fibrosis via MDM2","volume":"46","author":"He","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.lfs.2022.121040_bb0105","doi-asserted-by":"crossref","first-page":"F760","DOI":"10.1152\/ajprenal.00528.2016","article-title":"MDM2 mediates fibroblast activation and renal tubulointerstitial fibrosis via a p53-independent pathway","volume":"312","author":"Ye","year":"2017","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.lfs.2022.121040_bb0110","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3390\/toxins12110713","article-title":"Biological activity of berberine\u2014a summary update","volume":"12","author":"Och","year":"2020","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.lfs.2022.121040_bb0115","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/ptr.6252","article-title":"Berberine and barberry (Berberis vulgaris): a clinical review","volume":"33","author":"Imenshahidi","year":"2019","journal-title":"Phytother. Res."},{"key":"10.1016\/j.lfs.2022.121040_bb0120","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s11684-019-0724-6","article-title":"Biological properties and clinical applications of berberine","volume":"14","author":"Song","year":"2020","journal-title":"Front. Med."},{"key":"10.1016\/j.lfs.2022.121040_bb0125","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3892\/mmr.2017.6707","article-title":"Protective effect of berberine on renal fibrosis caused by diabetic nephropathy","volume":"16","author":"Li","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.lfs.2022.121040_bb0130","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.fct.2013.09.003","article-title":"Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative\/nitrosative stress, inflammation, autophagy and apoptosis","volume":"62","author":"Domitrovi\u0107","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.lfs.2022.121040_bb0135","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1177\/0192623312444765","article-title":"Tissue Kim-1 and urinary clusterin as early indicators of cisplatin-induced acute kidney injury in rats","volume":"40","author":"Vinken","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.lfs.2022.121040_bb0140","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jep.2006.04.019","article-title":"Effects of berberine on diabetes induced by alloxan and a high-fat\/high-cholesterol diet in rats","volume":"108","author":"Tang","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.lfs.2022.121040_bb0145","series-title":"Theory and Practice of Histological Techniques","author":"Bancroft","year":"2008"},{"key":"10.1016\/j.lfs.2022.121040_bb0150","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12088","article-title":"Automated quantification of renal fibrosis with sirius red and polarization contrast microscopy","volume":"2","author":"Street","year":"2014","journal-title":"Physiol Rep."},{"key":"10.1016\/j.lfs.2022.121040_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111130","article-title":"Dimethyl fumarate protects against intestinal ischemia\/reperfusion lesion: participation of Nrf2\/HO-1, GSK-3\u03b2 and Wnt\/\u03b2-catenin pathway","volume":"134","author":"Gendy","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2022.121040_bb0160","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/ajcp\/75.6.816","article-title":"The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics","volume":"75","author":"Hsu","year":"1981","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.lfs.2022.121040_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109276","article-title":"Antiulcerogenic effect of melittin via mitigating TLR4\/TRAF6 mediated NF-\u03baB and p38MAPK pathways in acetic acid-induced ulcerative colitis in mice","volume":"331","author":"Ahmedy","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.lfs.2022.121040_bb0170","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1369\/0022155419852932","article-title":"Renal inflammation and fibrosis: a double-edged sword","volume":"67","author":"Black","year":"2019","journal-title":"J.Histochem.Cytochem."},{"key":"10.1016\/j.lfs.2022.121040_bb0175","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/sj.ki.5002786","article-title":"Cisplatin nephrotoxicity: mechanisms and renoprotective strategies","volume":"73","author":"Pabla","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2022.121040_bb0180","doi-asserted-by":"crossref","first-page":"F674","DOI":"10.1152\/ajprenal.00196.2020","article-title":"C57BL\/6 mice require a higher dose of cisplatin to induce renal fibrosis and CCL2 correlates with cisplatin-induced kidney injury","volume":"319","author":"Sears","year":"2020","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.lfs.2022.121040_bb0185","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s007950200009","article-title":"Cellular and molecular events leading to renal tubulointerstitial fibrosis","volume":"35","author":"Razzaque","year":"2002","journal-title":"Med.Electron Microsc."},{"key":"10.1016\/j.lfs.2022.121040_bb0190","doi-asserted-by":"crossref","first-page":"R1456","DOI":"10.1152\/ajpregu.00620.2005","article-title":"TNF-\u03b1 neutralization ameliorates obstruction-induced renal fibrosis and dysfunction","volume":"292","author":"Meldrum","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.lfs.2022.121040_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-02864-1","article-title":"Effects of tumor necrosis factor-\u03b1 inhibition on kidney fibrosis and inflammation in a mouse model of aristolochic acid nephropathy","volume":"11","author":"Taguchi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2022.121040_bb0200","doi-asserted-by":"crossref","first-page":"1462802","DOI":"10.1155\/2018\/1462802","article-title":"Cisplatin-induced rodent model of kidney injury: characteristics and challenges","volume":"2018","author":"Per\u0161e","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.lfs.2022.121040_bb0205","doi-asserted-by":"crossref","first-page":"F560","DOI":"10.1152\/ajprenal.00512.2015","article-title":"Repeated administration of low-dose cisplatin in mice induces fibrosis","volume":"310","author":"Sharp","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.lfs.2022.121040_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12872-019-1198-9","article-title":"Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats","volume":"19","author":"Che","year":"2019","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.lfs.2022.121040_bb0215","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cbi.2018.08.016","article-title":"Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis induced by thioacetamide injection in rats","volume":"294","author":"Eissa","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.lfs.2022.121040_bb0220","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s00109-015-1283-1","article-title":"Berberine inhibits smad and non-smad signaling cascades and enhances autophagy against pulmonary fibrosis","volume":"93","author":"Chitra","year":"2015","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.lfs.2022.121040_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115162","article-title":"Berberine attenuates severity of chronic pancreatitis and fibrosis via AMPK-mediated inhibition of TGF-\u03b21\/Smad signaling and M2 polarization","volume":"403","author":"Bansod","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121040_bb0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2014.09.016","article-title":"P2X7 receptor blockade protects against cisplatin-induced nephrotoxicity in mice by decreasing the activities of inflammasome components, oxidative stress and caspase-3","volume":"281","author":"Zhang","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121040_bb0235","doi-asserted-by":"crossref","first-page":"862","DOI":"10.3389\/fimmu.2017.00862","article-title":"P2X7 receptor induces tumor necrosis factor-\u03b1 converting enzyme activation and release to boost TNF-\u03b1 production","volume":"8","author":"Barber\u00e0-Cremades","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2022.121040_bb0240","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/glia.22628","article-title":"P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-\u03b1 in cultured mouse microglia","volume":"62","author":"Shieh","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.lfs.2022.121040_bb0245","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1093\/infdis\/jiu135","article-title":"Extracellular adenosine triphosphate affects the response of human macrophages infected with Mycobacterium tuberculosis","volume":"210","author":"Dubois-Colas","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.lfs.2022.121040_bb0250","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s11302-015-9466-3","article-title":"The role of P2X7 receptors in tissue fibrosis: a brief review","volume":"11","author":"Gentile","year":"2015","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.lfs.2022.121040_bb0255","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1042\/CS20160400","article-title":"NLRP3 inflammasome as a target of berberine in experimental murine liver injury: interference with P2X7 signalling","volume":"130","author":"Vivoli","year":"2016","journal-title":"Clin. Sci."},{"key":"10.1016\/j.lfs.2022.121040_bb0260","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1111\/j.1471-4159.2008.05550.x","article-title":"Cisplatin-mediated activation of extracellular signal-regulated kinases 1\/2 (ERK1\/2) by inhibition of ERK1\/2 phosphatases","volume":"106","author":"Gozdz","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.lfs.2022.121040_bb0265","doi-asserted-by":"crossref","first-page":"C463","DOI":"10.1152\/ajpcell.00245.2014","article-title":"P2X7 receptor inhibition protects against ischemic acute kidney injury in mice","volume":"308","author":"Yan","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.lfs.2022.121040_bb0270","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1053\/j.ajkd.2004.08.039","article-title":"Involvement of extracellular signal-regulated kinase and p38 in human diabetic nephropathy","volume":"45","author":"Sakai","year":"2005","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.lfs.2022.121040_bb0275","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/ki.2008.160","article-title":"Activation of Erk1\/2 and Akt following unilateral ureteral obstruction","volume":"74","author":"Rodr\u00edguez-Pe\u00f1a","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2022.121040_bb0280","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3390\/ijms18050855","article-title":"Renalase protects against renal fibrosis by inhibiting the activation of the ERK signaling pathways","volume":"18","author":"Wu","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2022.121040_bb0285","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1681\/ASN.2018020209","article-title":"The MEK inhibitor trametinib ameliorates kidney fibrosis by suppressing ERK1\/2 and mTORC1 signaling","volume":"30","author":"Andrikopoulos","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.lfs.2022.121040_bb0290","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.3892\/mmr.2020.11317","article-title":"DUSP6 protects murine podocytes from high glucose-induced inflammation and apoptosis","volume":"22","author":"Chen","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.lfs.2022.121040_bb0295","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1177\/1753425920930074","article-title":"Effect of berberine on LPS-induced expression of NF-\u03ba B\/MAPK signalling pathway and related inflammatory cytokines in porcine intestinal epithelial cells","volume":"26","author":"Zhu","year":"2020","journal-title":"Innate Immun."},{"key":"10.1016\/j.lfs.2022.121040_bb0300","first-page":"1","article-title":"Berberine modulates hyper-inflammation in mouse macrophages stimulated with polyinosinic-polycytidylic acid via calcium-CHOP\/STAT pathway","volume":"11","author":"Kim","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2022.121040_bb0305","article-title":"Berberine regulated miR150-5p to inhibit P2X7 receptor, EMMPRIN and MMP-9 expression in oxLDL induced macrophages","volume":"12","author":"Lu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121040_bb0310","doi-asserted-by":"crossref","first-page":"H802","DOI":"10.1152\/ajpheart.00093.2018","article-title":"Antifibrotic cardioprotection of berberine via downregulating myocardial IGF-1 receptor-regulated MMP-2\/MMP-9 expression in diabetic rats","volume":"315","author":"Li","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.lfs.2022.121040_bb0315","first-page":"12509","article-title":"Berberine regulates proliferation, collagen synthesis and cytokine secretion of cardiac fibroblasts via AMPK-mTOR-p70S6K signaling pathway","volume":"8","author":"Ai","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.lfs.2022.121040_bb0320","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1080\/0886022X.2022.2079525","article-title":"Berberine protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition involving the inactivation of the NLRP3 inflammasome","volume":"44","author":"Ma","year":"2022","journal-title":"Ren. Fail."},{"key":"10.1016\/j.lfs.2022.121040_bb0325","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/ptr.6217","article-title":"Berberine alleviates oxidized low-density lipoprotein-induced macrophage activation by downregulating galectin-3 via the NF-\u03baB and AMPK signaling pathways","volume":"33","author":"Pei","year":"2019","journal-title":"Phytother. Res."},{"key":"10.1016\/j.lfs.2022.121040_bb0330","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7956274","article-title":"Inhibition of P2X7 purinergic receptor ameliorates cardiac fibrosis by suppressing NLRP3\/IL-1\u03b2 pathway","volume":"2020","author":"Zhou","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2022.121040_bb0335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110185","article-title":"P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica","volume":"9","author":"Mon\u00e7ao-Ribeiro","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2022.121040_bb0340","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1074\/jbc.M114.596551","article-title":"A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells","volume":"290","author":"L\u00f3pez-Cotarelo","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2022.121040_bb0345","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1152\/japplphysiol.00348.2011","article-title":"Involvement of JNK-AP-1 and ERK-NF-\u03baB signaling in tension-stimulated expression of type I collagen and MMP-1 in human periodontal ligament fibroblasts","volume":"111","author":"Kook","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.lfs.2022.121040_bb0350","first-page":"1","article-title":"Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2022.121040_bb0355","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1007\/s11010-021-04169-3","article-title":"P2X7 receptor antagonist BBG inhibits endoplasmic reticulum stress and pyroptosis to alleviate postherpetic neuralgia","volume":"476","author":"Zhu","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.lfs.2022.121040_bb0360","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.yexcr.2016.09.024","article-title":"PEP-1-SIRT2-induced matrix metalloproteinase-1 and-13 modulates type II collagen expression via ERK signaling in rabbit articular chondrocytes","volume":"348","author":"Eo","year":"2016","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.lfs.2022.121040_bb0365","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1124\/jpet.113.212076","article-title":"Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy","volume":"350","author":"Ponnusamy","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2022.121040_bb0370","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbrc.2013.06.053","article-title":"ERK1\/2 regulates SIRT2 deacetylase activity","volume":"437","author":"Choi","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2022.121040_bb0375","article-title":"Structural exploration of common pharmacophore based berberine derivatives as novel histone deacetylase inhibitor targeting HDACs enzymes","volume":"1\u201314","author":"Kandasamy","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.lfs.2022.121040_bb0380","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.taap.2015.12.006","article-title":"Concurrent acetylation of FoxO1\/3a and p53 due to sirtuins inhibition elicit Bim\/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells","volume":"291","author":"Shukla","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522007408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522007408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T17:50:38Z","timestamp":1735235438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320522007408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":76,"alternative-id":["S0024320522007408"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.121040","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insights into the role of P2X7R\/DUSP6\/ERK1\/2 and SIRT2\/MDM2 signaling in the nephroprotective effect of berberine against cisplatin-induced renal fibrosis in rats","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.121040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"121040"}}