{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:07:36Z","timestamp":1786993656081,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF-2021R1C1C1007936"],"award-info":[{"award-number":["NRF-2021R1C1C1007936"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.lfs.2022.121124","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T01:21:32Z","timestamp":1666660892000},"page":"121124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Regulators impeding erythropoiesis following iron supplementation in a clinically relevant rat model of iron deficiency anemia with inflammation"],"prefix":"10.1016","volume":"310","author":[{"given":"Sung Yeon","family":"Ham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hae","family":"Jun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Bin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Kwang","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Lan","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.lfs.2022.121124_bb0005","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/ejcts\/ezu200","article-title":"The impact of anaemia and intravenous iron replacement therapy on outcomes in cardiac surgery","volume":"47","author":"Hogan","year":"2015","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"6","key":"10.1016\/j.lfs.2022.121124_bb0010","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/anae.13423","article-title":"The incidence and importance of anaemia in patients undergoing cardiac surgery in the UK - the first Association of Cardiothoracic Anaesthetists national audit","volume":"71","author":"Klein","year":"2016","journal-title":"Anaesthesia"},{"issue":"10","key":"10.1016\/j.lfs.2022.121124_bb0015","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1001\/jama.2019.0554","article-title":"Patient blood management: recommendations from the 2018 Frankfurt consensus conference","volume":"321","author":"Mueller","year":"2019","journal-title":"JAMA"},{"issue":"10259","key":"10.1016\/j.lfs.2022.121124_bb0020","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0140-6736(20)31539-7","article-title":"Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial","volume":"396","author":"Richards","year":"2020","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.lfs.2022.121124_bb0025","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/icvts\/ivaa094","article-title":"Intravenous iron therapy for patients with preoperative iron deficiency or anaemia undergoing cardiac surgery reduces blood transfusions: a systematic review and meta-analysis","volume":"31","author":"Gupta","year":"2020","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"issue":"2","key":"10.1016\/j.lfs.2022.121124_bb0030","first-page":"232","article-title":"Effect of perioperative intravenous iron supplementation for complex cardiac surgery on transfusion requirements: a randomized","volume":"275","author":"Song","year":"2022","journal-title":"Double-blinded Placebo-controlled Trial, Ann Surg"},{"issue":"3","key":"10.1016\/j.lfs.2022.121124_bb0035","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/icvts\/ivy226","article-title":"Intravenous iron does not effectively correct preoperative anaemia in cardiac surgery: a pilot randomized controlled trial","volume":"28","author":"Padmanabhan","year":"2019","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"issue":"9","key":"10.1016\/j.lfs.2022.121124_bb0040","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.bbamcr.2012.01.014","article-title":"Hepcidin and iron homeostasis","volume":"1823","author":"Ganz","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2022.121124_bb0045","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.3389\/fphys.2019.01294","article-title":"Hepcidin and anemia: a tight relationship","volume":"10","author":"Pagani","year":"2019","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.lfs.2022.121124_bb0050","doi-asserted-by":"crossref","DOI":"10.1097\/HS9.0000000000000035","article-title":"Erythroferrone: an erythroid regulator of hepcidin and iron metabolism","volume":"2","author":"Coffey","year":"2018","journal-title":"Hemasphere"},{"issue":"14","key":"10.1016\/j.lfs.2022.121124_bb0055","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1182\/blood-2018-06-857995","article-title":"Erythroferrone inhibits the induction of hepcidin by BMP6","volume":"132","author":"Arezes","year":"2018","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.lfs.2022.121124_bb0060","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1182\/blood.2019002620","article-title":"Erythroferrone lowers hepcidin by sequestering BMP2\/6 heterodimer from binding to the BMP type I receptor ALK3","volume":"135","author":"Wang","year":"2020","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.lfs.2022.121124_bb0065","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/ki.2009.466","article-title":"FGF23-parathyroid interaction: implications in chronic kidney disease","volume":"77","author":"Komaba","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2022.121124_bb0070","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/bs.vh.2019.01.004","article-title":"Hepcidin and the BMP-SMAD pathway: an unexpected liaison","volume":"110","author":"Silvestri","year":"2019","journal-title":"Vitam. Horm."},{"issue":"7","key":"10.1016\/j.lfs.2022.121124_bb0075","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/ng.2996","article-title":"Identification of erythroferrone as an erythroid regulator of iron metabolism","volume":"46","author":"Kautz","year":"2014","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.lfs.2022.121124_bb0080","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1182\/blood-2013-08-521419","article-title":"A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin","volume":"123","author":"Kim","year":"2014","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.lfs.2022.121124_bb0085","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.mcna.2016.09.005","article-title":"Anemia of inflammation: a review","volume":"101","author":"Fraenkel","year":"2017","journal-title":"Med Clin North Am"},{"issue":"3","key":"10.1016\/j.lfs.2022.121124_bb0090","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0092-8674(04)00343-5","article-title":"Balancing acts: molecular control of mammalian iron metabolism","volume":"117","author":"Hentze","year":"2004","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.lfs.2022.121124_bb0095","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12185-017-2366-2","article-title":"Iron and infection","volume":"107","author":"Ganz","year":"2018","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.lfs.2022.121124_bb0100","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.f4822","article-title":"Safety and efficacy of intravenous iron therapy in reducing requirement for allogeneic blood transfusion: systematic review and meta-analysis of randomised clinical trials","volume":"347","author":"Litton","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.lfs.2022.121124_bb0105","doi-asserted-by":"crossref","first-page":"4357756","DOI":"10.1155\/2021\/4357756","article-title":"Changes in hepcidin levels in an animal model of anemia of chronic inflammation: mechanistic insights related to iron supplementation and hepcidin regulation","volume":"2021","author":"Kim","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2022.121124_bb0110","first-page":"390","article-title":"Iron metabolism: an overview on the main mechanisms involved in its homeostasis","volume":"30","author":"Grotto","year":"2018","journal-title":"Rev. Bras. Hematol. Hemoter."},{"key":"10.1016\/j.lfs.2022.121124_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101209","article-title":"IL-1 beta-mediated macrophage-hepatocyte crosstalk upregulates hepcidin under physiological low oxygen levels","volume":"24","author":"Silva","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2022.121124_bb0120","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.2147\/DDDT.S132612","article-title":"Markers of oxidative\/nitrosative stress and inflammation in lung tissue of rats exposed to different intravenous iron compounds","volume":"11","author":"Toblli","year":"2017","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.lfs.2022.121124_bb0125","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1749-6632.1994.tb55728.x","article-title":"Inhibition of erythropoietin production by cytokines. Implications for the anemia involved in inflammatory states","volume":"718","author":"Jelkmann","year":"1994","journal-title":"Ann N Y Acad Sci"},{"issue":"8","key":"10.1016\/j.lfs.2022.121124_bb0130","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1089\/jir.1998.18.555","article-title":"Proinflammatory cytokines lowering erythropoietin production","volume":"18","author":"Jelkmann","year":"1998","journal-title":"J. Interf. Cytokine Res."},{"issue":"16","key":"10.1016\/j.lfs.2022.121124_bb0135","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1182\/blood-2014-06-584607","article-title":"Erythroferrone contributes to recovery from anemia of inflammation","volume":"124","author":"Kautz","year":"2014","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.lfs.2022.121124_bb0140","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/MNH.0000000000000514","article-title":"Crosstalk between fibroblast growth factor 23, iron, erythropoietin, and inflammation in kidney disease","volume":"28","author":"Babitt","year":"2019","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"6","key":"10.1016\/j.lfs.2022.121124_bb0145","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/s11914-018-0492-2","article-title":"Non-renal-related mechanisms of FGF23 pathophysiology","volume":"16","author":"Hanudel","year":"2018","journal-title":"Curr Osteoporos Rep"},{"issue":"1","key":"10.1016\/j.lfs.2022.121124_bb0150","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ki.2015.290","article-title":"Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production","volume":"89","author":"David","year":"2016","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.lfs.2022.121124_bb0155","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.kint.2016.05.019","article-title":"Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease","volume":"90","author":"Singh","year":"2016","journal-title":"Kidney Int."},{"issue":"7","key":"10.1016\/j.lfs.2022.121124_bb0160","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1096\/fj.201700667R","article-title":"Inhibition of fibroblast growth factor 23 (FGF23) signaling rescues renal anemia","volume":"32","author":"Agoro","year":"2018","journal-title":"FASEB J."},{"issue":"7","key":"10.1016\/j.lfs.2022.121124_bb0165","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/ndt\/gfy318","article-title":"Effect of ferric citrate on serum phosphate and fibroblast growth factor 23 among patients with nondialysis-dependent chronic kidney disease: path analyses","volume":"34","author":"Block","year":"2019","journal-title":"Nephrol. Dial. Transplant."},{"issue":"6","key":"10.1016\/j.lfs.2022.121124_bb0170","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1681\/ASN.2016101053","article-title":"Effects of ferric citrate in patients with nondialysis-dependent CKD and iron deficiency anemia","volume":"28","author":"Fishbane","year":"2017","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"10.1016\/j.lfs.2022.121124_bb0175","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1159\/000489964","article-title":"Ferric citrate decreases fibroblast growth factor 23 and improves erythropoietin responsiveness in hemodialysis patients","volume":"47","author":"Maruyama","year":"2018","journal-title":"Am. J. Nephrol."},{"issue":"4","key":"10.1016\/j.lfs.2022.121124_bb0180","first-page":"241","article-title":"Management of Iron Deficiency Anemia","volume":"11","author":"Jimenez","year":"2015","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"10.1016\/j.lfs.2022.121124_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2020.100862","article-title":"Intravenous iron supplementation therapy","volume":"75","author":"Schaefer","year":"2020","journal-title":"Mol. Asp. Med."},{"issue":"4","key":"10.1016\/j.lfs.2022.121124_bb0190","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.bone.2009.06.017","article-title":"Hypophosphatemia induced by intravenous administration of saccharated ferric oxide: another form of FGF23-related hypophosphatemia","volume":"45","author":"Shimizu","year":"2009","journal-title":"Bone"},{"issue":"7","key":"10.1016\/j.lfs.2022.121124_bb0195","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1210\/jc.2008-2396","article-title":"FGF23 elevation and hypophosphatemia after intravenous iron polymaltose: a prospective study","volume":"94","author":"Schouten","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.lfs.2022.121124_bb0200","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/ajh.25366","article-title":"Iron, erythropoietin, and inflammation regulate hepcidin in Bmp2-deficient mice, but serum iron fails to induce hepcidin in Bmp6-deficient mice","volume":"94","author":"Wang","year":"2019","journal-title":"Am. J. Hematol."},{"issue":"8","key":"10.1016\/j.lfs.2022.121124_bb0205","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1172\/JCI25683","article-title":"Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload","volume":"115","author":"Niederkofler","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.lfs.2022.121124_bb0210","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cmet.2007.11.016","article-title":"The transferrin receptor modulates hfe-dependent regulation of hepcidin expression","volume":"7","author":"Schmidt","year":"2008","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.lfs.2022.121124_bb0215","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cmet.2009.01.010","article-title":"Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression","volume":"9","author":"Gao","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2022.121124_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115495","article-title":"Bone morphogenic proteins in iron homeostasis","volume":"138","author":"Xiao","year":"2020","journal-title":"Bone"},{"issue":"41","key":"10.1016\/j.lfs.2022.121124_bb0225","doi-asserted-by":"crossref","first-page":"16239","DOI":"10.1073\/pnas.0705971104","article-title":"Activin a is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia","volume":"104","author":"Jones","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.lfs.2022.121124_bb0230","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/MOH.0000000000000236","article-title":"Hepcidin regulation in the anemia of inflammation","volume":"23","author":"Wang","year":"2016","journal-title":"Curr. Opin. Hematol."},{"issue":"3","key":"10.1016\/j.lfs.2022.121124_bb0235","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1210\/en.2015-1747","article-title":"Activin B induces noncanonical SMAD1\/5\/8 signaling via BMP type I receptors in hepatocytes: evidence for a role in hepcidin induction by inflammation in male mice","volume":"157","author":"Canali","year":"2016","journal-title":"Endocrinology"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522008244?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522008244?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T22:14:24Z","timestamp":1761776064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320522008244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":47,"alternative-id":["S0024320522008244"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.121124","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulators impeding erythropoiesis following iron supplementation in a clinically relevant rat model of iron deficiency anemia with inflammation","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.121124","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"121124"}}