{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:33:12Z","timestamp":1791592392106,"version":"4.3.4"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.lfs.2022.121129","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T20:45:39Z","timestamp":1666730739000},"page":"121129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Xanthotoxin modulates oxidative stress, inflammation, and MAPK signaling in a rotenone-induced Parkinson's disease model"],"prefix":"10.1016","volume":"310","author":[{"given":"Aya S.","family":"Sayed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrine S.","family":"El Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Budzy\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystyna","family":"Skalicka-Wo\u017aniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam K.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esraa A.","family":"Kandil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2022.121129_bb0005","series-title":"Targets for Neuroprotection in Parkinson\u2019s Disease. Biochimica et Biophysica Acta - Molecular Basis of Disease","first-page":"676","author":"Yacoubian","year":"2009"},{"key":"10.1016\/j.lfs.2022.121129_bb0010","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1093\/hmg\/ddi308","article-title":"Molecular pathogenesis of Parkinson\u2019s disease","volume":"14","author":"Gandhi","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.lfs.2022.121129_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2003.tb07458.x","article-title":"Description of Parkinson\u2019s disease as a clinical syndrome","volume":"991","author":"Fahn","year":"2003","journal-title":"In Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.lfs.2022.121129_bb0020","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11481-013-9435-y","article-title":"Neural and immune mechanisms in the pathogenesis of Parkinson\u2019s disease","author":"Blandini","year":"2013","journal-title":"J. NeuroImmune Pharmacol."},{"key":"10.1016\/j.lfs.2022.121129_bb0025","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuroscience.2013.01.032","article-title":"Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson\u2019s disease in rats","volume":"236","author":"Karuppagounder","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2022.121129_bb0030","series-title":"Pathological Roles of MAPK Signaling Pathways in Human Diseases. Biochimica et Biophysica Acta - Molecular Basis of Disease","first-page":"396","author":"Kim","year":"2010"},{"key":"10.1016\/j.lfs.2022.121129_bb0035","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.nbd.2009.11.004","article-title":"Neuroinflammation in Parkinson\u2019s disease: its role in neuronal death and implications for therapeutic intervention","author":"Tansey","year":"2010","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.lfs.2022.121129_bb0040","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11064-008-9656-2","article-title":"Oxidative and inflammatory pathways in Parkinson\u2019s disease","volume":"34","author":"Miller","year":"2009","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.lfs.2022.121129_bb0045","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson\u2019s disease: mechanisms and models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"issue":"suppl 3","key":"10.1016\/j.lfs.2022.121129_bb0050","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1002\/ana.10483","article-title":"Oxidative stress in Parkinson\u2019s disease","volume":"53","author":"Jenner","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.lfs.2022.121129_bb0055","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.neuint.2012.12.016","article-title":"Neuroinflammation and oxidative stress: co-conspirators in the pathology of Parkinson\u2019s disease","author":"Taylor","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.lfs.2022.121129_bb0060","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1016\/j.neuropharm.2012.01.028","article-title":"Contributions of central and systemic inflammation to the pathophysiology of Parkinson\u2019s disease","author":"Collins","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lfs.2022.121129_bb0065","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrn2038","article-title":"Microglia-Mediated Neurotoxicity: Uncovering the Molecular Mechanisms","author":"Block","year":"2007","journal-title":"Nat. Rev. Neurosci"},{"issue":"6","key":"10.1016\/j.lfs.2022.121129_bb0070","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1006\/mcne.2000.0914","article-title":"Inflammatory regulators in Parkinson\u2019s disease: INOS, Lipocortin-1, and Cyclooxygenases-1 and -2","volume":"16","author":"Knott","year":"2000","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.lfs.2022.121129_bb0075","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bbapap.2005.08.017","article-title":"MAPK signalling pathways as molecular targets for anti-inflammatory therapy - from molecular mechanisms to therapeutic benefits","volume":"1754","author":"Kaminska","year":"2005","journal-title":"In Biochimica et Biophysica Acta - Proteins and Proteomics"},{"issue":"19","key":"10.1016\/j.lfs.2022.121129_bb0080","doi-asserted-by":"crossref","first-page":"20451","DOI":"10.1074\/jbc.M311164200","article-title":"Phosphorylation of P38 MAPK induced by oxidative stress is linked to activation of both Caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons","volume":"279","author":"Choi","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.lfs.2022.121129_bb0085","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.3390\/ijms19102973","article-title":"Role of mitogen activated protein kinase signaling in Parkinson\u2019s disease","volume":"19","author":"Bohush","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2022.121129_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2014.00057","article-title":"Parkinson\u2019s Disease-Implicated Kinases in the Brain; Insights into Disease Pathogenesis","volume":"7","author":"Dzamko","year":"2014","journal-title":"Front. Mol. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2022.121129_bb0095","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0006-8993(02)02422-8","article-title":"MPP+ increases \u03b1-synuclein expression and ERK\/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells","volume":"935","author":"G\u00f3mez-Santos","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.lfs.2022.121129_bb0100","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.pneurobio.2012.06.003","article-title":"Kinases and kinase signaling pathways: potential therapeutic targets in Parkinson\u2019s disease","author":"Wang","year":"2012","journal-title":"Prog. Neurobiol."},{"issue":"3","key":"10.1016\/j.lfs.2022.121129_bb0105","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1046\/j.1471-4159.2000.0751200.x","article-title":"MPTP activates C-Jun NH2-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo","volume":"75","author":"Saporito","year":"2000","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.lfs.2022.121129_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072046","article-title":"Rotenone directly induces BV2 cell activation via the P38 MAPK pathway","volume":"8","author":"Gao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2022.121129_bb0115","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/1521654031000121666","article-title":"The role of C-Jun N-terminal kinase (JNK) in Parkinson\u2019s disease","author":"Peng","year":"2003","journal-title":"IUBMB Life"},{"issue":"1","key":"10.1016\/j.lfs.2022.121129_bb0120","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11418-013-0774-z","article-title":"Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet a irradiation","volume":"68","author":"Sumiyoshi","year":"2014","journal-title":"J. Nat. Med."},{"issue":"48","key":"10.1016\/j.lfs.2022.121129_bb0125","first-page":"5863","article-title":"U. Phytochemical screening and insecticidal activity of three plants from chenopodiaceae family","volume":"6","author":"Alqasoumi","year":"2012","journal-title":"J. Med. Plants Res."},{"key":"10.1016\/j.lfs.2022.121129_bb0130","first-page":"7","article-title":"Monocyte-derived inflammatory langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation","author":"Singh","year":"2016","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.lfs.2022.121129_bb0135","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1021\/acschemneuro.8b00011","article-title":"Scopolamine-induced memory impairment is alleviated by xanthotoxin: role of acetylcholinesterase and oxidative stress processes","volume":"9","author":"Skalicka-Wozniak","year":"2018","journal-title":"ACS Chem. Neurosci."},{"issue":"9","key":"10.1016\/j.lfs.2022.121129_bb0140","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1002\/ptr.6686","article-title":"Xanthotoxin and umbelliferone attenuate cognitive dysfunction in a streptozotocin-induced rat model of sporadic Alzheimer\u2019s disease: the role of JAK2\/STAT3 and Nrf2\/HO-1 signalling pathway modulation","volume":"34","author":"Hindam","year":"2020","journal-title":"Phyther. Res."},{"key":"10.1016\/j.lfs.2022.121129_bb0145","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.fitote.2016.09.020","article-title":"Influence of xanthotoxin (8-Methoxypsoralen) on the anticonvulsant activity of various novel antiepileptic drugs against maximal electroshock-induced seizures in mice","volume":"115","author":"Zagaja","year":"2016","journal-title":"Fitoterapia"},{"key":"10.1016\/j.lfs.2022.121129_bb0150","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.intimp.2017.05.021","article-title":"Xanthotoxin Suppresses LPS-Induced Expression of INOS, COX-2, TNF-\u03b1, and IL-6 via AP-1, NF-\u039aB, and JAK-STAT Inactivation in RAW 264.7 Macrophages","volume":"49","author":"Lee","year":"2017","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.lfs.2022.121129_bb0155","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0024-3205(99)00642-6","article-title":"Antioxidative activity of natural products from plants","volume":"66","author":"Ng","year":"2000","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.lfs.2022.121129_bb0160","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s43440-020-00136-9","article-title":"Xanthotoxin reverses Parkinson\u2019s disease-like symptoms in zebrafish larvae and mice models: a comparative study","volume":"73","author":"Kozio\u0142","year":"2021","journal-title":"Pharmacol. Reports"},{"key":"10.1016\/j.lfs.2022.121129_bb0165","series-title":"Modulation of Histone Deacetylase, the Ubiquitin Proteasome System, and Autophagy Underlies the Neuroprotective Effects of Venlafaxine in a Rotenone-Induced","article-title":"U","author":"El-Saiy","year":"2022"},{"issue":"5","key":"10.1016\/j.lfs.2022.121129_bb0170","first-page":"4078","article-title":"Modulatory role of Nurr1 activation and thrombin inhibition in the neuroprotective effects of dabigatran etexilate in rotenone-induced Parkinson\u2019s disease in rats","volume":"55","author":"Kandil","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"12","key":"10.1016\/j.lfs.2022.121129_bb0175","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1007\/s00213-016-4279-9","article-title":"In vivo modulation of the behavioral effects of nicotine by the coumarins xanthotoxin, bergapten, and umbelliferone","volume":"233","author":"Budzynska","year":"2016","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.lfs.2022.121129_bb0180","author":"Walsh"},{"issue":"4","key":"10.1016\/j.lfs.2022.121129_bb0185","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.2042-7158.1968.tb09743.x","article-title":"The quantitative measurement of motor inco-ordination in naive mice using an accelerating rotarod","volume":"20","author":"Jones","year":"1968","journal-title":"J. Pharm. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2022.121129_bb0190","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.lfs.2022.121129_bb0195","doi-asserted-by":"crossref","first-page":"109191","DOI":"10.1016\/j.intimp.2022.109191","article-title":"Crosstalk between PI3K\/AKT\/KLF4 Signaling and Microglia M1\/M2 Polarization as a Novel Mechanistic Approach towards Flibanserin Repositioning in Parkinson\u2019s Disease","volume":"112","author":"El-Deeb","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"10","key":"10.1016\/j.lfs.2022.121129_bb0200","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1179\/016164110X12681290831207","article-title":"An experimental study on intracerebroventricular transplantation of human amniotic epithelial cells in a rat model of Parkinson\u2019s disease","volume":"32","author":"Yang","year":"2010","journal-title":"Neurol. Res."},{"key":"10.1016\/j.lfs.2022.121129_bb0205","series-title":"Molecular Profile of Reactive Astrocytes\u2014Implications for Their Role in Neurologic Disease","author":"Eddleston","year":"1993"},{"key":"10.1016\/j.lfs.2022.121129_bb0210","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.neuroscience.2012.11.006","article-title":"Anti-inflammatory properties rather than anti-oxidant capability is the major mechanism of neuroprotection by sodium salicylate in a chronic rotenone model of parkinson\u2019s disease","volume":"231","author":"Thakur","year":"2013","journal-title":"Neuroscience"},{"issue":"34","key":"10.1016\/j.lfs.2022.121129_bb0215","doi-asserted-by":"crossref","first-page":"10756","DOI":"10.1523\/JNEUROSCI.23-34-10756.2003","article-title":"Mechanism of toxicity in rotenone models of parkinson\u2019s disease","volume":"23","author":"Sherer","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2022.121129_bb0220","series-title":"Rotenone Destroys Dopaminergic Neurons and Induces Parkinsonian Symptoms in Rats","author":"Alam","year":"2002"},{"issue":"2","key":"10.1016\/j.lfs.2022.121129_bb0225","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1177\/0960327118788139","article-title":"Neuroprotective effect of agmatine (decarboxylated l-arginine) against oxidative stress and neuroinflammation in rotenone model of parkinson\u2019s disease","volume":"38","author":"El-Sayed","year":"2019","journal-title":"Hum. Exp. Toxicol."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2022.121129_bb0230","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jns.2009.09.032","article-title":"Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic parkinson model","volume":"290","author":"Huang","year":"2010","journal-title":"J. Neurol. Sci."},{"issue":"3","key":"10.1016\/j.lfs.2022.121129_bb0235","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1083\/jcb.200202130","article-title":"Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death","volume":"158","author":"Cregan","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.lfs.2022.121129_bb0240","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/nm0697-614","article-title":"The proto-oncogene Bcl-2 and its role in regulating apoptosis","author":"Kroemer","year":"1997","journal-title":"Nat. Med."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2022.121129_bb0245","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0006-8993(96)01293-0","article-title":"Vulnerability to glucose deprivation injury correlates with glutathione levels in astrocytes","volume":"748","author":"Papadopoulos","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.lfs.2022.121129_bb0250","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1353-8020(03)00023-3","article-title":"The rotenone model of Parkinson\u2019s disease: genes, environment and mitochondria","volume":"9","author":"Greenamyre","year":"2003","journal-title":"In Parkinsonism and Related Disorders"},{"issue":"1","key":"10.1016\/j.lfs.2022.121129_bb0255","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1326-4-24","article-title":"Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson\u2019s disease: how neurons are lost in the bermuda triangle","volume":"4","author":"Malkus","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.lfs.2022.121129_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134438","article-title":"Edaravone-caffeine combination for the effective Management of Rotenone Induced Parkinson\u2019s disease in rats: an evidence based affirmative from a comparative analysis of behavior and biomarker expression","volume":"711","author":"Bandookwala","year":"2019","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.lfs.2022.121129_bb0265","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1600-079X.2006.00412.x","article-title":"Melatonin protects against rotenone-induced oxidative stress in a hemiparkinsonian rat model","volume":"42","author":"Saravanan","year":"2007","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.lfs.2022.121129_bb0270","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s11481-009-9176-0","article-title":"Neuroinflammation in Parkinson\u2019s disease","author":"Lee","year":"2009","journal-title":"J. NeuroImmune Pharmacol."},{"key":"10.1016\/j.lfs.2022.121129_bb0275","article-title":"Annals of Neurology; Lippincott Williams and Wilkins","volume":"44","author":"Hirsch","year":"1998"},{"issue":"2","key":"10.1016\/j.lfs.2022.121129_bb0280","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0306-4522(95)00578-1","article-title":"Nitric oxide synthase and neuronal vulnerability in Parkinson\u2019s disease","volume":"72","author":"Hunot","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2022.121129_bb0285","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/B978-0-12-384913-7.00018-6","article-title":"The Role of Neuroinflammation in Parkinson\u2019s Disease","author":"Chen","year":"2011","journal-title":"Neuroinflammation"},{"key":"10.1016\/j.lfs.2022.121129_bb0290","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00702-010-0428-1","article-title":"Neuroinflammation is a key player in Parkinson\u2019s disease and a prime target for therapy","author":"Qian","year":"2010","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.lfs.2022.121129_bb0295","series-title":"Understanding Cell Death in Parkinson\u2019s Disease. In Annals of Neurology","volume":"44","author":"Jenner","year":"1998"},{"key":"10.1016\/j.lfs.2022.121129_bb0300","first-page":"280","article-title":"Dikshit M","author":"Kavya","year":"2006"},{"key":"10.1016\/j.lfs.2022.121129_bb0305","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0076-6879(96)69022-3","article-title":"Antibodies that recognize nitrotyrosine","volume":"269","author":"Ye","year":"1996","journal-title":"Methods Enzymol."},{"issue":"4","key":"10.1016\/j.lfs.2022.121129_bb0310","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000068322","article-title":"Role and mechanisms of Interleukin-1 in the modulation of neurotoxicity","volume":"10","author":"Ma","year":"2002","journal-title":"Neuroimmunomodulation"},{"issue":"4","key":"10.1016\/j.lfs.2022.121129_bb0315","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.3892\/mmr.2016.4948","article-title":"Role of neuroinflammation in neurodegenerative diseases (Review)","volume":"13","author":"Chen","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.lfs.2022.121129_bb0320","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.neuint.2013.01.007","article-title":"Nitric oxide synthase inhibitors protect against rotenone-induced, oxidative stress mediated parkinsonism in rats","volume":"62","author":"Madathil","year":"2013","journal-title":"Neurochem. Int."},{"issue":"12","key":"10.1016\/j.lfs.2022.121129_bb0325","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1038\/sj.npp.1301381","article-title":"Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation","volume":"32","author":"Zhou","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.lfs.2022.121129_bb0330","first-page":"1619","article-title":"The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. Biochimica et biophysica acta - molecular","author":"Plotnikov","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.lfs.2022.121129_bb0335","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.neulet.2015.04.040","article-title":"Phytic acid attenuates inflammatory responses and the levels of NF-\u039aB and p-ERK in MPTP-induced Parkinson\u2019s disease model of mice","volume":"597","author":"Lv","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.lfs.2022.121129_bb0340","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1358\/dnp.2004.17.10.873916","article-title":"JNK inhibition as a potential strategy in treating Parkinson\u2019s disease","author":"Wang","year":"2004","journal-title":"Drug News and Perspectives."},{"key":"10.1016\/j.lfs.2022.121129_bb0345","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0301-0082(99)00042-8","article-title":"JNK and P38 stresskinases - degenerative effectors of signal- transduction-cascades in the nervous system","author":"Mielke","year":"2000","journal-title":"Prog. Neurobiol."},{"issue":"3","key":"10.1016\/j.lfs.2022.121129_bb0350","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neuint.2013.05.006","article-title":"P38MAPK\/P53-mediated bax induction contributes to neurons degeneration in rotenone-induced cellular and rat models of cparkinson\u2019s disease","volume":"63","author":"Wu","year":"2013","journal-title":"Neurochem. Int."},{"issue":"2","key":"10.1016\/j.lfs.2022.121129_bb0355","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/labinvest.2009.124","article-title":"Small peptide inhibitor of JNKs protects against MPTP-induced nigral dopaminergic injury via inhibiting the JNK-signaling pathway","volume":"90","author":"Pan","year":"2010","journal-title":"Lab. Investig."},{"issue":"4","key":"10.1016\/j.lfs.2022.121129_bb0360","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1750-3639.2003.tb00478.x","article-title":"Localization of phosphorylated ERK\/MAP kinases to mitochondria and autophagosomes in lewy body diseases","volume":"13","author":"Zhu","year":"2003","journal-title":"Brain Pathol."},{"issue":"6","key":"10.1016\/j.lfs.2022.121129_bb0365","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1111\/j.1471-4159.2009.06112.x","article-title":"Activation of P38 MAPK in the substantia nigra leads to nuclear translocation of NF-\u039aB in MPTP-treated mice: implication in Parkinson\u2019s disease","volume":"109","author":"Karunakaran","year":"2009","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.lfs.2022.121129_bb0370","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.neurobiolaging.2006.11.013","article-title":"\u03b1-synuclein activates stress signaling protein kinases in THP-1 cells and microglia","volume":"29","author":"Klegeris","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.lfs.2022.121129_bb0375","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1745-7254.2007.00579.x","article-title":"JNK pathway: diseases and therapeutic potential","author":"Cui","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"issue":"7","key":"10.1016\/j.lfs.2022.121129_bb0380","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.neuint.2009.01.013","article-title":"Blockade of the translocation and activation of C-Jun N-terminal kinase 3 (JNK3) attenuates dopaminergic neuronal damage in mouse model of Parkinson\u2019s disease","volume":"54","author":"Pan","year":"2009","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.lfs.2022.121129_bb0385","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/toxsci\/kfh089","article-title":"Rotenone-induced apoptosis is mediated by P38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells","volume":"79","author":"Newhouse","year":"2004","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2022.121129_bb0390","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.brainres.2007.06.046","article-title":"Cytotoxicity of paraquat in microglial cells: involvement of PKC\u03b4- and ERK1\/2-dependent NADPH oxidase","volume":"1167","author":"Miller","year":"2007","journal-title":"Brain Res."},{"issue":"12","key":"10.1016\/j.lfs.2022.121129_bb9000","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.clinbiochem.2016.04.010","article-title":"High BAX\/BCL2 MRNA ratio predicts favorable prognosis in Laryngeal Squamous Cell Carcinoma, Particularly in Patients with Negative Lymph Nodes at the Time of Diagnosis.","volume":"49","author":"Giotakis","year":"2016","journal-title":"Clin. Biochem."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522008293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522008293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T22:13:04Z","timestamp":1761775984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320522008293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":79,"alternative-id":["S0024320522008293"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.121129","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xanthotoxin modulates oxidative stress, inflammation, and MAPK signaling in a rotenone-induced Parkinson's disease model","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.121129","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"121129"}}