{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:39:32Z","timestamp":1785191972331,"version":"3.55.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020430","name":"LG Chem","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020430","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.lfs.2022.121154","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T20:41:49Z","timestamp":1667853709000},"page":"121154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"PA","title":["Effects of intrauterine human chorionic gonadotropin administration on endometrial receptivity and embryo implantation"],"prefix":"10.1016","volume":"311","author":[{"given":"Danbi","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Gyeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon-Hwa","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn-Jung","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2022.121154_bb0005","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1093\/humrep\/deq124","article-title":"Assisted reproductive technology in Europe, 2006: results generated from european registers by ESHRE","volume":"25","author":"de Mouzon","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.lfs.2022.121154_bb0010","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1093\/humrep\/det278","article-title":"Assisted reproductive technology in Europe, 2009: results generated from european registers by ESHRE","volume":"28","author":"Ferraretti","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.lfs.2022.121154_bb0015","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12958-018-0414-2","article-title":"Recurrent implantation failure-update overview on etiology, diagnosis, treatment and future directions","volume":"16","author":"Bashiri","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.lfs.2022.121154_bb0020","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.bbadis.2012.05.017","article-title":"Molecular aspects of implantation failure","volume":"1822","author":"Koot","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2022.121154_bb0025","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12701","article-title":"Efficacy of intrauterine perfusion of granulocyte colony-stimulating factor (G-CSF) for infertile women with thin endometrium: a systematic review and meta-analysis","volume":"78","author":"Xie","year":"2017","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.lfs.2022.121154_bb0030","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2174\/1574888X14666181205120110","article-title":"Stem cells and endometrial regeneration: from basic research to clinical trial","volume":"14","author":"Zhu","year":"2019","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.lfs.2022.121154_bb0035","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000023386","article-title":"Efficacy and safety of platelet-rich plasma for the treatment of thin endometrium: a protocol for systematic review and meta-analysis","volume":"99","author":"Du","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.lfs.2022.121154_bb0040","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12958-016-0197-2","article-title":"Whether G-CSF administration has beneficial effect on the outcome after assisted reproductive technology? A systematic review and meta-analysis","volume":"14","author":"Zhao","year":"2016","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.lfs.2022.121154_bb0045","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1210\/er.2003-0020","article-title":"Molecular cues to implantation","volume":"25","author":"Dey","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.lfs.2022.121154_bb0050","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1242\/jcs.175943","article-title":"Embryo-epithelium interactions during implantation at a glance","volume":"130","author":"Aplin","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.lfs.2022.121154_bb0055","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1477-7827-12-53","article-title":"Endometrial beta3 integrin profile reflects endometrial receptivity defects in women with unexplained recurrent pregnancy loss","volume":"12","author":"Germeyer","year":"2014","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.lfs.2022.121154_bb0060","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jri.2009.04.007","article-title":"hCG and hyperglycosylated hCG in the establishment and evolution of hemochorial placentation","volume":"82","author":"Cole","year":"2009","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.lfs.2022.121154_bb0065","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jri.2009.11.008","article-title":"Human chorionic gonadotropin: a hormone with immunological and angiogenic properties","volume":"85","author":"Tsampalas","year":"2010","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.lfs.2022.121154_bb0070","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/oxfordjournals.humrep.a136808","article-title":"Chorionic gonadotrophin-beta mRNA, a trophoblast marker, is expressed in human 8-cell embryos derived from tripronucleate zygotes","volume":"3","author":"Bonduelle","year":"1988","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.lfs.2022.121154_bb0075","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/humrep\/4.suppl_1.87","article-title":"The potential of early human embryos to form blastocysts, hatch from their zona and secrete HCG in culture","volume":"4","author":"Lopata","year":"1989","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.lfs.2022.121154_bb0080","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/humupd\/4.5.532","article-title":"Novel insights into human endometrial paracrinology and embryo-maternal communication by intrauterine microdialysis","volume":"4","author":"Licht","year":"1998","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.lfs.2022.121154_bb0085","first-page":"10","article-title":"Molecular aspects of direct LH\/hCG effects on human endometrium\u2013lessons from intrauterine microdialysis in the human female in vivo","volume":"1","author":"Licht","year":"2001","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.lfs.2022.121154_bb0090","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.fertnstert.2011.09.044","article-title":"Intrauterine injection of human chorionic gonadotropin before embryo transfer significantly improves the implantation and pregnancy rates in in vitro fertilization\/intracytoplasmic sperm injection: a prospective randomized study","volume":"96","author":"Mansour","year":"2011","journal-title":"Fertil Steril."},{"key":"10.1016\/j.lfs.2022.121154_bb0095","first-page":"1","article-title":"Intrauterine administration of recombinant human chorionic gonadotropin before embryo transfer on outcome of in vitro fertilization\/intracytoplasmic sperm injection: a randomized clinical trial","volume":"12","author":"Zarei","year":"2014","journal-title":"Iran J. Reprod. Med."},{"key":"10.1016\/j.lfs.2022.121154_bb0100","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1093\/humrep\/dew236","article-title":"Intrauterine administration of hCG immediately after oocyte retrieval and the outcome of ICSI: a randomized controlled trial","volume":"31","author":"Navali","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.lfs.2022.121154_bb0105","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/09513590802360769","article-title":"Low-dose human chorionic gonadotropin during the proliferative phase may adversely affect endometrial receptivity in oocyte recipients","volume":"25","author":"Prapas","year":"2009","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.lfs.2022.121154_bb0110","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1093\/humrep\/det055","article-title":"Too much of a good thing? Experimental evidence suggests prolonged exposure to hCG is detrimental to endometrial receptivity","volume":"28","author":"Evans","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.lfs.2022.121154_bb0115","article-title":"Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction","volume":"10","author":"Craciunas","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.lfs.2022.121154_bb0120","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13077","article-title":"Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF\/ET cycle: the critical review","volume":"81","author":"Zhang","year":"2019","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.lfs.2022.121154_bb0125","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/humrep\/det433","article-title":"The role of the osteopontin-integrin alphavbeta3 interaction at implantation: functional analysis using three different in vitro models","volume":"29","author":"Kang","year":"2014","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.lfs.2022.121154_bb0130","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J Basic Clin Pharm."},{"key":"10.1016\/j.lfs.2022.121154_bb0135","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1007\/s43032-021-00496-4","article-title":"Non-invasive intrauterine administration of botulinum toxin a enhances endometrial angiogenesis and Improves the rates of embryo implantation","volume":"28","author":"Koo","year":"2021","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.lfs.2022.121154_bb0140","doi-asserted-by":"crossref","first-page":"7397","DOI":"10.1038\/s41598-021-86956-y","article-title":"CXCL12 enhances pregnancy outcome via improvement of endometrial receptivity in mice","volume":"11","author":"Koo","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2022.121154_bb0145","doi-asserted-by":"crossref","first-page":"51","DOI":"10.5455\/msm.2014.26.51-52","article-title":"Estrogen and progesterone receptors in endometrium in women with unexplained infertility","volume":"26","author":"Godinjak","year":"2014","journal-title":"Mater Sociomed."},{"key":"10.1016\/j.lfs.2022.121154_bb0150","first-page":"7","article-title":"Increased progesterone on the day of administration of hCG in controlled ovarian hyperstimulation affects the expression of HOXA10 in Primates' endometrial receptivity","author":"Sahar","year":"2019","journal-title":"Biomedicines"},{"key":"10.1016\/j.lfs.2022.121154_bb0155","first-page":"804","article-title":"MiR-145 suppresses embryo-epithelial juxtacrine communication at implantation by modulating maternal IGF1R","volume":"128","author":"Kang","year":"2015","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.lfs.2022.121154_bb0160","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/humrep\/deg072","article-title":"An in-vitro model for stromal invasion during implantation of the human blastocyst","volume":"18","author":"Carver","year":"2003","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.lfs.2022.121154_bb0165","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1477-7827-7-8","article-title":"New discoveries on the biology and detection of human chorionic gonadotropin","volume":"7","author":"Cole","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.lfs.2022.121154_bb0170","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1210\/en.2002-220922","article-title":"The central role of human chorionic gonadotropin in the formation of human placental syncytium","volume":"144","author":"Yang","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2022.121154_bb0175","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.fertnstert.2005.12.031","article-title":"Human chorionic gonadotropin inhibits insulin-like growth factor-binding protein-1 and prolactin in decidualized human endometrial stromal cells","volume":"86","author":"Fluhr","year":"2006","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.lfs.2022.121154_bb0180","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1093\/humrep\/der027","article-title":"Human chorionic gonadotrophin regulates FGF2 and other cytokines produced by human endometrial epithelial cells, providing a mechanism for enhancing endometrial receptivity","volume":"26","author":"Paiva","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.lfs.2022.121154_bb0185","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/molehr\/6.6.523","article-title":"HCG promotes proliferation of uterine leiomyomal cells more strongly than that of myometrial smooth muscle cells in vitro","volume":"6","author":"Horiuchi","year":"2000","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.lfs.2022.121154_bb0190","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s13770-018-0156-4","article-title":"Proliferation profile of uterine endometrial stromal cells during in vitro culture with gonadotropins: recombinant versus urinary follicle stimulating hormone","volume":"16","author":"Kim","year":"2019","journal-title":"Tissue Eng. Regen. Med."},{"key":"10.1016\/j.lfs.2022.121154_bb0195","first-page":"18","article-title":"The role of HCG in implantation: a mini-review of molecular and clinical evidence","author":"Makrigiannakis","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2022.121154_bb0200","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1530\/EJE-08-0756","article-title":"Glycodelin in reproductive endocrinology and hormone-related cancer","volume":"160","author":"Seppala","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.lfs.2022.121154_bb0205","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1073\/pnas.96.5.2543","article-title":"Modulation of the baboon (Papio anubis) uterine endometrium by chorionic gonadotrophin during the period of uterine receptivity","volume":"96","author":"Fazleabas","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2022.121154_bb0210","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1210\/jcem-70-2-421","article-title":"The presence of gonadotropin receptors in nonpregnant human uterus, human placenta, fetal membranes, and decidua","volume":"70","author":"Reshef","year":"1990","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2022.121154_bb0215","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.mce.2013.12.009","article-title":"Luteinizing hormone and human chorionic gonadotropin: origins of difference","volume":"383","author":"Choi","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.lfs.2022.121154_bb0220","doi-asserted-by":"crossref","first-page":"8624","DOI":"10.1038\/s41598-022-12495-9","article-title":"Expression and function of the luteinizing hormone choriogonadotropin receptor in human endometrial stromal cells","volume":"12","author":"Mann","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2022.121154_bb0225","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.imbio.2014.03.011","article-title":"The contribution of leukemia inhibitory factor (LIF) for embryo implantation differs among strains of mice","volume":"219","author":"Kobayashi","year":"2014","journal-title":"Immunobiology"},{"key":"10.1016\/j.lfs.2022.121154_bb0230","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/201514","article-title":"Leukemia inhibitory factor: roles in embryo implantation and in nonhormonal contraception","volume":"2014","author":"Salleh","year":"2014","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.lfs.2022.121154_bb0235","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1530\/rep.1.00283","article-title":"Dynamic expression of matrix metalloproteinases (MMP-2, -9 and -14) and the tissue inhibitors of MMPs (TIMP-1, -2 and -3) at the implantation site during tubal pregnancy","volume":"129","author":"Bai","year":"2005","journal-title":"Reproduction"},{"key":"10.1016\/j.lfs.2022.121154_bb0240","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00726-010-0689-x","article-title":"Physiology and pathophysiology of matrix metalloproteases","volume":"41","author":"Klein","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.lfs.2022.121154_bb0245","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.theriogenology.2020.02.002","article-title":"Matrix metalloproteinases improves trophoblast invasion and pregnancy potential in mice","volume":"151","author":"Zhang","year":"2020","journal-title":"Theriogenology"},{"key":"10.1016\/j.lfs.2022.121154_bb0250","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/molehr\/gax015","article-title":"hCG activates epac-Erk1\/2 signaling regulating progesterone receptor expression and function in human endometrial stromal cells","volume":"23","author":"Tapia-Pizarro","year":"2017","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.lfs.2022.121154_bb0255","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.fertnstert.2011.06.035","article-title":"Human chorionic gonadotropin from day 2 spent embryo culture media and its relationship to embryo development","volume":"96","author":"Ramu","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.lfs.2022.121154_bb0260","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0165-0378(01)00133-4","article-title":"Molecular regulation of progesterone secretion by the human corpus luteum throughout the menstrual cycle","volume":"55","author":"Devoto","year":"2002","journal-title":"J. Reprod. Immunol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522008542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522008542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:05:38Z","timestamp":1758402338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320522008542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":52,"alternative-id":["S0024320522008542"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.121154","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of intrauterine human chorionic gonadotropin administration on endometrial receptivity and embryo implantation","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.121154","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"121154"}}