{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:07:57Z","timestamp":1786993677373,"version":"build-2736575974"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.lfs.2022.121182","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T09:56:04Z","timestamp":1669283764000},"page":"121182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Myc-mediated circular RNA circMcph1\/miR-370-3p\/Irak2 axis is a progressive regulator in hepatic fibrosis"],"prefix":"10.1016","volume":"312","author":[{"given":"Jin-Jin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Feng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Xian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ming","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.lfs.2022.121182_bb0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.lfs.2022.121182_bb0010","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.lfs.2022.121182_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020461","article-title":"Cellular interplay as a consequence of inflammatory signals leading to liver fibrosis development","volume":"9","author":"Ignat","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0020","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Koyama","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2022.121182_bb0025","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.addr.2017.10.011","article-title":"Epigenetic reprogramming in liver fibrosis and cancer","volume":"121","author":"Wilson","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.lfs.2022.121182_bb0030","doi-asserted-by":"crossref","first-page":"166","DOI":"10.5483\/BMBRep.2022.55.4.022","article-title":"Roles of heterogenous hepatic macrophages in the progression of liver diseases","volume":"55","author":"Lee","year":"2022","journal-title":"BMB Rep."},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0035","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41423-020-00558-8","article-title":"Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities","volume":"18","author":"Wen","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"6","key":"10.1016\/j.lfs.2022.121182_bb0040","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/hep4.1356","article-title":"Liver macrophages: old dogmas and new insights","volume":"3","author":"Guillot","year":"2019","journal-title":"Hepatol. Commun."},{"issue":"2","key":"10.1016\/j.lfs.2022.121182_bb0045","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrgastro.2015.200","article-title":"Immunology in the liver\u2013from homeostasis to disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2022.121182_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120180","article-title":"Interleukin-9 attenuates inflammatory response and hepatocyte apoptosis in alcoholic liver injury","volume":"288","author":"Meng","year":"2022","journal-title":"Life Sci."},{"issue":"10","key":"10.1016\/j.lfs.2022.121182_bb0055","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1111\/liv.14940","article-title":"Hepatic macrophages: key players in the development and progression of liver fibrosis","volume":"41","author":"Cheng","year":"2021","journal-title":"Liver Int."},{"issue":"3","key":"10.1016\/j.lfs.2022.121182_bb0060","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/cmi.2015.104","article-title":"Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies","volume":"13","author":"Ju","year":"2016","journal-title":"Cell. Mol. Immunol."},{"issue":"7","key":"10.1016\/j.lfs.2022.121182_bb0065","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2022.121182_bb0070","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.lfs.2022.121182_bb0075","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/hep.27332","article-title":"Hepatic inflammation and fibrosis: functional links and key pathways","volume":"61","author":"Seki","year":"2015","journal-title":"Hepatology"},{"issue":"7441","key":"10.1016\/j.lfs.2022.121182_bb0080","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.lfs.2022.121182_bb0085","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.cell.2022.04.021","article-title":"Circular RNAs: characterization, cellular roles, and applications","volume":"185","author":"Liu","year":"2022","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.lfs.2022.121182_bb0090","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41418-022-00948-7","article-title":"Specific expression and functions of circular RNAs","volume":"29","author":"Misir","year":"2022","journal-title":"Cell Death Differ."},{"issue":"11","key":"10.1016\/j.lfs.2022.121182_bb0095","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.7150\/thno.42423","article-title":"Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p\/FBXW7 axis","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.lfs.2022.121182_bb0100","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002738R","article-title":"Circular RNA circUbe2k promotes hepatic fibrosis via sponging miR-149-5p\/TGF-beta2 axis","volume":"35","author":"Zhu","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2022.121182_bb0105","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.omtn.2021.01.007","article-title":"Circular RNA circPSD3 alleviates hepatic fibrogenesis by regulating the miR-92b-3p\/Smad7 axis","volume":"23","author":"Bu","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"8","key":"10.1016\/j.lfs.2022.121182_bb0110","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41580-020-0243-y","article-title":"The expanding regulatory mechanisms and cellular functions of circular RNAs","volume":"21","author":"Chen","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0115","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13046-019-1065-7","article-title":"FUS\/circ_002136\/miR-138-5p\/SOX13 feedback loop regulates angiogenesis in glioma","volume":"38","author":"He","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0120","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13046-020-01598-8","article-title":"Transcription activation of circ-STAT3 induced by Gli2 promotes the progression of hepatoblastoma via acting as a sponge for miR-29a\/b\/c-3p to upregulate STAT3\/Gli2","volume":"39","author":"Liu","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.lfs.2022.121182_bb0125","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.omtn.2021.10.006","article-title":"HnRNP-L-regulated circCSPP1\/miR-520h\/EGR1 axis modulates autophagy and promotes progression in prostate cancer","volume":"26","author":"Lu","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0130","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41368-022-00184-2","article-title":"circ_0003204 regulates the osteogenic differentiation of human adipose-derived stem cells via miR-370-3p\/HDAC4 axis","volume":"14","author":"Yu","year":"2022","journal-title":"Int. J. Oral Sci."},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0135","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12943-022-01599-5","article-title":"CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2","volume":"21","author":"Meng","year":"2022","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0140","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1038\/s41467-022-32322-z","article-title":"Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription","volume":"13","author":"Liu","year":"2022","journal-title":"Nat. Commun."},{"issue":"47","key":"10.1016\/j.lfs.2022.121182_bb0145","doi-asserted-by":"crossref","first-page":"6119","DOI":"10.1038\/s41388-018-0383-0","article-title":"PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis","volume":"37","author":"Yang","year":"2018","journal-title":"Oncogene"},{"issue":"15","key":"10.1016\/j.lfs.2022.121182_bb0150","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.7150\/thno.32710","article-title":"Methylation of RCAN1.4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through calcineurin\/NFAT3 signaling","volume":"9","author":"Pan","year":"2019","journal-title":"Theranostics"},{"issue":"10","key":"10.1016\/j.lfs.2022.121182_bb0155","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/s41419-018-1032-9","article-title":"Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.lfs.2022.121182_bb0160","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/s41374-021-00531-7","article-title":"Alternative activation of macrophages by prostacyclin synthase ameliorates alcohol induced liver injury","volume":"101","author":"Pan","year":"2021","journal-title":"Lab. Investig."},{"key":"10.1016\/j.lfs.2022.121182_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106125","article-title":"DNMT3a-mediated methylation of PSTPIP2 enhances inflammation in alcohol-induced liver injury via regulating STAT1 and NF-kappaB pathway","volume":"177","author":"Xu","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0170","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12943-020-01183-9","article-title":"The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer","volume":"19","author":"Zheng","year":"2020","journal-title":"Mol. Cancer"},{"issue":"15","key":"10.1016\/j.lfs.2022.121182_bb0175","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1158\/0008-5472.CAN-17-3009","article-title":"Twist1 regulates vimentin through Cul2 circular RNA to promote EMT in hepatocellular carcinoma","volume":"78","author":"Meng","year":"2018","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.lfs.2022.121182_bb0180","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1158\/0008-5472.CAN-16-0316","article-title":"Identification of MYC-dependent transcriptional programs in oncogene-addicted liver tumors","volume":"76","author":"Kress","year":"2016","journal-title":"Cancer Res."},{"issue":"31","key":"10.1016\/j.lfs.2022.121182_bb0185","doi-asserted-by":"crossref","first-page":"11455","DOI":"10.1073\/pnas.1404267111","article-title":"Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-Myc in mice","volume":"111","author":"Hartwell","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2022.121182_bb0190","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.omtn.2020.07.008","article-title":"MYC ASO impedes tumorigenesis and elicits oncogene addiction in autochthonous transgenic mouse models of HCC and RCC","volume":"21","author":"Dhanasekaran","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"10","key":"10.1016\/j.lfs.2022.121182_bb0195","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1158\/0008-5472.CAN-20-3747","article-title":"MYC-activated LncRNA MNX1-AS1 promotes the progression of colorectal cancer by stabilizing YB1","volume":"81","author":"Wu","year":"2021","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0200","doi-asserted-by":"crossref","first-page":"4980","DOI":"10.1038\/s41467-020-18735-8","article-title":"c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis","volume":"11","author":"Feng","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0205","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12943-022-01502-2","article-title":"Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1\/c-Myc positive feedback loop","volume":"21","author":"Wang","year":"2022","journal-title":"Mol. Cancer"},{"issue":"11","key":"10.1016\/j.lfs.2022.121182_bb0210","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/s41419-021-04366-4","article-title":"CircESRP1 inhibits clear cell renal cell carcinoma progression through the CTCF-mediated positive feedback loop","volume":"12","author":"Gong","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0215","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cmet.2019.05.009","article-title":"CircACC1 regulates assembly and activation of AMPK complex under metabolic stress","volume":"30","author":"Li","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2022.121182_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109517","article-title":"Circular RNA circ-FOXP1 induced by SOX9 promotes hepatocellular carcinoma progression via sponging miR-875-3p and miR-421","volume":"121","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0225","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s11658-022-00372-2","article-title":"circ_0086296 induced atherosclerotic lesions via the IFIT1\/STAT1 feedback loop by sponging miR-576-3p","volume":"27","author":"Zhang","year":"2022","journal-title":"Cell Mol. Biol. Lett."},{"key":"10.1016\/j.lfs.2022.121182_bb0230","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.canlet.2021.06.026","article-title":"ZEB1 represses biogenesis of circ-DOCK5 to facilitate metastasis in esophageal squamous cell carcinoma via a positive feedback loop with TGF-beta","volume":"519","author":"Meng","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.lfs.2022.121182_bb0235","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.omtn.2020.08.015","article-title":"ZEB1-mediated transcriptional upregulation of circWWC3 promotes breast cancer progression through activating Ras signaling pathway","volume":"22","author":"Meng","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"10","key":"10.1016\/j.lfs.2022.121182_bb0240","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1158\/0008-5472.CAN-17-1575","article-title":"ERbeta-mediated alteration of circATP2B1 and miR-204-3p signaling promotes invasion of clear cell renal cell carcinoma","volume":"78","author":"Han","year":"2018","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.lfs.2022.121182_bb0245","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948467","article-title":"Androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion","volume":"21","author":"Chen","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.lfs.2022.121182_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2016.12.036","article-title":"Androgen receptor (AR) promotes clear cell renal cell carcinoma (ccRCC) migration and invasion via altering the circHIAT1\/miR-195-5p\/29a-3p\/29c-3p\/CDC42 signals","volume":"394","author":"Wang","year":"2017","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.lfs.2022.121182_bb0255","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101645R","article-title":"Estrogen receptor beta increases clear cell renal cell carcinoma stem cell phenotype via altering the circPHACTR4\/miR-34b-5p\/c-Myc signaling","volume":"36","author":"Wang","year":"2022","journal-title":"FASEB J."},{"issue":"7441","key":"10.1016\/j.lfs.2022.121182_bb0260","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"issue":"7441","key":"10.1016\/j.lfs.2022.121182_bb0265","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"issue":"7483","key":"10.1016\/j.lfs.2022.121182_bb0270","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature12986","article-title":"The multilayered complexity of ceRNA crosstalk and competition","volume":"505","author":"Tay","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2022.121182_bb0275","doi-asserted-by":"crossref","first-page":"11215","DOI":"10.1038\/ncomms11215","article-title":"Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs","volume":"7","author":"Zheng","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2022.121182_bb0280","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.2147\/DDDT.S238124","article-title":"miR-370-3p alleviates ulcerative colitis-related colorectal cancer in mice through inhibiting the inflammatory response and epithelial-mesenchymal transition","volume":"14","author":"Lin","year":"2020","journal-title":"Drug Des. Dev.Ther."},{"issue":"6","key":"10.1016\/j.lfs.2022.121182_bb0285","article-title":"lncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p","volume":"9","author":"Xiao","year":"2020","journal-title":"Biol. Open"},{"key":"10.1016\/j.lfs.2022.121182_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118505","article-title":"Paclitaxel alleviates the sepsis-induced acute kidney injury via lnc-MALAT1\/miR-370-3p\/HMGB1 axis","volume":"262","author":"Xu","year":"2020","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0295","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12943-019-1076-1","article-title":"CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p\/RUVBL1 axis to enhance the transcriptional activity of beta-catenin\/LEF1 complex via effects on chromatin remodeling","volume":"18","author":"Chen","year":"2019","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0300","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12943-020-01191-9","article-title":"Circular RNA circ_0020710 drives tumor progression and immune evasion by regulating the miR-370-3p\/CXCL12 axis in melanoma","volume":"19","author":"Wei","year":"2020","journal-title":"Mol. Cancer"},{"issue":"6","key":"10.1016\/j.lfs.2022.121182_bb0305","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/ni0608-581","article-title":"IRAK2 takes its place in TLR signaling","volume":"9","author":"Meylan","year":"2008","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0310","first-page":"333","article-title":"LncRNA NEAT1 facilitates the progression of sepsis through up-regulating TSP-1 via sponging miR-370-3p","volume":"24","author":"Wu","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"16","key":"10.1016\/j.lfs.2022.121182_bb0315","doi-asserted-by":"crossref","first-page":"9135","DOI":"10.1093\/nar\/gkaa636","article-title":"Microcephaly family protein MCPH1 stabilizes RAD51 filaments","volume":"48","author":"Chang","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.lfs.2022.121182_bb0320","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","article-title":"The biogenesis, biology and characterization of circular RNAs","volume":"20","author":"Kristensen","year":"2019","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0325","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.molcel.2014.08.019","article-title":"circRNA biogenesis competes with pre-mRNA splicing","volume":"56","author":"Ashwal-Fluss","year":"2014","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0330","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13046-021-01896-9","article-title":"CircFAM73A promotes the cancer stem cell-like properties of gastric cancer through the miR-490-3p\/HMGA2 positive feedback loop and HNRNPK-mediated beta-catenin stabilization","volume":"40","author":"Xia","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0335","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13059-017-1368-y","article-title":"The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53\/YAP\/TEAD transcription-competent complex","volume":"18","author":"Verduci","year":"2017","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.lfs.2022.121182_bb0340","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12943-022-01514-y","article-title":"CircPVT1: a pivotal circular node intersecting long non-coding-PVT1 and c-MYC oncogenic signals","volume":"21","author":"Palcau","year":"2022","journal-title":"Mol. Cancer"},{"issue":"8","key":"10.1016\/j.lfs.2022.121182_bb0345","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/jclinpath-2019-205891","article-title":"Circular PVT1: an oncogenic non-coding RNA with emerging clinical importance","volume":"72","author":"Adhikary","year":"2019","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.lfs.2022.121182_bb0350","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev-pathol-052016-100322","article-title":"The role of cancer-associated fibroblasts and fibrosis in liver cancer","volume":"12","author":"Affo","year":"2017","journal-title":"Annu. Rev. Pathol."},{"issue":"5","key":"10.1016\/j.lfs.2022.121182_bb0355","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nri.2017.11","article-title":"Liver macrophages in tissue homeostasis and disease","volume":"17","author":"Krenkel","year":"2017","journal-title":"Nat. Rev. Immunol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522008827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522008827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:10:49Z","timestamp":1758402649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320522008827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":71,"alternative-id":["S0024320522008827"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.121182","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myc-mediated circular RNA circMcph1\/miR-370-3p\/Irak2 axis is a progressive regulator in hepatic fibrosis","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.121182","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"121182"}}