{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T17:41:45Z","timestamp":1785606105094,"version":"3.56.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007719","name":"University of East London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007719","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.lfs.2022.121194","type":"journal-article","created":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T13:30:13Z","timestamp":1668346213000},"page":"121194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Inhibition of mitochondrial function: An alternative explanation for the antipyretic and hypothermic actions of acetaminophen"],"prefix":"10.1016","volume":"312","author":[{"given":"Shazma","family":"Bashir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winston A.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2022.121194_bb0005","article-title":"Covid-19: ibuprofen should not be used for managing symptoms, say doctors and scientists","volume":"368","author":"Day","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.lfs.2022.121194_bb0010","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0002-9343(01)00834-8","article-title":"Antipyretics: mechanisms of action and clinical use in fever suppression","volume":"111","author":"Aronoff","year":"2001","journal-title":"Am. J. Med."},{"key":"10.1016\/j.lfs.2022.121194_bb0015","first-page":"131","article-title":"Acetaminophen-induced hepatotoxicity: a comprehensive update","volume":"4","author":"Yoon","year":"2016","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.lfs.2022.121194_bb0020","first-page":"54","article-title":"Effect of acetaminophen ingestion on thermoregulation of normothermic, non-febrile humans","volume":"7","author":"Foster","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121194_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.105.085431","article-title":"Acetaminophen and the cyclooxygenase-3 puzzle: sorting out facts, fictions, and uncertainties","volume":"315","author":"Kis","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2022.121194_bb0030","doi-asserted-by":"crossref","first-page":"13926","DOI":"10.1073\/pnas.162468699","article-title":"COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic\/antipyretic drugs: cloning, structure, and expression","volume":"99","author":"Chandrasekharan","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2022.121194_bb0035","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1096\/fj.07-8506com","article-title":"Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man","volume":"22","author":"Hinz","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2022.121194_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172609","article-title":"Loss of hypothermic and anti-pyretic action of paracetamol in cyclooxygenase-1 knockout mice is indicative of inhibition of cyclooxygenase-1 variant enzymes","volume":"861","author":"Ayoub","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121194_bb0045","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejphar.2006.08.079","article-title":"Human cyclooxygenase-1b is not the elusive target of acetaminophen","volume":"551","author":"Censarek","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121194_bb0050","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/00045391-200501000-00008","article-title":"Mechanism of action of paracetamol","volume":"12","author":"Graham","year":"2005","journal-title":"Am. J. Ther."},{"key":"10.1016\/j.lfs.2022.121194_bb0055","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1016\/0006-2952(82)90565-2","article-title":"Modification of anti-inflammatory drug effectiveness by ambient lipid peroxides","volume":"31","author":"Hanel","year":"1982","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121194_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113774","article-title":"Inhibition of lipolysis: a novel explanation for the hypothermic actions of acetaminophen in non-febrile rodents","volume":"172","author":"Bashir","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121194_bb0065","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jtherbio.2012.08.004","article-title":"Thermal physiology of laboratory mice: defining thermoneutrality","volume":"37","author":"Gordon","year":"2012","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.lfs.2022.121194_bb0070","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jhep.2010.11.006","article-title":"Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver","volume":"54","author":"Begriche","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2022.121194_bb0075","doi-asserted-by":"crossref","first-page":"927","DOI":"10.2353\/ajpath.2009.081155","article-title":"Mitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations","volume":"175","author":"De Pauw","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.lfs.2022.121194_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-6989(74)80010-X","article-title":"Equilibrium between metabolic pathways producing energy: a key factor in regulating lipolysis","volume":"6","author":"Fassina","year":"1974","journal-title":"Pharmacol. Res. Commun."},{"key":"10.1016\/j.lfs.2022.121194_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111282","article-title":"A mitochondrial journey through acetaminophen hepatotoxicity","volume":"140","author":"Ramachandran","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.lfs.2022.121194_bb0090","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/toxsci\/kfaa188","article-title":"Mitochondrial membrane potential drives early change in mitochondrial morphology after acetaminophen exposure","volume":"180","author":"Umbaugh","year":"2021","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.lfs.2022.121194_bb0095","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1021\/tx800464q","article-title":"Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity","volume":"22","author":"Chen","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.lfs.2022.121194_bb0100","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1002\/hep.22472","article-title":"The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system","volume":"48","author":"Copple","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2022.121194_bb0105","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1021\/tx5000443","article-title":"Acetaminophen reactive intermediates target hepatic thioredoxin reductase","volume":"27","author":"Jan","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.lfs.2022.121194_bb0110","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1002\/hep.1840190422","article-title":"Inhibition by perhexiline of oxidative phosphorylation and the beta-oxidation of fatty acids: possible role in pseudoalcoholic liver lesions","volume":"19","author":"Deschamps","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2022.121194_bb0115","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3565(25)22933-0","article-title":"Stereoselective and nonstereoselective effects of ibuprofen enantiomers on mitochondrial beta-oxidation of fatty acids","volume":"255","author":"Freneaux","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2022.121194_bb0120","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0163-7258(95)00012-6","article-title":"Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity","volume":"67","author":"Fromenty","year":"1995","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2022.121194_bb0125","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1472-8206.2008.00608.x","article-title":"Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies","volume":"22","author":"Labbe","year":"2008","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121194_bb0130","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.bbabio.2010.10.022","article-title":"Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells","volume":"1807","author":"Pike","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2022.121194_bb0135","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ab.2012.03.005","article-title":"Protocol for effective differentiation of 3T3-L1 cells to adipocytes","volume":"425","author":"Zebisch","year":"2012","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.lfs.2022.121194_bb0140","first-page":"421","article-title":"Melatonin and succinate reduce rat liver mitochondrial dysfunction in diabetes","volume":"62","author":"Zavodnik","year":"2011","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121194_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021746","article-title":"High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria","volume":"6","author":"Rogers","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2022.121194_bb0150","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0022-3565(25)29663-X","article-title":"Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism","volume":"187","author":"Mitchell","year":"1973","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2022.121194_bb0155","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0022-3565(25)29666-5","article-title":"Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione","volume":"187","author":"Mitchell","year":"1973","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2022.121194_bb0160","doi-asserted-by":"crossref","first-page":"R77","DOI":"10.1530\/JOE-16-0211","article-title":"Adipose tissue in control of metabolism","volume":"231","author":"Luo","year":"2016","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.lfs.2022.121194_bb0165","doi-asserted-by":"crossref","first-page":"232","DOI":"10.15252\/emmm.201505610","article-title":"mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue","volume":"8","author":"Albert","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.lfs.2022.121194_bb0170","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.celrep.2014.12.023","article-title":"Adipose fatty acid oxidation is required for thermogenesis and potentiates oxidative stress-induced inflammation","volume":"10","author":"Lee","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.lfs.2022.121194_bb0175","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1530\/JOE-12-0155","article-title":"\u03b2(1) adrenergic receptor is key to cold- and diet-induced thermogenesis in mice","volume":"214","author":"Ueta","year":"2012","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.lfs.2022.121194_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.1996.8074","article-title":"Selective protein covalent binding and target organ toxicity","volume":"143","author":"Cohen","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121194_bb0185","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/toxsci\/kfi336","article-title":"Intracellular signaling mechanisms of acetaminophen-induced liver cell death","volume":"89","author":"Jaeschke","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.lfs.2022.121194_bb0190","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0003-9861(89)90504-3","article-title":"In vitro effects of acetaminophen metabolites and analogs on the respiration of mouse liver mitochondria","volume":"273","author":"Ramsay","year":"1989","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.lfs.2022.121194_bb0195","doi-asserted-by":"crossref","first-page":"8098","DOI":"10.1038\/srep08098","article-title":"Serotonin deficiency exacerbates acetaminophen-induced liver toxicity in mice","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2022.121194_bb0200","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1016\/S0021-9258(19)67754-9","article-title":"Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes","volume":"266","author":"Burcham","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2022.121194_bb0205","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jhep.2004.09.015","article-title":"Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice","volume":"42","author":"Masubuchi","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2022.121194_bb0210","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/hep.20437","article-title":"Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes","volume":"40","author":"Kon","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2022.121194_bb0215","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0300-483X(95)03144-5","article-title":"Adenosine triphosphate (ATP) levels in paracetamol-induced cell injury in the rat in vivo and in vitro","volume":"104","author":"Martin","year":"1995","journal-title":"Toxicology"},{"key":"10.1016\/j.lfs.2022.121194_bb0220","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1006\/abbi.1996.0459","article-title":"In vitro interaction of nonsteroidal anti-inflammatory drugs on oxidative phosphorylation of rat kidney mitochondria: respiration and ATP synthesis","volume":"334","author":"Mingatto","year":"1996","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.lfs.2022.121194_bb0225","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0006-2952(91)90055-A","article-title":"Effect of paracetamol on mitochondrial membrane function in rat liver slices","volume":"42","author":"Nazareth","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121194_bb0230","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13550-016-0241-4","article-title":"Effects of acetaminophen on mitochondrial complex I activity in the rat liver and kidney: a PET study with 18F-BCPP-BF","volume":"6","author":"Ohba","year":"2016","journal-title":"EJNMMI Res."},{"key":"10.1016\/j.lfs.2022.121194_bb0235","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1016\/0006-2952(79)90613-0","article-title":"Inhibition of respiration and gluconeogenesis by paracetamol in rat kidney preparations","volume":"28","author":"Porter","year":"1979","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121194_bb0240","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1136\/gut.41.3.344","article-title":"Mitochondrial damage: a possible mechanism of the \"topical\" phase of NSAID induced injury to the rat intestine","volume":"41","author":"Somasundaram","year":"1997","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2022.121194_bb0245","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1046\/j.1365-2036.2000.00723.x","article-title":"Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat","volume":"14","author":"Somasundaram","year":"2000","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2022.121194_bb0250","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1124\/jpet.110.176321","article-title":"Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase","volume":"337","author":"Agarwal","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2022.121194_bb0255","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/hep.24493","article-title":"Aldo-keto reductase-7A protects liver cells and tissues from acetaminophen-induced oxidative stress and hepatotoxicity","volume":"54","author":"Ahmed","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2022.121194_bb0260","doi-asserted-by":"crossref","first-page":"11165","DOI":"10.1073\/pnas.0404185101","article-title":"Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein","volume":"101","author":"Ayoub","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2022.121194_bb0265","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/240410a0","article-title":"Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol)","volume":"240","author":"Flower","year":"1972","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2022.121194_bb0270","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1248\/bpb.b16-00728","article-title":"Serotonergic system does not contribute to the hypothermic action of acetaminophen","volume":"40","author":"Fukushima","year":"2017","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.lfs.2022.121194_bb0275","doi-asserted-by":"crossref","first-page":"12771","DOI":"10.1038\/srep12771","article-title":"TRPA1 mediates the hypothermic action of acetaminophen","volume":"5","author":"Gentry","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2022.121194_bb0280","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0300-483X(82)90029-4","article-title":"Acetaminophen-induced hypothermia in mice: evidence for a central action of the parent compound","volume":"25","author":"Massey","year":"1982","journal-title":"Toxicology"},{"key":"10.1016\/j.lfs.2022.121194_bb0285","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00204-012-0968-2","article-title":"Multi-cell type human liver microtissues for hepatotoxicity testing","volume":"87","author":"Messner","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.lfs.2022.121194_bb0290","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.tiv.2017.03.008","article-title":"Investigating acetaminophen hepatotoxicity in multi-cellular organotypic liver models","volume":"42","author":"Orbach","year":"2017","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.lfs.2022.121194_bb0295","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3389\/fphar.2017.00705","article-title":"Acetaminophen-induced liver injury alters the acyl ethanolamine-based anti-inflammatory signaling system in liver","volume":"8","author":"Rivera","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121194_bb0300","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/0041-008X(81)90303-3","article-title":"Acetaminophen-induced hypothermia, hepatic congestion, and modification by N-acetylcysteine in mice","volume":"59","author":"Walker","year":"1981","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121194_bb0305","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.prostaglandins.2007.10.007","article-title":"Acetaminophen: antipyretic or hypothermic in mice? In either case, PGHS-1b (COX-3) is irrelevant","volume":"85","author":"Li","year":"2008","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.lfs.2022.121194_bb0310","doi-asserted-by":"crossref","first-page":"5751","DOI":"10.1096\/fj.201800272R","article-title":"The antipyretic effect of paracetamol occurs independent of transient receptor potential ankyrin 1-mediated hypothermia and is associated with prostaglandin inhibition in the brain","volume":"32","author":"Mirrasekhian","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2022.121194_bb0315","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.lfs.2022.121194_bb0320","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2022.121194_bb0325","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-230X-11-20","article-title":"Acetaminophen-cysteine adducts during therapeutic dosing and following overdose","volume":"11","author":"Heard","year":"2011","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.lfs.2022.121194_bb0330","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.taap.2012.01.009","article-title":"Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans","volume":"259","author":"Jetten","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522008943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522008943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:03:02Z","timestamp":1758402182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320522008943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":66,"alternative-id":["S0024320522008943"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.121194","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of mitochondrial function: An alternative explanation for the antipyretic and hypothermic actions of acetaminophen","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.121194","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"121194"}}