{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:22:25Z","timestamp":1786972945284,"version":"build-2736575974"},"reference-count":184,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T00:00:00Z","timestamp":1704585600000},"content-version":"vor","delay-in-days":340,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.lfs.2022.121302","type":"journal-article","created":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T01:12:56Z","timestamp":1671239576000},"page":"121302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Kinins and their B1 and B2 receptors as potential therapeutic targets for pain relief"],"prefix":"10.1016","volume":"314","author":[{"given":"Indiara","family":"Brusco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda Pessano","family":"Fialho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne Silva","family":"Brum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Favarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara Panazzolo","family":"Marquezin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick Tuzi","family":"Serafini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2960-5284","authenticated-orcid":false,"given":"Sara Marchesan","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2022.121302_bb0005","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/nn.3811","article-title":"Reward and motivation in pain and pain relief","volume":"17","author":"Navratilova","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.lfs.2022.121302_bb0010","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1097\/j.pain.0000000000000613","article-title":"Updating the definition of pain","volume":"157","author":"Williams","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0015","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1097\/j.pain.0000000000001939","article-title":"The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises","volume":"161","author":"Raja","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0020","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1172\/JCI45178","article-title":"What is this thing called pain?","volume":"120","author":"Woolf","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2022.121302_bb0025","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nrd.2017.87","article-title":"Breaking barriers to novel analgesic drug development","volume":"16","author":"Yekkirala","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.lfs.2022.121302_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.abj9837","article-title":"Developing nociceptor-selective treatments for acute and chronic pain","volume":"13","author":"Jayakar","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.lfs.2022.121302_bb0035","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0304-3959(00)00361-4","article-title":"Pain as a reason to visit the doctor: a study in Finnish primary health care","volume":"89","author":"M\u00e4ntyselk\u00e4","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0040","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41422-022-00616-y","article-title":"Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects","volume":"32","author":"Zhang","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.lfs.2022.121302_bb0045","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","article-title":"Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis","volume":"14","author":"Finnerup","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.lfs.2022.121302_bb0050","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/physrev.00045.2019","article-title":"Neuropathic pain: frommechanisms to treatment","volume":"101","author":"Finnerup","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.lfs.2022.121302_bb0055","series-title":"WHO Guidelines for the Pharmacological and Radiotherapeutic Management of Cancer Pain in Adults and Adolescents","author":"WHO","year":"2018"},{"key":"10.1016\/j.lfs.2022.121302_bb0060","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.mayocp.2015.03.014","article-title":"Fibromyalgia and related conditions","volume":"90","author":"Clauw","year":"2015","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.lfs.2022.121302_bb0065","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41584-020-00506-w","article-title":"Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment","volume":"16","author":"Sarzi-Puttini","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.lfs.2022.121302_bb0070","doi-asserted-by":"crossref","unstructured":"L.M. Arnold, K.B. Gebke, E.H.S. Choy, Fibromyalgia: management strategies for primary care providers, (n.d.) 99\u2013112. doi:10.1111\/ijcp.12757.","DOI":"10.1111\/ijcp.12757"},{"key":"10.1016\/j.lfs.2022.121302_bb0075","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nrd1522","article-title":"Bradykinin receptor ligands: therapeutic perspectives","volume":"3","author":"Marceau","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.lfs.2022.121302_bb0080","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1124\/pr.57.1.2","article-title":"XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences","volume":"57","author":"Leeb-Lundberg","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.lfs.2022.121302_bb0085","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.pain.2004.03.031","article-title":"Sensitization to bradykinin B1 and B2 receptor activation in UV-B irradiated human skin","volume":"110","author":"Eisenbarth","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0090","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1213\/01.ANE.0000130348.85587.BE","article-title":"Bradykinin antagonists have no analgesic effect on incisional pain","volume":"99","author":"Leonard","year":"2004","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.lfs.2022.121302_bb0095","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1124\/jpet.109.159657","volume":"331","author":"Cialdai","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2022.121302_bb0100","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/art.39523","article-title":"Nociceptive sensitizers are regulated in damaged joint tissues, including articular cartilage, when osteoarthritic mice display pain behavior","volume":"68","author":"Driscoll","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.lfs.2022.121302_bb0105","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1136\/annrheumdis-2014-205739","article-title":"The role of kinin B 1 receptor and the effect of angiotensin I-converting enzyme inhibition on acute gout attacks in rodents","volume":"75","author":"Silva","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.lfs.2022.121302_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-019-2095-9","article-title":"Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists","volume":"17","author":"Minville","year":"2019","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.lfs.2022.121302_bb0115","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10571-020-00832-3","article-title":"Bradykinin receptors play a critical role in the chronic post-ischaemia pain model","volume":"41","author":"Gon\u00e7alves","year":"2021","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2022.121302_bb0120","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1124\/jpet.103.060335","article-title":"Switching of bradykinin-mediated nociception following partial sciatic nerve injury in mice","volume":"308","author":"Rashid","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2022.121302_bb0125","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.nbd.2013.02.007","article-title":"The role of kinin B1 and B2 receptors in the persistent pain induced by experimental autoimmune encephalomyelitis (EAE) in mice: evidence for the involvement of astrocytes","volume":"54","author":"Dutra","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.lfs.2022.121302_bb0130","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.peptides.2015.04.022","article-title":"Brain kinin B1 receptor is upregulated by the oxidative stress and its activation leads to stereotypic nociceptive behavior in insulin-resistant rats","volume":"69","author":"Dias","year":"2015","journal-title":"Peptides"},{"key":"10.1016\/j.lfs.2022.121302_bb0135","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s10787-019-00578-5","article-title":"The kinin B1 and B2 receptors and TNFR1\/p55 axis on neuropathic pain in the mouse brachial plexus","volume":"27","author":"Quint\u00e3o","year":"2019","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.lfs.2022.121302_bb0140","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.neuroscience.2015.05.015","article-title":"Contribution and interaction of kinin receptors and dynorphin a in a model of trigeminal neuropathic pain in mice","volume":"300","author":"Luiz","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2022.121302_bb0145","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/j.1476-5381.2011.01408.x","article-title":"Anti-nociceptive effect of kinin B 1 and B 2 receptor antagonists on peripheral neuropathy induced by paclitaxel in mice","volume":"164","author":"Costa","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121302_bb0150","doi-asserted-by":"crossref","first-page":"7824","DOI":"10.1007\/s12035-016-0275-7","article-title":"Potentiation of paclitaxel-induced pain syndrome in mice by angiotensin I converting enzyme inhibition and involvement of kinins","volume":"54","author":"Brusco","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2022.121302_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173870","article-title":"Inhibitors of angiotensin I converting enzyme potentiate fibromyalgia-like pain symptoms via kinin receptors in mice","volume":"895","author":"Brusco","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121302_bb0160","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/sj.bjp.0705724","article-title":"Involvement of bradykinin, cytokines, sympathetic amines and prostaglandins in formalin-induced orofacial nociception in rats","volume":"141","author":"Chichorro","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121302_bb0165","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1124\/jpet.103.059527","volume":"309","author":"Gougat","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2022.121302_bb0170","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/sj.bjp.0706139","article-title":"Antihyperalgesic activity of a novel nonpeptide bradykinin B 1 receptor antagonist in transgenic mice expressing the human B 1 receptor","volume":"144","author":"Fox","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121302_bb0175","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1124\/jpet.105.098368","article-title":"Antinociceptive pharmacology of N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl] methyl]-2-[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy] -N-methylacetamide, fumarate (LF22-0542), a novel nonpeptidic bradykinin B 1 receptor antagonist","volume":"318","author":"Porreca","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2022.121302_bb0180","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1016\/j.bmcl.2011.03.115","article-title":"3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation","volume":"21","author":"Chen","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.lfs.2022.121302_bb0185","doi-asserted-by":"crossref","first-page":"7232","DOI":"10.1021\/jm200808v","article-title":"Discovery of potent, orally bioavailable phthalazinone bradykinin B1 receptor antagonists","volume":"54","author":"Biswas","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.lfs.2022.121302_bb0190","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.1002\/anie.201200984","article-title":"Orally active peptidic bradykinin B 1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment","volume":"51","author":"Wong","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.lfs.2022.121302_bb0195","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/ejp.573","article-title":"The bradykinin B1 receptor antagonist BI113823 reverses inflammatory hyperalgesia by desensitization of peripheral and spinal neurons","volume":"19","author":"Schuelert","year":"2015","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0200","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000441060","article-title":"Icatibant for multiple hereditary angioedema attacks across the controlled and open-label extension phases of FAST-3","volume":"168","author":"Lumry","year":"2015","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.lfs.2022.121302_bb0205","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1586\/eci.12.67","article-title":"Clinical efficacy of icatibant in the treatment of acute hereditary angioedema during the FAST-3 trial","volume":"8","author":"Ba\u015f","year":"2012","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.lfs.2022.121302_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ph13080199","article-title":"A systematic review of molecular imaging agents targeting bradykinin B1 and B2 receptors","volume":"13","author":"Lau","year":"2020","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.lfs.2022.121302_bb0215","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/nn942","article-title":"Can we conquer pain?","volume":"5","author":"Scholz","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.lfs.2022.121302_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.neuro.051508.135531","article-title":"Neuropathic pain: a maladaptive response of the nervous system to damage","volume":"32","author":"Costigan","year":"2009","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.lfs.2022.121302_bb0225","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrn.2016.162","article-title":"Structural plasticity and reorganisation in chronic pain","volume":"18","author":"Kuner","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.lfs.2022.121302_bb0230","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/ALN.0b013e31827d415f","article-title":"Critical role of protease-activated receptor 2 activation by mast cell tryptase in the development of postoperative pain","volume":"118","author":"Oliveira","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.lfs.2022.121302_bb0235","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/nm.2231","article-title":"Central mechanisms of pathological pain","volume":"16","author":"Kuner","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2022.121302_bb0240","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2022.121302_bb0245","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1097\/j.pain.0000000000000160","article-title":"A classification of chronic pain for ICD-11","volume":"156","author":"Treede","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0250","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/j.pain.0000000000001384","article-title":"Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11)","volume":"160","author":"Treede","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0255","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S1474-4422(14)70024-9","article-title":"Painful and painless channelopathies","volume":"13","author":"Bennett","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.lfs.2022.121302_bb0260","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nri3621","article-title":"Pathological pain and the neuroimmune interface","volume":"14","author":"Grace","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.lfs.2022.121302_bb0265","first-page":"S35","article-title":"Quality of life in patients with rheumatoid arthritis: does abatacept make a difference?","volume":"25","author":"Michaud","year":"2007","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.lfs.2022.121302_bb0270","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/j.pain.0000000000001365","article-title":"The IASP classification of chronic pain for ICD-11: chronic neuropathic pain","volume":"160","author":"Scholz","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0275","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1097\/j.pain.0000000000000507","article-title":"Do we need a third mechanistic descriptor for chronic pain states?","volume":"157","author":"Kosek","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0280","doi-asserted-by":"crossref","first-page":"17002","DOI":"10.1038\/nrdp.2017.2","article-title":"Neuropathic pain","volume":"3","author":"Colloca","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.lfs.2022.121302_bb0285","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/S0140-6736(21)00392-5","article-title":"Nociplastic pain: towards an understanding of prevalent pain conditions","volume":"397","author":"Fitzcharles","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2022.121302_bb0290","first-page":"511","article-title":"Les substances hypotensives de l\u00farine humanine normale","volume":"61","author":"Abelous","year":"1909","journal-title":"C. R. Hebd. Seances Mem. Soc. Biol."},{"key":"10.1016\/j.lfs.2022.121302_bb0295","first-page":"440","article-title":"On pH-related modifications of kinin-producing alpha-globulin (kininogen) from bovine serum and the molecular weight of kininogen I","volume":"337","author":"Habermann","year":"1963","journal-title":"Biochem. Z."},{"key":"10.1016\/j.lfs.2022.121302_bb0300","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1139\/y77-115","article-title":"Receptors for bradykinin in rabbit aortae","volume":"55","author":"Regoli","year":"1977","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121302_bb0305","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1517\/17460441.2012.729038","article-title":"Discovery and therapeutic potential of kinin receptor antagonists","volume":"7","author":"Whalley","year":"2012","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.lfs.2022.121302_bb0310","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0196-9781(85)90033-6","article-title":"Competitive antagonists of bradykinin","volume":"6","author":"Vavrek","year":"1985","journal-title":"Peptides"},{"key":"10.1016\/j.lfs.2022.121302_bb0315","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3727\/096368915X687778","article-title":"Roles of kinins in the nervous system","volume":"24","author":"Negraes","year":"2015","journal-title":"Cell Transplant."},{"key":"10.1016\/j.lfs.2022.121302_bb0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01955578","article-title":"Ein neues Kreislaufhormon und seine Wirkung","volume":"133","author":"Frey","year":"1928","journal-title":"Naunyn Schmiedebergs Arch. Exp. Path Pharmak."},{"key":"10.1016\/j.lfs.2022.121302_bb0325","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3109\/1354750X.2013.787544","article-title":"The kinin\u2013kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers","volume":"18","author":"Kashuba","year":"2013","journal-title":"Biomarkers"},{"key":"10.1016\/j.lfs.2022.121302_bb0330","first-page":"1","article-title":"Bioregulation of kinins: kallikreins, kininogens, and kininases","volume":"44","author":"Bhoola","year":"1992","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.lfs.2022.121302_bb0335","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1152\/ajplegacy.1949.156.2.261","article-title":"Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin","volume":"156","author":"Rocha e Silva","year":"1949","journal-title":"Am. J. Physiol. Content"},{"key":"10.1016\/j.lfs.2022.121302_bb0340","article-title":"Kinin receptors: key regulators of autoimmunity","author":"Dutra","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.lfs.2022.121302_bb0345","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0006-2952(62)90119-3","article-title":"An enzyme in human blood plasma that inactivates bradykinin and kallidins","volume":"11","author":"Erd\u00f6s","year":"1962","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121302_bb0350","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/2151402a0","article-title":"Second kininase in human blood plasma","volume":"215","author":"Yang","year":"1967","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2022.121302_bb0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-7258(02)00166-3","article-title":"Kallikrein cascade and cytokines in inflamed joints","volume":"94","author":"Cassim","year":"2002","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2022.121302_bb0360","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1067\/mai.2002.121316","article-title":"Pathways for bradykinin formation and inflammatory disease","volume":"109","author":"Kaplan","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.lfs.2022.121302_bb0365","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.exer.2017.05.007","article-title":"Four decades of ocular renin-angiotensin and kallikrein-kinin systems (1977\u20132017)","volume":"166","author":"Igi\u0107","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.lfs.2022.121302_bb0370","first-page":"3006","article-title":"The elusive physiologic role of factor XII","volume":"118","author":"Schmaier","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2022.121302_bb0375","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1254\/jphs.SRJ05001X","article-title":"The kallikrein-kinin system: current and future pharmacological targets","volume":"99","author":"Moreau","year":"2005","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.lfs.2022.121302_bb0380","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1134\/S1068162015030115","article-title":"Past and present research on the kallikrein-kinin system (on the 90th anniversary of the discovery of the system)","volume":"41","author":"Yarovaya","year":"2015","journal-title":"Russ. J. Bioorg. Chem."},{"key":"10.1016\/j.lfs.2022.121302_bb0385","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0009-8981(03)00004-4","article-title":"Role of kallikrein enzymes in the central nervous system","volume":"329","author":"Yousef","year":"2003","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.lfs.2022.121302_bb0390","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.2174\/138161206777698710","article-title":"Regulation of angiogenesis by the kallikrein-kinin system","volume":"12","author":"Colman","year":"2006","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.lfs.2022.121302_bb0395","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1016\/0006-2952(73)90090-7","article-title":"Kinin-converting aminopeptidase from human serum","volume":"22","author":"Guimar\u00e3es","year":"1973","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121302_bb0400","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1515\/hsz-2012-0290","article-title":"Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output","volume":"394","author":"Zhang","year":"2013","journal-title":"Biol. Chem."},{"key":"10.1016\/j.lfs.2022.121302_bb0405","doi-asserted-by":"crossref","first-page":"7994","DOI":"10.1074\/jbc.M709837200","article-title":"Carboxypeptidase M and kinin B1 receptors interact to facilitate efficient B1 signaling from B2 agonists","volume":"283","author":"Zhang","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2022.121302_bb0410","doi-asserted-by":"crossref","first-page":"18547","DOI":"10.1074\/jbc.M110.214940","article-title":"Cross-talk between carboxypeptidase M and the kinin B1 receptor mediates a new mode of G protein-coupled receptor signaling","volume":"286","author":"Zhang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2022.121302_bb0415","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1161\/HYPERTENSIONAHA.109.144600","article-title":"Angiotensin I-converting enzyme inhibitors are allosteric enhancers of kinin B1 and B2 receptor function","volume":"55","author":"Erd\u00f6s","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2022.121302_bb0420","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1124\/jpet.105.083063","article-title":"Potentiation of des-Arg 9 -kallidin-induced vasoconstrictor responses by metallopeptidase inhibition in isolated human umbilical artery","volume":"313","author":"Pelorosso","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2022.121302_bb0425","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1152\/physiol.00003.2005","article-title":"New fACEs to the renin-angiotensin system","volume":"20","author":"Fleming","year":"2005","journal-title":"Physiology"},{"key":"10.1016\/j.lfs.2022.121302_bb0430","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1111\/bph.15790","article-title":"Peptide fragments of bradykinin show unexpected biological activity not mediated by B 1 or B 2 receptors","volume":"179","author":"Souza-silva","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121302_bb0435","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1161\/hc0502.102965","article-title":"Induction of functional bradykinin B1-receptors in normotensive rats and mice under chronic angiotensin-converting enzyme inhibitor treatment","volume":"105","author":"Marin-Casta\u00f1o","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2022.121302_bb0440","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH Guidelines for the management of arterial hypertension","volume":"39","author":"Williams","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lfs.2022.121302_bb0445","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0076-6879(95)48020-X","article-title":"Peptidyl dipeptidase A: angiotensin I-converting enzyme","author":"Corvol","year":"1995","journal-title":"Methods Enzym."},{"key":"10.1016\/j.lfs.2022.121302_bb0450","doi-asserted-by":"crossref","first-page":"16847","DOI":"10.1074\/jbc.M200355200","article-title":"Novel mode of action of angiotensin I converting enzyme inhibitors: DIRECT ACTIVATION OF BRADYKININ B1 RECEPTOR","volume":"277","author":"Ignjatovic","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2022.121302_bb0455","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1096\/fj.06-6113com","article-title":"Human ACE and bradykinin B 2 receptors form a complex at the plasma membrane","volume":"20","author":"Chen","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2022.121302_bb0460","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nrneurol.2009.73","article-title":"Pain: do ACE inhibitors exacerbate complex regional pain syndrome?","volume":"5","author":"Borsook","year":"2009","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.lfs.2022.121302_bb0465","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.pain.2008.12.032","article-title":"The association between ACE inhibitors and the complex regional pain syndrome: suggestions for a neuro-inflammatory pathogenesis of CRPS","volume":"142","author":"De Mos","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105020","article-title":"Inhibition of angiotensin converting enzyme induces mechanical allodynia through increasing substance P expression in mice","volume":"146","author":"Choi","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.lfs.2022.121302_bb0475","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/ejp.1660","article-title":"Blockade of bradykinin receptors or angiotensin II type 2 receptor prevents paclitaxel-associated acute pain syndrome in mice","volume":"25","author":"Zanata","year":"2021","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0480","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1046\/j.1439-0272.2003.00533.x","article-title":"Structure and signalling pathways of kinin receptors","volume":"35","author":"Blaukat","year":"2003","journal-title":"Andrologia"},{"key":"10.1016\/j.lfs.2022.121302_bb0485","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/s41594-021-00645-y","article-title":"Molecular basis for kinin selectivity and activation of the human bradykinin receptors","volume":"28","author":"Yin","year":"2021","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.lfs.2022.121302_bb0490","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s41467-022-28399-1","article-title":"Cryo-EM structures of human bradykinin receptor-Gq proteins complexes","volume":"13","author":"Shen","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2022.121302_bb0495","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1100\/tsw.2006.226","article-title":"Pharmacologic targets and prototype therapeutics in the kallikrein-kinin system: bradykinin receptor agonists or antagonists","volume":"6","author":"Sharma","year":"2006","journal-title":"Sci. World J."},{"key":"10.1016\/j.lfs.2022.121302_bb0500","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.neuropharm.2007.11.008","article-title":"The role of kinin B1 receptors in the nociception produced by peripheral protein kinase C activation in mice","volume":"54","author":"Ferreira","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lfs.2022.121302_bb0505","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/sj.bjp.0706012","article-title":"Kinin B 1 receptors: key G-protein-coupled receptors and their role in inflammatory and painful processes","volume":"143","author":"Calixto","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121302_bb0510","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0306-4522(01)00387-6","article-title":"The expression of bradykinin B 1 receptors on primary sensory neurones that give rise to small caliber sciatic nerve fibres in rats","volume":"107","author":"Ma","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2022.121302_bb0515","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1097\/00001756-200012180-00020","article-title":"Basal expression of bradykinin B1 receptor in peripheral sensory ganglia in the rat","volume":"11","author":"Ma","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.lfs.2022.121302_bb0520","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1189\/jlb.1205744","article-title":"Activation of kinin B1 receptors induces chemotaxis of human neutrophils","volume":"80","author":"Ehrenfeld","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.lfs.2022.121302_bb0525","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0006-2952(00)00554-2","article-title":"Detection of bradykinin B 1 receptors in rat aortic smooth muscle cells","volume":"61","author":"Schaeffer","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121302_bb0530","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1007\/s12035-017-0475-9","article-title":"Kinin receptors sensitize TRPV4 channel and induce mechanical hyperalgesia: relevance to paclitaxel-induced peripheral neuropathy in mice","volume":"55","author":"Costa","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2022.121302_bb0535","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neuropharm.2007.04.013","article-title":"Peripheral kinin B1 and B2 receptor-operated mechanisms are implicated in neuropathic nociception induced by spinal nerve ligation in rats","volume":"53","author":"Werner","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lfs.2022.121302_bb0540","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/rheumatology\/kep016","article-title":"Kallikreins, kininogens and kinin receptors on circulating and synovial fluid neutrophils: role in kinin generation in rheumatoid arthritis","volume":"48","author":"Cassim","year":"2008","journal-title":"Rheumatology"},{"key":"10.1016\/j.lfs.2022.121302_bb0545","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3959(00)00335-3","article-title":"Kinins in pain and inflammation","volume":"87","author":"Calixto","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0550","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF02737658","article-title":"Kinin receptors","volume":"16","author":"Marceau","year":"1998","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.lfs.2022.121302_bb0555","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00001503-200110000-00010","article-title":"Inflammatory pain: kinins and antagonists","volume":"14","author":"Calixto","year":"2001","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"10.1016\/j.lfs.2022.121302_bb0560","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1523\/JNEUROSCI.2466-04.2005","article-title":"Reduced nerve injury-induced neuropathic pain in kinin B1 receptor knock-out mice","volume":"25","author":"Ferreira","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2022.121302_bb0565","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/sj.jcbfm.9600096","article-title":"Release of bradykinin and expression of kinin B 2 receptors in the brain: role for cell death and brain edema formation after focal cerebral ischemia in mice","volume":"25","author":"Gr\u00f6ger","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.lfs.2022.121302_bb0570","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1523\/JNEUROSCI.5349-07.2008","article-title":"Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity","volume":"28","author":"Kohno","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2022.121302_bb0575","doi-asserted-by":"crossref","first-page":"7986","DOI":"10.1523\/JNEUROSCI.2393-05.2005","article-title":"Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission","volume":"25","author":"Wang","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2022.121302_bb0580","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra1808012","article-title":"Hereditary angioedema","volume":"382","author":"Busse","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2022.121302_bb0585","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.canlet.2013.12.009","article-title":"The role of kinin receptors in cancer and therapeutic opportunities","volume":"345","author":"da Costa","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.lfs.2022.121302_bb0590","first-page":"572","article-title":"Pain regulation by non-neuronal cells and inflammation","volume":"354","author":"Ji","year":"2016","journal-title":"Pain Res."},{"key":"10.1016\/j.lfs.2022.121302_bb0595","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.3389\/fimmu.2017.01014","article-title":"Neuroinflammation, bone marrow stem cells, and chronic pain","volume":"8","author":"Huh","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2022.121302_bb0600","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.it.2016.10.001","article-title":"Nociceptor sensory neuron-immune interactions in pain and inflammation","volume":"38","author":"Pinho-Ribeiro","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.lfs.2022.121302_bb0605","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1136\/annrheumdis-2019-216515","article-title":"Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017","author":"Safiri","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.lfs.2022.121302_bb0610","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41584-020-00523-9","article-title":"Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines","volume":"17","author":"Arden","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.lfs.2022.121302_bb0615","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and management of rheumatoid arthritis: a review","volume":"320","author":"Aletaha","year":"2018","journal-title":"JAMA - J. Am. Med. Assoc."},{"key":"10.1016\/j.lfs.2022.121302_bb0620","doi-asserted-by":"crossref","first-page":"S685","DOI":"10.1136\/annrheumdis-2019-216655","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update","volume":"79","author":"Smolen","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.lfs.2022.121302_bb0625","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0162-3109(97)00023-4","article-title":"Generation of kinins in synovial fluid from patients with arthropathy","volume":"36","author":"Bond","year":"1997","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.lfs.2022.121302_bb0630","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejphar.2005.10.014","article-title":"MEN16132, a novel potent and selective nonpeptide antagonist for the human bradykinin B2 receptor. In vitro pharmacology and molecular characterization","volume":"528","author":"Cucchi","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121302_bb0635","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1152\/jn.00486.2009","article-title":"Proteinase-activated receptor-4 (PAR4) activation leads to sensitization of rat joint primary afferents via a bradykinin B2 receptor-dependent mechanism","volume":"103","author":"Russell","year":"2010","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.lfs.2022.121302_bb0640","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neulet.2006.03.074","article-title":"Colonic hyperalgesia triggered by proteinase-activated receptor-2 in mice: involvement of endogenous bradykinin","volume":"402","author":"Kawabata","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.lfs.2022.121302_bb0645","doi-asserted-by":"crossref","DOI":"10.1186\/ar3338","article-title":"Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type a and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis","volume":"13","author":"Kaufman","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.lfs.2022.121302_bb0650","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d8190","article-title":"Antihypertensive drugs and risk of incident gout among patients with hypertension: population based case-control study","volume":"344","author":"Choi","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.lfs.2022.121302_bb0655","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1124\/jpet.107.120352","article-title":"Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 receptor antagonist ELN441958","volume":"322","author":"Hawkinson","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2022.121302_bb0660","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1515\/hsz-2012-0305","article-title":"Role of kinin B2 receptors in opioid-induced hyperalgesia in inflammatory pain in mice","volume":"394","author":"Grastilleur","year":"2013","journal-title":"Biol. Chem."},{"key":"10.1016\/j.lfs.2022.121302_bb0665","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113439","article-title":"Blockade of the kinin B1 receptor counteracts the depressive-like behaviour and mechanical allodynia in ovariectomised mice","volume":"412","author":"de Souza Maciel","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.lfs.2022.121302_bb0670","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1172\/JCI41084","article-title":"The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels","volume":"120","author":"Liu","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2022.121302_bb0675","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/jnr.24538","article-title":"Peripheral nerve injury and myelination: potential therapeutic strategies","volume":"98","author":"Modrak","year":"2020","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.lfs.2022.121302_bb0680","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2337\/dc16-2042","article-title":"Diabetic neuropathy: a position statement by the American Diabetes Association","volume":"40","author":"Pop-Busui","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.lfs.2022.121302_bb0685","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1097\/j.pain.0000000000001530","article-title":"Structure\u2013function relationships in peripheral nerve contributions to diabetic peripheral neuropathy","volume":"160","author":"Frank","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0690","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/j.pain.0000000000000785","article-title":"Risk factors for neuropathic pain in diabetes mellitus","volume":"158","author":"H\u00e9bert","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0695","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00011-004-1310-0","article-title":"Pathways for the bradykinin B1 receptor-mediated diabetic hyperalgesia in mice","volume":"53","author":"Gabra","year":"2004","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.lfs.2022.121302_bb0700","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1097\/00001756-200411150-00006","article-title":"Expression of kinin B1 receptors in the spinal cord of streptozotocin-diabetic rat","volume":"15","author":"Ongali","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.lfs.2022.121302_bb0705","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.regpep.2004.12.003","article-title":"Absence of diabetic hyperalgesia in bradykinin B1 receptor-knockout mice","volume":"127","author":"Gabra","year":"2005","journal-title":"Regul. Pept."},{"key":"10.1016\/j.lfs.2022.121302_bb0710","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1097\/01.jnen.0000178448.79713.5f","article-title":"Inhibition of type 1 diabetic hyperalgesia in streptozotocin-induced wistar versus spontaneous gene-prone BB\/Worchester rats: efficacy of a selective bradykinin B 1 receptor antagonist","volume":"64","author":"Gabra","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.lfs.2022.121302_bb0715","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejphar.2005.03.018","article-title":"Hyperalgesia in non-obese diabetic (NOD) mice: a role for the inducible bradykinin B1 receptor","volume":"514","author":"Gabra","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121302_bb0720","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1515\/BC.2006.018","article-title":"The kinin system mediates hyperalgesia through the inducible bradykinin B1 receptor subtype: evidence in various experimental animal models of type 1 and type 2 diabetic neuropathy","volume":"387","author":"Gabra","year":"2006","journal-title":"Biol. Chem."},{"key":"10.1016\/j.lfs.2022.121302_bb0725","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-2094-7-36","article-title":"Key role for spinal dorsal horn microglial kinin B1receptor in early diabetic pain neuropathy","volume":"7","author":"Talbot","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.lfs.2022.121302_bb0730","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.npep.2007.09.005","article-title":"Involvement of kinin B1 receptor and oxidative stress in sensory abnormalities and arterial hypertension in an experimental rat model of insulin resistance","volume":"41","author":"Lungu","year":"2007","journal-title":"Neuropeptides"},{"key":"10.1016\/j.lfs.2022.121302_bb0735","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0012622","article-title":"Kinin B1 receptor enhances the oxidative stress in a rat model of insulin resistance: outcome in hypertension, allodynia and metabolic complications","volume":"5","author":"Dias","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2022.121302_bb0740","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/sj.bjp.0707388","article-title":"The kinin B 1 receptor antagonist SSR240612 reverses tactile and cold allodynia in an experimental rat model of insulin resistance","volume":"152","author":"Dias","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121302_bb0745","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000110788","article-title":"Effect of bradykinin receptor antagonists on vincristine- and streptozotocin-induced hyperalgesia in a rat model of chemotherapy-induced and diabetic neuropathy","volume":"81","author":"Bujalska","year":"2008","journal-title":"Pharmacology"},{"key":"10.1016\/j.lfs.2022.121302_bb0750","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S1734-1140(09)70115-X","article-title":"Bradykinin receptor antagonists and cyclooxygenase inhibitors in vincristine-and streptozotocin-induced hyperalgesia","volume":"61","author":"Bujalska","year":"2009","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.lfs.2022.121302_bb0755","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ejp.905","article-title":"Neuropathic pain prevalence following spinal cord injury: a systematic review and meta-analysis","volume":"21","author":"Burke","year":"2017","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0760","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12883-015-0329-x","article-title":"Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms","volume":"15","author":"Teixeira","year":"2015","journal-title":"BMC Neurol."},{"key":"10.1016\/j.lfs.2022.121302_bb0765","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.intimp.2007.09.009","article-title":"Role of kinin B1 and B2 receptors in a rat model of neuropathic pain","volume":"8","author":"Petcu","year":"2008","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2022.121302_bb0770","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3390\/ijms21030821","article-title":"Reciprocal regulatory interaction between TRPV1 and kinin B1 receptor in a rat neuropathic pain model","volume":"21","author":"Cernit","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2022.121302_bb0775","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/sj.bjp.0705546","article-title":"Contribution of vanilloid receptors to the overt nociception induced by B 2 kinin receptor activation in mice","volume":"141","author":"Ferreira","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121302_bb0780","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1523\/JNEUROSCI.4389-07.2008","article-title":"Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors","volume":"28","author":"Quint\u00e3o","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2022.121302_bb0785","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.neuropharm.2005.11.007","article-title":"Long-lasting neuropathic pain induced by brachial plexus injury in mice: role triggered by the pro-inflammatory cytokine, tumour necrosis factor \u03b1","volume":"50","author":"Quint\u00e3o","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lfs.2022.121302_bb0790","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1056\/NEJMra1914484","article-title":"Trigeminal neuralgia","volume":"383","author":"Cruccu","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2022.121302_bb0795","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1177\/0333102417721677","article-title":"Triggering trigeminal neuralgia","volume":"38","author":"Di Stefano","year":"2018","journal-title":"Cephalalgia"},{"key":"10.1016\/j.lfs.2022.121302_bb0800","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.npep.2009.10.005","article-title":"Kinin B1 and B2 receptors contribute to orofacial heat hyperalgesia induced by infraorbital nerve constriction injury in mice and rats","volume":"44","author":"Luiz","year":"2010","journal-title":"Neuropeptides"},{"key":"10.1016\/j.lfs.2022.121302_bb0805","series-title":"Dynorphin A Activates Bradykinin Receptors to Maintain Neuropathic Pain","first-page":"1534","volume":"9","author":"Lai","year":"2006"},{"key":"10.1016\/j.lfs.2022.121302_bb0810","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neulet.2008.03.088","article-title":"Pronociceptive actions of dynorphin via bradykinin receptors","volume":"437","author":"Lai","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.lfs.2022.121302_bb0815","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/j.pain.0000000000001363","article-title":"The IASP classification of chronic pain for ICD-11: chronic cancer-related pain","volume":"160","author":"Bennett","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0820","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1200\/JCO.2013.51.7219","article-title":"Pain and nociception: mechanisms of cancer-induced bone pain","volume":"32","author":"Falk","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.lfs.2022.121302_bb0825","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.jpain.2005.06.010","article-title":"Analgesic efficacy of bradykinin B1 antagonists in a murine bone cancer pain model","volume":"6","author":"Sevcik","year":"2005","journal-title":"J. Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0830","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.ejpain.2009.10.010","article-title":"Roles of kinin B1 and B2 receptors in skin cancer pain produced by orthotopic melanoma inoculation in mice","volume":"14","author":"Fujita","year":"2010","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0835","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/j.pain.0000000000001540","article-title":"Chemotherapy-induced peripheral neuropathy: where are we now?","volume":"160","author":"Colvin","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0840","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.jpain.2009.04.006","article-title":"Chemotherapy-induced peripheral neuropathy as a predictor of neuropathic pain in breast cancer patients previously treated with paclitaxel","volume":"10","author":"Reyes-Gibby","year":"2009","journal-title":"J. Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0845","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10549-011-1505-3","article-title":"Examining the influence of beta blockers and ACE inhibitors on the risk for breast cancer recurrence: results from the LACE cohort","volume":"129","author":"Ganz","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.lfs.2022.121302_bb0850","doi-asserted-by":"crossref","first-page":"549","DOI":"10.7150\/jca.6888","article-title":"Use of ACE inhibitors and angiotensin receptor blockers and primary breast cancer outcomes","volume":"4","author":"Chae","year":"2013","journal-title":"J. Cancer"},{"key":"10.1016\/j.lfs.2022.121302_bb0855","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD012622.pub2","article-title":"Non-pharmacological interventions for chronic pain in multiple sclerosis","author":"Amatya","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.lfs.2022.121302_bb0860","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1001\/archneur.62.5.795","article-title":"Kinin B1 receptor expression on multiple sclerosis mononuclear cells","volume":"62","author":"Prat","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.lfs.2022.121302_bb0865","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027875","article-title":"The role of kinin receptors in preventing neuroinflammation and its clinical severity during experimental autoimmune encephalomyelitis in mice","volume":"6","author":"Dutra","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2022.121302_bb0870","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1073\/pnas.1810020116","article-title":"Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release","volume":"116","author":"G\u00f6bel","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.lfs.2022.121302_bb0875","first-page":"1","article-title":"Capturing novel non-opioid pain targets","author":"Woolf","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.lfs.2022.121302_bb0880","doi-asserted-by":"crossref","unstructured":"E.da S. Brum, G. Becker, M.F.P. Fialho, S.M. Oliveira, Animal models of fibromyalgia: what is the best choice?, Pharmacol. Ther. 230 (2021) 107959, doi: 10.1016\/j.pharmthera.2021.107959.","DOI":"10.1016\/j.pharmthera.2021.107959"},{"key":"10.1016\/j.lfs.2022.121302_bb0885","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nrrheum.2015.56","article-title":"The role of sleep in pain and fibromyalgia","volume":"11","author":"Choy","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.lfs.2022.121302_bb0890","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1001\/jama.2014.3266","article-title":"Fibromyalgia","volume":"311","author":"Clauw","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.lfs.2022.121302_bb0895","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/AJP.0b013e3182a0e383","article-title":"Review of overlap between thermoregulation and pain modulation in fibromyalgia","volume":"30","author":"Larson","year":"2014","journal-title":"Clin. J. Pain"},{"key":"10.1016\/j.lfs.2022.121302_bb0900","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00281-018-0672-2","article-title":"Neurogenic inflammation in fibromyalgia","volume":"40","author":"Littlejohn","year":"2018","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.lfs.2022.121302_bb0905","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1002\/art.27497","article-title":"Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity","volume":"62","author":"Napadow","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.lfs.2022.121302_bb0910","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/PR9.0000000000000598","article-title":"Diagnostic confounders of chronic widespread pain: not always fibromyalgia","volume":"2","author":"H\u00e4user","year":"2017","journal-title":"PAIN Rep."},{"key":"10.1016\/j.lfs.2022.121302_bb0915","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bcp.2019.06.023","article-title":"Kinins and their B1 and B2 receptors are involved in fibromyalgia-like pain symptoms in mice","volume":"168","author":"Brusco","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121302_bb0920","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1152\/japplphysiol.01340.2003","article-title":"Kinin peptides in human trapezius muscle during sustained isometric contraction and their relation to pain","volume":"98","author":"Boix","year":"2005","journal-title":"J. Appl. Physiol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522010025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522010025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T10:51:18Z","timestamp":1736333478000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320522010025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":184,"alternative-id":["S0024320522010025"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.121302","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kinins and their B1 and B2 receptors as potential therapeutic targets for pain relief","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.121302","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"121302"}}