{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T10:17:47Z","timestamp":1793614667669,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070751"],"award-info":[{"award-number":["82070751"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.lfs.2022.121355","type":"journal-article","created":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T15:47:24Z","timestamp":1672501644000},"page":"121355","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Metabolomics reveals the defense mechanism of histidine supplementation on high-salt exposure-induced hepatic oxidative stress"],"prefix":"10.1016","volume":"314","author":[{"given":"Pengfei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenfen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangbo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.lfs.2022.121355_bb0005","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1073\/pnas.1713837115","article-title":"High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism","volume":"115","author":"Lanaspa","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.lfs.2022.121355_bb0010","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12944-015-0002-9","article-title":"High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice","volume":"14","author":"Uetake","year":"2015","journal-title":"Lipids Health Dis"},{"issue":"21","key":"10.1016\/j.lfs.2022.121355_bb0015","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1093\/eurheartj\/ehaa947","article-title":"Sodium intake, life expectancy, and all-cause mortality","volume":"42","author":"Messerli","year":"2021","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.lfs.2022.121355_bb0020","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1017\/S1368980009991431","article-title":"Salt intake in young Swedish men","volume":"13","author":"Hulthen","year":"2010","journal-title":"Public Health Nutr"},{"issue":"5","key":"10.1016\/j.lfs.2022.121355_bb0025","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/CIRCULATIONAHA.121.055600","article-title":"Zhu, salt-induced hepatic inflammatory memory contributes to cardiovascular damage through epigenetic modulation of SIRT3","volume":"145","author":"Gao","year":"2022","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.lfs.2022.121355_bb0030","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1021\/acs.jafc.5b05897","article-title":"Yang, liver fibrosis can be induced by high salt intake through excess reactive oxygen species (ROS) production","volume":"64","author":"Wang","year":"2016","journal-title":"J. Agric. Food Chem."},{"issue":"25","key":"10.1016\/j.lfs.2022.121355_bb0035","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.3748\/wjg.v20.i25.8082","article-title":"Oxidative stress as a crucial factor in liver diseases","volume":"20","author":"Cichoz-Lach","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"7","key":"10.1016\/j.lfs.2022.121355_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/nu10070855","article-title":"Curcumin in liver diseases: a systematic review of the cellular mechanisms of oxidative stress and clinical perspective","volume":"10","author":"Farzaei","year":"2018","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.lfs.2022.121355_bb0045","doi-asserted-by":"crossref","first-page":"6020","DOI":"10.3390\/nu6126020","article-title":"Resources and biological activities of natural polyphenols","volume":"6","author":"Li","year":"2014","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.lfs.2022.121355_bb0050","doi-asserted-by":"crossref","first-page":"26087","DOI":"10.3390\/ijms161125942","article-title":"Feng, the role of oxidative stress and antioxidants in liver diseases","volume":"16","author":"Li","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.lfs.2022.121355_bb0055","article-title":"Influences of beta-alanine and l-histidine supplementation on growth performance, meat quality, carnosine content, and mRNA expression of carnosine-related enzymes in broilers","volume":"11","author":"Qi","year":"2021","journal-title":"Animals (Basel)"},{"issue":"Suppl 1","key":"10.1016\/j.lfs.2022.121355_bb0060","doi-asserted-by":"crossref","first-page":"2570S","DOI":"10.1093\/jn\/nxaa079","article-title":"Histidine metabolism and function","volume":"150","author":"Brosnan","year":"2020","journal-title":"J. Nutr."},{"issue":"5","key":"10.1016\/j.lfs.2022.121355_bb0065","first-page":"523","article-title":"Anti-inflammatory and antisecretory potential of histidine in Salmonella-challenged mouse small intestine","volume":"78","author":"Peterson","year":"1998","journal-title":"Lab Invest"},{"key":"10.1016\/j.lfs.2022.121355_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119134","article-title":"Tian, protective effect of oral histidine on hypertension in dahl salt-sensitive rats induced by high-salt diet","volume":"270","author":"Yang","year":"2021","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.lfs.2022.121355_bb0075","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/10715762.2020.1856830","article-title":"Carini, understanding the antioxidant and carbonyl sequestering activity of carnosine: direct and indirect mechanisms","volume":"55","author":"Aldini","year":"2021","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.lfs.2022.121355_bb0080","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.brainres.2013.07.004","article-title":"Role of histidine\/histamine in carnosine-induced neuroprotection during ischemic brain damage","volume":"1527","author":"Bae","year":"2013","journal-title":"Brain Res."},{"issue":"1-2","key":"10.1016\/j.lfs.2022.121355_bb0085","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ejphar.2005.02.010","article-title":"Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation","volume":"513","author":"Lee","year":"2005","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"10.1016\/j.lfs.2022.121355_bb0090","doi-asserted-by":"crossref","first-page":"H259","DOI":"10.1111\/j.1750-3841.2009.01330.x","article-title":"Protective effects from carnosine and histidine on acetaminophen-induced liver injury","volume":"74","author":"Yan","year":"2009","journal-title":"J. Food Sci."},{"issue":"3","key":"10.1016\/j.lfs.2022.121355_bb0095","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/jbt.20370","article-title":"Said, effect of histidine on autotaxin activity in experimentally induced liver fibrosis","volume":"25","author":"El-Batch","year":"2011","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"1-3","key":"10.1016\/j.lfs.2022.121355_bb0100","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejphar.2010.12.001","article-title":"Histidine and carnosine alleviated hepatic steatosis in mice consumed high saturated fat diet","volume":"653","author":"Mong","year":"2011","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"10.1016\/j.lfs.2022.121355_bb0105","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.numecd.2020.11.023","article-title":"Ke, identification of biomarkers for essential hypertension based on metabolomics","volume":"31","author":"Deng","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"issue":"8","key":"10.1016\/j.lfs.2022.121355_bb0110","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1080\/00498254.2020.1714791","article-title":"Zhao, metabonomics analysis of liver in rats administered with chronic low-dose acrylamide","volume":"50","author":"Liu","year":"2020","journal-title":"Xenobiotica"},{"issue":"1","key":"10.1016\/j.lfs.2022.121355_bb0115","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbrc.2020.09.016","article-title":"Tian, revealing metabolic pathways relevant to prediabetes based on metabolomics profiling analysis","volume":"533","author":"OuYang","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.lfs.2022.121355_bb0120","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1039\/C8FO01818A","article-title":"Tian, the protective role of hawthorn fruit extract against high salt-induced hypertension in dahl salt-sensitive rats: impact on oxidative stress and metabolic patterns","volume":"10","author":"Zheng","year":"2019","journal-title":"Food Funct."},{"issue":"7","key":"10.1016\/j.lfs.2022.121355_bb0125","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1002\/jsfa.11611","article-title":"Tian, effects of almonds on ameliorating salt-induced hypertension in dahl salt-sensitive rats","volume":"102","author":"Zeng","year":"2022","journal-title":"J. Sci. Food Agric."},{"issue":"2","key":"10.1016\/j.lfs.2022.121355_bb0130","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1039\/D1FO03577K","article-title":"Tian, supplementation of amino acids and organic acids prevents the increase in blood pressure induced by high salt in dahl salt-sensitive rats","volume":"13","author":"Yang","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.lfs.2022.121355_bb0135","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbrc.2022.04.079","article-title":"Li, inhibition of NAD kinase elevates the hepatic NAD(+) pool and alleviates acetaminophen-induced acute liver injury in mice","volume":"612","author":"Liao","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2022.121355_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113196","article-title":"Serum metabonomics coupled with HPLC-LTQ\/orbitrap MS and multivariate data analysis on the ameliorative effects of Bidens bipinnata L. In hyperlipidemic rats","volume":"262","author":"Wang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.lfs.2022.121355_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2021.03.069","article-title":"Reconstruction and analysis of correlation networks based on GC-MS metabolomics data for hypercholesterolemia","volume":"553","author":"OuYang","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"10.1016\/j.lfs.2022.121355_bb0150","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1021\/acs.jproteome.8b00316","article-title":"Metabonomics profiling reveals biochemical pathways associated with pulmonary arterial hypertension in broiler chickens","volume":"17","author":"Shao","year":"2018","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.lfs.2022.121355_bb0155","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3892\/ijmm.2013.1544","article-title":"Tsubouchi, hypertension exacerbates liver injury and hepatic fibrosis induced by a choline-deficient L-amino acid-defined diet in rats","volume":"33","author":"Arima","year":"2014","journal-title":"Int. J. Mol. Med."},{"issue":"8","key":"10.1016\/j.lfs.2022.121355_bb0160","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1097\/00004872-199715080-00008","article-title":"Effect of a chronic high-salt diet on whole-body and organ sodium contents of dahl rats","volume":"15","author":"Tsunooka","year":"1997","journal-title":"J. Hypertens."},{"issue":"7","key":"10.1016\/j.lfs.2022.121355_bb0165","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/BF02578242","article-title":"Effect of dietary carnosine on plasma and tissue antioxidant concentrations and on lipid oxidation in rat skeletal muscle","volume":"29","author":"Chan","year":"1994","journal-title":"Lipids"},{"issue":"4","key":"10.1016\/j.lfs.2022.121355_bb0170","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/10715762.2019.1580499","article-title":"Shi, short-term high salt intake impairs hepatic mitochondrial bioenergetics and biosynthesis in SIRT3 knockout mice","volume":"53","author":"Jiang","year":"2019","journal-title":"Free Radic. Res."},{"issue":"1","key":"10.1016\/j.lfs.2022.121355_bb0175","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/s12876-021-01912-4","article-title":"Yu, transcriptome sequencing reveals high-salt diet-induced abnormal liver metabolic pathways in mice","volume":"21","author":"Li","year":"2021","journal-title":"BMC Gastroenterol."},{"issue":"3","key":"10.1016\/j.lfs.2022.121355_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/nu12030848","article-title":"Histidine in health and disease: metabolism, physiological importance, and use as a supplement","volume":"12","author":"Holecek","year":"2020","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.lfs.2022.121355_bb0185","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1006\/abbi.1995.1340","article-title":"Stimulation of glycolysis by histidine buffers in mammalian liver during cold hypoxia","volume":"320","author":"Churchill","year":"1995","journal-title":"Arch Biochem Biophys"},{"issue":"5","key":"10.1016\/j.lfs.2022.121355_bb0190","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1432-2277.1995.tb01538.x","article-title":"An underlying mechanism for improved liver preservation with a combined histidine-lactobionate-raffinose flush solution","volume":"8","author":"Churchill","year":"1995","journal-title":"Transpl Int"},{"issue":"Pt 6","key":"10.1016\/j.lfs.2022.121355_bb0195","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-77779-1","article-title":"Temperature adaptations of the thermophilic snail Echinolittorina malaccana: insights from metabolomic analysis","volume":"224","author":"Chen","year":"2021","journal-title":"J Exp Biol"},{"issue":"1","key":"10.1016\/j.lfs.2022.121355_bb0200","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/s41467-021-21301-5","article-title":"Renal metabolism and hypertension","volume":"12","author":"Tian","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2022.121355_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115033","article-title":"Tang, methionine cycle in nonalcoholic fatty liver disease and its potential applications","volume":"200","author":"Wang","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.lfs.2022.121355_bb0210","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1093\/ajcn\/77.5.1094","article-title":"Methionine metabolism in liver diseases","volume":"77","author":"Finkelstein","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"issue":"14","key":"10.1016\/j.lfs.2022.121355_bb0215","first-page":"1931","article-title":"Protective effect of glycine on liver injury during liver transplantation","volume":"123","author":"Wang","year":"2010","journal-title":"Chin Med J (Engl)"},{"issue":"4","key":"10.1016\/j.lfs.2022.121355_bb0220","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2174\/0929866525666180406142451","article-title":"He, long-term effects of lysine restriction on liver global proteins, meat quality, and blood biochemical parameters in pigs","volume":"25","author":"Liu","year":"2018","journal-title":"Protein Pept. Lett."},{"issue":"1","key":"10.1016\/j.lfs.2022.121355_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147408","article-title":"Feng, co- and post-treatment with lysine protects primary fish enterocytes against Cu-induced oxidative damage","volume":"11","author":"Li","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2022.121355_bb0230","series-title":"InsufficientFumarase Contributes to Generating Reactive Oxygen Species in Dahl Salt-SensitiveRats","author":"Hou","year":"2018"},{"issue":"11","key":"10.1016\/j.lfs.2022.121355_bb0235","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1038\/s41440-019-0290-y","article-title":"Tian, insufficient fumarase contributes to hypertension by an imbalance of redox metabolism in dahl salt-sensitive rats","volume":"42","author":"Zheng","year":"2019","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.lfs.2022.121355_bb0240","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ejphar.2017.10.048","article-title":"Nicotinamide prevents sweet beverage-induced hepatic steatosis in rats by regulating the G6PD, NADPH\/NADP(+) and GSH\/GSSG ratios and reducing oxidative and inflammatory stress","volume":"818","author":"Mejia","year":"2018","journal-title":"Eur J Pharmacol"},{"issue":"12","key":"10.1016\/j.lfs.2022.121355_bb0245","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.jnutbio.2013.06.006","article-title":"High dietary salt decreases antioxidant defenses in the liver of fructose-fed insulin-resistant rats","volume":"24","author":"Dornas","year":"2013","journal-title":"J Nutr Biochem"},{"issue":"11\u201312","key":"10.1016\/j.lfs.2022.121355_bb0250","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1080\/10715762.2020.1734588","article-title":"Emerging connections between oxidative stress, defective proteolysis, and metabolic diseases","volume":"54","author":"Homma","year":"2020","journal-title":"Free Radic. Res."},{"issue":"1","key":"10.1016\/j.lfs.2022.121355_bb0255","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00005344-199501000-00023","article-title":"Ashraf, antioxidative properties of histidine and its effect on myocardial injury during ischemia\/reperfusion in isolated rat heart","volume":"25","author":"Cai","year":"1995","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.lfs.2022.121355_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102093","article-title":"Pazdro, quantitative trait mapping in diversity outbred mice identifies novel genomic regions associated with the hepatic glutathione redox system","volume":"46","author":"Gould","year":"2021","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.lfs.2022.121355_bb0265","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.patbio.2009.09.011","article-title":"Joubet, maillard reaction, mitochondria and oxidative stress: potential role of antioxidants","volume":"58","author":"Edeas","year":"2010","journal-title":"Pathol. Biol. (Paris)"},{"key":"10.1016\/j.lfs.2022.121355_bb0270","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.fsi.2016.07.002","article-title":"Changes in integrity of the gill during histidine deficiency or excess due to depression of cellular anti-oxidative ability, induction of apoptosis, inflammation and impair of cell-cell tight junctions related to Nrf2, TOR and NF-kappaB signaling in fish","volume":"56","author":"Jiang","year":"2016","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.lfs.2022.121355_bb0275","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1749-6632.2002.tb04059.x","article-title":"Nitric oxide protects astrocytes from oxidative stress","volume":"962","author":"Robb","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"7","key":"10.1016\/j.lfs.2022.121355_bb0280","first-page":"766","article-title":"Inducible nitric oxide synthase in the liver: regulation and function","volume":"63","author":"Taylor","year":"1998","journal-title":"Biochemistry (Mosc)"},{"issue":"6","key":"10.1016\/j.lfs.2022.121355_bb0285","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2174\/1566524033479582","article-title":"Role of nitric oxide in liver injury","volume":"3","author":"Chen","year":"2003","journal-title":"Curr Mol Med"},{"issue":"10","key":"10.1016\/j.lfs.2022.121355_bb0290","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1002\/jor.20244","article-title":"Nitric oxide protects osteoblasts from oxidative stress-induced apoptotic insults via a mitochondria-dependent mechanism","volume":"24","author":"Chang","year":"2006","journal-title":"J. Orthop. Res."},{"issue":"Pt 2","key":"10.1016\/j.lfs.2022.121355_bb0295","first-page":"55","article-title":"Hyperuricemia induces liver injury by upregulating HIF-1alpha and inhibiting arginine biosynthesis pathway in mouse liver and human L02 hepatocytes","volume":"617","author":"Huang","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.lfs.2022.121355_bb0300","first-page":"C827","article-title":"Carbonell, nitric oxide inhibits superoxide production by inflammatory polymorphonuclear leukocytes","volume":"274","author":"Rodenas","year":"1998","journal-title":"Am. J. Phys."},{"issue":"8","key":"10.1016\/j.lfs.2022.121355_bb0305","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.celrep.2017.04.071","article-title":"Tian, malate and aspartate increase L-arginine and nitric oxide and attenuate hypertension","volume":"19","author":"Hou","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.lfs.2022.121355_bb0310","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.niox.2018.12.010","article-title":"Antioxidant activity of endogenously produced nitric oxide against the zinc oxide nanoparticle-induced oxidative stress in primary hepatocytes of air-breathing catfish, Clarias magur","volume":"84","author":"Koner","year":"2019","journal-title":"Nitric Oxide"},{"issue":"8","key":"10.1016\/j.lfs.2022.121355_bb0315","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.plaphy.2007.05.005","article-title":"Wei, exogenous nitric oxide protect cucumber roots against oxidative stress induced by salt stress","volume":"45","author":"Shi","year":"2007","journal-title":"Plant Physiol. Biochem."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522010554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320522010554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T10:51:51Z","timestamp":1736333511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320522010554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":63,"alternative-id":["S0024320522010554"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2022.121355","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomics reveals the defense mechanism of histidine supplementation on high-salt exposure-induced hepatic oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2022.121355","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"121355"}}