{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:38:38Z","timestamp":1790609918653,"version":"4.1.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.lfs.2023.121379","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T20:11:37Z","timestamp":1673035897000},"page":"121379","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Fortified anti-proliferative activity of niclosamide for breast cancer treatment: In-vitro and in-vivo assessment"],"prefix":"10.1016","volume":"316","author":[{"given":"Amira","family":"Mansour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Y.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa F.","family":"Bakr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monira G.","family":"Ghoniem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima A.","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim M.","family":"El-Sherbiny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.lfs.2023.121379_bb0005","first-page":"E359","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2012","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.lfs.2023.121379_bb0010","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/jama.2018.19323","article-title":"Breast cancer treatment: a review","volume":"321","author":"Waks","year":"2019","journal-title":"JAMA - J. Am. Med. Assoc."},{"key":"10.1016\/j.lfs.2023.121379_bb0015","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2147\/BCTT.S273058","article-title":"Approaching neoadjuvant therapy in the management of early-stage breast cancer","volume":"13","author":"Hyder","year":"2021","journal-title":"Breast Cancer Targets Ther."},{"issue":"8","key":"10.1016\/j.lfs.2023.121379_bb0020","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd1468","article-title":"Drug repositioning: identifying and developing new uses for existing drugs","volume":"3","author":"Ashburn","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.lfs.2023.121379_bb0025","first-page":"68","article-title":"New tricks for old drugs","volume":"13","author":"Nunes-Alves","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.lfs.2023.121379_bb0030","series-title":"WHO Model Prescribing Information: Drugs Used in Parasitic Diseases","author":"WHo","year":"1995"},{"issue":"2","key":"10.1016\/j.lfs.2023.121379_bb0035","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0306-3623(96)00149-8","article-title":"The mechanisms of action of antiprotozoal and anthelmintic drugs in man","volume":"28","author":"Frayha","year":"1997","journal-title":"Gen. Pharmacol."},{"issue":"11","key":"10.1016\/j.lfs.2023.121379_bb0040","first-page":"1850","article-title":"Some biochemical effects of amiodarone","volume":"19","author":"Broeckhuysen","year":"1969","journal-title":"Arzneimittel-Forschung\/Drug Res."},{"issue":"6","key":"10.1016\/j.lfs.2023.121379_bb0045","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nchembio790","article-title":"Identifying off-target effects and hidden phenotypes of drugs in human cells","volume":"2","author":"MacDonald","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.lfs.2023.121379_bb0050","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1158\/0008-5472.CAN-10-3978","article-title":"Anti-helminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations","volume":"12","author":"Osada","year":"2011","journal-title":"Cancer Res."},{"issue":"9","key":"10.1016\/j.lfs.2023.121379_bb0055","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1021\/ml100146z","article-title":"Identification of niclosamide as a new small-molecule inhibitor of the STAT3 signaling pathway","volume":"1","author":"Ren","year":"2010","journal-title":"ACS Med. Chem. Lett."},{"issue":"4","key":"10.1016\/j.lfs.2023.121379_bb0060","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/jcb.22065","article-title":"The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells","volume":"106","author":"Wang","year":"2009","journal-title":"J. Cell. Biochem."},{"issue":"12","key":"10.1016\/j.lfs.2023.121379_bb0065","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s00011-015-0888-8","article-title":"Niclosamide inhibits the inflammatory and angiogenic activation of human umbilical vein endothelial cells","volume":"64","author":"Huang","year":"2015","journal-title":"Inflamm. Res."},{"issue":"21","key":"10.1016\/j.lfs.2023.121379_bb0070","doi-asserted-by":"crossref","first-page":"17530","DOI":"10.1074\/jbc.M112.359638","article-title":"Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling","volume":"287","author":"Fonseca","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.lfs.2023.121379_bb0075","doi-asserted-by":"crossref","first-page":"776","DOI":"10.3892\/ijmm.2016.2689","article-title":"Niclosamide inhibits colon cancer progression through downregulation of the notch pathway and upregulation of the tumor suppressor miR-200 family","volume":"38","author":"Suliman","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.lfs.2023.121379_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118458","article-title":"Niclosamide-loaded polymeric micelles ameliorate hepatocellular carcinoma in vivo through targeting Wnt and Notch pathways","volume":"261","author":"Zeyada","year":"2020","journal-title":"Life Sci."},{"issue":"13","key":"10.1016\/j.lfs.2023.121379_bb0085","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1002\/pros.23015","article-title":"Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition","volume":"75","author":"Liu","year":"2015","journal-title":"Prostate"},{"issue":"1","key":"10.1016\/j.lfs.2023.121379_bb0090","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ygyno.2014.04.005","article-title":"Inhibition of Wnt\/\u03b2-catenin pathway by niclosamide: a therapeutic target for ovarian cancer","volume":"134","author":"Arend","year":"2014","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.lfs.2023.121379_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-47707-2","article-title":"Niclosamide reverses adipocyte induced epithelial-mesenchymal transition in breast cancer cells via suppression of the interleukin-6\/STAT3 signalling axis","volume":"9","author":"Gyamfi","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.lfs.2023.121379_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085887","article-title":"The anthelmintic drug niclosamide induces apoptosis, impairs metastasis and reduces immunosuppressive cells in breast cancer model","volume":"9","author":"Ye","year":"2014","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.lfs.2023.121379_bb0105","first-page":"1","article-title":"Drug screening identifies niclosamide as an inhibitor of breast cancer stem-like cells","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2023.121379_bb0110","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ejpb.2019.05.004","article-title":"Niclosamide repositioning for treating cancer: challenges and nano-based drug delivery opportunities","volume":"141","author":"Barbosa","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1","key":"10.1016\/j.lfs.2023.121379_bb0115","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3136\/fsti9596t9798.2.24","article-title":"Photochemical isomerization of piperine, a pungent constituent in pepper","volume":"2","author":"Hashimoto","year":"1996","journal-title":"Food Sci. Technol. Int. Tokyo"},{"issue":"4","key":"10.1016\/j.lfs.2023.121379_bb0120","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/aps.2011.209","article-title":"Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model","volume":"33","author":"Lai","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.lfs.2023.121379_bb0125","first-page":"1893","article-title":"Piperine enhances the efficacy of TRAIL-based therapy for triple-negative breast","volume":"1900","author":"Abdelhamed","year":"2014","journal-title":"Cancer Cells"},{"issue":"2","key":"10.1016\/j.lfs.2023.121379_bb0130","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1124\/jpet.102.034728","article-title":"Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4","volume":"302","author":"Bhardwaj","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2023.121379_bb0135","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.phymed.2011.06.031","article-title":"Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells","volume":"19","author":"Li","year":"2011","journal-title":"Phytomedicine"},{"issue":"19","key":"10.1016\/j.lfs.2023.121379_bb0140","doi-asserted-by":"crossref","first-page":"16547","DOI":"10.1074\/jbc.M110629200","article-title":"The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c","volume":"277","author":"Karpinich","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.lfs.2023.121379_bb0145","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1007\/s13277-013-1433-4","article-title":"Piperine induces apoptosis of lung cancer A549 cells via p53-dependent mitochondrial signaling pathway","volume":"35","author":"Lin","year":"2014","journal-title":"Tumor Biol."},{"key":"10.1016\/j.lfs.2023.121379_bb0150","doi-asserted-by":"crossref","first-page":"642","DOI":"10.18632\/oncotarget.28227","article-title":"Combined treatment with niclosamide and camptothecin enhances anticancer effect in U87 MG human glioblastoma cells","volume":"13","author":"Valdez","year":"2022","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.lfs.2023.121379_bb0155","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11010-014-2214-0","article-title":"Piperine inhibits IL-1 b-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells","volume":"398","author":"Xia","year":"2015","journal-title":"Mol. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.lfs.2023.121379_bb0160","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.bbrc.2016.08.047","article-title":"Anthelmintic drug niclosamide enhances the sensitivity of chronic myeloid leukemia cells to dasatinib through inhibiting Erk\/Mnk1\/eIF4E pathway","volume":"478","author":"Liu","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.lfs.2023.121379_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-68574-2","article-title":"Piperine suppresses the Wnt\/\u03b2-catenin pathway and has anti-cancer effects on colorectal cancer cells","volume":"10","author":"De Almeida","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.lfs.2023.121379_bb0170","first-page":"1","article-title":"Evidences for piperine inhibiting cancer by targeting human G-quadruplex DNA sequences","volume":"6","author":"Tawani","year":"2016","journal-title":"Nat. Publ. Gr."},{"issue":"12","key":"10.1016\/j.lfs.2023.121379_bb0175","first-page":"1","article-title":"Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations","volume":"7l","author":"Osada","year":"2012","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.lfs.2023.121379_bb0180","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.toxlet.2011.02.013","article-title":"Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKC \u2423 \/ERK1\/2-dependent matrix metalloproteinase-9 expression","volume":"203","author":"Pil","year":"2011","journal-title":"Toxicol. Lett."},{"issue":"3","key":"10.1016\/j.lfs.2023.121379_bb0185","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1016\/j.foodchem.2013.04.125","article-title":"Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells","volume":"141","author":"Truong","year":"2013","journal-title":"Food Chem."},{"issue":"12","key":"10.1016\/j.lfs.2023.121379_bb0190","doi-asserted-by":"crossref","DOI":"10.7150\/jca.41418","article-title":"Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics","volume":"11","author":"Shangguan","year":"2020","journal-title":"J. Cancer"},{"issue":"3","key":"10.1016\/j.lfs.2023.121379_bb0195","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1208\/s12248-017-0044-1","article-title":"Scientific and regulatory considerations for generic complex drug products containing nanomaterials","volume":"19","author":"Zheng","year":"2017","journal-title":"AAPS J."},{"issue":"16","key":"10.1016\/j.lfs.2023.121379_bb0200","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.2217\/nnm-2020-0003","article-title":"Phenyl boronic acid-modified lipid nanocarriers of niclosamide for targeting triple-negative breast cancer","volume":"15","author":"Ss Pindiprolu","year":"2020","journal-title":"Nanomedicine"},{"issue":"11","key":"10.1016\/j.lfs.2023.121379_bb0205","doi-asserted-by":"crossref","DOI":"10.1098\/rsos.170611","article-title":"Niclosamide loaded biodegradable chitosan nanocargoes: an in vitro study for potential application in cancer therapy","volume":"4","author":"Naqvi","year":"2017","journal-title":"R. Soc. Open Sci."},{"issue":"4","key":"10.1016\/j.lfs.2023.121379_bb0210","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1039\/C5TB02351C","article-title":"Fabrication of electrospun poly(ethylene oxide)-poly(capro lactone) composite nanofibers for co-delivery of niclosamide and silver nanoparticles exhibits enhanced anti-cancer effects in vitro","volume":"4","author":"Dubey","year":"2016","journal-title":"J. Mater. Chem. B"},{"issue":"5","key":"10.1016\/j.lfs.2023.121379_bb0215","first-page":"1","article-title":"Dual drug delivery of curcumin and niclosamide using PLGA nanoparticles for improved therapeutic effect on breast cancer cells","volume":"27","author":"P. R.S","year":"2020","journal-title":"J. Polym. Res."},{"key":"10.1016\/j.lfs.2023.121379_bb0220","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jddst.2015.08.009","article-title":"Piperine loaded PEG-PLGA nanoparticles: preparation, characterization and targeted delivery for adjuvant breast cancer chemotherapy","volume":"29","author":"Pachauri","year":"2015","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"7","key":"10.1016\/j.lfs.2023.121379_bb0225","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.3109\/10717544.2015.1039667","article-title":"Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment","volume":"23","author":"Katiyar","year":"2016","journal-title":"Drug Deliv."},{"issue":"13","key":"10.1016\/j.lfs.2023.121379_bb0230","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.addr.2009.05.006","article-title":"Combination therapy: opportunities and challenges for polymer \u2013 drug conjugates as anticancer nanomedicines","volume":"61","author":"Vicent","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"8","key":"10.1016\/j.lfs.2023.121379_bb0235","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1039\/C4NR07677J","article-title":"Programmable nanomedicine: synergistic and sequential drug delivery systems","volume":"7","author":"Pacardo","year":"2015","journal-title":"Nanoscale"},{"issue":"7","key":"10.1016\/j.lfs.2023.121379_bb0240","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.ctrv.2008.04.003","article-title":"Multi-functional nanocarriers to overcome tumor drug resistance","volume":"34","author":"Jabr-Milane","year":"2008","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.lfs.2023.121379_bb0245","series-title":"Handbook of Pharmaceutical Excipients","author":"Raymond","year":"2009"},{"issue":"1","key":"10.1016\/j.lfs.2023.121379_bb0250","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/jfb9010011","article-title":"Formulation of poloxamers for drug delivery","volume":"9","author":"Bodratti","year":"2018","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.lfs.2023.121379_bb0255","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ejps.2018.03.030","article-title":"Development of core-shell nanocarrier system for augmenting piperine cytotoxic activity against human brain cancer cell line","volume":"118","author":"Sedeky","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"issue":"8","key":"10.1016\/j.lfs.2023.121379_bb0260","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.2174\/138945011795906615","article-title":"PEO-PPO block copolymers for passive micellar targeting and overcoming multidrug resistance in cancer therapy","volume":"12","author":"Alvarez-Lorenzo","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.lfs.2023.121379_bb0265","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/jat.1261","article-title":"In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine","volume":"28","author":"Odorico","year":"2008","journal-title":"J. Appl. Toxicol."},{"issue":"3","key":"10.1016\/j.lfs.2023.121379_bb0270","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1258\/la.2012.150312","article-title":"Guide for the care and use of laboratory animals","volume":"46","author":"Albus","year":"2012","journal-title":"Lab. Anim."},{"issue":"1","key":"10.1016\/j.lfs.2023.121379_bb0275","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.canlet.2014.11.017","article-title":"Piperine inhibits the growth and motility of triple-negative breast cancer cells","volume":"357","author":"Greenshields","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.lfs.2023.121379_bb0280","article-title":"Switching indication of PEGylated lipid nanocapsules-loaded with rolapitant and deferasirox against breast cancer: enhanced in-vitro and in-vivo cytotoxicity","volume":"305","author":"Fawzi","year":"2022","journal-title":"Life Sci."},{"issue":"22","key":"10.1016\/j.lfs.2023.121379_bb0285","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1016\/j.lfs.2005.10.006","article-title":"Ascitic and solid ehrlich tumor inhibition by Chenopodium ambrosioides L. treatment","volume":"78","author":"Nascimento","year":"2006","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.lfs.2023.121379_bb0290","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijpharm.2017.08.064","article-title":"Nanoprecipitation process: from encapsulation to drug delivery","volume":"532","author":"Mart\u00ednez Rivas","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.lfs.2023.121379_bb0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics13010097","article-title":"Amorphous solid dispersions and the contribution of nanoparticles to in vitro dissolution and in vivo testing: niclosamide as a case study","volume":"13","author":"Jara","year":"2021","journal-title":"Pharmaceutics"},{"issue":"46","key":"10.1016\/j.lfs.2023.121379_bb0300","doi-asserted-by":"crossref","first-page":"23068","DOI":"10.1021\/jp0634149","article-title":"Effect of acid on the aggregation of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymers","volume":"110","author":"Yang","year":"2006","journal-title":"J. Phys. Chem. B"},{"issue":"7","key":"10.1016\/j.lfs.2023.121379_bb0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jnci\/djv073","article-title":"MCF-7 cells - changing the course of breast cancer research and care for 45 years","volume":"107","author":"Lee","year":"2015","journal-title":"J. Natl. Cancer Inst."},{"issue":"13","key":"10.1016\/j.lfs.2023.121379_bb0310","first-page":"2375","article-title":"Ehrlich ascites carcinoma","volume":"10","author":"Ozaslan","year":"2011","journal-title":"Afr. J. Biotechnol."},{"issue":"18","key":"10.1016\/j.lfs.2023.121379_bb0315","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1200\/JCO.2005.05.064","article-title":"Cyclin D1 in breast cancer pathogenesis","volume":"23","author":"Arnold","year":"2014","journal-title":"J. Clin. Oncol."},{"issue":"18","key":"10.1016\/j.lfs.2023.121379_bb0320","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.4161\/cc.7.18.6733","article-title":"GSK-3\u03b2 inhibition: at the crossroad between akt and mTOR constitutive activation to enhance cyclin D1 protein stability in mantle cell lymphoma","volume":"7","author":"Dal Col","year":"2016","journal-title":"Cell Cycle"},{"issue":"10","key":"10.1016\/j.lfs.2023.121379_bb0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jbt.22869","article-title":"Polydatin gold nanoparticles potentiate antitumor effect of doxorubicin in Ehrlich ascites carcinoma-bearing mice","volume":"35","author":"Samra","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.lfs.2023.121379_bb0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcell.2018.00010","article-title":"Cancer chemoprevention and piperine: molecular mechanisms and therapeutic opportunities","volume":"6","author":"Rather","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"issue":"7","key":"10.1016\/j.lfs.2023.121379_bb0335","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1074\/jbc.M607368200","article-title":"MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines","volume":"282","author":"Chrestensen","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"22","key":"10.1016\/j.lfs.2023.121379_bb0340","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1016\/S0021-9258(18)63504-5","article-title":"Superoxide dismutase: an enzymic function for erthrocuprein (hemocuprein)","volume":"244","author":"McCord","year":"1969","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.lfs.2023.121379_bb0345","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF03179070","article-title":"Superoxide dismutases: a physiopharmacological update","volume":"65","author":"Valdivia","year":"2009","journal-title":"J. Physiol. Biochem."},{"issue":"2022","key":"10.1016\/j.lfs.2023.121379_bb0350","article-title":"Piperine is capable of improving pancreatic \u03b2-cell apoptosis in high fat diet and streptozotocin induced diabetic mice","volume":"88","author":"He","year":"2022","journal-title":"J. Funct. Foods"},{"issue":"2","key":"10.1016\/j.lfs.2023.121379_bb0355","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1365-2710.2001.00334.x","article-title":"Plasma malondialdehyde (MDA) levels in breast and lung cancer patients","volume":"26","author":"G\u00f6nen\u00e7","year":"2001","journal-title":"J. Clin. Pharm. Ther."},{"issue":"4","key":"10.1016\/j.lfs.2023.121379_bb0360","first-page":"49","article-title":"Cytotoxicity potential of piperine ans sorafenib combination in human MDA-MB-231","volume":"14","author":"Mohany","year":"2019","journal-title":"Biochem. Lett."},{"issue":"6","key":"10.1016\/j.lfs.2023.121379_bb0365","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","article-title":"Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor","volume":"96","author":"Brunet","year":"1999","journal-title":"Cell"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523000139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523000139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:07:48Z","timestamp":1758402468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320523000139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":73,"alternative-id":["S0024320523000139"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2023.121379","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fortified anti-proliferative activity of niclosamide for breast cancer treatment: In-vitro and in-vivo assessment","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2023.121379","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"121379"}}