{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:27:52Z","timestamp":1788269272690,"version":"build-2803163510"},"reference-count":155,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009392","name":"Prince Sattam bin Abdulaziz University","doi-asserted-by":"publisher","award":["PSAU\/2023\/R\/1444"],"award-info":[{"award-number":["PSAU\/2023\/R\/1444"]}],"id":[{"id":"10.13039\/100009392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.lfs.2023.121389","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T20:37:13Z","timestamp":1673642233000},"page":"121389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Guaiazulene and related compounds: A review of current perspective on biomedical applications"],"prefix":"10.1016","volume":"316","author":[{"given":"Wasim","family":"Akram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priti","family":"Tagde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakeel","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swamita","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talha Bin","family":"Emran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad O.","family":"Babalghith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherouk Hussein","family":"Sweilam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Simal-Gandara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0005","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tiv.2010.09.008","article-title":"Cytotoxic activity of guaiazulene on gingival fibroblasts and the influence of light exposure on guaiazulene-induced cell death","volume":"25","author":"Fiori","year":"2011","journal-title":"Toxicol. in Vitro"},{"issue":"2","key":"10.1016\/j.lfs.2023.121389_bb0010","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/14767058.2012.722711","article-title":"Guaiazulene: a new treatment option for recalcitrant diaper dermatitis in NICU patients","volume":"26","author":"Gunes","year":"2013","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0015","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/10575630290013585","article-title":"Synthesis and antioxidant activity of 3-substituted guaiazulene derivatives","volume":"16","author":"Pratsinis","year":"2002","journal-title":"Nat. Prod. Lett."},{"issue":"2\u20133","key":"10.1016\/j.lfs.2023.121389_bb0020","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jphotochem.2010.02.007","article-title":"Photoirradiation of azulene and guaiazulene\u2014formation of reactive oxygen species and induction of lipid peroxidation","volume":"211","author":"Chiang","year":"2010","journal-title":"J. Photochem. Photobiol. A Chem."},{"issue":"2","key":"10.1016\/j.lfs.2023.121389_bb0025","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/cbdd.12753","article-title":"Synthesis and biological evaluation of 3, 8-dimethyl-5-isopropylazulene derivatives as anti-gastric ulcer agent","volume":"88","author":"Cao","year":"2016","journal-title":"Chem. Biol. Drug Des."},{"issue":"2","key":"10.1016\/j.lfs.2023.121389_bb0030","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jare.2015.07.003","article-title":"Chemical and biological profile of cespitularia species: a mini review","volume":"7","author":"Elshamy","year":"2016","journal-title":"J. Adv. Res."},{"issue":"10","key":"10.1016\/j.lfs.2023.121389_bb0035","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1248\/cpb.48.1452","article-title":"Isolation and characterization of bioactive metabolites from marine-derived filamentous fungi collected from tropical and sub-tropical coral reefs","volume":"48","author":"Namikoshi","year":"2000","journal-title":"Chem. Pharm. Bull."},{"issue":"2","key":"10.1016\/j.lfs.2023.121389_bb0040","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF02976537","article-title":"Anti-ulcer activity of newly synthesized acylquinoline derivatives","volume":"22","author":"Cheon","year":"1999","journal-title":"Arch. Pharm. Res."},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0045","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/003655202753387293","article-title":"Expression and immunolocalization of heat shock proteins in the healing of gastric ulcers in rats","volume":"37","author":"Guo","year":"2002","journal-title":"Scand. J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0050","doi-asserted-by":"crossref","first-page":"29","DOI":"10.5455\/jice.20141124062203","article-title":"Guaiazulene biochemical activity and cytotoxic and genotoxic effects on rat neuron and N2a neuroblastom cells","volume":"4","author":"Togar","year":"2015","journal-title":"J. Intercult. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0055","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0939-6411(03)00100-0","article-title":"Stabilization of sodium guaiazulene sulfonate in granules for tableting prepared using a twin-screw extruder","volume":"56","author":"Nakamichi","year":"2003","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0060","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13321-017-0247-6","article-title":"The CompTox chemistry dashboard: a community data resource for environmental chemistry","volume":"9","author":"Williams","year":"2017","journal-title":"J. Cheminform."},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0065","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijfoodmicro.2010.03.032","article-title":"Effect of Matricaria chamomilla L. flower essential oil on the growth and ultrastructure of aspergillus Niger van tieghem","volume":"139","author":"Tolouee","year":"2010","journal-title":"Int. J. Food Microbiol."},{"issue":"9","key":"10.1016\/j.lfs.2023.121389_bb0070","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.2042-7158.1997.tb06140.x","article-title":"Antioxidant activity of guaiazulene and protection against paracetamol hepatotoxicity in rats","volume":"49","author":"Kourounakis","year":"1997","journal-title":"J. Pharm. Pharmacol."},{"issue":"6","key":"10.1016\/j.lfs.2023.121389_bb0075","first-page":"347","article-title":"Pharmacological studies of lumisantonin derivatives, with special reference to anti-inflammatory effect and to histamine-release inhibitory action","volume":"15","author":"Yamasaki","year":"1961","journal-title":"Acta Med. Okayama (1952)"},{"issue":"3_suppl","key":"10.1016\/j.lfs.2023.121389_bb0080","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/109158189901800304","article-title":"Final report on the safety assessment of azulene","volume":"18","author":"Andersen","year":"2016","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.lfs.2023.121389_bb0085","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jchromb.2018.03.041","article-title":"Determination and pharmacokinetic study of guaiol in rat plasma by gas chromatography-mass spectrometry with selected ion monitoring","volume":"1085","author":"Yang","year":"2018","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"issue":"6 Suppl. 1","key":"10.1016\/j.lfs.2023.121389_bb0090","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1016\/j.bj.2020.06.009","article-title":"Antinociceptive effect and mechanism of supercritical carbon dioxide extract of Aloysia gratissima leaves in mice","volume":"44","author":"Souza","year":"2021","journal-title":"Biomed. J."},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0095","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0015-6264(77)80386-6","article-title":"Regeneration of rat liver in the presence of essential oils and their components","volume":"15","author":"Gershbein","year":"1977","journal-title":"Food Cosmet. Toxicol."},{"issue":"2\u20133","key":"10.1016\/j.lfs.2023.121389_bb0100","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tox.2005.04.017","article-title":"Effects of a low dose of bentazon on spermatogenesis of mice exposed during foetal, postnatal and adult life","volume":"212","author":"Garagna","year":"2005","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.lfs.2023.121389_bb0105","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.canlet.2004.03.049","article-title":"Inhibitory effects of 7-hydroxy-3-methoxy-cadalene on 4-(methylinitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A\/J mice","volume":"213","author":"Kim","year":"2004","journal-title":"Cancer Lett."},{"key":"10.1016\/j.lfs.2023.121389_bb0110","series-title":"Development of Heterocycle-Substituted and Fused Azulenes in the Last Decade (2010\u20132020)","first-page":"7087","volume":"21(19)","author":"Shoji","year":"2020"},{"issue":"10","key":"10.1016\/j.lfs.2023.121389_bb0115","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202000628","article-title":"Azulene-based molecules, polymers, and frameworks for optoelectronic and energy applications","volume":"4","author":"Huang","year":"2020","journal-title":"Small Methods"},{"issue":"72","key":"10.1016\/j.lfs.2023.121389_bb0120","doi-asserted-by":"crossref","first-page":"17318","DOI":"10.1002\/chem.202002163","article-title":"Germacrene A-A central intermediate in sesquiterpene biosynthesis","volume":"26","author":"Xu","year":"2020","journal-title":"Chemistry"},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0125","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.aca.2008.10.013","article-title":"Use of headspace mulberry paper bag micro solid phase extraction for characterization of volatile aromas of essential oils from bulgarian rose and provence lavender","volume":"631","author":"Won","year":"2009","journal-title":"Anal. Chim. Acta"},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0130","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40490-016-0068-9","article-title":"Temporal and spatial expression of terpene synthase genes associated with agarwood formation in Aquilaria malaccensis lam","volume":"46","author":"Azzarina","year":"2016","journal-title":"N. Z. J. For. Sci."},{"issue":"5","key":"10.1016\/j.lfs.2023.121389_bb0135","doi-asserted-by":"crossref","first-page":"8521","DOI":"10.3390\/molecules20058521","article-title":"A comprehensive review on the phytochemical constituents and pharmacological activities of Pogostemon cablin benth.: an aromatic medicinal plant of industrial importance","volume":"20","author":"Swamy","year":"2015","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0140","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.dld.2011.10.012","article-title":"Can clinical features stratify use of endoscopy for dyspeptic patients with high background prevalence of upper gastrointestinal cancer?","volume":"44","author":"Hsu","year":"2012","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.lfs.2023.121389_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/7854_2020_141","article-title":"A review of the cholinergic system and therapeutic approaches to treat brain disorders","volume":"45","author":"Bertrand","year":"2020","journal-title":"Curr. Top. Behav. Neurosci."},{"issue":"9","key":"10.1016\/j.lfs.2023.121389_bb0150","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1017\/S0031182017002335","article-title":"The in vitro antileishmanial activity of essential oil from Aloysia gratissima and guaiol, its major sesquiterpene against leishmania amazonensis","volume":"145","author":"Garcia","year":"2018","journal-title":"Parasitology"},{"issue":"8","key":"10.1016\/j.lfs.2023.121389_bb0155","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1080\/15384047.2018.1451277","article-title":"(-)-guaiol regulates autophagic cell death depending on mTOR signaling in NSCLC","volume":"19","author":"Yang","year":"2018","journal-title":"Cancer Biol. Ther."},{"issue":"38","key":"10.1016\/j.lfs.2023.121389_bb0160","doi-asserted-by":"crossref","first-page":"62585","DOI":"10.18632\/oncotarget.11540","article-title":"(-)-guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.lfs.2023.121389_bb0165","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jbior.2016.12.001","article-title":"Discrete signaling mechanisms of mTORC1 and mTORC2: connected yet apart in cellular and molecular aspects","volume":"64","author":"Jhanwar-Uniyal","year":"2017","journal-title":"Adv. Biol. Regul."},{"issue":"5","key":"10.1016\/j.lfs.2023.121389_bb0170","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1158\/0008-5472.CAN-08-3014","article-title":"TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2","volume":"69","author":"Copp","year":"2009","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.lfs.2023.121389_bb0175","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1158\/1535-7163.MCT-15-0029","article-title":"Inhibition of mTORC2 induces cell-cycle arrest and enhances the cytotoxicity of doxorubicin by suppressing MDR1 expression in HCC cells","volume":"14","author":"Chen","year":"2015","journal-title":"Mol. Cancer Ther."},{"issue":"11","key":"10.1016\/j.lfs.2023.121389_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/agronomy10111650","article-title":"The prospect of bentazone-tolerant soybean for conventional cultivation","volume":"10","author":"Ali","year":"2020","journal-title":"Agronomy"},{"key":"10.1016\/j.lfs.2023.121389_bb0185","first-page":"111","article-title":"Environmental behavior of bentazon herbicide","volume":"137","author":"Huber","year":"1994","journal-title":"Rev. Environ. Contam. Toxicol."},{"issue":"2","key":"10.1016\/j.lfs.2023.121389_bb0190","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1017\/wet.2016.16","article-title":"Postemergence weed control in onion with bentazon, flumioxazin, and oxyfluorfen","volume":"31","author":"Herrmann","year":"2017","journal-title":"Weed Technol."},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0195","doi-asserted-by":"crossref","DOI":"10.32473\/edis-ag367-2020","article-title":"Diagnosing herbicide injury in cotton","volume":"2020","author":"Devkota","year":"2020","journal-title":"Edis"},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0200","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/10412905.2001.9699594","article-title":"Azulenes, Costols and \u0393-Lactones from Cypress-Pines (Callitris columellaris, C. glaucophyllaandC. intratropica) distilled oils and methanol extracts","volume":"13","author":"Doimo","year":"2001","journal-title":"J. Essent. Oil Res."},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0205","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/plants11010021","article-title":"Exploring pharmacological mechanisms of essential oils on the central nervous system","volume":"11","author":"Soares","year":"2021","journal-title":"Plants"},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0210","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tetasy.2010.12.013","article-title":"Lewis acid- and bronsted acid-catalyzed stereoselective rearrangement of epoxides derived from himachalenes: access to new chiral polycyclic structures","volume":"22","author":"El Haib","year":"2011","journal-title":"Tetrahedron Asymmetry"},{"key":"10.1016\/j.lfs.2023.121389_bb0215","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5620530","article-title":"Synthesis, electrochemical, thermodynamic, and quantum chemical investigations of amino cadalene as a corrosion inhibitor for stainless steel type 321 in sulfuric acid 1M","volume":"2020","author":"Koumya","year":"2020","journal-title":"Int. J. Electrochem."},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0220","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/molecules21010042","article-title":"The prodrug approach: a successful tool for improving drug solubility","volume":"21","author":"Jornada","year":"2015","journal-title":"Molecules"},{"issue":"22","key":"10.1016\/j.lfs.2023.121389_bb0225","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.1016\/j.bmcl.2007.08.071","article-title":"Enhanced efficacy of 7-hydroxy-3-methoxycadalene via glycosylation in in vivo xenograft study","volume":"17","author":"Lee","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"5","key":"10.1016\/j.lfs.2023.121389_bb0230","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ptr.1427","article-title":"Antioxidative effects of 7-hydroxy-3-methoxy-cadalene extracted from Zelkova serrata on 4-(methylinitros amino)-1-(3-pyridyl)-1-butanone-induced oxidative stress in A\/J mice","volume":"18","author":"Kim","year":"2004","journal-title":"Phytother. Res."},{"issue":"2","key":"10.1016\/j.lfs.2023.121389_bb0235","first-page":"332","article-title":"Anticancer and antioxidant activities of Matricaria chamomilla L. and Marjorana hortensis essential oils","volume":"4","author":"Romeilah","year":"2009","journal-title":"Res. J. Med. Med. Sci."},{"issue":"10","key":"10.1016\/j.lfs.2023.121389_bb0240","first-page":"83","article-title":"PHCOG MAG.: research article retardation of biofilm formation with reduced productivity of alginate as a result of Pseudomonas aeruginosa exposure to Matricaria chamomilla essential oil","volume":"3","author":"Owliaa","year":"2007","journal-title":"Pharmacogn. Mag."},{"issue":"7","key":"10.1016\/j.lfs.2023.121389_bb0245","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/BF01967917","article-title":"Bioactive marine metabolites I. Isolation of guaiazulene from the gorgonianEuplexaura erecta","volume":"37","author":"Fusetani","year":"1981","journal-title":"Experientia"},{"key":"10.1016\/j.lfs.2023.121389_bb0250","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1071\/CH9830211","article-title":"Studies of Australian Soft Corals. XXX*. A Novel Trisnorsesquiterpene from a Cespitularpia Species and the Isolation of Guaiazulene from a Small Blue Alcyonium Species","volume":"36","author":"Matsubara","year":"1983","journal-title":"Aust. J. Chem."},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0255","first-page":"69","article-title":"Antioxidant effect of the essential oil and extract of Matricaria chamomilla L. on isolated rat hepatocytes","volume":"1","author":"Asgary","year":"2002","journal-title":"J. Med. Plant"},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0260","doi-asserted-by":"crossref","first-page":"12","DOI":"10.25004\/IJPSDR.2010.020102","article-title":"Pharmacological potential of Matricaria recutita-a review","volume":"2","author":"Gupta","year":"2010","journal-title":"Int. J. Pharm. Sci. Drug Res."},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-016-1401-9","article-title":"Essential oils: in vitro activity against Leishmania amazonensis, cytotoxicity and chemical composition","volume":"16","author":"Andrade","year":"2016","journal-title":"BMC Complement. Altern. Med."},{"issue":"9","key":"10.1016\/j.lfs.2023.121389_bb0270","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1007\/s12161-014-9821-y","article-title":"Analysis of essential oils from Cassia bark and Cassia twig samples by GC-MS combined with multivariate data analysis","volume":"7","author":"Deng","year":"2014","journal-title":"Food Anal. Methods"},{"issue":"5","key":"10.1016\/j.lfs.2023.121389_bb0275","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3390\/plants9050613","article-title":"The extracts of cinnamon and clove as potential biofungicides against strawberry grey mould","volume":"9","author":"\u0160ernait\u0117","year":"2020","journal-title":"Plants"},{"key":"10.1016\/j.lfs.2023.121389_bb0280","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11102076","article-title":"Phytochemical profile, preliminary toxicity, and antioxidant capacity of the essential oils of Myrciaria floribunda (H. West ex Willd.) O. Berg. and Myrcia sylvatica (G. Mey) DC. (Myrtaceae)","author":"de Moraes","year":"2022","journal-title":"Antioxidants"},{"issue":"19","key":"10.1016\/j.lfs.2023.121389_bb0285","doi-asserted-by":"crossref","first-page":"5722","DOI":"10.1016\/j.bmcl.2011.08.018","article-title":"Synthesis and antigastric ulcer activity of novel 5-isoproyl-3,8-dimethylazulene derivatives","volume":"21","author":"Zhang","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"9","key":"10.1016\/j.lfs.2023.121389_bb0290","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.21873\/anticanres.14491","article-title":"Antitumor effects and tumor-specificity of Guaiazulene-3-carboxylate derivatives against Oral squamous cell carcinoma in vitro","volume":"40","author":"Teratani","year":"2020","journal-title":"Anticancer Res."},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0295","first-page":"385","article-title":"Relationship between electronic structure and cytotoxic activity of azulenes","volume":"20","author":"Kurihara","year":"2006","journal-title":"In Vivo"},{"issue":"4","key":"10.1016\/j.lfs.2023.121389_bb0300","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s00044-021-02701-0","article-title":"In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine","volume":"30","author":"Bakun","year":"2021","journal-title":"Med. Chem. Res."},{"issue":"25","key":"10.1016\/j.lfs.2023.121389_bb0305","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.1021\/jm010307o","article-title":"3-(Arylacetylamino)-N-methylbenzamides: a novel class of selective anti-helicobacter pylori agents","volume":"44","author":"Ando","year":"2001","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.lfs.2023.121389_bb0310","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.foodchem.2013.09.039","article-title":"Hepatoprotection of sesquiterpenoids: a quantitative structure\u2013activity relationship (QSAR) approach","volume":"146","author":"Vinholes","year":"2014","journal-title":"Food Chem."},{"issue":"2","key":"10.1016\/j.lfs.2023.121389_bb0315","first-page":"49","article-title":"The effect of bentazone TP, an herbicide, on hematologic indicators in sheep during acute and subchronic poisoning","volume":"40","author":"S\u00e1ly","year":"1995","journal-title":"Vet. Med."},{"issue":"10","key":"10.1016\/j.lfs.2023.121389_bb0320","article-title":"Guaiol-a naturally occurring insecticidal sesquiterpene","volume":"8","author":"Liu","year":"2013","journal-title":"Nat. Prod. Commun."},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0325","doi-asserted-by":"crossref","first-page":"435","DOI":"10.5650\/jos.ess21241","article-title":"Sesquiterpenoid-rich essential oils from two Magnolia plants: contact and repellent activity to three stored-product insects","volume":"71","author":"Feng","year":"2022","journal-title":"J. Oleo Sci."},{"issue":"2","key":"10.1016\/j.lfs.2023.121389_bb0330","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/14767058.2012.722711","article-title":"Guaiazulene: a new treatment option for recalcitrant diaper dermatitis in NICU patients","volume":"26","author":"Gunes","year":"2013","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.lfs.2023.121389_bb0335","series-title":"Chamomile: Industrial Profiles","author":"Franke","year":"2005"},{"issue":"5","key":"10.1016\/j.lfs.2023.121389_bb0340","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0360-3016(97)00903-6","article-title":"Mucosa-adhesive water-soluble polymer film for treatment of acute radiation-induced oral mucositis","volume":"40","author":"Oguchi","year":"1998","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.lfs.2023.121389_bb0345","series-title":"Recognition and Management of Pesticide Poisonings","first-page":"10","author":"Morgan","year":"1982"},{"key":"10.1016\/j.lfs.2023.121389_bb0350","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/bs.apha.2017.03.004","article-title":"Cannabis pharmacology: the usual suspects and a few promising leads","volume":"80","author":"Russo","year":"2017","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.lfs.2023.121389_bb0355","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ejmech.2018.07.040","article-title":"Azulene-based compounds for targeting orexin receptors","volume":"157","author":"Leino","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.lfs.2023.121389_bb0360","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.mib.2019.10.008","article-title":"Antibiotics: past, present and future","volume":"51","author":"Hutchings","year":"2019","journal-title":"Curr. Opin. Microbiol."},{"issue":"4","key":"10.1016\/j.lfs.2023.121389_bb0365","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s00044-021-02701-0","article-title":"In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine","volume":"30","author":"Bakun","year":"2021","journal-title":"Med. Chem. Res."},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0370","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12011-021-02624-2","article-title":"Mitochondrial dysfunction in arsenic-induced hepatotoxicity: pathogenic and therapeutic implications","volume":"200","author":"Prakash","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"issue":"13","key":"10.1016\/j.lfs.2023.121389_bb0375","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.3748\/wjg.v27.i13.1296","article-title":"COVID-19 and comorbidities of hepatic diseases in a global perspective","volume":"27","author":"Ahmad","year":"2021","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.lfs.2023.121389_bb0380","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jiph.2021.12.014","article-title":"The SARS-CoV-2 mutations versus vaccine effectiveness: new opportunities to new challenges","volume":"15","author":"Malik","year":"2022","journal-title":"J. Infect Public Health"},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0385","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/MPG.0000000000003204","article-title":"Gastrointestinal perspective of coronavirus disease 2019 in children-an updated review","volume":"73","author":"Assa","year":"2021","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"issue":"6","key":"10.1016\/j.lfs.2023.121389_bb0390","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/0006-2952(88)90499-6","article-title":"Interaction of flavonoids with 1,1-diphenyl-2-picrylhydrazyl free radical, liposomal membranes and soybean lipoxygenase-1","volume":"37","author":"Ratty","year":"1988","journal-title":"Biochem. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2023.121389_bb0395","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/03602539509029821","article-title":"Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury","volume":"27","author":"Nelson","year":"1995","journal-title":"Drug Metab. Rev."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2023.121389_bb0400","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0027-5107(03)00131-3","article-title":"Photomutagenicity of cosmetic ingredient chemicals azulene and guaiazulene","volume":"530","author":"Wang","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.lfs.2023.121389_bb0405","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.toxrep.2017.02.005","article-title":"Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes","volume":"4","author":"Banerjee","year":"2017","journal-title":"Toxicol. Rep."},{"issue":"04","key":"10.1016\/j.lfs.2023.121389_bb0410","first-page":"167","article-title":"Effect of a guaiazulene-containing ointment on nipple and areola area health of women","volume":"06","author":"Furau","year":"2016","journal-title":"J. Cosmetics Dermatol. Sci. Appl."},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0415","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.pop.2011.05.001","article-title":"Peptic ulcer disease","volume":"38","author":"Najm","year":"2011","journal-title":"Prim. Care"},{"issue":"7","key":"10.1016\/j.lfs.2023.121389_bb0420","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1248\/cpb.50.904","article-title":"Synthesis of new azulene derivatives and study of their effect on lipid peroxidation and lipoxygenase activity","volume":"50","author":"Rekka","year":"2002","journal-title":"Chem. Pharm. Bull."},{"issue":"4","key":"10.1016\/j.lfs.2023.121389_bb0425","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s002800050583","article-title":"Gastric mucosal blood flow and gastric secretion following intravenous administration of 5-fluorouracil in anesthetized rats","volume":"39","author":"Kakinuma","year":"1997","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10715769009148569","article-title":"How to characterize a biological antioxidant","volume":"9","author":"Halliwell","year":"1990","journal-title":"Free Radic. Res. Commun."},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0435","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/0016-5085(86)90622-0","article-title":"Induction of duodenal ulcers in rats under water-immersion stress conditions. Influence of stress on gastric acid and duodenal alkaline secretion","volume":"91","author":"Takeuchi","year":"1986","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.lfs.2023.121389_bb0440","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1527-3466.2001.tb00072.x","article-title":"A review of HNS-32: a novel azulene-l-carboxamidine derivative with multiple cardiovascular protective actions","volume":"19","author":"Tanaka","year":"2001","journal-title":"Cardiovasc. Drug Rev."},{"issue":"4","key":"10.1016\/j.lfs.2023.121389_bb0445","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1159\/000215593","article-title":"Skin care in the NICU patient: effects of wipes versus cloth and water on stratum corneum integrity","volume":"96","author":"Visscher","year":"2009","journal-title":"Neonatology"},{"issue":"4","key":"10.1016\/j.lfs.2023.121389_bb0450","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0031-3955(05)70248-0","article-title":"Diaper dermatitis","volume":"47","author":"Kazaks","year":"2000","journal-title":"Pediatr. Clin. N. Am."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2023.121389_bb0455","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/03602539509029821","article-title":"Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury","volume":"27","author":"Nelson","year":"1995","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.lfs.2023.121389_bb0460","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ejca.2018.07.005","article-title":"Cancer incidence and mortality patterns in Europe: estimates for 40 countries and 25 major cancers in 2018","volume":"103","author":"Ferlay","year":"2018","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.lfs.2023.121389_bb0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112375","article-title":"Drugs repurposed: an advanced step towards the treatment of breast cancer and associated challenges","volume":"145","author":"Malik","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2023.121389_bb0470","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27227668","article-title":"Can natural products targeting EMT serve as the future anticancer therapeutics?","author":"Anwar","year":"2022","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.lfs.2023.121389_bb0475","first-page":"1","article-title":"Chamazulene-rich Artemisia arborescens essential oils affect the cell growth of human melanoma cells","volume":"9","author":"Russo","year":"2020","journal-title":"Plants (Basel)"},{"issue":"6","key":"10.1016\/j.lfs.2023.121389_bb0480","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s10616-014-9729-9","article-title":"Cytotoxicity and genotoxicity of zingiberene on different neuron cell lines in vitro","volume":"67","author":"Togar","year":"2015","journal-title":"Cytotechnology"},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0485","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1590\/S1516-8913201502880","article-title":"In vitro cytotoxic, genotoxic and antioxidant\/oxidant effects of guaiazulene on human lymphocytes","volume":"58","author":"To\u011far","year":"2015","journal-title":"Braz. Arch. Biol. Technol."},{"issue":"20","key":"10.1016\/j.lfs.2023.121389_bb0490","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.1016\/j.bmcl.2010.08.025","article-title":"Novel azulene-based derivatives as potent multi-receptor tyrosine kinase inhibitors","volume":"20","author":"Chen","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"April","key":"10.1016\/j.lfs.2023.121389_bb0495","article-title":"Guaiazulene triggers ROS-induced apoptosis and protective autophagy in non-small cell lung cancer","volume":"12","author":"Ye","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0500","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.3390\/ijerph10031062","article-title":"UVA photoirradiation of nitro-polycyclic aromatic hydrocarbons-induction of reactive oxygen species and formation of lipid peroxides","volume":"10","author":"Xia","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.lfs.2023.121389_bb0505","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.pdpdt.2018.10.015","article-title":"Effects of photodynamic therapy with azulene on peripheral blood mononuclear cell viability and singlet oxygen formation","volume":"24","author":"Damrongrungruang","year":"2018","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"8","key":"10.1016\/j.lfs.2023.121389_bb0510","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1902\/jop.2005.76.8.1275","article-title":"Comparative study between the effects of photodynamic therapy and conventional therapy on microbial reduction in ligature-induced peri-implantitis in dogs","volume":"76","author":"Hayek","year":"2005","journal-title":"J. Periodontol."},{"issue":"2","key":"10.1016\/j.lfs.2023.121389_bb0515","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s10266-017-0321-6","article-title":"Effect of antimicrobial photodynamic therapy (aPDT) on the sterilization of infected dentin in vitro","volume":"106","author":"Nagai","year":"2018","journal-title":"Odontology"},{"issue":"2","key":"10.1016\/j.lfs.2023.121389_bb0520","doi-asserted-by":"crossref","first-page":"208","DOI":"10.5507\/bp.2012.083","article-title":"In vitro antimicrobial activities of cinnamon bark oil, anethole, carvacrol, eugenol and guaiazulene against mycoplasma hominis clinical isolates","volume":"158","author":"Sleha","year":"2014","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub."},{"key":"10.1016\/j.lfs.2023.121389_bb0525","first-page":"42","article-title":"Bioactive compounds from marine invertebrates for potential medicines - an overview","volume":"34","author":"Datta","year":"2015","journal-title":"Int. Lett. Nat. Sci."},{"issue":"8","key":"10.1016\/j.lfs.2023.121389_bb0530","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/ptj\/pzx056","article-title":"Impact of inflammation and anti-inflammatory modalities on skeletal muscle healing: from fundamental research to the clinic","volume":"97","author":"Duchesne","year":"2017","journal-title":"Phys. Ther."},{"issue":"2","key":"10.1016\/j.lfs.2023.121389_bb0535","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1080\/09168451.2019.1682511","article-title":"Chamazulene reverses osteoarthritic inflammation through regulation of matrix metalloproteinases (MMPs) and NF-k\u03b2 pathway in in-vitro and in-vivo models","volume":"84","author":"Ma","year":"2020","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"2","key":"10.1016\/j.lfs.2023.121389_bb0540","first-page":"79","article-title":"Essential oils of aromatic plants with antibacterial, antifungal, antiviral, and cytotoxic properties--an overview","volume":"16","author":"Reichling","year":"2009","journal-title":"Forsch. Komplementmed. (2006)"},{"issue":"12","key":"10.1016\/j.lfs.2023.121389_bb0545","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1248\/cpb.38.3355","article-title":"Studies on anti-ulcer agents. II. Synthesis and anti-ulcer activities of 6-isopropylazulene-1-sodium sulfonate derivatives","volume":"38","author":"Yanagisawa","year":"1990","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.lfs.2023.121389_bb0550","doi-asserted-by":"crossref","first-page":"9191743","DOI":"10.1155\/2018\/9191743","article-title":"Anti-inflammatory effect of columbianetin on lipopolysaccharide-stimulated human peripheral blood mononuclear cells","volume":"2018","author":"Lu","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.lfs.2023.121389_bb0555","article-title":"The effect of some cosolvents and surfactants on viability of cancerous cell lines","volume":"1","author":"Hamzeloo-Moghadam","year":"2014","journal-title":"Res. J. Pharmacogn."},{"key":"10.1016\/j.lfs.2023.121389_bb0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.101747","article-title":"Anti-inflammatory effect of photodynamic therapy using guaiazulene and red lasers on peripheral blood mononuclear cells","volume":"31","author":"Phutim-Mangkhalthon","year":"2020","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0565","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1080\/14756366.2018.1474212","article-title":"Synthesis and in vivo anti-ulcer evaluation of some novel piperidine linked dihydropyrimidinone derivatives","volume":"33","author":"Ahmad Bhat","year":"2018","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"7","key":"10.1016\/j.lfs.2023.121389_bb0570","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.2042-7158.1991.tb03519.x","article-title":"Effect of hydroxyethyl rutosides and related compounds on lipid peroxidation and free radical scavenging activity. Some structural aspects","volume":"43","author":"Rekka","year":"1991","journal-title":"J. Pharm. Pharmacol."},{"issue":"9","key":"10.1016\/j.lfs.2023.121389_bb0575","article-title":"Substituent constants for correlation analysis in chemistry and biology. By Corwin Hansch and Albert Leo. Wiley, 605 Third Ave., New York, NY 10016. 1979. 339 pp. 21 \u00c3\u2014 28 cm. Price $24.95","volume":"69","author":"Flynn","year":"1980","journal-title":"J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0580","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/tx00031a001","article-title":"Mechanisms and biological relevance of lipid peroxidation initiation","volume":"6","author":"Dix","year":"2002","journal-title":"Chem. Res. Toxicol."},{"issue":"11","key":"10.1016\/j.lfs.2023.121389_bb0585","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1021\/jm00037a017","article-title":"Antipsoriatic anthrones with modulated redox properties. 2. Novel derivatives of chrysarobin and isochrysarobin-antiproliferative activity and 5-lipoxygenase inhibition","volume":"37","author":"M\u00c3\u00bcller","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.lfs.2023.121389_bb0590","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.lfs.2023.121389_bb0595","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1439-0531.2011.01756.x","article-title":"Effects of guaiazulene on in vitro bovine embryo production and on mRNA transcripts related to embryo quality","volume":"46","author":"Dovolou","year":"2011","journal-title":"Reprod. Domest. Anim."},{"issue":"7","key":"10.1016\/j.lfs.2023.121389_bb0600","doi-asserted-by":"crossref","first-page":"568","DOI":"10.34172\/aim.2021.80","article-title":"Prevalence of dyspepsia in Iran: a systematic review and meta-analysis","volume":"24","author":"Karimian","year":"2021","journal-title":"Arch. Iran. Med."},{"key":"10.1016\/j.lfs.2023.121389_bb0605","doi-asserted-by":"crossref","first-page":"17081","DOI":"10.1038\/nrdp.2017.81","article-title":"Functional dyspepsia","volume":"3","author":"Enck","year":"2017","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0610","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/MCG.0b013e318241b335","article-title":"Dyspepsia: organic versus functional","volume":"46","author":"Oustamanolakis","year":"2012","journal-title":"J. Clin. Gastroenterol."},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0615","doi-asserted-by":"crossref","first-page":"349","DOI":"10.5009\/gnl16055","article-title":"Functional dyspepsia: advances in diagnosis and therapy","volume":"11","author":"Talley","year":"2017","journal-title":"Gut Liver"},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0620","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1136\/flgastro-2019-101386","article-title":"Side effects of drug treatments for gastro-oesophageal reflux disease: current controversies","volume":"13","author":"Dhar","year":"2022","journal-title":"Frontline Gastroenterol."},{"key":"10.1016\/j.lfs.2023.121389_bb0625","author":"Marakhouski"},{"issue":"4","key":"10.1016\/j.lfs.2023.121389_bb0630","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000056135","article-title":"Inhibitory effect of egualen sodium: a new stable derivative of azulene on histamine release from mast cell-like cells in the stomach","volume":"63","author":"Akagi","year":"2001","journal-title":"Pharmacology"},{"issue":"6-7","key":"10.1016\/j.lfs.2023.121389_bb0635","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0399-8320(05)82156-6","article-title":"Quality of life scale and impact of a topical treatment on symptoms of gastro-esophageal reflux without severe esophagitis","volume":"29","author":"Lepl\u00c3\u00a8ge","year":"2005","journal-title":"Gastroenterol. Clin. Biol."},{"issue":"4","key":"10.1016\/j.lfs.2023.121389_bb0640","doi-asserted-by":"crossref","first-page":"537","DOI":"10.15403\/jgld.2014.1121.254.dea","article-title":"Mucosal protective compounds in the treatment of gastroesophageal reflux disease. A position paper based on evidence of the Romanian Society of Neurogastroenterology","volume":"25","author":"Surdea-Blaga","year":"2016","journal-title":"J. Gastrointestin. Liver Dis."},{"issue":"24","key":"10.1016\/j.lfs.2023.121389_bb0645","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.2174\/092986707782023253","article-title":"Plant troponoids: chemistry, biological activity, and biosynthesis","volume":"14","author":"Zhao","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.lfs.2023.121389_bb0650","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ctim.2019.02.002","article-title":"Promising effects of purslane cream on the breast fissure in lactating women: a clinical trial","volume":"43","author":"Niazi","year":"2019","journal-title":"Complement. Ther. Med."},{"issue":"2","key":"10.1016\/j.lfs.2023.121389_bb0655","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/jnu.12010","article-title":"A systematic review of the interventions for nipple trauma in breastfeeding mothers","volume":"45","author":"Vieira","year":"2013","journal-title":"J. Nurs. Scholarsh."},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0660","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3831\/KPI.2018.21.017","article-title":"A systematic review on prevention and treatment of nipple pain and fissure: are they curable?","volume":"21","author":"Niazi","year":"2018","journal-title":"J. Pharmacopuncture"},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0665","first-page":"242","article-title":"Anti-melanogenic activity of Viola odorata different extracts on B16F10 murine melanoma cells","volume":"20","author":"Rahimi","year":"2017","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.lfs.2023.121389_bb0670","article-title":"Protective effect of Diospyros kaki against glucose-oxygen-serum deprivation-induced PC12 cells injury","volume":"2016","author":"Forouzanfar","year":"2016","journal-title":"Adv. Pharmacol. Sci."},{"key":"10.1016\/j.lfs.2023.121389_bb0675","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.biopha.2018.02.098","article-title":"beta-Amyrin, the cannabinoid receptors agonist, abrogates mice brain microglial cells inflammation induced by lipopolysaccharide\/interferon-gammaand regulates Mphi1\/Mphi2 balances","volume":"101","author":"Askari","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0680","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst. Rev."},{"key":"10.1016\/j.lfs.2023.121389_bb0685","series-title":"Prevention of Nipple Cracks With Guaiazulene Versus Breast Milk in Nursing Mother: A Randomized, Controlled, Double-Blind Trial","author":"G\u00f6rgen","year":"2005"},{"issue":"4","key":"10.1016\/j.lfs.2023.121389_bb0690","first-page":"279","article-title":"Prevention of nipple cracks with guaiazulene versus breast milk in nursing mother: a randomized, controlled, double-blind trial","volume":"6","author":"Api","year":"2005","journal-title":"J. Turk. Ger. Gynecol. Assoc."},{"issue":"10","key":"10.1016\/j.lfs.2023.121389_bb0695","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biomedicines9101429","article-title":"Type 2 diabetes mellitus and cancer: epidemiology, physiopathology and prevention","volume":"9","author":"Rey-Renones","year":"2021","journal-title":"Biomedicines"},{"issue":"9","key":"10.1016\/j.lfs.2023.121389_bb0700","doi-asserted-by":"crossref","DOI":"10.2174\/1573399818666211213103315","article-title":"Multifaceted effects of intermittent fasting on the treatment and prevention of diabetes, cancer, obesity or other chronic diseases","volume":"18","author":"Tagde","year":"2022","journal-title":"Curr. Diabetes Rev."},{"issue":"13","key":"10.1016\/j.lfs.2023.121389_bb0705","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1016\/j.bmc.2013.03.067","article-title":"Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: discovery of YM543","volume":"21","author":"Ikegai","year":"2013","journal-title":"Bioorg. Med. Chem."},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0710","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3109\/07435800.2012.746364","article-title":"Pharmacological characterization of YM543, a newly synthesized, orally active SGLT2 selective inhibitor","volume":"38","author":"Yokono","year":"2013","journal-title":"Endocr. Res."},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0715","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/MED.0000000000000311","article-title":"An update on sodium-glucose co-transporter-2 inhibitors for the treatment of diabetes mellitus","volume":"24","author":"Hsia","year":"2017","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"issue":"23","key":"10.1016\/j.lfs.2023.121389_bb0720","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1016\/j.bmcl.2012.09.064","article-title":"Novel azulene derivatives for the treatment of erectile dysfunction","volume":"22","author":"Lober","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0725","doi-asserted-by":"crossref","first-page":"231","DOI":"10.23736\/S2724-5683.21.05538-9","article-title":"Cardiovascular disease burden: Italian and global perspectives","volume":"69","author":"Saglietto","year":"2021","journal-title":"Minerva Cardiol. Angiol."},{"key":"10.1016\/j.lfs.2023.121389_bb0730","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ajem.2020.10.022","article-title":"Cardiovascular diseases burden in COVID-19: systematic review and meta-analysis","volume":"46","author":"Hessami","year":"2021","journal-title":"Am. J. Emerg. Med."},{"issue":"4","key":"10.1016\/j.lfs.2023.121389_bb0735","doi-asserted-by":"crossref","first-page":"955","DOI":"10.2165\/00003495-200060040-00007","article-title":"Nicorandil. An updated review of its use in Ischaemic heart disease with emphasis on its cardioprotective effects","volume":"60","author":"Markham","year":"2000","journal-title":"Drugs"},{"issue":"11","key":"10.1016\/j.lfs.2023.121389_bb0740","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.3390\/molecules27113516","article-title":"A prospective viewpoint on neurological diseases and their biomarkers","volume":"27","author":"Zehravi","year":"2022","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.lfs.2023.121389_bb0745","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1124\/pr.111.004515","article-title":"Mechanisms of penile erection and basis for pharmacological treatment of erectile dysfunction","volume":"63","author":"Andersson","year":"2011","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.lfs.2023.121389_bb0750","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2174\/2212798406666140131122641","article-title":"Recent advances in the treatment of neurogenic erectile dysfunction","volume":"9","author":"Calabro","year":"2014","journal-title":"Recent Pat. CNS Drug Discov."},{"issue":"9","key":"10.1016\/j.lfs.2023.121389_bb0755","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/cmdc.201900074","article-title":"Structure-activity relationships of 1-benzoylazulenes at the OX(1) and OX(2) orexin receptors","volume":"14","author":"Turku","year":"2019","journal-title":"ChemMedChem"},{"issue":"3","key":"10.1016\/j.lfs.2023.121389_bb0760","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1021\/acs.orglett.7b00012","article-title":"Ganotheaecolin a, a neurotrophic conjugated ergosterol with a Naphtho[1,8-ef]azulene scaffold from ganoderma theaecolum","volume":"19","author":"Luo","year":"2017","journal-title":"Org. Lett."},{"key":"10.1016\/j.lfs.2023.121389_bb0765","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ejmech.2013.02.036","article-title":"Heterocyclic bismuth carboxylates based on a diphenyl sulfone scaffold: synthesis and antifungal activity against Saccharomyces cerevisiae","volume":"63","author":"Murafuji","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.lfs.2023.121389_bb0770","series-title":"Determination of the Protective Effects of Fungus Species Belonging to the Genus Pleurotus Against the Longevity Toxicity of Guaiazulene in Drosophila melanogaster (Oregon R)","author":"Uysal","year":"2020"},{"key":"10.1016\/j.lfs.2023.121389_bb0775","series-title":"Smart Healthcare Analytics: State of the Art","first-page":"65","article-title":"Clinical study on itching relief caused by dry skin of cosmetics containing ceramide NP and guaiazulene in smart healthcare products","author":"Park","year":"2022"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523000231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523000231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:07:27Z","timestamp":1758402447000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320523000231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":155,"alternative-id":["S0024320523000231"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2023.121389","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Guaiazulene and related compounds: A review of current perspective on biomedical applications","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2023.121389","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"121389"}}