{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:23:03Z","timestamp":1791969783134,"version":"4.3.4"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.lfs.2023.121438","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T03:43:05Z","timestamp":1674704585000},"page":"121438","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["DLL4-Notch signalling in acute-on-chronic liver failure: State of the art and perspectives"],"prefix":"10.1016","volume":"317","author":[{"given":"Qian","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2023.121438_bb0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/gutjnl-2020-323973","article-title":"Acute-on-chronic liver failure: a global disease","volume":"71","author":"Schulz","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2023.121438_bb0010","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1136\/gutjnl-2020-322161","article-title":"Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis","volume":"71","author":"Mezzano","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2023.121438_bb0015","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1053\/j.gastro.2013.02.042","article-title":"Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis","volume":"144","author":"Moreau","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2023.121438_bb0020","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/hep.27077","article-title":"Survival in infection-related acute-on-chronic liver failure is defined by extrahepatic organ failures","volume":"60","author":"Bajaj","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121438_bb0025","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s12072-019-09946-3","article-title":"Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update","volume":"13","author":"Sarin","year":"2019","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.lfs.2023.121438_bb0030","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1136\/gutjnl-2017-314641","article-title":"Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure","volume":"67","author":"Wu","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2023.121438_bb0035","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1136\/gutjnl-2020-323395","article-title":"PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF","volume":"71","author":"Li","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2023.121438_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.935160","article-title":"The immune pathogenesis of acute-on-chronic liver failure and the danger hypothesis","volume":"13","author":"Qiang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2023.121438_bb0045","first-page":"21","article-title":"Role of immune dysfunction in acute-on-chronic liver failure: from pathogenesis to clinical prognosis","volume":"31","author":"Huang","year":"2021","journal-title":"Discov. Med."},{"issue":"Suppl 1","key":"10.1016\/j.lfs.2023.121438_bb0050","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/j.jhep.2021.01.002","article-title":"Pathophysiology of decompensated cirrhosis: portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction","volume":"75","author":"Engelmann","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121438_bb0055","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1146\/annurev.immunol.021908.132719","article-title":"Functions of notch signalling in the immune system: consensus and controversies","volume":"28","author":"Yuan","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.lfs.2023.121438_bb0060","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1253\/circj.CJ-13-0873","article-title":"Expanding role of delta-like 4 mediated notch signalling in cardiovascular and metabolic diseases","volume":"77","author":"Fukuda","year":"2013","journal-title":"Circ. J."},{"key":"10.1016\/j.lfs.2023.121438_bb0065","doi-asserted-by":"crossref","first-page":"10315","DOI":"10.1038\/s41598-022-14437-x","article-title":"Probing Notch1-Dll4 signalling in regulating osteogenic differentiation of human mesenchymal stem cells using single cell nanobiosensor","volume":"12","author":"Zhao","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2023.121438_bb0070","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1089\/scd.2016.0331","article-title":"Mesenchymal stem cell migration and proliferation are mediated by hypoxia-inducible factor-1alpha upstream of notch and SUMO pathways","volume":"26","author":"Ciria","year":"2017","journal-title":"Stem Cells Dev."},{"issue":"967\u2013977","key":"10.1016\/j.lfs.2023.121438_bb0075","article-title":"Disruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice","volume":"142","author":"Dill","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2023.121438_bb0080","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.1038\/s41467-020-18633-z","article-title":"Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis","volume":"11","author":"Hultgren","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2023.121438_bb0085","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1136\/gutjnl-2015-311146","article-title":"Quantitative evaluation of human bone mesenchymal stem cells rescuing fulminant hepatic failure in pigs","volume":"66","author":"Shi","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2023.121438_bb0090","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/j.ajpath.2016.03.010","article-title":"Delta-like ligand 4 modulates liver damage by down-regulating chemokine expression","volume":"186","author":"Shen","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.lfs.2023.121438_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.792667","article-title":"The role of notch signalling pathway in non-alcoholic fatty liver disease","volume":"8","author":"Xu","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.lfs.2023.121438_bb0100","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrgastro.2015.219","article-title":"Acute-on-chronic liver failure: terminology, mechanisms and management","volume":"13","author":"Sarin","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2023.121438_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/cells9122632","article-title":"Leukocytes, systemic inflammation and immunopathology in acute-on-chronic liver failure","volume":"9","author":"Casulleras","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2023.121438_bb0110","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrgastro.2015.200","article-title":"Immunology in the liver\u2013from homeostasis to disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2023.121438_bb0115","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12829","article-title":"TNF-alpha\/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury","volume":"53","author":"Wang","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.lfs.2023.121438_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.867261","article-title":"Lipids in liver failure syndromes: a focus on eicosanoids, specialized pro-resolving lipid mediators and lysophospholipids","volume":"13","author":"Artru","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2023.121438_bb0125","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1152\/physrev.00027.2008","article-title":"The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair","volume":"89","author":"Vollmar","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.lfs.2023.121438_bb0130","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/cc10424","article-title":"Bench-to-beside review: acute-on-chronic liver failure - linking the gut, liver and systemic circulation","volume":"15","author":"Verbeke","year":"2011","journal-title":"Crit. Care"},{"key":"10.1016\/j.lfs.2023.121438_bb0135","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41392-022-00934-y","article-title":"Notch signalling pathway: architecture, disease, and therapeutics","volume":"7","author":"Zhou","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.lfs.2023.121438_bb0140","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s42255-022-00533-9","article-title":"The endothelial Dll4-muscular Notch2 axis regulates skeletal muscle mass","volume":"4","author":"Fujimaki","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.lfs.2023.121438_bb0145","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrg3272","article-title":"The Notch signalling system: recent insights into the complexity of a conserved pathway","volume":"13","author":"Guruharsha","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.lfs.2023.121438_bb0150","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1002\/hep.29752","article-title":"Wnt\/beta-catenin signalling controls intrahepatic biliary network formation in zebrafish by regulating notch activity","volume":"67","author":"So","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121438_bb0155","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nature24998","article-title":"A non-canonical Notch complex regulates adherens junctions and vascular barrier function","volume":"552","author":"Polacheck","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2023.121438_bb0160","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.jhep.2013.11.028","article-title":"Notch signalling and new therapeutic options in liver disease","volume":"60","author":"Morell","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121438_bb0165","first-page":"9","article-title":"The roles of notch signalling in liver development and disease","author":"Adams","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.lfs.2023.121438_bb0170","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/hep.27268","article-title":"Emerging roles of Notch signalling in liver disease","volume":"61","author":"Geisler","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121438_bb0175","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12964-017-0214-x","article-title":"Notch signalling triggered via the ligand DLL4 impedes M2 macrophage differentiation and promotes their apoptosis","volume":"16","author":"Pagie","year":"2018","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.lfs.2023.121438_bb0180","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1161\/ATVBAHA.116.306926","article-title":"Delta-like ligand 4-notch signalling in macrophage activation","volume":"36","author":"Nakano","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.lfs.2023.121438_bb0185","doi-asserted-by":"crossref","first-page":"7243","DOI":"10.1158\/1078-0432.CCR-07-1393","article-title":"Delta-like 4\/Notch signalling and its therapeutic implications","volume":"13","author":"Yan","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.lfs.2023.121438_bb0190","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.phrs.2016.09.001","article-title":"DLL4(+) dendritic cells: key regulators of notch signalling in effector T cell responses","volume":"113","author":"Meng","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2023.121438_bb0195","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jhep.2019.11.009","article-title":"Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF","volume":"72","author":"Moreau","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121438_bb0200","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.cell.2015.05.051","article-title":"A conserved circular network of coregulated lipids modulates innate immune responses","volume":"162","author":"Koberlin","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2023.121438_bb0205","first-page":"1902996","article-title":"Switching from fatty acid oxidation to glycolysis improves the outcome of acute-on-chronic liver failure","volume":"7","author":"Yu","year":"2020","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.lfs.2023.121438_bb0210","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1161\/ATVBAHA.107.157685","article-title":"Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient mice","volume":"28","author":"Subramanian","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.lfs.2023.121438_bb0215","doi-asserted-by":"crossref","first-page":"E1868","DOI":"10.1073\/pnas.1116889109","article-title":"Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders","volume":"109","author":"Fukuda","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2023.121438_bb0220","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1161\/CIRCULATIONAHA.117.029733","article-title":"Inhibition of endothelial notch signalling impairs fatty acid transport and leads to metabolic and vascular remodeling of the adult heart","volume":"137","author":"Jabs","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2023.121438_bb0225","doi-asserted-by":"crossref","first-page":"23168","DOI":"10.1074\/jbc.M114.576512","article-title":"Fatty acid-binding protein 4, a point of convergence for angiogenic and metabolic signalling pathways in endothelial cells","volume":"289","author":"Harjes","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2023.121438_bb0230","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.671081","article-title":"Capillarized liver sinusoidal endothelial cells undergo partial endothelial-mesenchymal transition to actively deposit sinusoidal ECM in liver fibrosis","volume":"9","author":"Ruan","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.lfs.2023.121438_bb0235","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.750509","article-title":"The impact of inflammatory immune reactions of the vascular niche on organ fibrosis","volume":"12","author":"Zhou","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2023.121438_bb0240","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/j.jhep.2015.01.003","article-title":"Evolution in the understanding of the pathophysiological basis of portal hypertension: how changes in paradigm are leading to successful new treatments","volume":"62","author":"Bosch","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121438_bb0245","first-page":"H2736","article-title":"Regulation of hepatic blood flow during resuscitation from hemorrhagic shock: role of NO and endothelins","volume":"272","author":"Pannen","year":"1997","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.lfs.2023.121438_bb0250","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41575-018-0097-3","article-title":"Hepatic microcirculation and mechanisms of portal hypertension","volume":"16","author":"Gracia-Sancho","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2023.121438_bb0255","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/hep.28713","article-title":"Endothelial notch signalling is essential to prevent hepatic vascular malformations in mice","volume":"64","author":"Cuervo","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121438_bb0260","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1111\/bph.15743","article-title":"A novel peptide inhibitor of Dll4-Notch1 signalling and its pro-angiogenic functions","volume":"179","author":"Zhu","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2023.121438_bb0265","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s10456-020-09726-w","article-title":"RHOQ is induced by DLL4 and regulates angiogenesis by determining the intracellular route of the notch intracellular domain","volume":"23","author":"Bridges","year":"2020","journal-title":"Angiogenesis"},{"key":"10.1016\/j.lfs.2023.121438_bb0270","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/hep.29834","article-title":"Endothelial notch activation reshapes the angiocrine of sinusoidal endothelia to aggravate liver fibrosis and blunt regeneration in mice","volume":"68","author":"Duan","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121438_bb0275","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/j.bbamcr.2019.06.011","article-title":"Delta-like ligand 4\/DLL4 regulates the capillarization of liver sinusoidal endothelial cell and liver fibrogenesis","volume":"1866","author":"Chen","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.lfs.2023.121438_bb0280","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1182\/blood-2005-03-1000","article-title":"Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function","volume":"107","author":"Williams","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2023.121438_bb0285","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/stcltm\/szac034","article-title":"Dll4 inhibition promotes graft retention in fat grafting enriched with adipose-derived stem cells","volume":"11","author":"Lee","year":"2022","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.lfs.2023.121438_bb0290","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature23015","article-title":"Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration","volume":"547","author":"Raven","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2023.121438_bb0295","first-page":"14","article-title":"Notch-IGF1 signalling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation","author":"Minnis-Lyons","year":"2021","journal-title":"Sci. Signal."},{"key":"10.1016\/j.lfs.2023.121438_bb0300","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jhep.2013.02.025","article-title":"Notch signalling regulates tubular morphogenesis during repair from biliary damage in mice","volume":"59","author":"Fiorotto","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121438_bb0305","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1101\/gad.214601.113","article-title":"Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signalling","volume":"27","author":"Kitade","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.lfs.2023.121438_bb0310","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nm.2667","article-title":"Macrophage-derived Wnt opposes Notch signalling to specify hepatic progenitor cell fate in chronic liver disease","volume":"18","author":"Boulter","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2023.121438_bb0315","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/hep.23048","article-title":"Notch2 signalling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice","volume":"50","author":"Tchorz","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121438_bb0320","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/hep.23431","article-title":"Notch signalling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice","volume":"51","author":"Sparks","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121438_bb0325","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/hep.25722","article-title":"Immediate intraportal transplantation of human bone marrow mesenchymal stem cells prevents death from fulminant hepatic failure in pigs","volume":"56","author":"Li","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121438_bb0330","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00441-019-03130-7","article-title":"Dose-dependent mechanism of Notch action in promoting osteogenic differentiation of mesenchymal stem cells","volume":"379","author":"Semenova","year":"2020","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.lfs.2023.121438_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2020.101900","article-title":"DLL4 restores damaged liver by enhancing hBMSC differentiation into cholangiocytes","volume":"47","author":"Sun","year":"2020","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.lfs.2023.121438_bb0340","first-page":"8407257","article-title":"Hepatitis B-associated symptomatic iron overload, with complete resolution after nucleoside analogue treatment","volume":"2021","author":"Tey","year":"2021","journal-title":"Case Rep. Gastrointest. Med."},{"key":"10.1016\/j.lfs.2023.121438_bb0345","article-title":"Glucocorticoid treatment strategies in liver failure","volume":"13","author":"Ye","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2023.121438_bb0350","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s12072-012-9352-9","article-title":"Systematic review: extracorporeal bio-artificial liver-support system for liver failure","volume":"6","author":"Gu","year":"2012","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.lfs.2023.121438_bb0355","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.885829","article-title":"Granulocyte colony-stimulating factor accelerates the recovery of hepatitis B virus-related acute-on-chronic liver failure by promoting M2-like transition of monocytes","volume":"13","author":"Tong","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2023.121438_bb0360","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x20209728","article-title":"A novel stem cell therapy for hepatitis B virus-related acute-on-chronic liver failure","volume":"53","author":"Zhu","year":"2020","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.lfs.2023.121438_bb0365","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2010.01.004","article-title":"Notch signalling in the immune system","volume":"32","author":"Radtke","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.lfs.2023.121438_bb0370","unstructured":"X. Chen, J. Li, L. Li, inventors; Univ Zhejiang (Uyzh-C) Univ Zhejiang (Uyzh-C) Univ Zhejiang (Uyzh-C), assignee. Use of DLL4 cytokine in preparing drug for treating fulminant liver failure patent CN105267953-A; US2017080052-A1; WO2017045377-A1; CN105267953-B; US10328122-B2."},{"key":"10.1016\/j.lfs.2023.121438_bb0375","unstructured":"V. Luca, P. Rodriguez, D. Gonzalez-Perez, inventors; Moffitt Cancer Cent & Res Inst Inc H Lee (Moff-C) Moffitt Cancer Cent & Res Inst Inc H Lee (Moff-C) Moffitt Cancer Cent & Res Inst Inc H Lee (Moff-C), assignee. Activating Notch signalling by contacting T cells (comprising comprises CD8 positive T cell or chimeric antigen receptorT cell or marrow infiltrating lymphocyte) with chemically designed Notch ligand comprising delta-like (DLL)4 protein patent WO2021007573-A1; CA3147049-A1; EP3996725-A1; US2022241335-A1."},{"key":"10.1016\/j.lfs.2023.121438_bb0380","unstructured":"M. Wu, M. Wang, S. Wang, W. Fei, Y. Zhao, H. Wen, et al., inventors; Univ China Pharm (Uycp-C), assignee. Conjugate HLmD4 of anti-human DLL4 humanized antibody THL4 and maytansine alkaloid DM1 used for preparing medicine for treating cancer, in which anti-human DLL4 humanized antibody THL4 is coupled with alkaloid DM1 by linker molecule, BMPEO patent CN111494645-A; CN111494645-B."},{"key":"10.1016\/j.lfs.2023.121438_bb0385","unstructured":"R.J. Stagg, S.E. Benner, inventors, Therapeutic combination and methods of treatment with a DLL4 antagonist and an anti-hypertensive agent patent US 10870693 22 (2020 Dec) 2020."},{"key":"10.1016\/j.lfs.2023.121438_bb0390","unstructured":"M. Aikawa, D. Fukuda, T. Miyazaki, E. Aikawa, inventors; Notch inhibition in the treatment and prevention of nonalcoholic fatty liver disease patent US 10988530 27 (2021 Apr) 2021."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523000723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523000723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:04:36Z","timestamp":1758402276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320523000723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":78,"alternative-id":["S0024320523000723"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2023.121438","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DLL4-Notch signalling in acute-on-chronic liver failure: State of the art and perspectives","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2023.121438","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"121438"}}