{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T10:49:57Z","timestamp":1772880597702,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T00:00:00Z","timestamp":1717286400000},"content-version":"vor","delay-in-days":306,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.lfs.2023.121819","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:23:23Z","timestamp":1685406203000},"page":"121819","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Topiramate treatment during the peripubertal period does not alter aortic endothelial function in female Wistar rats"],"prefix":"10.1016","volume":"327","author":[{"given":"Deborah Gomes da","family":"Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kawane Fabricio","family":"Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Cristina de","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenny Gutemberg Nunes da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Borecki","family":"Vidigal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"da Silva Jezu\u00edno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafaella Cardoso","family":"Gravena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gislaine Garcia","family":"Pelosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Cristina Ceccato","family":"Gerardin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"do Carmo Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziela Scalianti","family":"Ceravolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2023.121819_bb0005","first-page":"5","article-title":"Relationship between antiepileptic drugs and biological markers affecting long-term cardiovascular function in children and adolescents","volume":"17","author":"Cheng","year":"2010","journal-title":"J. Popul. Ther. Clin. Pharmacol."},{"key":"10.1016\/j.lfs.2023.121819_bb0010","first-page":"108","article-title":"Effects of long-term treatment with antiepileptic drugs on serum lipid levels in epileptic children","volume":"11","author":"Castro-Gago","year":"1994","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.lfs.2023.121819_bb0015","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s11940-010-0080-y","article-title":"Antiepileptic drugs and markers of vascular risk","volume":"12","author":"LoPinto-Khoury","year":"2010","journal-title":"Curr. Treat. Options Neurol."},{"key":"10.1016\/j.lfs.2023.121819_bb0020","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1528-1167.2011.03316.x","article-title":"Effects of long-term antiepileptic drug monotherapy on vascular risk factors and atherosclerosis","volume":"53","author":"Chuang","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.lfs.2023.121819_bb0025","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/ana.21615","article-title":"Effects of antiepileptic drugs on lipids, homocysteine, and C-reactive protein","volume":"65","author":"Mintzer","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.lfs.2023.121819_bb0030","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.eplepsyres.2011.10.001","article-title":"Conversion from enzyme-inducing antiepileptic drugs to topiramate: effects on lipids and c-reactive protein","volume":"98","author":"Mintzer","year":"2012","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.lfs.2023.121819_bb0035","unstructured":"US Food and Drug Administration, FDA approves Topamax for migraine prevention in adolescents [news release]. 2014. (n.d.). https:\/\/wayback.archive-it.org\/7993\/20170112222908\/http:\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm391026.htm (accessed May 29, 2023)."},{"key":"10.1016\/j.lfs.2023.121819_bb0040","series-title":"Topamax\u00ae Inf. Prescr","author":"Farmac\u00eautica","year":"2007"},{"key":"10.1016\/j.lfs.2023.121819_bb0045","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/epi.12338","article-title":"Effects of new antiepileptic drugs on circulatory markers for vascular risk in patients with newly diagnosed epilepsy","volume":"54","author":"Kim","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.lfs.2023.121819_bb0050","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1528-1167.2009.02303.x","article-title":"Hyperhomocysteinemia in epileptic patients on new antiepileptic drugs","volume":"51","author":"Belcastro","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.lfs.2023.121819_bb0055","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1177\/0883073814551388","article-title":"Atherosclerotic effects of long-term old and new antiepileptic drugs monotherapy: a cross-sectional comparative study","volume":"30","author":"El-Farahaty","year":"2015","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.lfs.2023.121819_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120189","article-title":"Topiramate treatment in Wistar rats during childhood induces sex-specific vascular dysfunction in adulthood","volume":"288","author":"Vidigal","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2023.121819_bb0065","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1152\/ajpheart.00217.2016","article-title":"Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease","volume":"313","author":"Boese","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.lfs.2023.121819_bb0070","doi-asserted-by":"crossref","first-page":"H1569","DOI":"10.1152\/ajpheart.00396.2018","article-title":"Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan","volume":"315","author":"Stanhewicz","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.lfs.2023.121819_bb0075","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/nn1326","article-title":"The neural basis of puberty and adolescence","volume":"7","author":"Sisk","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.lfs.2023.121819_bb0080","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1053\/beem.2002.0177","article-title":"Oestrogens and puberty","volume":"16","author":"Alonso","year":"2002","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2023.121819_bb0085","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1113\/EP085367","article-title":"Sex differences in vascular endothelial function and health in humans: impacts of exercise","volume":"101","author":"Green","year":"2016","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.lfs.2023.121819_bb0090","article-title":"Gender, sex hormones, and vascular tone","volume":"286","author":"Orshal","year":"2004","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.lfs.2023.121819_bb0095","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1161\/CIRCRESAHA.110.236687","article-title":"Estrogen signaling and cardiovascular disease","volume":"109","author":"Murphy","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2023.121819_bb0100","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1016\/j.neubiorev.2011.02.011","article-title":"Neurobehavioral adaptations to methylphenidate: the issue of early adolescent exposure","volume":"35","author":"Marco","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.lfs.2023.121819_bb0105","author":"Spear"},{"key":"10.1016\/j.lfs.2023.121819_bb0110","series-title":"Harmonization in Interspecies Extrapolation: Use of BW 3\/4 as Default Method in Derivation of the Oral RfD","first-page":"1","author":"Epa","year":"2006"},{"key":"10.1016\/j.lfs.2023.121819_bb0115","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1080\/13813455.2018.1517804","article-title":"Can maternal treatment with metformin during gestation and lactation cause metabolic and cardiovascular disorders in rat offspring?","volume":"126","author":"Novi","year":"2020","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.lfs.2023.121819_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2017.05.005","article-title":"Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases","volume":"100","author":"Incalza","year":"2018","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.lfs.2023.121819_bb0125","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1111\/bph.13517","article-title":"Targeting vascular (endothelial) dysfunction","volume":"174","author":"Daiber","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2023.121819_bb0130","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.pbb.2006.12.001","article-title":"Adolescent cortical development: a critical period of vulnerability for addiction","volume":"86","author":"Crews","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.lfs.2023.121819_bb0135","doi-asserted-by":"crossref","first-page":"494","DOI":"10.2223\/JPED.1728","article-title":"Origens desenvolvimentistas da sa\u00fade e da doen\u00e7a (DOHaD)","volume":"83","author":"Silveira","year":"2007","journal-title":"J. Pediatr."},{"key":"10.1016\/j.lfs.2023.121819_bb0140","first-page":"610","article-title":"West-Eberhard 2005 phenotypic accommodation adaptive innovation","volume":"304B","author":"West-Eberhard","year":"2005","journal-title":"J. Exp. Zool. Part A Ecol. Genet. Physiol."},{"key":"10.1016\/j.lfs.2023.121819_bb0145","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.vph.2011.06.003","article-title":"The G protein-coupled estrogen receptor GPER\/GPR30 as a regulator of cardiovascular function","volume":"55","author":"Meyer","year":"2011","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.lfs.2023.121819_bb0150","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.mce.2014.02.002","article-title":"Estrogen biology: new insights into GPER function and clinical opportunities","volume":"389","author":"Prossnitz","year":"2014","journal-title":"Mol. Cell. Endocrinol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523004538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523004538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T01:10:38Z","timestamp":1736385038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320523004538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":30,"alternative-id":["S0024320523004538"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2023.121819","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Topiramate treatment during the peripubertal period does not alter aortic endothelial function in female Wistar rats","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2023.121819","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"121819"}}