{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:24:48Z","timestamp":1792095888753,"version":"4.4.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.lfs.2023.121861","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T01:57:23Z","timestamp":1687139843000},"page":"121861","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Grb2-related adaptor protein GRAP is a novel regulator of liver fibrosis"],"prefix":"10.1016","volume":"327","author":[{"given":"Xiaoyan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2023.121861_bb0005","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1002\/hep.32743","article-title":"Health disparities in chronic liver disease","volume":"77","author":"Kardashian","year":"2023","journal-title":"Hepatology."},{"key":"10.1016\/j.lfs.2023.121861_bb0010","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/hep.32163","article-title":"Population screening for liver fibrosis: toward early diagnosis and intervention for chronic liver diseases","volume":"75","author":"Gines","year":"2022","journal-title":"Hepatology."},{"key":"10.1016\/j.lfs.2023.121861_bb0015","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000062","article-title":"Increasing economic burden in hospitalized patients with cirrhosis: analysis of a national database","volume":"10","author":"Desai","year":"2019","journal-title":"Clin. Transl. Gastroenterol."},{"key":"10.1016\/j.lfs.2023.121861_bb0020","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrgastro.2010.97","article-title":"Evolving challenges in hepatic fibrosis","volume":"7","author":"Friedman","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2023.121861_bb0025","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2023.121861_bb0030","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2023.121861_bb0035","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/hep.28948","article-title":"The origin of fibrogenic myofibroblasts in fibrotic liver","volume":"65","author":"Kisseleva","year":"2017","journal-title":"Hepatology."},{"key":"10.1016\/j.lfs.2023.121861_bb0040","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jhep.2008.01.032","article-title":"Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury","volume":"49","author":"Douglass","year":"2008","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121861_bb0045","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41419-020-2372-9","article-title":"Myofibroblast induces hepatocyte-to-ductal metaplasia via laminin-avbeta6 integrin in liver fibrosis","volume":"11","author":"Xu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2023.121861_bb0050","doi-asserted-by":"crossref","first-page":"12129","DOI":"10.1074\/jbc.271.21.12129","article-title":"Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway","volume":"271","author":"Feng","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2023.121861_bb0055","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/hep.20054","article-title":"PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation","volume":"39","author":"Fiorucci","year":"2004","journal-title":"Hepatology."},{"key":"10.1016\/j.lfs.2023.121861_bb0060","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.biopha.2017.05.142","article-title":"Role of growth factor receptor-bound 2 in CCl(4)-induced hepatic fibrosis","volume":"92","author":"Ge","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2023.121861_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.688","article-title":"Myocardin-related transcription factor A drives ROS-fueled expansion of hepatic stellate cells by regulating p38-MAPK signalling","volume":"12","author":"Dong","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.lfs.2023.121861_bb0070","article-title":"XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression","volume":"4","author":"Wang","year":"2022","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"10.1016\/j.lfs.2023.121861_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120878","article-title":"Angiotensin II can trigger HSC-LX2 pyroptosis through both classical and non-classical pathways","volume":"307","author":"Xie","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2023.121861_bb0080","article-title":"Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators","volume":"4","author":"Pastore","year":"2022","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"10.1016\/j.lfs.2023.121861_bb0085","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41419-022-04944-0","article-title":"Trans-activation of eotaxin-1 by Brg1 contributes to liver regeneration","volume":"13","author":"Fan","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2023.121861_bb0090","article-title":"Swelling-induced upregulation of miR-141-3p inhibits hepatocyte proliferation","volume":"4","author":"Bardeck","year":"2022","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"10.1016\/j.lfs.2023.121861_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121470","article-title":"Myocardin-related transcription factor a, regulated by serum response factor, contributes to diabetic cardiomyopathy in mice","volume":"317","author":"Liu","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2023.121861_bb0100","article-title":"Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice","volume":"5","author":"Seedorf","year":"2023","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"10.1016\/j.lfs.2023.121861_bb0105","article-title":"TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling","volume":"5","author":"Su","year":"2023","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"10.1016\/j.lfs.2023.121861_bb0110","article-title":"Spatial molecular and cellular determinants of STAT3 activation in liver fibrosis progression in non-alcoholic fatty liver disease","volume":"5","author":"Jiao","year":"2023","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"10.1016\/j.lfs.2023.121861_bb0115","article-title":"SCYL3, as a novel binding partner and regulator of ROCK2, promotes hepatocellular carcinoma progression","volume":"5","author":"Lei","year":"2023","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"10.1016\/j.lfs.2023.121861_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhepr.2023.100805","article-title":"C-C motif chemokine CCL11 is a novel regulator and a potential therapeutic target in non-alcoholic fatty liver disease","author":"Fan","year":"2023","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"10.1016\/j.lfs.2023.121861_bb0125","article-title":"Zinc finger transcription factor Egf1 promotes non-alcoholic fatty liver disease","volume":"5","author":"Guo","year":"2023","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"10.1016\/j.lfs.2023.121861_bb0130","article-title":"Systemic ASBT inactivation protects against liver damage in obstructive cholestasis in mice","volume":"4","author":"Kunst","year":"2022","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"10.1016\/j.lfs.2023.121861_bb0135","article-title":"ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis","volume":"4","author":"Nalkurthi","year":"2022","journal-title":"JHEP Rep. Innov. Hepatol."},{"issue":"1","key":"10.1016\/j.lfs.2023.121861_bb0140","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/HEP.0000000000000287","article-title":"Regulatory role and translational potential of CCL11 in liver fibrosis","volume":"78","author":"Kong","year":"2023","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.lfs.2023.121861_bb0145","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202216592","article-title":"Targetable Brg1-CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking","volume":"15","author":"Li","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.lfs.2023.121861_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102586","article-title":"MKL1 fuels ROS-induced proliferation of vascular smooth muscle cells by modulating FOXM1 transcription","volume":"59","author":"Wu","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2023.121861_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121657","article-title":"Bone mesenchymal stem cells promote gastric cancer progression through TGF-beta1\/Smad2 positive feedback loop","volume":"323","author":"Fan","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2023.121861_bb0160","article-title":"Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency","volume":"4","author":"Li","year":"2022","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"10.1016\/j.lfs.2023.121861_bb0165","article-title":"Slug enables redox-sensitive trans-activation of LRP1 by COUP-TFII: implication in antifibrotic intervention in the kidneys","volume":"121412","author":"Wu","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2023.121861_bb0170","doi-asserted-by":"crossref","DOI":"10.1038\/s12276-023-00990-6","article-title":"An MRTF-A-ZEB1-IRF9 axis contributes to fibroblast-myofibroblast transition and renal fibrosis","author":"Zhao","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.lfs.2023.121861_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121598","article-title":"Collagen matricryptin promotes cardiac function by mediating scar formation","volume":"321","author":"Grilo","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2023.121861_bb0180","article-title":"Acetaminophen-induced reduction of NIMA-related kinase 7 expression exacerbates acute liver injury","volume":"4","author":"Sun","year":"2022","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"10.1016\/j.lfs.2023.121861_bb0185","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/S0016-5085(99)70413-0","article-title":"The virtuosity of hepatic stellate cells","volume":"117","author":"Friedman","year":"1999","journal-title":"Gastroenterology."},{"key":"10.1016\/j.lfs.2023.121861_bb0190","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","article-title":"Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury","volume":"275","author":"Friedman","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2023.121861_bb0195","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.cld.2008.07.004","article-title":"Stellate cell contraction: role, regulation, and potential therapeutic target","volume":"12","author":"Soon","year":"2008","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.lfs.2023.121861_bb0200","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1053\/gast.2003.50012","article-title":"Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors","volume":"124","author":"Yang","year":"2003","journal-title":"Gastroenterology."},{"key":"10.1016\/j.lfs.2023.121861_bb0205","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.stem.2016.05.005","article-title":"In vivo hepatic reprogramming of Myofibroblasts with AAV vectors as a therapeutic strategy for liver fibrosis","volume":"18","author":"Rezvani","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.lfs.2023.121861_bb0210","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1038\/s41598-018-22544-x","article-title":"Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells","volume":"8","author":"Vanshylla","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2023.121861_bb0215","doi-asserted-by":"crossref","first-page":"5650","DOI":"10.1021\/acs.jmedchem.6b00389","article-title":"Discovery of (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an extracellular signal-regulated kinase 1\/2 (ERK1\/2) inhibitor in early clinical development","volume":"59","author":"Blake","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.lfs.2023.121861_bb0220","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1007\/s00109-019-01831-8","article-title":"Ablation of serum response factor in hepatic stellate cells attenuates liver fibrosis","volume":"97","author":"Kong","year":"2019","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.lfs.2023.121861_bb0225","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1007\/s12265-012-9397-0","article-title":"The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation","volume":"5","author":"Small","year":"2012","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.lfs.2023.121861_bb0230","article-title":"Epiregulin (EREG) and myocardin related transcription factor a (MRTF-A) form a feedforward loop to drive hepatic stellate cell activation","volume":"8","author":"Wu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.lfs.2023.121861_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101302","article-title":"Serum response factor (SRF) promotes ROS generation and hepatic stellate cell activation by epigenetically stimulating NCF1\/2 transcription","volume":"26","author":"Kong","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2023.121861_bb0240","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.bbapap.2009.09.029","article-title":"Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling","volume":"1804","author":"Cummins","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2023.121861_bb0245","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/jphp.12504","article-title":"Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-beta1\/Smad and GRAP pathways","volume":"68","author":"Al-Onazi","year":"2016","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.lfs.2023.121861_bb0250","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1128\/MCB.22.10.3230-3236.2002","article-title":"Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction","volume":"22","author":"Shen","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.lfs.2023.121861_bb0255","first-page":"5","article-title":"Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity","author":"Panayiotou","year":"2016","journal-title":"elife"},{"key":"10.1016\/j.lfs.2023.121861_bb0260","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3389\/fcell.2019.00243","article-title":"A cAbl-MRTF-A feedback loop contributes to hepatic stellate cell activation","volume":"7","author":"Lu","year":"2019","journal-title":"Front Cell. Dev. Biol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523004964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523004964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T20:11:24Z","timestamp":1736367084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320523004964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":52,"alternative-id":["S0024320523004964"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2023.121861","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Grb2-related adaptor protein GRAP is a novel regulator of liver fibrosis","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2023.121861","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"121861"}}