{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:45:06Z","timestamp":1791582306676,"version":"4.3.4"},"reference-count":176,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/06082-8"],"award-info":[{"award-number":["2022\/06082-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/13402-9"],"award-info":[{"award-number":["2022\/13402-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/16633-1"],"award-info":[{"award-number":["2022\/16633-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2023\/08751-7"],"award-info":[{"award-number":["2023\/08751-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.lfs.2023.121994","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T06:08:48Z","timestamp":1691042928000},"page":"121994","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Past, present, and future of chemically induced hepatocarcinogenesis rodent models: Perspectives concerning classic and new cancer hallmarks"],"prefix":"10.1016","volume":"330","author":[{"given":"Guilherme Ribeiro","family":"Romualdo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Heidor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Prata","family":"Bacil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Salvador","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Fernando","family":"Barbisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2023.121994_bb0005","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.lfs.2023.121994_bb0010","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/CEJ.0000000000000428","article-title":"Worldwide incidence of hepatocellular carcinoma cases attributable to major risk factors","volume":"27","author":"Baecker","year":"2018","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.lfs.2023.121994_bb0015","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1002\/ijc.31280","article-title":"Fraction and incidence of liver cancer attributable to hepatitis B and C viruses worldwide","volume":"142","author":"Maucort-Boulch","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.lfs.2023.121994_bb0020","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejca.2021.11.023","article-title":"ScienceDirect Global, regional and national burden of primary liver cancer by subtype","volume":"161","author":"Rumgay","year":"2022","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.lfs.2023.121994_bb0025","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.cell.2017.05.046","article-title":"Comprehensive and integrative genomic characterization of hepatocellular carcinoma","volume":"169","author":"Cancer Genome Atlas Research Network","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2023.121994_bb0030","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.lfs.2023.121994_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13215583","article-title":"In vivo and in vitro models of hepatocellular carcinoma: current strategies for translational modeling","volume":"13","author":"Romualdo","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"10127","key":"10.1016\/j.lfs.2023.121994_bb0040","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(18)30010-2","article-title":"Hepatocellular carcinoma","volume":"391","author":"Forner","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2023.121994_bb0045","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-020-00381-6","article-title":"Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention","volume":"18","author":"Huang","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2023.121994_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13578-021-00683-5","article-title":"The hepatic senescence-associated secretory phenotype promotes hepatocarcinogenesis through Bcl3-dependent activation of macrophages","volume":"11","author":"Huang","year":"2021","journal-title":"Cell Biosci."},{"issue":"2","key":"10.1016\/j.lfs.2023.121994_bb0055","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3390\/cancers15020533","article-title":"Hepatitis virus and hepatocellular carcinoma: recent advances","volume":"15","author":"Shen","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.lfs.2023.121994_bb0060","first-page":"1335","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review","volume":"2023","author":"Younossi","year":"2022","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.lfs.2023.121994_bb0065","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/hepr.12349","article-title":"Stem and progenitor cell systems in liver development and regeneration","volume":"45","author":"Kamiya","year":"2015","journal-title":"Hepatology Res."},{"issue":"5","key":"10.1016\/j.lfs.2023.121994_bb0070","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1172\/JCI66027","article-title":"Hepatic stem cell niches","volume":"123","author":"Kordes","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.lfs.2023.121994_bb0075","doi-asserted-by":"crossref","first-page":"7920897","DOI":"10.1155\/2016\/7920897","article-title":"Advances in liver regeneration: revisiting hepatic stem\/progenitor cells and their origin","volume":"2016","author":"Sadri","year":"2016","journal-title":"Stem Cells Int."},{"issue":"4","key":"10.1016\/j.lfs.2023.121994_bb0080","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1053\/j.gastro.2016.11.048","article-title":"Liver cancer cell of origin, molecular class, and effects on patient prognosis","volume":"152","author":"Sia","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2023.121994_bb0085","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1172\/JCI77995","article-title":"Hepatocellular carcinoma originates from hepatocytes and not from the progenitor\/biliary compartment","volume":"125","author":"Mu","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.lfs.2023.121994_bb0090","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/hep.28602","article-title":"Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice","volume":"64","author":"Shin","year":"2016","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.lfs.2023.121994_bb0095","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nrc4017","article-title":"Functional and genetic deconstruction of the cellular origin in liver cancer","volume":"15","author":"Marquardt","year":"2015","journal-title":"Nat. Rev. Cancer"},{"issue":"4260","key":"10.1016\/j.lfs.2023.121994_bb0100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1126\/science.959840","article-title":"The clonal evolution of tumor cell populations","volume":"194","author":"Nowell","year":"1976","journal-title":"Science (New York, N.Y.)"},{"issue":"3","key":"10.1016\/j.lfs.2023.121994_bb0105","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41575-019-0229-4","article-title":"Tumour evolution in hepatocellular carcinoma","volume":"17","author":"Craig","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.lfs.2023.121994_bb0110","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nm1377","article-title":"A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells","volume":"12","author":"Lee","year":"2006","journal-title":"Nat. Med."},{"issue":"23","key":"10.1016\/j.lfs.2023.121994_bb0115","article-title":"Hepatocyte dedifferentiation profiling in alcohol-related liver disease identifies CXCR4 as a driver of cell reprogramming","volume":"S0168-8278","author":"Aguilar-Bravo","year":"2023","journal-title":"Journal of Hepatol."},{"issue":"6","key":"10.1016\/j.lfs.2023.121994_bb0120","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1002\/hep.27353","article-title":"Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells","volume":"60","author":"Dubois-Pot-Schneider","year":"2014","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.lfs.2023.121994_bb0125","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1158\/0008-5472.CAN-18-2110","article-title":"Retrodifferentiation of human tumor hepatocytes to stem cells leads to metabolic reprogramming and chemoresistance","volume":"79","author":"Fekir","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2023.121994_bb0130","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2020.02.008","article-title":"NRF2\/SHH signaling cascade promotes tumor-initiating cell lineage and drug resistance in hepatocellular carcinoma","volume":"476","author":"Leung","year":"2020","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.lfs.2023.121994_bb0135","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41575-021-00508-3","article-title":"Cancer stem cells in hepatocellular carcinoma - from origin to clinical implications","volume":"19","author":"Lee","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.lfs.2023.121994_bb0140","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/hep.29778","article-title":"Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma","volume":"68","author":"Zheng","year":"2018","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"10.1016\/j.lfs.2023.121994_bb0145","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/bjc.2017.54","article-title":"A unified model of the hierarchical and stochastic theories of gastric cancer","volume":"116","author":"Song","year":"2017","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.lfs.2023.121994_bb0150","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1124\/jpet.117.245555","article-title":"Higher CYP2E1 activity correlates with hepatocarcinogenesis induced by diethylnitrosamine","volume":"365","author":"Gao","year":"2018","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.lfs.2023.121994_bb0155","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/hep.31659","article-title":"DNA methylation profiling of human hepatocarcinogenesis","volume":"74","author":"Hernandez-Meza","year":"2021","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.lfs.2023.121994_bb0160","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1002\/hep.31614","article-title":"Genomic analysis of vascular invasion in HCC reveals molecular drivers and predictive biomarkers","volume":"73","author":"Krishnan","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121994_bb0165","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.jhep.2021.04.049","article-title":"Molecular characterisation of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis","volume":"75","author":"Pinyol","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121994_bb0170","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.cell.2020.11.041","article-title":"Single-cell landscape of the ecosystem in early- relapse hepatocellular carcinoma","volume":"184","author":"Sun","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2023.121994_bb0175","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of cancer: new dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"issue":"1","key":"10.1016\/j.lfs.2023.121994_bb0180","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2023.121994_bb0185","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2023.121994_bb0190","article-title":"Stemness analysis in hepatocellular carcinoma identifies an extracellular matrix gene \u2013 related signature associated with prognosis and therapy response","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.lfs.2023.121994_bb0195","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3390\/cancers14030563","article-title":"Implications of stemness features in 1059 hepatocellular carcinoma patients from five cohorts: prognosis, treatment response, and identification of potential compounds","volume":"14","author":"Mai","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.lfs.2023.121994_bb0200","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12866-021-02171-9","article-title":"Defining the temporal evolution of gut dysbiosis and inflammatory responses leading to hepatocellular carcinoma in Mdr2 \u2212\/\u2212 mouse model","volume":"21","author":"Behary","year":"2021","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.lfs.2023.121994_bb0205","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1038\/s41467-022-31312-5","article-title":"Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment","volume":"13","author":"Schneider","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2023.121994_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-49452-y","article-title":"Defining dysbiosis for a cluster of chronic diseases","volume":"9","author":"Wilkins","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2023.121994_bb0215","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3390\/microorganisms7050121","article-title":"Role of gut microbiota in hepatocarcinogenesis","volume":"7","author":"Gupta","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.lfs.2023.121994_bb0220","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jhep.2019.08.016","article-title":"Gut microbiome in HCC \u2013 mechanisms, diagnosis and therapy","volume":"72","author":"Schwabe","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121994_bb0225","first-page":"1","article-title":"Cellular senescence affects energy metabolism, immune infiltration and immunotherapeutic response in hepatocellular carcinoma","volume":"13","author":"Gao","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2023.121994_bb0230","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","article-title":"Cellular senescence: defining a path forward","volume":"179","author":"Gorgoulis","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2023.121994_bb0235","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/oem.2008.043711","article-title":"Exposure-response relationship between lung cancer and polycyclic aromatic hydrocarbons (PAHs)","volume":"66","author":"Armstrong","year":"2009","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.lfs.2023.121994_bb0240","doi-asserted-by":"crossref","first-page":"9872","DOI":"10.3390\/nu7125505","article-title":"Dietary nitrates, nitrites, and nitrosamines intake and the risk of gastric cancer: a meta-analysis","volume":"7","author":"Song","year":"2015","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.lfs.2023.121994_bb0245","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23287","article-title":"The effect of silica exposure on the risk of lung cancer: a meta-analysis","volume":"37","author":"Zhou","year":"2023","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.lfs.2023.121994_bb0250","first-page":"68","article-title":"Percivall Pott (1714\u20131788) and chimney sweepers\u2019 cancer of the scrotum","volume":"14","author":"Brown","year":"1957","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.lfs.2023.121994_bb0255","doi-asserted-by":"crossref","DOI":"10.1038\/bjc.1947.36","article-title":"A new, quantitative, approach to the study of the stages of chemical carcino- genesis in the mouse\u2019s skin","volume":"1","author":"Berenblum","year":"1947","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.lfs.2023.121994_bb0260","first-page":"2338","article-title":"Cocarcinogenic principles from the seed oil of Croton tiglium and from other Euphorbiaceae","volume":"28","author":"Hecker","year":"1968","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2023.121994_bb0265","first-page":"3732","article-title":"Inhibition of mouse skin tumor promotion and of promoter-stimulated epidermal polyamine biosynthesis by \u03b1-difluoromethylornithine","volume":"43","author":"Takigawa","year":"1983","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lfs.2023.121994_bb0270","first-page":"123","article-title":"Experimental study of the pathogenesis of carcinoma","volume":"27","author":"Yamagiwa","year":"1918","journal-title":"J. Cancer Res."},{"key":"10.1016\/j.lfs.2023.121994_bb0275","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF00525219","article-title":"Carcinoma of the respiratory tract following treatment of the golden hamster with diethylnitrosamine","volume":"64","author":"Dontenwill","year":"1961","journal-title":"Z. Krebsforsch."},{"key":"10.1016\/j.lfs.2023.121994_bb0280","first-page":"773","article-title":"Induction of tumors in the Syrian hamster with diethylnitrosamine (N-nitrosodiethylamine)","volume":"23","author":"Herrold","year":"1963","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2023.121994_bb0285","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/BF00525135","article-title":"On the morphology of diethylnitrosamine induced liver changes and tumors in rats","volume":"64","author":"Thomas","year":"1961","journal-title":"Z. Krebsforsch."},{"key":"10.1016\/j.lfs.2023.121994_bb0290","first-page":"2435s","article-title":"Formation and occurrence of nitrosamines in food","volume":"43","author":"Scanlan","year":"1983","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2023.121994_bb0295","author":"International Agency for Research on Cancer"},{"issue":"3\u20134","key":"10.1016\/j.lfs.2023.121994_bb0300","first-page":"152","article-title":"Experimental induction of hepatocellular carcinoma as a paradigm for carcinogenesis","volume":"5","author":"Farber","year":"1987","journal-title":"Clin. Physiol. Biochem."},{"key":"10.1016\/j.lfs.2023.121994_bb0305","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2307\/3430578","article-title":"Possible etiologic mechanisms in chemical carcinogenesis","volume":"75","author":"Farber","year":"1987","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.lfs.2023.121994_bb0310","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.pa.31.040191.003201","article-title":"Scientific concepts, value, and significance of chemical carcinogenesis studies","volume":"31","author":"Huff","year":"1991","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"1\u20133","key":"10.1016\/j.lfs.2023.121994_bb0315","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/1040-8428(94)00169-3","article-title":"Concepts in multistage carcinogenesis","volume":"21","author":"Ito","year":"1995","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.lfs.2023.121994_bb0320","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev-cancerbio-050216-122002","article-title":"Chemical carcinogenesis models of cancer: back to the future","volume":"1","author":"McCreery","year":"2017","journal-title":"Annu. Rev. Cancer Biol."},{"issue":"2","key":"10.1016\/j.lfs.2023.121994_bb0325","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/jsscb.380170202","article-title":"Current concepts and controversies in chemical carcinogenesis","volume":"17","author":"Weinstein","year":"1981","journal-title":"J. Supramol. Struct. Cell. Biochem."},{"key":"10.1016\/j.lfs.2023.121994_bb0330","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0163-7258(96)00062-9","article-title":"N-Nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation","volume":"71","author":"Verna","year":"1996","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2023.121994_bb0335","doi-asserted-by":"crossref","first-page":"11141","DOI":"10.1158\/0008-5472.CAN-07-1369","article-title":"Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo","volume":"67","author":"Jin","year":"2007","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.lfs.2023.121994_bb0340","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/hep.32408","article-title":"Liver zonation, revisited","volume":"76","author":"Paris","year":"2022","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.lfs.2023.121994_bb0345","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.ccell.2018.05.003","article-title":"Liver cancer initiation requires p53 inhibition by CD44-enhanced growth factor signaling","volume":"33","author":"Dhar","year":"2018","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.lfs.2023.121994_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhepr.2021.100315","article-title":"Cell fate analysis of zone 3 hepatocytes in liver injury and tumorigenesis","volume":"3","author":"Kurosaki","year":"2021","journal-title":"JHEP Reports"},{"issue":"March","key":"10.1016\/j.lfs.2023.121994_bb0355","first-page":"1","article-title":"A novel liver zonation phenotype-associated molecular classification of hepatocellular carcinoma","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2023.121994_bb0360","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/mc.2940060110","article-title":"Role of mutations at codon 61 of the c-Ha-ras gene during diethylnitrosamine-induced hepatocarcinogenesis in C3H\/He mice","volume":"6","author":"Bauer-Hofmann","year":"1992","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.lfs.2023.121994_bb0365","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.jhep.2018.06.009","article-title":"Mutational landscape of a chemically-induced mouse model of liver cancer","volume":"69","author":"Connor","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121994_bb0370","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/mc.22510","article-title":"Role of the BrafV637E mutation in hepatocarcinogenesis induced by treatment with diethylnitrosamine in neonatal B6C3F1 mice","volume":"56","author":"Yamamoto","year":"2017","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.lfs.2023.121994_bb0375","doi-asserted-by":"crossref","first-page":"E9879","DOI":"10.1073\/pnas.1811029115","article-title":"Integrative genomic analysis of mouse and human hepatocellular carcinoma","volume":"115","author":"Dow","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2023.121994_bb0380","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1023\/A:1022438528634","article-title":"Early bioenergetic changes in hepatocarcinogenesis: preneoplastic phenotypes mimic responses to insulin and thyroid hormone","volume":"29","author":"Bannasch","year":"1997","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.lfs.2023.121994_bb0385","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1002\/hep.29677","article-title":"C\/EBP\u03b1-dependent preneoplastic tumor foci are the origin of hepatocellular carcinoma and aggressive pediatric liver cancer","volume":"67","author":"Cast","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121994_bb0390","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/cas.12700","article-title":"Differential reactivation of fetal\/neonatal genes in mouse liver tumors induced in cirrhotic and non-cirrhotic conditions","volume":"106","author":"Chen","year":"2015","journal-title":"Cancer Sci."},{"key":"10.1016\/j.lfs.2023.121994_bb0395","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1002\/ijc.28610","article-title":"Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice","volume":"134","author":"Chappell","year":"2014","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.lfs.2023.121994_bb0400","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/carcin\/bgv112","article-title":"MiR-17-92 cluster promotes hepatocarcinogenesis","volume":"36","author":"Zhu","year":"2015","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lfs.2023.121994_bb0405","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.ajpath.2013.08.004","article-title":"Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure","volume":"183","author":"Hsu","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.lfs.2023.121994_bb0410","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/hep.23845","article-title":"Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents","volume":"52","author":"Yu","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121994_bb0415","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jhep.2012.06.011","article-title":"Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats","volume":"57","author":"Zhang","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121994_bb0420","first-page":"169","article-title":"The effect of L-asparaginase on mitotic activity during N-2-fluorenylacetamide hepatocarcinogenesis: subpopulations of nodular cells","volume":"31","author":"Becker","year":"1971","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2023.121994_bb0425","first-page":"3888","article-title":"A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver","volume":"36","author":"Cameron","year":"1976","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2023.121994_bb0430","first-page":"5463","article-title":"Cellular biochemistry of the stepwise development of cancer with chemicals: G. H. A. Clowes memorial lecture","volume":"44","author":"Farber","year":"1984","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2023.121994_bb0435","first-page":"3879","article-title":"The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens","volume":"36","author":"Farber","year":"1976","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2023.121994_bb0440","first-page":"1662","article-title":"Competitive RNA-DNA hybridization of nuclear and microsomal RNA during diethylnitrosamine hepatocarcinogenesis","volume":"33","author":"Garrett","year":"1973","journal-title":"Cancer Res."},{"issue":"49","key":"10.1016\/j.lfs.2023.121994_bb0445","first-page":"93","article-title":"Quantitative study on foci of altered liver cells induced in the rat by a single dose of diethylnitrosamine and partial hepatectomy","volume":"1972","author":"Scherer","year":"1972","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.lfs.2023.121994_bb0450","first-page":"3209","article-title":"Strand breakage in rat liver DNA and its repair following administration of cyclic nitrosamines","volume":"33","author":"Stewart","year":"1973","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2023.121994_bb0455","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/263701a0","article-title":"New principle for the analysis of chemical carcinogenesis","volume":"263","author":"Solt","year":"1976","journal-title":"Nature."},{"key":"10.1016\/j.lfs.2023.121994_bb0460","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1093\/carcin\/12.10.1817","article-title":"Inhibitory effects of beta-carotene on preneoplastic lesions induced in Wistar rats by the resistant hepatocyte model","volume":"12","author":"Moreno","year":"1991","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lfs.2023.121994_bb0465","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cbi.2007.04.011","article-title":"Lutein presents suppressing but not blocking chemopreventive activity during diethylnitrosamine-induced hepatocarcinogenesis and this involves inhibition of DNA damage","volume":"168","author":"Moreno","year":"2007","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.lfs.2023.121994_bb0470","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/ijc.2910400512","article-title":"Alternative methods of selecting rat hepatocellular nodules resistant to 2-acetylaminofluorene","volume":"40","author":"Semple-Roberts","year":"1987","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.lfs.2023.121994_bb0475","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/carcin\/22.2.357","article-title":"Resistance of Copenhagen rats to hepatocarcinogenesis does not involve T-cell immunity","volume":"22","author":"Wood","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lfs.2023.121994_bb0480","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0163-7258(96)00063-0","article-title":"2-Acetylaminofluorene mechanistic data and risk assessment: DNA reactivity, enhanced cell proliferation and tumor initiation","volume":"71","author":"Verna","year":"1996","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2023.121994_bb0485","first-page":"5049","article-title":"Redifferentiation as a basis for remodeling of carcinogen-induced hepatocyte nodules to normal appearing liver","volume":"43","author":"Tatematsu","year":"1983","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2023.121994_bb0490","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/jcb.21420","article-title":"Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-\u03baB pathways","volume":"103","author":"Mazzantini","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.lfs.2023.121994_bb0495","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1002\/hep.20962","article-title":"Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer","volume":"42","author":"Pascale","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121994_bb0500","doi-asserted-by":"crossref","first-page":"24339","DOI":"10.18632\/oncotarget.8248","article-title":"Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein","volume":"7","author":"Ortega","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.lfs.2023.121994_bb0505","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1002\/hep.23488","article-title":"Progenitor-derived hepatocellular carcinoma model in the rat","volume":"51","author":"Andersen","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121994_bb0510","doi-asserted-by":"crossref","first-page":"38749","DOI":"10.18632\/oncotarget.5501","article-title":"Cytokeratin-19 positivity is acquired along cancer progression and does not predict cell origin in rat hepatocarcinogenesis","volume":"6","author":"Kowalik","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.lfs.2023.121994_bb0515","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.canlet.2010.12.008","article-title":"Hippo signaling in oval cells and hepatocarcinogenesis","volume":"302","author":"Zheng","year":"2011","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.lfs.2023.121994_bb0520","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.jhep.2014.06.033","article-title":"YAP activation is an early event and a potential therapeutic target in liver cancer development","volume":"61","author":"Perra","year":"2014","journal-title":"J. Hepatol."},{"issue":"31","key":"10.1016\/j.lfs.2023.121994_bb0525","doi-asserted-by":"crossref","first-page":"49194","DOI":"10.18632\/oncotarget.10246","article-title":"Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease","volume":"7","author":"Simile","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.lfs.2023.121994_bb0530","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/hep.26616","article-title":"MicroRNA\/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC)","volume":"59","author":"Petrelli","year":"2014","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.lfs.2023.121994_bb0535","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.3390\/cancers12082305","article-title":"Distinct mechanisms are responsible for Nrf2-Keap1 pathway activation at different stages of rat hepatocarcinogenesis","volume":"12","author":"Orr\u00f9","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.lfs.2023.121994_bb0540","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/hep.27790","article-title":"Nrf2, but not \u03b2-catenin, mutation represents an early event in rat hepatocarcinogenesis","volume":"62","author":"Zavattari","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121994_bb0545","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jcmgh.2021.08.011","article-title":"Nrf2 mutation\/activation is dispensable for the development of","volume":"13","author":"Mattu","year":"2022","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2023.121994_bb0550","first-page":"256","article-title":"Regulation of microsomal, xenobiotic epoxide hydrolase messenger RNA in persistent hepatocyte nodules and hepatomas induced by chemical carcinogens","volume":"50","author":"Ding","year":"1990","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2023.121994_bb0555","doi-asserted-by":"crossref","first-page":"14189","DOI":"10.1074\/jbc.M113.458414","article-title":"Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue","volume":"288","author":"Bettaieb","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2023.121994_bb0560","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.livres.2019.01.002","article-title":"Endoplasmic reticulum stress and liver diseases","volume":"3","author":"Liu","year":"2019","journal-title":"Liver Res."},{"key":"10.1016\/j.lfs.2023.121994_bb0565","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.toxlet.2017.09.015","article-title":"An integrative analysis of chemically-induced cirrhosis-associated hepatocarcinogenesis: histological, biochemical and molecular features","volume":"281","author":"Romualdo","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.lfs.2023.121994_bb0570","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0203879","article-title":"Fibrosis-associated hepatocarcinogenesis revisited: establishing standard medium-term chemically-induced male and female models","volume":"13","author":"Romualdo","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2023.121994_bb0575","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/toxsci\/kfs342","article-title":"Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis","volume":"132","author":"Uehara","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.lfs.2023.121994_bb0580","article-title":"Global epidemiology of cirrhosis \u2014 aetiology, trends and predictions","author":"Huang","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2023.121994_bb0585","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1293\/tox.25.189","article-title":"Comparative histomorphological review of rat and human hepatocellular proliferative lesions","volume":"25","author":"Thoolen","year":"2012","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.lfs.2023.121994_bb0590","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cgh.2010.08.019","article-title":"Cirrhosis is present in most patients with hepatitis B and hepatocellular carcinoma","volume":"9","author":"Yang","year":"2011","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2023.121994_bb0595","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.etp.2013.01.012","article-title":"Involvement of multiple cell cycle aberrations in early preneoplastic liver cell lesions by tumor promotion with thioacetamide in a two-stage rat hepatocarcinogenesis model","volume":"65","author":"Kimura","year":"2013","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.lfs.2023.121994_bb0600","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.lfs.2023.121994_bb0605","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1021\/tx3002719","article-title":"Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes","volume":"25","author":"Hajovsky","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.lfs.2023.121994_bb0610","first-page":"1171","article-title":"Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma","volume":"23","author":"Piao","year":"2008","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.lfs.2023.121994_bb0615","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.jhep.2010.05.012","article-title":"Epigenetic inactivation of the tumor suppressor gene RIZ1 in hepatocellular carcinoma involves both DNA methylation and histone modifications","volume":"53","author":"Zhang","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121994_bb0620","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.toxlet.2016.11.022","article-title":"Identification of epigenetically downregulated Tmem70 and Ube2e2 in rat liver after 28-day treatment with hepatocarcinogenic thioacetamide showing gene product downregulation in hepatocellular preneoplastic and neoplastic lesions produced by tumor promoti","volume":"266","author":"Mizukami","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.lfs.2023.121994_bb0625","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1080\/09168451.2017.1308242","article-title":"MicroRNA signatures associated with thioacetamide-induced liver fibrosis in mice","volume":"81","author":"Hong","year":"2017","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.lfs.2023.121994_bb0630","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms17060961","article-title":"MicroRNA expression profiling in CCl4-induced liver fibrosis of mus musculus","volume":"17","author":"Hyun","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2023.121994_bb0635","first-page":"1","article-title":"Identification of differentially expressed long noncoding RNAs and pathways in liver tissues from rats with hepatic fibrosis","volume":"16","author":"Wang","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2023.121994_bb0640","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023037","article-title":"Gut microbiota dysbiosis is associated with inflammation and bacterial translocation in mice with CCl 4-induced fibrosis","volume":"6","author":"G\u00f3mez-Hurtado","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2023.121994_bb0645","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fncel.2022.994404","article-title":"The gut\u2013microbiota\u2013brain changes across the liver disease spectrum","volume":"16","author":"Higarza","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.lfs.2023.121994_bb0650","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/hep.30349","article-title":"Intestinal immune dysregulation driven by dysbiosis promotes barrier disruption and bacterial translocation in rats with cirrhosis","volume":"70","author":"Mu\u00f1oz","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121994_bb0655","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.jhep.2019.06.017","article-title":"FXR modulates the gut-vascular barrier by regulating the entry sites for bacterial translocation in experimental cirrhosis","volume":"71","author":"Sorribas","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121994_bb0660","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2020.00018","article-title":"Gut microbial dysbiosis is associated with profibrotic factors in liver fibrosis mice","volume":"10","author":"Wan","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.lfs.2023.121994_bb0665","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3390\/biomedicines8020028","article-title":"NAFLD preclinical models: more than a handful, less of a concern?","volume":"8","author":"Oligschlaeger","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.lfs.2023.121994_bb0670","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jhep.2016.05.005","article-title":"A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer","volume":"65","author":"Asgharpour","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121994_bb0675","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3390\/antiox12020290","article-title":"Unraveling hepatic metabolomic profiles and morphological outcomes in a hybrid model of NASH in different mouse strains","volume":"12","author":"Bacil","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.lfs.2023.121994_bb0680","article-title":"Western diet-induced mouse model of non-alcoholic fatty liver disease associated with metabolic outcomes: features of gut microbiome\u2013liver\u2013adipose tissue axis","volume":"103\u2013104","author":"Romualdo","year":"2022","journal-title":"Nutrition"},{"key":"10.1016\/j.lfs.2023.121994_bb0685","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jhep.2018.03.011","article-title":"A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer","volume":"69","author":"Tsuchida","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121994_bb0690","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jhep.2014.10.024","article-title":"Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine","volume":"62","author":"Healy","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121994_bb0695","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/carcin\/bgy141","article-title":"Liver tumorigenesis is promoted by a high saturated fat diet specifically in male mice and is associated with hepatic expression of the proto-oncogene Agap2 and enrichment of the intestinal microbiome with Coprococcus","volume":"40","author":"Pedersen","year":"2019","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lfs.2023.121994_bb0700","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1749-6632.1954.tb36443.x","article-title":"Liver carcinoma and related lesions in chronic choline deficiency","volume":"57","author":"Salmon","year":"1954","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.lfs.2023.121994_bb0705","first-page":"1092","article-title":"Early histological and functional alterations of ethionine liver carcinogenesis in rats fed a choline-deficient diet","volume":"38","author":"Shinozuka","year":"1978","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2023.121994_bb0710","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/carcin\/5.10.1367","article-title":"The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens","volume":"5","author":"Ghoshal","year":"1984","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lfs.2023.121994_bb0715","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2022.103854","article-title":"Differentiation therapy: unlocking phenotypic plasticity of hepatocellular carcinoma","volume":"180","author":"Zheng","year":"2022","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.lfs.2023.121994_bb0720","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/hep.28281","article-title":"Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase","volume":"63","author":"Kim","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121994_bb0725","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.ajpath.2014.01.034","article-title":"Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat\/fructose diet and sedentary lifestyle","volume":"184","author":"Dowman","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.lfs.2023.121994_bb0730","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1136\/gutjnl-2020-321767","article-title":"RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease","volume":"70","author":"Afonso","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2023.121994_bb0735","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/978-981-10-8684-7_7","article-title":"Dysregulated epigenetic modifications in the pathogenesis of NAFLD-HCC","volume":"1061","author":"Zhao","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.lfs.2023.121994_bb0740","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0304-3835(02)00408-1","article-title":"De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate\/methyl deficiency in rats","volume":"187","author":"Pogribny","year":"2002","journal-title":"Cancer Lett."},{"key":"10.1016\/j.lfs.2023.121994_bb0745","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/toxsci\/kfz110","article-title":"Gene expression and DNA methylation alterations in the glycine N-methyltransferase gene in diet-induced nonalcoholic fatty liver disease-associated carcinogenesis","volume":"170","author":"Borowa-Mazgaj","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.lfs.2023.121994_bb0750","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/hep.22159","article-title":"Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice","volume":"47","author":"Mart\u00ednez-Chantar","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2023.121994_bb0755","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13073-022-01071-5","article-title":"Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease","volume":"14","author":"Assante","year":"2022","journal-title":"Genome Med."},{"key":"10.1016\/j.lfs.2023.121994_bb0760","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12885-015-2007-1","article-title":"MicroRNA expression analysis in high fat diet-induced NAFLD-NASH-HCC progression: study on C57BL\/6J mice","volume":"16","author":"Tessitore","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.lfs.2023.121994_bb0765","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/s42003-022-03714-0","article-title":"miR-182-5p promotes hepatocyte-stellate cell crosstalk to facilitate liver regeneration","volume":"5","author":"Xiao","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.lfs.2023.121994_bb0770","article-title":"Overexpression of miR-125a-5p inhibits hepatocyte proliferation through the STAT3 regulation in vivo and in vitro","volume":"23","author":"Zhang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2023.121994_bb0775","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/mc.20484","article-title":"Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet","volume":"48","author":"Tryndyak","year":"2009","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.lfs.2023.121994_bb0780","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/hep4.1331","article-title":"Role of the gut-liver axis in liver inflammation, fibrosis, and cancer: a special focus on the gut microbiota relationship","volume":"3","author":"Ohtani","year":"2019","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.lfs.2023.121994_bb0785","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1136\/gutjnl-2012-303816","article-title":"Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice","volume":"62","author":"Le Roy","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2023.121994_bb0790","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/gutjnl-2019-319664","article-title":"Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites","volume":"70","author":"Zhang","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2023.121994_bb0795","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jhep.2022.02.030","article-title":"Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis","volume":"77","author":"Sun","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121994_bb0800","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1530-0277.2011.01660.x","article-title":"Chronic ethanol feeding accelerates hepatocellular carcinoma progression in a sex-dependent manner in a mouse model of hepatocarcinogenesis","volume":"36","author":"Brandon-Warner","year":"2012","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.lfs.2023.121994_bb0805","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1158\/1940-6207.CAPR-13-0444-T","article-title":"Alcohol consumption promotes diethylnitrosamine-induced hepatocarcinogenesis in male mice through activation of the Wnt\/\u03b2-catenin signaling pathway","volume":"7","author":"Mercer","year":"2014","journal-title":"Cancer Prev. Res."},{"issue":"2","key":"10.1016\/j.lfs.2023.121994_bb0810","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1349-7006.2007.00677.x","article-title":"Chronic ethanol intake promotes double gluthatione S-transferase\/transforming growth factor-alpha-positive hepatocellular lesions in male Wistar rats","volume":"9","author":"Pires","year":"2008","journal-title":"Cancer Sci."},{"key":"10.1016\/j.lfs.2023.121994_bb0815","first-page":"1","article-title":"Chronic alcohol consumption promotes diethylnitrosamine-induced hepatocarcinogenesis via immune disturbances","volume":"7","author":"Yan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2023.121994_bb0820","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/ijms22115717","article-title":"Pathophysiological aspects of alcohol metabolism in the liver","volume":"22","author":"Hyun","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2023.121994_bb0825","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2020.108479","article-title":"The combination of coffee compounds attenuates early fibrosis-associated hepatocarcinogenesis in mice: involvement of miRNA profile modulation","volume":"85","author":"Romualdo","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.lfs.2023.121994_bb0830","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1007\/s00464-013-2808-8","article-title":"Obesity, but not ethanol, promotes tumor incidence and progression in a mouse model of hepatocellular carcinoma in vivo","volume":"27","author":"Thompson","year":"2013","journal-title":"Surg. Endosc."},{"key":"10.1016\/j.lfs.2023.121994_bb0835","first-page":"47","article-title":"Epigenetic effects of ethanol on the liver and gastrointestinal system","volume":"35","author":"Shukla","year":"2012","journal-title":"Alcohol Res. Curr. Rev."},{"key":"10.1016\/j.lfs.2023.121994_bb0840","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041949","article-title":"Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N\/+) mice to hepatic steatosis upon feeding liquid alcohol diet","volume":"7","author":"Kutay","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2023.121994_bb0845","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jhep.2016.01.035","article-title":"The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis","volume":"64","author":"Bala","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121994_bb0850","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jhep.2014.09.033","article-title":"Alcohol directly stimulates epigenetic modifications in hepatic stellate cells","volume":"62","author":"Page","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2023.121994_bb0855","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep21340","article-title":"Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and MIR-122-mediated HIF-1\u03b1 activation","volume":"6","author":"Ambade","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2023.121994_bb0860","doi-asserted-by":"crossref","first-page":"14433","DOI":"10.18632\/aging.203059","article-title":"Chronic alcohol exposure promotes HCC stemness and metastasis through \u03b2-catenin\/miR-22-3p\/TET2 axis","volume":"13","author":"Chen","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.lfs.2023.121994_bb0865","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cpr.13378","article-title":"ZNF281 drives hepatocyte senescence in alcoholic liver disease by reducing HK2-stabilized PINK1\/Parkin-mediated mitophagy","volume":"56","author":"Lu","year":"2023","journal-title":"Cell Prolif."},{"key":"10.1016\/j.lfs.2023.121994_bb0870","first-page":"137","article-title":"LncRNA-ZNF281 interacts with miR-539 to promote hepatocellular carcinoma cell invasion and migration","volume":"35","author":"Zhang","year":"2020","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.lfs.2023.121994_bb0875","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/19490976.2019.1595300","article-title":"Intestinal and hepatic microbiota changes associated with chronic ethanol administration in mice","volume":"11","author":"Bluemel","year":"2020","journal-title":"Gut Microbes"},{"issue":"12","key":"10.1016\/j.lfs.2023.121994_bb0880","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/ng1481","article-title":"Application of comparative functional genomics to identify best-fit mouse models to study human cancer","volume":"36","author":"Lee","year":"2004","journal-title":"Nat. Genet."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052300629X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052300629X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:11:19Z","timestamp":1758402679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002432052300629X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":176,"alternative-id":["S002432052300629X"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2023.121994","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Past, present, and future of chemically induced hepatocarcinogenesis rodent models: Perspectives concerning classic and new cancer hallmarks","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2023.121994","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"121994"}}