{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:58:44Z","timestamp":1789167524737,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.lfs.2023.122008","type":"journal-article","created":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T01:51:38Z","timestamp":1691200298000},"page":"122008","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Stattic ameliorates the cecal ligation and puncture-induced cardiac injury in septic mice via IL-6-gp130-STAT3 signaling pathway"],"prefix":"10.1016","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2130-2724","authenticated-orcid":false,"given":"Samar","family":"Imbaby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2023.122008_bb0005","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for Sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA."},{"key":"10.1016\/j.lfs.2023.122008_bb0010","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/CIRCULATIONAHA.111.040766","article-title":"Cardiac complications in patients with community-acquired pneumonia: incidence, timing, risk factors, and association with short-term mortality","volume":"125","author":"Corrales-Medina","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2023.122008_bb0015","first-page":"392","article-title":"Cardiac dysfunction in severe sepsis and septic shock","volume":"15","author":"Zanotti-Cavazzoni","year":"2009","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.lfs.2023.122008_bb0020","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.117.004040","article-title":"Myocardial injury in patients with Sepsis and its association with long-term outcome","volume":"11","author":"Frencken","year":"2018","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"10.1016\/j.lfs.2023.122008_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2016.05.001","article-title":"STAT3 signaling in immunity","volume":"31","author":"Hillmer","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.lfs.2023.122008_bb0030","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2183\/pjab.86.717","article-title":"Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir","volume":"86","author":"Hirano","year":"2010","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"10.1016\/j.lfs.2023.122008_bb0035","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuroscience.2017.06.055","article-title":"Deep hypothermia therapy attenuates LPS-induced microglia neuroinflammation via the STAT3 pathway","volume":"358","author":"Tong","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2023.122008_bb0040","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1096\/fba.2019-00070","article-title":"Pharmacological inhibition of STAT3 pathway ameliorates acute liver injury in vivo via inactivation of inflammatory macrophages and hepatic stellate cells","volume":"2","author":"\u00d6zt\u00fcrk Akcora","year":"2020","journal-title":"FASEB Bioadv."},{"key":"10.1016\/j.lfs.2023.122008_bb0045","doi-asserted-by":"crossref","first-page":"15316","DOI":"10.1038\/s41598-020-72136-x","article-title":"Beneficial effect of STAT3 decoy oligodeoxynucleotide transfection on organ injury and mortality in mice with cecal ligation and puncture-induced sepsis","volume":"10","author":"Imbaby","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2023.122008_bb0050","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.chembiol.2006.09.018","article-title":"Stattic: a small-molecule inhibitor of STAT3 activation and dimerization","volume":"13","author":"Schust","year":"2006","journal-title":"Chem. Biol."},{"key":"10.1016\/j.lfs.2023.122008_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.172987","article-title":"\u03ba-opioid receptor activation promotes mitochondrial fusion and enhances myocardial resistance to ischemia and reperfusion injury via STAT3-OPA1 pathway","volume":"874","author":"Wang","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2023.122008_bb0060","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/1753425920988330","article-title":"Stattic alleviates acute hepatic damage induced by LPS\/d-galactosamine in mice","volume":"27","author":"Li","year":"2021","journal-title":"Innate Immun."},{"key":"10.1016\/j.lfs.2023.122008_bb0065","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.imlet.2020.10.004","article-title":"STAT3 inhibition protects against neuroinflammation and BACE1 upregulation induced by systemic inflammation","volume":"228","author":"Millot","year":"2020","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.lfs.2023.122008_bb0070","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3390\/pharmaceutics13070925","article-title":"Pharmacological inhibition of STAT3 by Stattic ameliorates clinical symptoms and reduces autoinflammation in myeloid, lymphoid, and neuronal tissue compartments in relapsing-remitting model of experimental autoimmune encephalomyelitis in SJL\/J mice","volume":"13","author":"Alhazzani","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.lfs.2023.122008_bb0075","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.taap.2017.09.003","article-title":"Prostacyclin mimetics afford protection against lipopolysaccharide\/d-galactosamine-induced acute liver injury in mice","volume":"334","author":"Misawa","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.lfs.2023.122008_bb0080","doi-asserted-by":"crossref","first-page":"e435","DOI":"10.1097\/CCM.0000000000003009","article-title":"Activator protein-1 decoy oligodeoxynucleotide transfection is beneficial in reducing organ injury and mortality in septic mice","volume":"46","author":"Imaizumi","year":"2018","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.lfs.2023.122008_bb0085","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1007\/s00210-020-01947-6","article-title":"Vascular endothelial growth factor contributes to lung vascular hyperpermeability in sepsis-associated acute lung injury","volume":"393","author":"Tomita","year":"2020","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.lfs.2023.122008_bb0090","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1177\/0960327114527628","article-title":"Cardioprotective effects of curcumin and nebivolol against doxorubicin-induced cardiac toxicity in rats","volume":"33","author":"Imbaby","year":"2014","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.lfs.2023.122008_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121561","article-title":"Cardioprotective and renoprotective effects of venlafaxine on cisplatin-induced cardiotoxicity and nephrotoxicity in rats","volume":"320","author":"Ali","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2023.122008_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2022.102206","article-title":"Protective effects of evening primrose oil on behavioral activities, nigral microglia and histopathological changes in a rat model of rotenone-induced parkinsonism","volume":"127","author":"Mohammad","year":"2023","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.lfs.2023.122008_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121496","article-title":"The GSTP1\/MAPKs\/BIM\/SMAC modulatory actions of nitazoxanide: bioinformatics and experimental evidence in subcutaneous solid Ehrlich carcinoma-inoculated mice","volume":"319","author":"Imbaby","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2023.122008_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115005","article-title":"The immunomodulatory effects of probiotics and azithromycin in dextran sodium sulfate-induced ulcerative colitis in rats via TLR4-NF-\u03baB and p38-MAPK pathway","volume":"165","author":"Elkholy","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2023.122008_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110306","article-title":"Acute toxic effects of new synthetic cannabinoid on brain: neurobehavioral and histological: preclinical studies","volume":"370","author":"Ali","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.lfs.2023.122008_bb0120","first-page":"130","article-title":"\u03b2-arrestin 2 attenuates cardiac dysfunction in polymicrobial sepsis through gp130 and p38","volume":"7","author":"Yan","year":"2016","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.lfs.2023.122008_bb0125","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/SHK.0000000000000272","article-title":"Impaired heart rate regulation and depression of cardiac chronotropic and dromotropic function in polymicrobial sepsis","volume":"43","author":"Hoover","year":"2015","journal-title":"Shock"},{"key":"10.1016\/j.lfs.2023.122008_bb0130","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.biopha.2018.11.142","article-title":"Tropisetron inhibits sepsis by repressing hyper-inflammation and regulating the cardiac action potential in rat models","volume":"110","author":"Liu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2023.122008_bb0135","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.autneu.2007.10.006","article-title":"Autonomic dysfunction in experimental sepsis induced by cecal ligation and puncture","volume":"138","author":"Pancoto","year":"2008","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.lfs.2023.122008_bb0140","first-page":"187","article-title":"The heart in sepsis: from basic mechanisms to clinical management","volume":"11","author":"Rudiger","year":"2013","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.lfs.2023.122008_bb0145","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.lfs.2018.11.055","article-title":"Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice","volume":"217","author":"Zhang","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2023.122008_bb0150","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1101\/gad.1553707","article-title":"Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB","volume":"21","author":"Yang","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.lfs.2023.122008_bb0155","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1002\/eji.201040540","article-title":"Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis","volume":"40","author":"Pe\u00f1a","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.lfs.2023.122008_bb0160","doi-asserted-by":"crossref","first-page":"H1224","DOI":"10.1152\/ajpheart.00828.2016","article-title":"Diminished responsiveness to dobutamine as an inotrope in mice with cecal ligation and puncture-induced sepsis: attribution to phosphodiesterase 4 upregulation","volume":"312","author":"Sakai","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.lfs.2023.122008_bb0165","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1749-6632.2009.04911.x","article-title":"Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?","volume":"1171","author":"Aggarwal","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.lfs.2023.122008_bb0170","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nrc2734","article-title":"STATs in cancer inflammation and immunity: a leading role for STAT3","volume":"9","author":"Yu","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.lfs.2023.122008_bb0175","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.molonc.2014.01.007","article-title":"NF\u03baB and STAT3 synergistically activate the expression of FAT10, a gene counteracting the tumor suppressor p53","volume":"8","author":"Choi","year":"2014","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.lfs.2023.122008_bb0180","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nri1995","article-title":"Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment","volume":"7","author":"Yu","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.lfs.2023.122008_bb0185","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1476-4598-11-12","article-title":"A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line","volume":"11","author":"Souissi","year":"2012","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.lfs.2023.122008_bb0190","first-page":"859","article-title":"Inhibition of Janus kinase 2 and signal transduction and activator of transcription 3 protect against cecal ligation and puncture-induced multiple organ damage and mortality","volume":"66","author":"Hui","year":"2009","journal-title":"J. Trauma"},{"key":"10.1016\/j.lfs.2023.122008_bb0195","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1002\/hep.21837","article-title":"Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice","volume":"46","author":"Sakamori","year":"2007","journal-title":"Hepatology."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523006434?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523006434?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:12:37Z","timestamp":1758402757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320523006434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":39,"alternative-id":["S0024320523006434"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2023.122008","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stattic ameliorates the cecal ligation and puncture-induced cardiac injury in septic mice via IL-6-gp130-STAT3 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2023.122008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"122008"}}