{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:44:08Z","timestamp":1780515848105,"version":"3.54.1"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FOOD-CT-2003-506487"],"award-info":[{"award-number":["FOOD-CT-2003-506487"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["ITMS2014+:313011V455"],"award-info":[{"award-number":["ITMS2014+:313011V455"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.lfs.2023.122036","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T06:06:05Z","timestamp":1692857165000},"page":"122036","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Influence of Escherichia coli infection on intestinal mucosal barrier integrity of germ-free piglets"],"prefix":"10.1016","volume":"331","author":[{"given":"\u0160tefan","family":"T\u00f3th","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Fagov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Holodov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dema","family":"Zeidan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hartel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krist\u00edna","family":"\u010curgali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Mech\u00edrov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Maretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radom\u00edra","family":"Nemcov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So\u0148a","family":"Gancar\u010d\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Dankov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2023.122036_bb0005","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.trsl.2015.01.004","article-title":"Porcine models of digestive disease: the future of large animal translational research","volume":"166","author":"Gonzalez","year":"2015","journal-title":"Transl. Res."},{"key":"10.1016\/j.lfs.2023.122036_bb0010","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/ismej.2008.29","article-title":"The immediate environment during postnatal development has long-term impact on gut community structure in pigs","volume":"2","author":"Thompson","year":"2008","journal-title":"ISME J."},{"key":"10.1016\/j.lfs.2023.122036_bb0015","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3920\/BM2016.0225","article-title":"Effect of antibiotic, probiotic, and human rotavirus infection on colonisation dynamics of defined commensal microbiota in a gnotobiotic pig model","volume":"9","author":"Huang","year":"2018","journal-title":"Benef. Microbes"},{"key":"10.1016\/j.lfs.2023.122036_bb0020","doi-asserted-by":"crossref","first-page":"7060","DOI":"10.1111\/febs.15731","article-title":"The role of goblet cells in viral pathogenesis","volume":"288","author":"Cortez","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.lfs.2023.122036_bb0025","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1177\/153537020623100807","article-title":"Effects of commensal bacteria on intestinal morphology and expression of proinflammatory cytokines in the gnotobiotic pig","volume":"231","author":"Shirkey","year":"2006","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.lfs.2023.122036_bb0030","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ni.2640","article-title":"Commensal bacteria at the interface of host metabolism and the immune system","volume":"14","author":"Brestoff","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.lfs.2023.122036_bb0035","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2527\/af.2016-0031","article-title":"The role of gut microbiota in the health and disease of pigs","volume":"6","author":"Fouhse","year":"2016","journal-title":"Anim. Front."},{"key":"10.1016\/j.lfs.2023.122036_bb0040","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0378-1135(01)00504-1","article-title":"Prevalence of serogroups and virulence genes in Escherichia coli associated with postweaning diarrhoea and edema disease in pigs and a comparison of diagnostic approaches","volume":"85","author":"Frydendahl","year":"2002","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.lfs.2023.122036_bb0045","series-title":"Diseases of Swine","first-page":"441","article-title":"Postweaning, Escherichia coli diarrhea and edema disease","author":"Bertschinger","year":"1999"},{"key":"10.1016\/j.lfs.2023.122036_bb0050","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0378-1135(92)90080-D","article-title":"The pathogenesis of edema disease in pigs","volume":"31","author":"Imberechts","year":"1992","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.lfs.2023.122036_bb0055","first-page":"259","article-title":"Enterotoxigenic E. coli (ETEC) in farm animals","volume":"30","author":"Nagy","year":"1999","journal-title":"Vet. Res."},{"key":"10.1016\/j.lfs.2023.122036_bb0060","first-page":"237","article-title":"Identification of EaeA protein in the outer membrane of attaching and effacing E. coli O45 from pigs FEMS","volume":"129","author":"Zhu","year":"1995","journal-title":"Microbiol. Lett."},{"key":"10.1016\/j.lfs.2023.122036_bb0065","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3181\/0709-MR-262","article-title":"The pig as an experimental model for elucidating the mechanisms governing dietary influence on mineral absorption","volume":"233","author":"Patterson","year":"2008","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.lfs.2023.122036_bb0070","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/S0041-1345(00)01238-0","article-title":"An evaluation of methods for grading histologic injury following ischemia\/reperfusion of the small bowel","volume":"32","author":"Quaedackers","year":"2000","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.lfs.2023.122036_bb0075","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1053\/j.gastro.2006.01.041","article-title":"Therapeutic action of ghrelin in a mouse model of colitis","volume":"130","author":"Gonzalez-Rey","year":"2006","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.lfs.2023.122036_bb0080","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00441-014-1886-9","article-title":"Glucagon-like peptide 1 and peptide YY are in separate storage organelles in enteroendocrine cells","volume":"357","author":"Cho","year":"2014","journal-title":"Cell Tissue Res."},{"issue":"23","key":"10.1016\/j.lfs.2023.122036_bb0085","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1113\/jphysiol.2014.272955","article-title":"Can Bayliss and Starling gut hormones cure a worldwide pandemic?","volume":"592","author":"Scott","year":"2014","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.lfs.2023.122036_bb0090","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/00004836-200603000-00016","article-title":"Probiotics for children: use in diarrhea","volume":"40","author":"Guandalini","year":"2006","journal-title":"J. Clin. Gastroenterol."},{"issue":"2","key":"10.1016\/j.lfs.2023.122036_bb0095","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/MCG.0b013e3181674087","article-title":"Probiotics for children with diarrhea: an update","volume":"42","author":"Guandalini","year":"2008","journal-title":"J. Clin. Gastroenterol."},{"issue":"1","key":"10.1016\/j.lfs.2023.122036_bb0100","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12182","article-title":"The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system","volume":"260","author":"Pelaseyed","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.lfs.2023.122036_bb0105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/0192623313518113","article-title":"Comparative anatomy, physiology, and mechanisms of disease production of the esophagus, stomach, and small intestine","volume":"42","author":"Gelberg","year":"2014","journal-title":"Toxicol. Pathol."},{"issue":"3","key":"10.1016\/j.lfs.2023.122036_bb0110","first-page":"71","article-title":"Light and scanning electron microscopy evaluation of the postnatal small intestinal mucosa development in pigs","volume":"56","author":"Skrzypek","year":"2005","journal-title":"J. Physiol. Pharmacol."},{"issue":"3","key":"10.1016\/j.lfs.2023.122036_bb0115","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1083\/jcb.5.3.363","article-title":"An electron microscopic study of the intestinal villus: I. The fasting animal","volume":"5","author":"Palay","year":"1959","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.lfs.2023.122036_bb0120","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1128\/iai.6.6.918-927.1972","article-title":"Role of the K88 antigen in the pathogenesis of neonatal diarrhea caused by Escherichia coli in piglets","volume":"6","author":"Jones","year":"1972","journal-title":"Infect. Immun."},{"key":"10.1016\/j.lfs.2023.122036_bb0125","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/01652176.1998.9694973","article-title":"Enteric bacterial pathogens, villus atrophy and microbial growth","volume":"20","author":"Isaacson","year":"1998","journal-title":"Vet. Q."},{"issue":"1","key":"10.1016\/j.lfs.2023.122036_bb0130","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1017\/S1357729800014429","article-title":"Villous height and crypt depth in piglets in response to increases in the intake of cows\u2019 milk after weaning","volume":"62","author":"Pluske","year":"1996","journal-title":"Anim. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2023.122036_bb0135","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1017\/S1357729800053686","article-title":"Interrelationships between gut morphology and faeces consistency in newly weaned piglets","volume":"77","author":"Vente-Spreeuwenberg","year":"2003","journal-title":"Anim. Sci."},{"key":"10.1016\/j.lfs.2023.122036_bb0140","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/gut.26.6.570","article-title":"Enteropathogenic Escherichia coli enteritis: evaluation of the gnotobiotic piglet as a model of human infection","volume":"26","author":"Tzipori","year":"1985","journal-title":"Gut"},{"issue":"8074","key":"10.1016\/j.lfs.2023.122036_bb0145","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0140-6736(78)90299-4","article-title":"Escherichia coli strains that cause diarrhea but do not produce heat-labile or heat-stable enterotoxins are non-invasive","volume":"311","author":"Levine","year":"1978","journal-title":"Lancet."},{"key":"10.1016\/j.lfs.2023.122036_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104570","article-title":"Experimental infection with Escherichia coli in broilers: impacts of the disease and benefits of preventive consumption of a stimulator of homeopathic immunity","volume":"149","author":"Glombowsky","year":"2020","journal-title":"Microb. Pathog."},{"issue":"2","key":"10.1016\/j.lfs.2023.122036_bb0155","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/01.mog.0000203864.48255.4f","article-title":"Regulation of the intestinal epithelial barrier by the apical junctional complex","volume":"22","author":"Laukoetter","year":"2006","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.lfs.2023.122036_bb0160","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3390\/microorganisms7120663","article-title":"Establishing boundaries: the relationship that exists between intestinal epithelial cells and gut-dwelling bacteria","volume":"7","author":"O\u2019Callaghan","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.lfs.2023.122036_bb0165","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s10735-022-10079-5","article-title":"Immunohistochemical visualisation of the enteric nervous system architecture in the germ-free piglets","volume":"53","author":"Dankov\u00e1","year":"2022","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.lfs.2023.122036_bb0170","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.lfs.2023.122036_bb0175","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1136\/gut.2010.212704","article-title":"Sweet-talk: role of host glycosylation in bacterial pathogenesis of the gastrointestinal tract","volume":"60","author":"Moran","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2023.122036_bb0180","first-page":"183","article-title":"Functional biology of intestinal goblet cells","volume":"260","author":"Specian","year":"1991","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.lfs.2023.122036_bb0185","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.3382\/ps\/pev104","article-title":"Early intestinal growth and development in poultry","volume":"94","author":"Lilburn","year":"2015","journal-title":"Poul. Sci."},{"key":"10.1016\/j.lfs.2023.122036_bb0190","doi-asserted-by":"crossref","first-page":"13057","DOI":"10.1074\/jbc.M011248200","article-title":"Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland","volume":"276","author":"Schroeder","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2023.122036_bb0195","doi-asserted-by":"crossref","first-page":"20607","DOI":"10.1074\/jbc.M310538200","article-title":"The MUC1 oncoprotein activates the anti-apoptotic phosphoinositide 3-kinase\/Akt and Bcl-xL pathways in rat 3Y1 fibroblasts","volume":"279","author":"Raina","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2023.122036_bb0200","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ccr.2005.01.008","article-title":"Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response","volume":"7","author":"Wei","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.lfs.2023.122036_bb0205","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S1535-6108(04)00020-0","article-title":"Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents","volume":"5","author":"Ren","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.lfs.2023.122036_bb0210","first-page":"3","article-title":"Mucin dynamics in intestinal bacterial infection","author":"Linden","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2023.122036_bb0215","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.tcb.2006.07.006","article-title":"Cell surface-associated mucins in signal transduction","volume":"16","author":"Singh","year":"2006","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.lfs.2023.122036_bb0220","doi-asserted-by":"crossref","first-page":"5276","DOI":"10.3168\/jds.2009-2216","article-title":"Bovine MUC1 is a highly polymorphic gene encoding an extensively glycosylated mucin that binds bacteria","volume":"92","author":"Sando","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.lfs.2023.122036_bb0225","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10719-009-9269-2","article-title":"Bovine MUC1 inhibits binding of enteric bacteria to caco-2 cells","volume":"27","author":"Parker","year":"2010","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.lfs.2023.122036_bb0230","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fcimb.2019.00117","article-title":"The role of the cell surface mucin MUC1 as a barrier to infection and regulator of inflammation","volume":"9","author":"Dhar","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.lfs.2023.122036_bb0235","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000071488","article-title":"Oral administration of probiotic Escherichia coli after birth reduces frequency of allergies and repeated infections later in life (after 10 and 20\u00a0years)","volume":"131","author":"Lodinova-Zadnikova","year":"2003","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.lfs.2023.122036_bb0240","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.micinf.2013.05.001","article-title":"The inhibition of COPII trafficking is important for intestinal epithelial tight junction disruption during enteropathogenic Escherichia coli and Citrobacter rodentium infection","volume":"15","author":"Thanabalasuriar","year":"2013","journal-title":"Microb. Infect."},{"key":"10.1016\/j.lfs.2023.122036_bb0245","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrm.2016.80","article-title":"Tight junctions: from simple barriers to multifunctional molecular gates","volume":"17","author":"Zihni","year":"2016","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.lfs.2023.122036_bb0250","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1136\/gut.52.3.439","article-title":"Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation","volume":"52","author":"Berkes","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2023.122036_bb0255","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3945\/jn.110.135657","article-title":"Regulation of tight junction permeability by intestinal bacteria and dietary components","volume":"141","author":"Ulluwishewa","year":"2011","journal-title":"J. Nutr."},{"key":"10.1016\/j.lfs.2023.122036_bb0260","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ceb.2005.08.003","article-title":"Mammalian tight junctions in the regulation of epithelial differentiation and proliferation","volume":"17","author":"Matter","year":"2005","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.lfs.2023.122036_bb0265","doi-asserted-by":"crossref","unstructured":"J. L. Roxas, A. Koutsouris, S. Bellmeyer, S. Tesfay, S. Royan, K. Falzari, A. Harris, H. Cheng, K.J. Rhee, G. Hecht, Enterohemorrhagic E. coli alters murine intestinal epithelial tight junction protein expression and barrier function in a Shiga toxin independent manner. Lab. Investig. 2010; 90:152\u20131168. doi:https:\/\/doi.org\/10.1038\/labinvest.2010.91.","DOI":"10.1038\/labinvest.2010.91"},{"key":"10.1016\/j.lfs.2023.122036_bb0270","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1152\/ajpgi.00048.2015","article-title":"Homeostasis of the gut barrier and potential biomarkers","volume":"312","author":"Wells","year":"2017","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"4","key":"10.1016\/j.lfs.2023.122036_bb0275","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/01.mnh.0000232883.43093.76","article-title":"Epithelial paracellular proteins in health and disease","volume":"15","author":"Landau","year":"2006","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.lfs.2023.122036_bb0280","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00018-012-1070-x","article-title":"Regulation of intestinal epithelial permeability by tight junctions","volume":"70","author":"Suzuki","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.lfs.2023.122036_bb0285","first-page":"107","article-title":"Probiotics, immunity and exercise: a review","volume":"15","author":"West","year":"2009","journal-title":"Exerc. Immunol. Rev."},{"key":"10.1016\/j.lfs.2023.122036_bb0290","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.aninu.2017.10.001","article-title":"Intestinal challenge with enterotoxigenic Escherichia coli in pigs, and nutritional intervention to prevent postweaning diarrhea","volume":"3","author":"Sun","year":"2017","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.lfs.2023.122036_bb0295","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011247","article-title":"Toll-like receptor signaling","volume":"5","author":"Lim","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.lfs.2023.122036_bb0300","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/MED.0b013e3282f43a73","article-title":"Enteroendocrine cells: a site of \u2018taste\u2019 in gastrointestinal chemosensing","volume":"15","author":"Sternini","year":"2008","journal-title":"Curr. Opin. Endocrinol. Diabet. Obes."},{"issue":"1","key":"10.1016\/j.lfs.2023.122036_bb0305","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cell.2017.05.034","article-title":"Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways","volume":"170","author":"Bellono","year":"2017","journal-title":"Cell"},{"issue":"6408","key":"10.1016\/j.lfs.2023.122036_bb0310","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat5236","article-title":"A gut-brain neural circuit for nutrient sensory transduction","volume":"361","author":"Kaelberer","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.lfs.2023.122036_bb0315","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/MED.0b013e32835bc703","article-title":"5-Hydroxytryptamine (serotonin) in the gastrointestinal tract","volume":"20","author":"Gershon","year":"2013","journal-title":"Curr. Opin. Endocrinol. Diabet. Obes."},{"issue":"2","key":"10.1016\/j.lfs.2023.122036_bb0320","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.chom.2020.11.011","article-title":"Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways","volume":"29","author":"Lihua","year":"2021","journal-title":"Cell Host Microbe"},{"issue":"2","key":"10.1016\/j.lfs.2023.122036_bb0325","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2982.2007.00965.x","article-title":"Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: alterations in 5-HT signalling and metabolism in human disease","volume":"19","author":"Spiller","year":"2007","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.lfs.2023.122036_bb0330","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1053\/j.gastro.2006.11.002","article-title":"The serotonin signaling system: from basic understanding to drug development for functional GI disorders","volume":"132","author":"Gershon","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2023.122036_bb0335","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1046\/j.1365-2036.1997.d01-1389.x","article-title":"In vivo effects of the 5-HT3 antagonist alosetron on basal and cholera toxin-induced secretion in the human jejunum: a segmental perfusion study","volume":"11","author":"Bearcroft","year":"1997","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.lfs.2023.122036_bb0340","doi-asserted-by":"crossref","first-page":"258","DOI":"10.5056\/jnm.2012.18.3.258","article-title":"An update on post-infectious irritable bowel syndrome: role of genetics, immune activation, serotonin and altered microbiome","volume":"18","author":"Spiller","year":"2012","journal-title":"J. Neurogastroenterol. Motil."},{"key":"10.1016\/j.lfs.2023.122036_bb0345","first-page":"2031480","article-title":"The role of mast cells in irritable bowel syndrome","volume":"11","author":"Lee","year":"2016","journal-title":"Gastroenterol. Res. Pract."},{"key":"10.1016\/j.lfs.2023.122036_bb0350","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.bbi.2010.06.002","article-title":"Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress","volume":"24","author":"Vicario","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.lfs.2023.122036_bb0355","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/gut.48.5.630","article-title":"Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat","volume":"48","author":"Santos","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2023.122036_bb0360","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1136\/gutjnl-2013-305690","article-title":"Psychological stress and corticotropin-releasing hormone increaseintestinal permeability in by a mast cell-dependent mechanism","volume":"63","author":"Vanuytsel","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2023.122036_bb0365","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nri3690","article-title":"Mast cell secretory granules: armed for battle","volume":"14","author":"Wernersson","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.lfs.2023.122036_bb0370","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nri2018","article-title":"Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data","volume":"7","author":"Bischoff","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.lfs.2023.122036_bb0375","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1365-2222.2010.03639.x","article-title":"Gut permeability and food allergies","volume":"41","author":"Perrier","year":"2010","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.lfs.2023.122036_bb0380","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ejphar.2016.02.018","article-title":"Mast cells in gastrointestinal disorders","volume":"778","author":"Bischoff","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2023.122036_bb0385","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1034\/j.1600-065X.2001.790102.x","article-title":"Mast cells modulation of immune responses to bacteria","volume":"179","author":"Malaviya","year":"2001","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.lfs.2023.122036_bb0390","first-page":"490","article-title":"Complement receptors promote the phagocytosis of bacteria by rat peritoneal mast cells","volume":"41","author":"Sher","year":"1979","journal-title":"Lab. Investig."},{"key":"10.1016\/j.lfs.2023.122036_bb0395","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1126\/science.289.5480.785","article-title":"Involvement of cellular caveolae in bacterial entry into mast cells","volume":"289","author":"Shin","year":"2000","journal-title":"Sci"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523006719?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523006719?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T12:40:56Z","timestamp":1736340056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320523006719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":79,"alternative-id":["S0024320523006719"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2023.122036","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of Escherichia coli infection on intestinal mucosal barrier integrity of germ-free piglets","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2023.122036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"122036"}}