{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:49:57Z","timestamp":1793508597792,"version":"4.5.0"},"reference-count":173,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.lfs.2023.122119","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T19:30:48Z","timestamp":1695324648000},"page":"122119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury"],"prefix":"10.1016","volume":"332","author":[{"given":"Vicen\u00e7","family":"Ruiz de Porras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariona","family":"Figols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Font","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Pardina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.lfs.2023.122119_bb0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"4","key":"10.1016\/j.lfs.2023.122119_bb0010","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.gendis.2022.02.007","article-title":"Cancer chemotherapy and beyond: current status, drug candidates, associated risks and progress in targeted therapeutics","volume":"10","author":"Anand","year":"2023","journal-title":"Genes Dis."},{"key":"10.1016\/j.lfs.2023.122119_bb0015","doi-asserted-by":"crossref","first-page":"960317","DOI":"10.3389\/fonc.2022.960317","article-title":"Cancer chemotherapy: insights into cellular and tumor microenvironmental mechanisms of action","volume":"12","author":"Tilsed","year":"2022","journal-title":"Front. Oncol."},{"issue":"11","key":"10.1016\/j.lfs.2023.122119_bb0020","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41571-022-00685-3","article-title":"Mitigating acute chemotherapy-associated adverse events in patients with cancer","volume":"19","author":"Kuderer","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.lfs.2023.122119_bb0025","first-page":"1","article-title":"Mitigating long-term and delayed adverse events associated with cancer treatment: implications for survivorship","author":"Lustberg","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.lfs.2023.122119_bb0030","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/annonc\/mdv249","article-title":"A standardised, generic, validated approach to stratify the magnitude of clinical benefit that can be anticipated from anti-cancer therapies: the European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS)","volume":"26","author":"Cherny","year":"2015","journal-title":"Ann. Oncol."},{"issue":"9","key":"10.1016\/j.lfs.2023.122119_bb0035","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1093\/annonc\/mdv283","article-title":"Planning and reporting of quality-of-life outcomes in cancer trials","volume":"26","author":"Schandelmaier","year":"2015","journal-title":"Ann. Oncol."},{"issue":"9","key":"10.1016\/j.lfs.2023.122119_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15092483","article-title":"Patient-related characteristics associated with treatment modifications and suboptimal relative dose intensity of neoadjuvant chemotherapy in patients with breast cancer-a retrospective study","volume":"15","author":"Kjeldsted","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.lfs.2023.122119_bb0045","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3389\/fphar.2020.00329","article-title":"Patient-related risk factors for chemotherapy-induced nausea and vomiting: a systematic review","volume":"11","author":"Mosa","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.lfs.2023.122119_bb0050","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/ijd.13906","article-title":"Pathogenesis and treatment options for chemotherapy-induced alopecia: a systematic review","volume":"57","author":"Rubio-Gonzalez","year":"2018","journal-title":"Int. J. Dermatol."},{"issue":"4","key":"10.1016\/j.lfs.2023.122119_bb0055","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.3390\/curroncol30040275","article-title":"Prevention and treatment of chemotherapy-induced alopecia: what is available and what is coming?","volume":"30","author":"Wikramanayake","year":"2023","journal-title":"Curr. Oncol."},{"issue":"10","key":"10.1016\/j.lfs.2023.122119_bb0060","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrclinonc.2014.127","article-title":"Cancer-related fatigue\u2014mechanisms, risk factors, and treatments","volume":"11","author":"Bower","year":"2014","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0065","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/01635581.2015.990577","article-title":"The impact of cancer treatment on the diets and food preferences of patients receiving outpatient treatment","volume":"67","author":"Coa","year":"2015","journal-title":"Nutr. Cancer"},{"issue":"10","key":"10.1016\/j.lfs.2023.122119_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/nu11102285","article-title":"Chemosensory changes from cancer treatment and their effects on patients\u2019 food behavior: a scoping review","volume":"11","author":"Nolden","year":"2019","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.lfs.2023.122119_bb0075","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.clnu.2016.12.003","article-title":"Association between cachexia, chemotherapy and outcomes in older cancer patients: a systematic review","volume":"36","author":"Caillet","year":"2017","journal-title":"Clin. Nutr."},{"issue":"19","key":"10.1016\/j.lfs.2023.122119_bb0080","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1093\/jnci\/91.19.1616","article-title":"Chemotherapy-induced anemia in adults: incidence and treatment","volume":"91","author":"Groopman","year":"1999","journal-title":"J. Natl. Cancer Inst."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0085","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s12672-023-00616-3","article-title":"Chemotherapy-induced thrombocytopenia: literature review","volume":"14","author":"Gao","year":"2023","journal-title":"Discov. Oncol."},{"issue":"7","key":"10.1016\/j.lfs.2023.122119_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/ph14070681","article-title":"Comprehensive analysis of chemotherapeutic agents that induce infectious neutropenia","volume":"14","author":"Okunaka","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"issue":"7","key":"10.1016\/j.lfs.2023.122119_bb0095","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s40265-018-0909-3","article-title":"Chemotherapy-induced neutropenia as a prognostic and predictive marker of outcomes in solid-tumor patients","volume":"78","author":"Kasi","year":"2018","journal-title":"Drugs"},{"key":"10.1016\/j.lfs.2023.122119_bb0100","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/bs.acr.2022.02.007","article-title":"Chemotherapy induced gastrointestinal toxicities","volume":"155","author":"Akbarali","year":"2022","journal-title":"Adv. Cancer Res."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0105","first-page":"106","article-title":"Systemic treatment-induced gastrointestinal toxicity: incidence, clinical presentation and management","volume":"25","author":"Boussios","year":"2012","journal-title":"Ann. Gastroenterol."},{"key":"10.1016\/j.lfs.2023.122119_bb0110","doi-asserted-by":"crossref","DOI":"10.1177\/15347354221144309","article-title":"Orally administered probiotics in the prevention of chemotherapy (+\/\u2212 radiotherapy)-induced gastrointestinal toxicity: a systematic review with meta-analysis of randomized trials","volume":"21","author":"Danis","year":"2022","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.lfs.2023.122119_bb0115","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2147\/CMAR.S44261","article-title":"Chemotherapy-induced peripheral neuropathy in adults: a comprehensive update of the literature","volume":"6","author":"Argyriou","year":"2014","journal-title":"Cancer Manag. Res."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0120","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s40487-021-00168-y","article-title":"Chemotherapy-induced peripheral neuropathy: epidemiology, pathomechanisms and treatment","volume":"9","author":"Burgess","year":"2021","journal-title":"Oncol. Ther."},{"key":"10.1016\/j.lfs.2023.122119_bb0125","doi-asserted-by":"crossref","first-page":"113141","DOI":"10.1016\/j.expneurol.2019.113141","article-title":"Pathogenesis of platinum-induced peripheral neurotoxicity: insights from preclinical studies","volume":"325","author":"Calls","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.lfs.2023.122119_bb0130","doi-asserted-by":"crossref","first-page":"750507","DOI":"10.3389\/fphar.2022.750507","article-title":"Mechanisms of chemotherapy-induced neurotoxicity","volume":"13","author":"Was","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.lfs.2023.122119_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20061451","article-title":"Mechanisms of chemotherapy-induced peripheral neuropathy","volume":"20","author":"Zajaczkowska","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0140","first-page":"10","article-title":"Efficacy and safety of cardioprotective drugs in chemotherapy-induced cardiotoxicity: an updated systematic review & network meta-analysis","volume":"9","author":"Mir","year":"2023","journal-title":"Cardiooncology"},{"issue":"7","key":"10.1016\/j.lfs.2023.122119_bb0145","first-page":"3461","article-title":"Management of hepatotoxicity of chemotherapy and targeted agents","volume":"11","author":"Mudd","year":"2021","journal-title":"Am. J. Cancer Res."},{"issue":"9","key":"10.1016\/j.lfs.2023.122119_bb0150","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1097\/JTO.0b013e3181e9dbb9","article-title":"Chemotherapy-induced pulmonary toxicity in lung cancer patients","volume":"5","author":"Ryu","year":"2010","journal-title":"J. Thorac. Oncol."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0155","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1378\/chest.07-0851","article-title":"Pulmonary complications of novel antineoplastic agents for solid tumors","volume":"133","author":"Vahid","year":"2008","journal-title":"Chest"},{"issue":"12","key":"10.1016\/j.lfs.2023.122119_bb0160","first-page":"4151","article-title":"Management of nephrotoxicity of chemotherapy and targeted agents: 2020","volume":"10","author":"Chiruvella","year":"2020","journal-title":"Am. J. Cancer Res."},{"issue":"6","key":"10.1016\/j.lfs.2023.122119_bb0165","first-page":"924","article-title":"Nephrotoxicity of anticancer treatment","volume":"32","author":"Malyszko","year":"2017","journal-title":"Nephrol. Dial. Transplant."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cld.2016.08.001","article-title":"Drug metabolism in the liver","volume":"21","author":"Almazroo","year":"2017","journal-title":"Clin. Liver Dis."},{"issue":"5","key":"10.1016\/j.lfs.2023.122119_bb0175","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF02353473","article-title":"Overview of enzymes of drug metabolism","volume":"24","author":"Meyer","year":"1996","journal-title":"J. Pharmacokinet. Biopharm."},{"issue":"1612","key":"10.1016\/j.lfs.2023.122119_bb0180","doi-asserted-by":"crossref","first-page":"20120431","DOI":"10.1098\/rstb.2012.0431","article-title":"Human cytochromes P450 in health and disease","volume":"368","author":"Nebert","year":"2013","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"issue":"3","key":"10.1016\/j.lfs.2023.122119_bb0185","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00280-020-04181-2","article-title":"Involvement of cytochrome P450 enzymes in inflammation and cancer: a review","volume":"87","author":"Stipp","year":"2021","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"10","key":"10.1016\/j.lfs.2023.122119_bb0190","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s40262-018-0644-7","article-title":"Individualization of Irinotecan treatment: a review of pharmacokinetics, pharmacodynamics, and pharmacogenetics","volume":"57","author":"de Man","year":"2018","journal-title":"Clin. Pharmacokinet."},{"issue":"10","key":"10.1016\/j.lfs.2023.122119_bb0195","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1007\/s00204-020-02885-1","article-title":"Drug induced liver injury: an update","volume":"94","author":"Garcia-Cortes","year":"2020","journal-title":"Arch. Toxicol."},{"issue":"8","key":"10.1016\/j.lfs.2023.122119_bb0200","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1093\/annonc\/mdx158","article-title":"Drug-induced liver injury in oncology","volume":"28","author":"Ricart","year":"2017","journal-title":"Ann. Oncol."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cld.2007.02.009","article-title":"Epidemiology and natural history of NAFLD and NASH","volume":"11","author":"Ong","year":"2007","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.lfs.2023.122119_bb0210","doi-asserted-by":"crossref","DOI":"10.1177\/1756284820924194","article-title":"Chemotherapy-associated liver injury in colorectal cancer","volume":"13","author":"Gangi","year":"2020","journal-title":"Therap. Adv. Gastroenterol."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0215","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3390\/ijms17020224","article-title":"Hepatotoxicity by drugs: the most common implicated agents","volume":"17","author":"Bjornsson","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.lfs.2023.122119_bb0220","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrc1074","article-title":"5-fluorouracil: mechanisms of action and clinical strategies","volume":"3","author":"Longley","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.lfs.2023.122119_bb0225","series-title":"LiverTox: Clinical and Research Information on Drug-Induced Liver Injury","year":"2012"},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0230","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.critrevonc.2013.05.011","article-title":"Chemotherapy induced hepatotoxicity in metastatic colorectal cancer: a review of mechanisms and outcomes","volume":"88","author":"McWhirter","year":"2013","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0235","article-title":"Severe and late acute liver injury induced by capecitabine","volume":"13","author":"Habib","year":"2021","journal-title":"Cureus"},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0240","first-page":"95","article-title":"Hepatotoxicity secondary to chemotherapy","volume":"2","author":"Grigorian","year":"2014","journal-title":"J. Clin. Transl. Hepatol."},{"issue":"5","key":"10.1016\/j.lfs.2023.122119_bb0245","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1158\/1535-7163.MCT-08-0709","article-title":"The role of floxuridine in metastatic liver disease","volume":"8","author":"Power","year":"2009","journal-title":"Mol. Cancer Ther."},{"issue":"8","key":"10.1016\/j.lfs.2023.122119_bb0250","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1001\/jamasurg.2019.1694","article-title":"Role of hepatic artery infusion chemotherapy in treatment of initially unresectable colorectal liver metastases: a review","volume":"154","author":"Datta","year":"2019","journal-title":"JAMA Surg."},{"issue":"10","key":"10.1016\/j.lfs.2023.122119_bb0255","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/FPC.0b013e328343dd93","article-title":"PharmGKB summary: methotrexate pathway","volume":"21","author":"Mikkelsen","year":"2011","journal-title":"Pharmacogenet. Genomics"},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0260","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1634\/theoncologist.6-2-162","article-title":"Hepatotoxicity of chemotherapy","volume":"6","author":"King","year":"2001","journal-title":"Oncologist"},{"issue":"26","key":"10.1016\/j.lfs.2023.122119_bb0265","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.4254\/wjh.v9.i26.1092","article-title":"Risk of liver disease in methotrexate treated patients","volume":"9","author":"Conway","year":"2017","journal-title":"World J. Hepatol."},{"issue":"3","key":"10.1016\/j.lfs.2023.122119_bb0270","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00210-020-01991-2","article-title":"Protective effects of apigenin on altered lipid peroxidation, inflammation, and antioxidant factors in methotrexate-induced hepatotoxicity","volume":"394","author":"Goudarzi","year":"2021","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"5","key":"10.1016\/j.lfs.2023.122119_bb0275","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.7150\/thno.69424","article-title":"Platinum-based drugs for cancer therapy and anti-tumor strategies","volume":"12","author":"Zhang","year":"2022","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ASN.0000042803.28024.92","article-title":"Metabolism of cisplatin to a nephrotoxin in proximal tubule cells","volume":"14","author":"Townsend","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0285","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/toxsci\/kfj031","article-title":"Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1","volume":"89","author":"Lu","year":"2006","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.lfs.2023.122119_bb0290","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/annonc\/mdh095","article-title":"Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer","volume":"15","author":"Rubbia-Brandt","year":"2004","journal-title":"Ann. Oncol."},{"issue":"6","key":"10.1016\/j.lfs.2023.122119_bb0295","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.eururo.2013.07.022","article-title":"Taxane mechanisms of action: potential implications for treatment sequencing in metastatic castration-resistant prostate cancer","volume":"65","author":"Fitzpatrick","year":"2014","journal-title":"Eur. Urol."},{"issue":"8","key":"10.1016\/j.lfs.2023.122119_bb0300","first-page":"440","article-title":"Cabazitaxel (jevtana): a novel agent for metastatic castration-resistant prostate cancer","volume":"37","author":"Nightingale","year":"2012","journal-title":"P T"},{"issue":"12","key":"10.1016\/j.lfs.2023.122119_bb0305","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1097\/FPC.0b013e3283335277","article-title":"Taxane pathway","volume":"19","author":"Oshiro","year":"2009","journal-title":"Pharmacogenet. Genomics"},{"issue":"5","key":"10.1016\/j.lfs.2023.122119_bb0310","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.3892\/mmr.2017.6295","article-title":"Effects of gap junction intercellular communication on the docetaxel-induced cytotoxicity in rat hepatocytes","volume":"15","author":"Tang","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0315","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12935-022-02624-9","article-title":"Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine","volume":"22","author":"Dhyani","year":"2022","journal-title":"Cancer Cell Int."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0320","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/tpj.2013.13","article-title":"Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent","volume":"14","author":"Aminkeng","year":"2014","journal-title":"Pharmacogenomics J."},{"issue":"3","key":"10.1016\/j.lfs.2023.122119_bb0325","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26854","article-title":"CYP3A5 genotype and its impact on vincristine pharmacokinetics and development of neuropathy in Kenyan children with cancer","volume":"65","author":"Skiles","year":"2018","journal-title":"Pediatr. Blood Cancer"},{"issue":"12","key":"10.1016\/j.lfs.2023.122119_bb0330","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1002\/(SICI)1097-0142(19970615)79:12<2435::AID-CNCR21>3.0.CO;2-R","volume":"79","author":"Ortega","year":"1997","journal-title":"Cancer"},{"issue":"4","key":"10.1016\/j.lfs.2023.122119_bb0335","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/stem.5530130408","article-title":"Mechanism of action of DNA topoisomerase inhibitors","volume":"13","author":"Binaschi","year":"1995","journal-title":"Stem Cells"},{"issue":"6","key":"10.1016\/j.lfs.2023.122119_bb0340","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.aohep.2019.11.012","article-title":"Chemotherapy-associated steatohepatitis","volume":"19","author":"Meunier","year":"2020","journal-title":"Ann. Hepatol."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0345","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1570-0232(02)00798-5","article-title":"Determination of plasma topotecan and its metabolite N-desmethyl topotecan as both lactone and total form by reversed-phase liquid chromatography with fluorescence detection","volume":"784","author":"Bai","year":"2003","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0350","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2165\/00003088-199631020-00001","article-title":"Clinical pharmacokinetics of topotecan","volume":"31","author":"Herben","year":"1996","journal-title":"Clin. Pharmacokinet."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gastrohep.2020.05.017","article-title":"Topotecan induces hepatocellular injury via ASCT2 mediated oxidative stress","volume":"44","author":"Zhou","year":"2021","journal-title":"Gastroenterol. Hepatol."},{"issue":"7","key":"10.1016\/j.lfs.2023.122119_bb0360","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/FPC.0b013e32832e0e7f","article-title":"Etoposide pathway","volume":"19","author":"Yang","year":"2009","journal-title":"Pharmacogenet. Genomics"},{"issue":"3","key":"10.1016\/j.lfs.2023.122119_bb0365","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/S0022-3565(24)37724-9","article-title":"A study on the metabolism of etoposide and possible interactions with antitumor or supporting agents by human liver microsomes","volume":"286","author":"Kawashiro","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2023.122119_bb0370","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1081\/DMR-120001392","article-title":"Summary of information on human CYP enzymes: human P450 metabolism data","volume":"34","author":"Rendic","year":"2002","journal-title":"Drug Metab. Rev."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0375","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0168-8278(91)90905-Q","article-title":"Etoposide (VP 16-213) induced hepatitis. Report of three cases following standard-dose treatments","volume":"12","author":"Tran","year":"1991","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.lfs.2023.122119_bb0380","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1200\/JCO.2000.18.5.981","article-title":"Prospective randomized comparison of single-dose versus hyperfractionated total-body irradiation in patients with hematologic malignancies","volume":"18","author":"Girinsky","year":"2000","journal-title":"J. Clin. Oncol."},{"issue":"2 Suppl 1","key":"10.1016\/j.lfs.2023.122119_bb0385","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1002\/hep.20969","article-title":"Liver regeneration","volume":"43","author":"Fausto","year":"2006","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.lfs.2023.122119_bb0390","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/mpo.2950070410","article-title":"Hepatic toxicity of adjuvant chemotherapy for carcinoma of the breast","volume":"7","author":"Vaughan","year":"1979","journal-title":"Med. Pediatr. Oncol."},{"issue":"11","key":"10.1016\/j.lfs.2023.122119_bb0395","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1097\/FPC.0b013e328313aaa4","article-title":"Relations between polymorphisms in drug-metabolising enzymes and toxicity of chemotherapy with cyclophosphamide, thiotepa and carboplatin","volume":"18","author":"Ekhart","year":"2008","journal-title":"Pharmacogenet. Genomics"},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0400","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1665-2681(19)31651-5","article-title":"Effects of systemic chemotherapy on the liver","volume":"9","author":"Ramadori","year":"2010","journal-title":"Ann. Hepatol."},{"issue":"5","key":"10.1016\/j.lfs.2023.122119_bb0405","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s00280-019-03932-0","article-title":"Polymorphisms of genes encoding drug transporters or cytochrome P450 enzymes and association with clinical response in cancer patients: a systematic review","volume":"84","author":"Kulma","year":"2019","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"8","key":"10.1016\/j.lfs.2023.122119_bb0410","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/phar.1946","article-title":"Oncology drug dosing in Gilbert syndrome associated with UGT1A1: a summary of the literature","volume":"37","author":"Ha","year":"2017","journal-title":"Pharmacotherapy"},{"issue":"4","key":"10.1016\/j.lfs.2023.122119_bb0415","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/tpj.2016.31","article-title":"Determinants of Gefitinib toxicity in advanced non-small cell lung cancer (NSCLC): a pharmacogenomic study of metabolic enzymes and transporters","volume":"17","author":"Ma","year":"2017","journal-title":"Pharmacogenomics J."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0420","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2478\/10004-1254-60-2009-1885","article-title":"Genetic polymorphism of metabolic enzymes P450 (CYP) as a susceptibility factor for drug response, toxicity, and cancer risk","volume":"60","author":"Bozina","year":"2009","journal-title":"Arh. Hig. Rada Toksikol."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0425","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.hepres.2005.09.030","article-title":"CYP17 polymorphism and tamoxifen-induced hepatic steatosis","volume":"33","author":"Ohnishi","year":"2005","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.lfs.2023.122119_bb0430","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejca.2020.02.041","article-title":"Characterization of risk factors and efficacy of medical management of immune-related hepatotoxicity in real-world patients with metastatic melanoma treated with immune checkpoint inhibitors","volume":"130","author":"Romanski","year":"2020","journal-title":"Eur. J. Cancer"},{"issue":"3","key":"10.1016\/j.lfs.2023.122119_bb0435","first-page":"661","article-title":"Patterns of expression of cytochrome P450 genes in progression of hepatitis C virus-associated hepatocellular carcinoma","volume":"27","author":"Tsunedomi","year":"2005","journal-title":"Int. J. Oncol."},{"issue":"12","key":"10.1016\/j.lfs.2023.122119_bb0440","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1158\/1535-7163.MCT-15-0274","article-title":"Severely impaired and dysregulated cytochrome P450 expression and activities in hepatocellular carcinoma: implications for personalized treatment in patients","volume":"14","author":"Yan","year":"2015","journal-title":"Mol. Cancer Ther."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0445","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41572-019-0105-0","article-title":"Drug-induced liver injury","volume":"5","author":"Andrade","year":"2019","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"6","key":"10.1016\/j.lfs.2023.122119_bb0450","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/jcp.2008.058248","article-title":"Histological patterns in drug-induced liver disease","volume":"62","author":"Ramachandran","year":"2009","journal-title":"J. Clin. Pathol."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0455","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/17425255.2017.1246534","article-title":"Drug-induced steatohepatitis","volume":"13","author":"Dash","year":"2017","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0460","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/cancers3011351","article-title":"Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects","volume":"3","author":"Florea","year":"2011","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.lfs.2023.122119_bb0465","first-page":"2398","article-title":"Oxaliplatin aggravates hepatic oxidative stress, inflammation and fibrosis in a non-alcoholic fatty liver disease mouse model","volume":"43","author":"Lu","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.lfs.2023.122119_bb0470","doi-asserted-by":"crossref","first-page":"153402","DOI":"10.1016\/j.phymed.2020.153402","article-title":"Protection against chemotherapy- and radiotherapy-induced side effects: a review based on the mechanisms and therapeutic opportunities of phytochemicals","volume":"80","author":"Liu","year":"2021","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.lfs.2023.122119_bb0475","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.fct.2011.05.012","article-title":"Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFkappaB, TNF-alpha and caspase-3 expression in wistar rats","volume":"49","author":"Arjumand","year":"2011","journal-title":"Food Chem. Toxicol."},{"issue":"9","key":"10.1016\/j.lfs.2023.122119_bb0480","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1124\/dmd.107.015511","article-title":"Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes","volume":"35","author":"Aitken","year":"2007","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0485","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00280-017-3331-8","article-title":"Possible involvement of the lipoxygenase and leukotriene signaling pathways in cisplatin-mediated renal toxicity","volume":"80","author":"Alkhamees","year":"2017","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"23","key":"10.1016\/j.lfs.2023.122119_bb0490","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222312947","article-title":"Steatosis, steatohepatitis and cancer immunotherapy: an intricate story","volume":"22","author":"Cataldi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0495","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jsps.2017.12.013","article-title":"Antioxidants as precision weapons in war against cancer chemotherapy induced toxicity - exploring the armoury of obscurity","volume":"26","author":"Singh","year":"2018","journal-title":"Saudi Pharm. J."},{"issue":"11","key":"10.1016\/j.lfs.2023.122119_bb0500","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.ejca.2008.04.018","article-title":"Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies","volume":"44","author":"Wolf","year":"2008","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.lfs.2023.122119_bb0505","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.fct.2018.12.002","article-title":"Mechanistic insights of hepatoprotective effects of curcumin: therapeutic updates and future prospects","volume":"124","author":"Khan","year":"2019","journal-title":"Food Chem. Toxicol."},{"issue":"22","key":"10.1016\/j.lfs.2023.122119_bb0510","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214058","article-title":"Curcumin: a novel way to improve quality of life for colorectal cancer patients?","volume":"23","author":"Layos","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.lfs.2023.122119_bb0515","doi-asserted-by":"crossref","DOI":"10.3390\/nu11102376","article-title":"Curcumin and cancer","volume":"11","author":"Giordano","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2023.122119_bb0520","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.semcancer.2020.09.004","article-title":"Curcumin: a therapeutic strategy for colorectal cancer?","volume":"73","author":"Ruiz de Porras","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.lfs.2023.122119_bb0525","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.semcancer.2020.02.011","article-title":"Curcumin and colorectal cancer: an update and current perspective on this natural medicine","volume":"80","author":"Weng","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"10","key":"10.1016\/j.lfs.2023.122119_bb0530","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1002\/ptr.6703","article-title":"Curcumin effect on cancer cells\u2019 multidrug resistance: an update","volume":"34","author":"Keyvani-Ghamsari","year":"2020","journal-title":"Phytother. Res."},{"key":"10.1016\/j.lfs.2023.122119_bb0535","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.3389\/fphar.2018.01374","article-title":"Preventive effect of curcumin against chemotherapy-induced side-effects","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2023.122119_bb0540","doi-asserted-by":"crossref","first-page":"111699","DOI":"10.1016\/j.fct.2020.111699","article-title":"Curcumin as a preventive or therapeutic measure for chemotherapy and radiotherapy induced adverse reaction: a comprehensive review","volume":"145","author":"Akbari","year":"2020","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0545","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1248\/bpb.30.74","article-title":"Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives","volume":"30","author":"Somparn","year":"2007","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0550","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/antiox4010025","article-title":"Curcumin stimulates the antioxidant mechanisms in mouse skin exposed to fractionated gamma-irradiation","volume":"4","author":"Jagetia","year":"2015","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0555","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cbi.2008.05.003","article-title":"Antioxidant and radical scavenging properties of curcumin","volume":"174","author":"Ak","year":"2008","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.lfs.2023.122119_bb0560","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1096\/fj.02-0566fje","article-title":"Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression","volume":"17","author":"Dickinson","year":"2003","journal-title":"FASEB J."},{"issue":"7","key":"10.1016\/j.lfs.2023.122119_bb0565","doi-asserted-by":"crossref","DOI":"10.3390\/nu10070855","article-title":"Curcumin in liver diseases: a systematic review of the cellular mechanisms of oxidative stress and clinical perspective","volume":"10","author":"Farzaei","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2023.122119_bb0570","doi-asserted-by":"crossref","first-page":"866343","DOI":"10.3389\/fmed.2022.866343","article-title":"Combination of vitamin C and curcumin safeguards against methotrexate-induced acute liver injury in mice by synergistic antioxidant effects","volume":"9","author":"Hasan Khudhair","year":"2022","journal-title":"Front. Med. (Lausanne)"},{"issue":"10","key":"10.1016\/j.lfs.2023.122119_bb0575","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1007\/s00210-020-01888-0","article-title":"Curcumin nanoparticles ameliorate hepatotoxicity and nephrotoxicity induced by cisplatin in rats","volume":"393","author":"El-Gizawy","year":"2020","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2023.122119_bb0580","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ejphar.2011.06.006","article-title":"Synergistic activity of curcumin with methotrexate in ameliorating Freund\u2019s complete adjuvant induced arthritis with reduced hepatotoxicity in experimental animals","volume":"668","author":"Banji","year":"2011","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0585","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.arcmed.2017.01.010","article-title":"Mitochondria as the target for the modulatory effect of curcumin in oxaliplatin-induced toxicity in isolated rat liver mitochondria","volume":"48","author":"Waseem","year":"2017","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.lfs.2023.122119_bb0590","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.fct.2012.11.055","article-title":"Mitochondrial dysfunction mediated cisplatin induced toxicity: modulatory role of curcumin","volume":"53","author":"Waseem","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.lfs.2023.122119_bb0595","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.arcmed.2014.07.006","article-title":"Ameliorative action of curcumin in cisplatin-mediated hepatotoxicity: an in vivo study in Wistar rats","volume":"45","author":"Waseem","year":"2014","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.lfs.2023.122119_bb0600","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.fct.2013.07.032","article-title":"Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion","volume":"59","author":"Gao","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0605","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1158\/1535-7163.MCT-05-0293","article-title":"Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin","volume":"5","author":"Shen","year":"2006","journal-title":"Mol. Cancer Ther."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0610","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23010215","article-title":"Curcumin attenuates on carbon tetrachloride-induced acute liver injury in mice via modulation of the Nrf2\/HO-1 and TGF-beta1\/Smad3 pathway","volume":"23","author":"Peng","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.lfs.2023.122119_bb0615","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.fct.2018.07.024","article-title":"The role of nuclear factor erythroid 2-related factor 2 in hepatoprotective activity of natural products: a review","volume":"120","author":"Iranshahy","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"Suppl. 1","key":"10.1016\/j.lfs.2023.122119_bb0620","first-page":"S84","article-title":"Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2","volume":"52","author":"Eggler","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.lfs.2023.122119_bb0625","doi-asserted-by":"crossref","first-page":"153755","DOI":"10.1016\/j.phymed.2021.153755","article-title":"Targeting Nrf2\/Keap1 signaling pathway by bioactive natural agents: possible therapeutic strategy to combat liver disease","volume":"92","author":"Jayasuriya","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2023.122119_bb0630","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2147\/DDDT.S224318","article-title":"Curcumin attenuates oxaliplatin-induced liver injury and oxidative stress by activating the Nrf2 pathway","volume":"14","author":"Lu","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"issue":"4","key":"10.1016\/j.lfs.2023.122119_bb0635","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3109\/01480545.2014.992437","article-title":"Cisplatin hepatotoxicity mediated by mitochondrial stress","volume":"38","author":"Waseem","year":"2015","journal-title":"Drug Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0640","first-page":"895","article-title":"Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling","volume":"40","author":"Ren","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.lfs.2023.122119_bb0645","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-kappaB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target Ther."},{"issue":"6","key":"10.1016\/j.lfs.2023.122119_bb0650","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.pharep.2019.06.003","article-title":"Inhibition of NF-kappaB and the oxidative stress-dependent caspase-3 apoptotic pathway by betaine supplementation attenuates hepatic injury mediated by cisplatin in rats","volume":"71","author":"Hagar","year":"2019","journal-title":"Pharmacol. Rep."},{"issue":"6","key":"10.1016\/j.lfs.2023.122119_bb0655","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1172\/JCI200215606","article-title":"TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity","volume":"110","author":"Ramesh","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.lfs.2023.122119_bb0660","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1111\/bph.12131","article-title":"Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers","volume":"169","author":"Aggarwal","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.lfs.2023.122119_bb0665","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.4049\/jimmunol.163.6.3474","article-title":"Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity","volume":"163","author":"Jobin","year":"1999","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.lfs.2023.122119_bb0670","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2174\/1381612822666161006151605","article-title":"Curcumin: an effective inhibitor of Interleukin-6","volume":"23","author":"Ghandadi","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.lfs.2023.122119_bb0675","doi-asserted-by":"crossref","first-page":"24675","DOI":"10.1038\/srep24675","article-title":"Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-chemokine\/NF-kappaB signalling pathway","volume":"6","author":"Ruiz de Porras","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0680","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0304-3835(01)00655-3","article-title":"Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells","volume":"172","author":"Goel","year":"2001","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0685","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/gut.2004.047100","article-title":"Prostaglandins and cancer","volume":"55","author":"Wang","year":"2006","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0690","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biocel.2008.06.010","article-title":"Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases","volume":"41","author":"Aggarwal","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"6","key":"10.1016\/j.lfs.2023.122119_bb0695","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jhep.2004.08.010","article-title":"Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice","volume":"41","author":"Leclercq","year":"2004","journal-title":"J. Hepatol."},{"issue":"16","key":"10.1016\/j.lfs.2023.122119_bb0700","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease","volume":"346","author":"Angulo","year":"2002","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.lfs.2023.122119_bb0705","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.freeradbiomed.2009.06.015","article-title":"Curcumin ameliorates rabbits\u2019s steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha","volume":"47","author":"Ramirez-Tortosa","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2023.122119_bb0710","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.2147\/OTT.S199601","article-title":"Curcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-beta\/Smad2\/3 signaling pathway","volume":"12","author":"Yin","year":"2019","journal-title":"Onco. Targets. Ther."},{"issue":"10","key":"10.1016\/j.lfs.2023.122119_bb0715","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.jnutbio.2011.08.004","article-title":"Curcumin protects against thioacetamide-induced hepatic fibrosis by attenuating the inflammatory response and inducing apoptosis of damaged hepatocytes","volume":"23","author":"Wang","year":"2012","journal-title":"J. Nutr. Biochem."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0720","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0725","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1039\/D1FO02481G","article-title":"Steatosis induced by nonylphenol in HepG2 cells and the intervention effect of curcumin","volume":"13","author":"Shan","year":"2022","journal-title":"Food Funct."},{"issue":"14","key":"10.1016\/j.lfs.2023.122119_bb0730","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13789","article-title":"Curcumin supplementation mitigates NASH development and progression in female Wistar rats","volume":"6","author":"Cunningham","year":"2018","journal-title":"Physiol. Rep."},{"issue":"10","key":"10.1016\/j.lfs.2023.122119_bb0735","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1194\/jlr.M069807","article-title":"Cholesterol 7alpha-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis","volume":"57","author":"Liu","year":"2016","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.lfs.2023.122119_bb0740","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4162\/nrp.2010.4.3.191","article-title":"Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet","volume":"4","author":"Kim","year":"2010","journal-title":"Nutr. Res. Pract."},{"issue":"17","key":"10.1016\/j.lfs.2023.122119_bb0745","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.2174\/138161210791208875","article-title":"Insulin resistance in nonalcoholic fatty liver disease","volume":"16","author":"Bugianesi","year":"2010","journal-title":"Curr. Pharm. Des."},{"issue":"5","key":"10.1016\/j.lfs.2023.122119_bb0750","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1111\/j.1476-5381.2010.00956.x","article-title":"Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase","volume":"161","author":"Tang","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2023.122119_bb0755","doi-asserted-by":"crossref","first-page":"102843","DOI":"10.1016\/j.ctim.2022.102843","article-title":"Curcumin as adjuvant treatment in patients with non-alcoholic fatty liver (NAFLD) disease: a systematic review and meta-analysis","volume":"68","author":"Ngu","year":"2022","journal-title":"Complement. Ther. Med."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0760","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.18549\/PharmPract.2019.1.1350","article-title":"The impact of turmeric or its curcumin extract on nonalcoholic fatty liver disease: a systematic review of clinical trials","volume":"17","author":"White","year":"2019","journal-title":"Pharm. Pract. (Granada)"},{"issue":"9","key":"10.1016\/j.lfs.2023.122119_bb0765","doi-asserted-by":"crossref","first-page":"15989","DOI":"10.1002\/jcb.28877","article-title":"Curcuminoids plus piperine improve nonalcoholic fatty liver disease: a clinical trial","volume":"120","author":"Panahi","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.lfs.2023.122119_bb0770","doi-asserted-by":"crossref","first-page":"102322","DOI":"10.1016\/j.ctim.2020.102322","article-title":"Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: a randomized controlled trial","volume":"49","author":"Saberi-Karimian","year":"2020","journal-title":"Complement. Ther. Med."},{"issue":"9","key":"10.1016\/j.lfs.2023.122119_bb0775","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/ptr.5659","article-title":"Treatment of non-alcoholic fatty liver disease with curcumin: a randomized placebo-controlled trial","volume":"30","author":"Rahmani","year":"2016","journal-title":"Phytother. Res."},{"issue":"9","key":"10.1016\/j.lfs.2023.122119_bb0780","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/s41430-018-0386-5","article-title":"A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial","volume":"73","author":"Chashmniam","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0785","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00394-019-01916-7","article-title":"Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial","volume":"59","author":"Cicero","year":"2020","journal-title":"Eur. J. Nutr."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0790","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12876-019-1055-4","article-title":"Curcumin and inflammation in non-alcoholic fatty liver disease: a randomized, placebo controlled clinical trial","volume":"19","author":"Saadati","year":"2019","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.lfs.2023.122119_bb0795","doi-asserted-by":"crossref","first-page":"1163950","DOI":"10.3389\/fnut.2023.1163950","article-title":"The effect of curcumin on anthropometric indices, blood pressure, lipid profiles, fasting blood glucose, liver enzymes, fibrosis, and steatosis in non-alcoholic fatty livers","volume":"10","author":"Safari","year":"2023","journal-title":"Front. Nutr."},{"issue":"7","key":"10.1016\/j.lfs.2023.122119_bb0800","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1053\/j.gastro.2020.01.052","article-title":"Nonalcoholic fatty liver disease 2020: the state of the disease","volume":"158","author":"Cotter","year":"2020","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.lfs.2023.122119_bb0805","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of curcumin: problems and promises","volume":"4","author":"Anand","year":"2007","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.lfs.2023.122119_bb0810","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4143\/crt.2014.46.1.2","article-title":"Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice","volume":"46","author":"Prasad","year":"2014","journal-title":"Cancer Res. Treat."},{"issue":"7","key":"10.1016\/j.lfs.2023.122119_bb0815","first-page":"1894","article-title":"Pharmacodynamic and pharmacokinetic study of oral curcuma extract in patients with colorectal cancer","volume":"7","author":"Sharma","year":"2001","journal-title":"Clin. Cancer Res."},{"issue":"9","key":"10.1016\/j.lfs.2023.122119_bb0820","doi-asserted-by":"crossref","DOI":"10.3390\/nu11092147","article-title":"Dietary curcumin: correlation between bioavailability and health potential","volume":"11","author":"Dei Cas","year":"2019","journal-title":"Nutrients"},{"issue":"10","key":"10.1016\/j.lfs.2023.122119_bb0825","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9101476","article-title":"Antitumoral activities of curcumin and recent advances to improve its oral bioavailability","volume":"9","author":"Nocito","year":"2021","journal-title":"Biomedicines"},{"issue":"6","key":"10.1016\/j.lfs.2023.122119_bb0830","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25061397","article-title":"Highly bioavailable forms of curcumin and promising avenues for curcumin-based research and application: a review","volume":"25","author":"Stohs","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.lfs.2023.122119_bb0835","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ejmech.2019.07.034","article-title":"Recent advances of analogues of curcumin for treatment of cancer","volume":"180","author":"Zhao","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"2","key":"10.1016\/j.lfs.2023.122119_bb0840","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.canlet.2015.05.005","article-title":"Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy","volume":"364","author":"James","year":"2015","journal-title":"Cancer Lett."},{"issue":"7","key":"10.1016\/j.lfs.2023.122119_bb0845","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/jn\/nxz029","article-title":"Curcumin combined with FOLFOX chemotherapy is safe and tolerable in patients with metastatic colorectal cancer in a randomized phase IIa trial","volume":"149","author":"Howells","year":"2019","journal-title":"J. Nutr."},{"key":"10.1016\/j.lfs.2023.122119_bb0850","doi-asserted-by":"crossref","first-page":"153218","DOI":"10.1016\/j.phymed.2020.153218","article-title":"Efficacy and safety of curcumin in combination with paclitaxel in patients with advanced, metastatic breast cancer: a comparative, randomized, double-blind, placebo-controlled clinical trial","volume":"70","author":"Saghatelyan","year":"2020","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.lfs.2023.122119_bb0855","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ptr.5014","article-title":"A controlled study of a lecithinized delivery system of curcumin (Meriva(R)) to alleviate the adverse effects of cancer treatment","volume":"28","author":"Belcaro","year":"2014","journal-title":"Phytother. Res."},{"key":"10.1016\/j.lfs.2023.122119_bb0860","doi-asserted-by":"crossref","first-page":"101247","DOI":"10.1016\/j.ctcp.2020.101247","article-title":"Turmeric supplementation improves the quality of life and hematological parameters in breast cancer patients on paclitaxel chemotherapy: a case series","volume":"41","author":"Kalluru","year":"2020","journal-title":"Complement. Ther. Clin. Pract."},{"key":"10.1016\/j.lfs.2023.122119_bb0865","author":"Amjad","year":"2023","journal-title":"Cancer Chemother."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523007543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523007543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T05:59:11Z","timestamp":1736315951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320523007543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":173,"alternative-id":["S0024320523007543"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2023.122119","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2023.122119","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"122119"}}