{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:16:40Z","timestamp":1791919000953,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070330"],"award-info":[{"award-number":["82070330"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016345","name":"Renmin Hospital of Wuhan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.lfs.2023.122184","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T08:19:19Z","timestamp":1697789959000},"page":"122184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Vericiguat alleviates ventricular remodeling and arrhythmias in mouse models of myocardial infarction via CaMKII signaling"],"prefix":"10.1016","volume":"334","author":[{"given":"Tao","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.lfs.2023.122184_bb0005","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00395-018-0668-z","article-title":"Molecular imaging of cardiac remodelling after myocardial infarction","volume":"113","author":"Curley","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.lfs.2023.122184_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.716219","article-title":"Abrogation of CC chemokine receptor 9 ameliorates ventricular electrical remodeling in mice after myocardial infarction","volume":"8","author":"Huang","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.lfs.2023.122184_bb0015","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.120.009422","article-title":"Predicting sudden cardiac death after myocardial infarction: a great unsolved challenge","volume":"14","author":"Parkash","year":"2021","journal-title":"Circ. Arrhythm. Electrophysiol."},{"issue":"1","key":"10.1016\/j.lfs.2023.122184_bb0020","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41401-018-0060-4","article-title":"Wnt signaling pathways in myocardial infarction and the therapeutic effects of Wnt pathway inhibitors","volume":"40","author":"Fu","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"issue":"2","key":"10.1016\/j.lfs.2023.122184_bb0025","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3390\/cells12020230","article-title":"Electrical remodelling in cardiac disease","volume":"12","author":"Ravens","year":"2023","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.lfs.2023.122184_bb0030","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s40265-021-01496-z","article-title":"Vericiguat: first approval","volume":"81","author":"Markham","year":"2021","journal-title":"Drugs"},{"issue":"14","key":"10.1016\/j.lfs.2023.122184_bb0035","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1080\/14656566.2021.1937121","article-title":"Vericiguat for the treatment of heart failure: mechanism of action and pharmacological properties compared with other emerging therapeutic options","volume":"22","author":"Hulot","year":"2021","journal-title":"Expert Opin. Pharmacother."},{"issue":"6","key":"10.1016\/j.lfs.2023.122184_bb0040","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/bph.14137","article-title":"The soluble guanylate cyclase stimulator IW-1973 prevents inflammation and fibrosis in experimental non-alcoholic steatohepatitis","volume":"175","author":"Flores-Costa","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.lfs.2023.122184_bb0045","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00395-014-0421-1","article-title":"Soluble guanylyl cyclase activation improves progressive cardiac remodeling and failure after myocardial infarction. Cardioprotection over ACE inhibition","volume":"109","author":"Fraccarollo","year":"2014","journal-title":"Basic Res. Cardiol."},{"issue":"11","key":"10.1016\/j.lfs.2023.122184_bb0050","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1111\/bph.15333","article-title":"Stimulation of soluble guanylyl cyclase (sGC) by riociguat attenuates heart failure and pathological cardiac remodelling","volume":"179","author":"R\u00fcdebusch","year":"2022","journal-title":"Br. J. Pharmacol."},{"issue":"18","key":"10.1016\/j.lfs.2023.122184_bb0055","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1111\/bph.15910","article-title":"Riociguat attenuates the changes in left ventricular proteome and microRNA profile after experimental aortic stenosis in mice","volume":"179","author":"Benkner","year":"2022","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.lfs.2023.122184_bb0060","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00395-018-0688-8","article-title":"Physiological and unappreciated roles of CaMKII in the heart","volume":"113","author":"Beckendorf","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.lfs.2023.122184_bb0065","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.yjmcc.2019.01.001","article-title":"CaMKII signaling in heart diseases: emerging role in diabetic cardiomyopathy","volume":"127","author":"Hegyi","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"4","key":"10.1016\/j.lfs.2023.122184_bb0070","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.cardiores.2006.12.003","article-title":"CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia\u2013reperfusion injury[J]","volume":"73","author":"Martin","year":"2007","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.lfs.2023.122184_bb0075","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/cvr\/cvu163","article-title":"Delayed phospholamban phosphorylation in post-conditioned heart favours Ca2+ normalization and contributes to protection","volume":"103","author":"Inserte","year":"2014","journal-title":"Cardiovasc. Res."},{"issue":"17","key":"10.1016\/j.lfs.2023.122184_bb0080","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1111\/bph.15492","article-title":"Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso-occlusion and nephropathy in mouse models of sickle cell disease","volume":"178","author":"Tchernychev","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2023.122184_bb0085","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3389\/fphys.2020.00345","article-title":"Enhanced cardiomyocyte function in hypertensive rats with diastolic dysfunction and human heart failure patients after acute treatment with soluble guanylyl cyclase (sGC) activator","volume":"11","author":"Kolijn","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lfs.2023.122184_bb0090","doi-asserted-by":"crossref","first-page":"33124","DOI":"10.1038\/srep33124","article-title":"Extracellular cGMP modulates learning biphasically by modulating glycine receptors, CaMKII and glutamate-nitric oxide-cGMP pathway","volume":"6","author":"Cabrera-Pastor","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2023.122184_bb0095","first-page":"330","article-title":"Serial echocardiographic assessment of left ventricular dimensions and function after myocardial infarction in mice","volume":"2","author":"Xiao-Ming","year":"2000","journal-title":"Cardiovasc. Res."},{"issue":"13","key":"10.1016\/j.lfs.2023.122184_bb0100","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1161\/CIRCULATIONAHA.120.051517","article-title":"Targeting 5-HT(2B) receptor signaling prevents border zone expansion and improves microstructural remodeling after myocardial infarction","volume":"143","author":"Snider","year":"2021","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.lfs.2023.122184_bb0105","doi-asserted-by":"crossref","first-page":"5146","DOI":"10.1021\/acs.jmedchem.7b00449","article-title":"Discovery of the soluble guanylate cyclase stimulator vericiguat (BAY 1021189) for the treatment of chronic heart failure","volume":"60","author":"Follmann","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.lfs.2023.122184_bb0110","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cjca.2018.11.020","article-title":"MD1 deficiency promotes inflammatory atrial Remodelling induced by high-fat diets","volume":"35","author":"Shuai","year":"2019","journal-title":"Can. J. Cardiol."},{"issue":"8","key":"10.1016\/j.lfs.2023.122184_bb0115","first-page":"5343","article-title":"Wnt5a protects motor neurons in amyotrophic lateral sclerosis by regulating the Wnt\/ca(2+) signaling pathway","volume":"14","author":"Liu","year":"2022","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.lfs.2023.122184_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110896","article-title":"Over-expression of Kv4.3 gene reverses cardiac remodeling and transient-outward K(+) current (Ito) reduction via CaMKII inhibition in myocardial infarction","volume":"132","author":"Tao","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.lfs.2023.122184_bb0125","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/j.2040-4603.2017.tb00771.x","article-title":"Cardiac fibrosis and arrhythmogenesis","volume":"7","author":"Nguyen","year":"2017","journal-title":"Compr. Physiol."},{"issue":"3","key":"10.1016\/j.lfs.2023.122184_bb0130","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/13543776.2021.1866538","article-title":"Soluble guanylate cyclase stimulators and their potential use: a patent review","volume":"31","author":"Sandner","year":"2021","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.lfs.2023.122184_bb0135","first-page":"1","article-title":"Soluble GC stimulators and activators: past, present and future","author":"Sandner","year":"2021","journal-title":"Br. J. Pharmacol."},{"issue":"45","key":"10.1016\/j.lfs.2023.122184_bb0140","doi-asserted-by":"crossref","first-page":"28263","DOI":"10.1073\/pnas.2000466117","article-title":"Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP\/NF-kappaB\/NLRP3 inflammasome circuit","volume":"117","author":"Flores-Costa","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.lfs.2023.122184_bb0145","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1111\/bph.15425","article-title":"Activation of soluble guanylyl cyclase signalling with cinaciguat improves impaired kidney function in diabetic mice","volume":"179","author":"Harloff","year":"2022","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.lfs.2023.122184_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052557","article-title":"Targeted delivery of soluble guanylate cyclase (sGC) activator cinaciguat to renal mesangial cells via virus-mimetic nanoparticles potentiates anti-fibrotic effects by cGMP-mediated suppression of the TGF-beta pathway","volume":"22","author":"Fleischmann","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.lfs.2023.122184_bb0155","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.3390\/cells11121911","article-title":"Integrated analysis reveals S100a8\/a9 regulates autophagy and apoptosis through the MAPK and PI3K-AKT signaling pathway in the early stage of myocardial infarction","volume":"11","author":"Yi","year":"2022","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.lfs.2023.122184_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules24071376","article-title":"KMUP-1 ameliorates ischemia-induced cardiomyocyte apoptosis through the NOcGMPMAPK signaling pathways[J]","volume":"24","author":"Lee","year":"2019","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.lfs.2023.122184_bb0165","first-page":"1","article-title":"Soluble epoxide hydrolase inhibitors, t-AUCB, downregulated miR-133 in a mouse model of myocardial infarction","volume":"17","author":"Yajun","year":"2018","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.lfs.2023.122184_bb0170","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1016\/j.ijcard.2012.07.009","article-title":"Upregulation of microRNA-1 and microRNA-133 contributes to arsenic-induced cardiac electrical remodeling","volume":"167","author":"Shan","year":"2013","journal-title":"Int. J. Cardiol."},{"issue":"11","key":"10.1016\/j.lfs.2023.122184_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells10112923","article-title":"Cardiac conduction velocity, remodeling and arrhythmogenesis","volume":"10","author":"Han","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2023.122184_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2020.08.006","article-title":"Phosphoproteomic analysis identifies phospho-Threonine-17 site of phospholamban important in low molecular weight isoform of fibroblast growth factor 2-induced protection against post-ischemic cardiac dysfunction","volume":"148","author":"Manning","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2023.122184_bb0185","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.yjmcc.2019.12.002","article-title":"Ca(2+)\/calmodulin-dependent protein kinase II is essential in hyperacute pressure overload","volume":"138","author":"Baier","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2023.122184_bb0190","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.3389\/fphys.2018.01622","article-title":"Saxagliptin but not sitagliptin inhibits CaMKII and PKC via DPP9 inhibition in cardiomyocytes","volume":"9","author":"Koyani","year":"2018","journal-title":"Front. Physiol."},{"issue":"15","key":"10.1016\/j.lfs.2023.122184_bb0195","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.024285","article-title":"Candesartan cilexetil attenuates arrhythmogenicity following pressure overload in rats via the modulation of cardiac electrical and structural remodeling and calcium handling dysfunction","volume":"11","author":"Chang","year":"2022","journal-title":"J. Am. Heart Assoc."},{"issue":"1","key":"10.1016\/j.lfs.2023.122184_bb0200","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s00395-021-00860-0","article-title":"Cardiomyocyte depolarization triggers NOS-dependent NO transient after calcium release, reducing the subsequent calcium transient","volume":"116","author":"Mosqueira","year":"2021","journal-title":"Basic Res. Cardiol."},{"issue":"1","key":"10.1016\/j.lfs.2023.122184_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2019.165586","article-title":"Intracellular calcium mishandling leads to cardiac dysfunction and ventricular arrhythmias in a mouse model of propionic acidemia","volume":"1866","author":"Tamayo","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"3","key":"10.1016\/j.lfs.2023.122184_bb0210","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/cvr\/cvy213","article-title":"Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+\/calmodulin kinase II constitutive phosphorylation of ryanodine receptors","volume":"115","author":"Valverde","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2023.122184_bb0215","doi-asserted-by":"crossref","first-page":"5988","DOI":"10.2741\/3131","article-title":"Phospholamban phosphorylation by CaMKII under pathophysiological conditions","volume":"13","author":"Vittone","year":"2008","journal-title":"Front. Biosci."},{"issue":"6","key":"10.1016\/j.lfs.2023.122184_bb0220","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/CIRCEP.109.863118","article-title":"Targeted SERCA2a gene expression identifies molecular mechanism and therapeutic target for arrhythmogenic cardiac alternans","volume":"2","author":"Cutler","year":"2009","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.lfs.2023.122184_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173614","article-title":"Chronic sigma-1 receptor activation ameliorates ventricular remodeling and decreases susceptibility toventricular arrhythmias after myocardial infarction in rats","volume":"889","author":"Fo","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.lfs.2023.122184_bb0230","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/cvr\/cvz205","article-title":"HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling","volume":"116","author":"Hu","year":"2020","journal-title":"Cardiovasc. Res."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523008196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523008196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T09:42:59Z","timestamp":1750239779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320523008196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":46,"alternative-id":["S0024320523008196"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2023.122184","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vericiguat alleviates ventricular remodeling and arrhythmias in mouse models of myocardial infarction via CaMKII signaling","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2023.122184","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"122184"}}