{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:33:04Z","timestamp":1792153984798,"version":"4.4.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.lfs.2023.122185","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T11:42:34Z","timestamp":1697542954000},"page":"122185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["NLRP3-inflammasome inhibition by MCC950 attenuates cardiac and pulmonary artery remodelling in heart failure with preserved ejection fraction"],"prefix":"10.1016","volume":"333","author":[{"given":"Xiaocheng","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanru","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuliang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2023.122185_bb0005","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1001\/jama.2023.2020","article-title":"Heart failure with preserved ejection fraction: a review","volume":"329","author":"Redfield","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.lfs.2023.122185_bb0010","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41569-020-0363-2","article-title":"Evaluation and management of heart failure with preserved ejection fraction","volume":"17","author":"Borlaug","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.lfs.2023.122185_bb0015","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1016\/j.jacc.2017.08.074","article-title":"Heart failure with preserved, borderline, and reduced ejection fraction: 5-year outcomes","volume":"70","author":"Shah","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.lfs.2023.122185_bb0020","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-med-042220-022745","article-title":"Heart failure with preserved ejection fraction: mechanisms and treatment strategies","volume":"73","author":"Omote","year":"2022","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.lfs.2023.122185_bb0025","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/eurheartj\/ehs070","article-title":"Discriminating clinical features of heart failure with preserved vs. reduced ejection fraction in the community","volume":"33","author":"Ho","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lfs.2023.122185_bb0030","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jchf.2020.04.016","article-title":"Hemodynamic and functional impact of epicardial adipose tissue in heart failure with preserved ejection fraction","volume":"8","author":"Koepp","year":"2020","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.lfs.2023.122185_bb0035","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrcardio.2017.65","article-title":"Epidemiology of heart failure with preserved ejection fraction","volume":"14","author":"Dunlay","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.lfs.2023.122185_bb0040","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/CIRCULATIONAHA.116.026807","article-title":"Evidence supporting the existence of a distinct obese phenotype of heart failure with preserved ejection fraction","volume":"136","author":"Obokata","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2023.122185_bb0045","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1161\/CIRCRESAHA.121.318159","article-title":"From systemic inflammation to myocardial fibrosis: the heart failure with preserved ejection fraction paradigm revisited","volume":"128","author":"Paulus","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2023.122185_bb0050","doi-asserted-by":"crossref","first-page":"13344","DOI":"10.1038\/ncomms13344","article-title":"Macrophage-dependent IL-1\u03b2 production induces cardiac arrhythmias in diabetic mice","volume":"7","author":"Monnerat","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2023.122185_bb0055","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1161\/CIRCRESAHA.118.314402","article-title":"Endothelial Foxp1 suppresses atherosclerosis via modulation of Nlrp3 inflammasome activation","volume":"125","author":"Zhuang","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2023.122185_bb0060","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006277","article-title":"Empagliflozin blunts worsening cardiac dysfunction associated with reduced NLRP3 (nucleotide-binding domain-like receptor protein 3) inflammasome activation in heart failure","volume":"13","author":"Byrne","year":"2020","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.lfs.2023.122185_bb0065","first-page":"828","article-title":"The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction","volume":"38","author":"van Hout","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lfs.2023.122185_bb0070","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1161\/CIRCULATIONAHA.118.035202","article-title":"Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation","volume":"138","author":"Yao","year":"2018","journal-title":"Circulation"},{"issue":"2021","key":"10.1016\/j.lfs.2023.122185_bb0075","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lfs.2023.122185_bb0080","doi-asserted-by":"crossref","first-page":"103370","DOI":"10.1016\/j.ebiom.2021.103370","article-title":"TNAP is a novel regulator of cardiac fibrosis after myocardial infarction by mediating TGF-\u03b2\/Smads and ERK1\/2 signaling pathways","volume":"67","author":"Cheng","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.lfs.2023.122185_bb0085","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41586-019-1100-z","article-title":"Nitrosative stress drives heart failure with preserved ejection fraction","volume":"568","author":"Schiattarella","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2023.122185_bb0090","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41589-019-0278-6","article-title":"MCC950 closes the active conformation of NLRP3 to an inactive state","volume":"15","author":"Tapia-Abell\u00e1n","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.lfs.2023.122185_bb0095","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1093\/eurheartj\/ehv305","article-title":"Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications","volume":"36","author":"M\u00fcnzel","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lfs.2023.122185_bb0100","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.lfs.2023.122185_bb0105","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/ejhf.2821","article-title":"Disproportionate exercise-induced pulmonary hypertension in relation to cardiac output in heart failure with preserved ejection fraction: a non-invasive echocardiographic study","volume":"25","author":"LSaito","year":"2023","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.lfs.2023.122185_bb0110","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1016\/j.jacc.2019.09.063","article-title":"Echocardiographic features of patients with heart failure and preserved left ventricular ejection fraction","volume":"74","author":"Shah","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.lfs.2023.122185_bb0115","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/cvr\/cvaa217","article-title":"Metabolic inflammation in heart failure with preserved ejection fraction","volume":"117","author":"Schiattarella","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.lfs.2023.122185_bb0120","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1161\/CIRCRESAHA.120.317933","article-title":"Targeting mitochondria-inflammation circuit by \u03b2-hydroxybutyrate mitigates HFpEF","volume":"128","author":"Deng","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2023.122185_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175126","article-title":"Colchicine alleviates inflammation and improves diastolic dysfunction in heart failure rats with preserved ejection fraction","volume":"929","author":"Shen","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2023.122185_bb0130","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006277","article-title":"Empagliflozin blunts worsening cardiac dysfunction associated with reduced NLRP3 (nucleotide-binding domain-like receptor protein 3) inflammasome activation in heart failure","volume":"13","author":"Byrne","year":"2020","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.lfs.2023.122185_bb0135","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1056\/NEJMcp1511175","article-title":"Heart failure with preserved ejection fraction","volume":"375","author":"Redfield","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2023.122185_bb0140","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1056\/NEJMoa2206286","article-title":"Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction","volume":"387","author":"Solomon","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2023.122185_bb0145","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s41232-022-00203-z","article-title":"Diet-induced obesity impairs spermatogenesis: the critical role of NLRP3 in Sertoli cells","volume":"42","author":"Mu","year":"2022","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.lfs.2023.122185_bb0150","doi-asserted-by":"crossref","first-page":"121301","DOI":"10.1016\/j.lfs.2022.121301","article-title":"Bisphenol A exacerbates anxiety-like behavior and neuroinflammation in prefrontal cortex of adult obese mice","volume":"313","author":"Lama","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2023.122185_bb0155","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/eurheartj\/ehm554","article-title":"Prognosis of heart failure with preserved ejection fraction: a 5 year prospective population-based study","volume":"29","author":"Tribouilloy","year":"2008","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lfs.2023.122185_bb0160","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1093\/eurheartj\/ehu315","article-title":"Pulmonary capillary wedge pressure during exercise and long-term mortality in patients with suspected heart failure with preserved ejection fraction","volume":"35","author":"Dorfs","year":"2014","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.lfs.2023.122185_bb0165","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jacep.2022.09.012","article-title":"Systemic delivery of extracellular vesicles attenuates atrial fibrillation in heart failure with preserved ejection fraction","volume":"9","author":"Zhang","year":"2023","journal-title":"JACC Clin. Electrophysiol."},{"key":"10.1016\/j.lfs.2023.122185_bb0170","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1161\/CIRCULATIONAHA.118.034621","article-title":"Inflammation and NLRP3 Inflammasome activation initiated in response to pressure overload by Ca2+\/calmodulin-dependent protein kinase II \u03b4 signaling in cardiomyocytes are essential for adverse cardiac remodeling","volume":"2138","author":"Suetomi","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2023.122185_bb0175","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jacbts.2020.11.002","article-title":"Interleukin-1\u03b2, oxidative stress, and abnormal calcium handling mediate diabetic arrhythmic risk","volume":"6","author":"Liu","year":"2021","journal-title":"JACC Basic Transl. Sci."},{"issue":"2","key":"10.1016\/j.lfs.2023.122185_bb0180","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jacbts.2022.08.003","article-title":"Inflammatory macrophage interleukin-1\u03b2 mediates high-fat diet-induced heart failure with preserved ejection fraction","volume":"8","author":"Liu","year":"2022","journal-title":"JACC Basic Transl. Sci."},{"issue":"8","key":"10.1016\/j.lfs.2023.122185_bb0185","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005036","article-title":"IL-1 blockade in patients with heart failure with preserved ejection fraction","volume":"11","author":"Van Tassell","year":"2018","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.lfs.2023.122185_bb0190","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ccm.2020.11.002","article-title":"Pulmonary hypertension in left heart disease","volume":"42","author":"Reddy","year":"2021","journal-title":"Clin. Chest Med."},{"key":"10.1016\/j.lfs.2023.122185_bb0195","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1093\/eurheartj\/ehac389","article-title":"Riociguat in pulmonary hypertension and heart failure with preserved ejection fraction: the haemoDYNAMIC trial","volume":"43","author":"Dachs","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lfs.2023.122185_bb0200","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.jacc.2017.01.051","article-title":"Pulmonary hypertension in heart failure: pathophysiology, pathobiology, and emerging clinical perspectives","volume":"69","author":"Guazzi","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.lfs.2023.122185_bb0205","doi-asserted-by":"crossref","first-page":"1801897","DOI":"10.1183\/13993003.01897-2018","article-title":"Pulmonary hypertension due to left heart disease","volume":"53","author":"Vachi\u00e9ry","year":"2019","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.lfs.2023.122185_bb0210","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1164\/rccm.202110-2274OC","article-title":"Macrophage-NLRP3 activation promotes right ventricle failure in pulmonary arterial hypertension","volume":"206","author":"Al-Qazazi","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523008202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523008202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:06:34Z","timestamp":1762211194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320523008202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":42,"alternative-id":["S0024320523008202"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2023.122185","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NLRP3-inflammasome inhibition by MCC950 attenuates cardiac and pulmonary artery remodelling in heart failure with preserved ejection fraction","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2023.122185","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"122185"}}