{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:39:28Z","timestamp":1783107568493,"version":"3.54.6"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971754"],"award-info":[{"award-number":["81971754"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873772"],"award-info":[{"award-number":["81873772"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.lfs.2023.122287","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T03:23:16Z","timestamp":1700623396000},"page":"122287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Targeting HIF-1\u03b1 alleviates the inflammatory responses and rebuilds the CD4+ T cell subsets balance in the experimental autoimmune myasthenia gravis inflammation model via regulating cellular and humoral immunity"],"prefix":"10.1016","volume":"336","author":[{"given":"Lu","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2023.122287_bb0005","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.3390\/jcm10112235","article-title":"Myasthenia gravis: epidemiology, pathophysiology and clinical manifestations","volume":"10","author":"Dresser","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.lfs.2023.122287_bb0010","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41572-019-0079-y","article-title":"Myasthenia gravis","volume":"5","author":"Gilhus","year":"2019","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.lfs.2023.122287_bb0015","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2147\/IJGM.S88552","article-title":"Animal models of myasthenia gravis: utility and limitations","volume":"9","author":"Mantegazza","year":"2016","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.lfs.2023.122287_bb0020","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/clim.1999.4807","article-title":"Animal models of myasthenia gravis","volume":"94","author":"Christadoss","year":"2000","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0025","first-page":"903","article-title":"Lipopolysaccharide hyporesponsiveness: protective or damaging response to the brain?","volume":"56","author":"Pardon","year":"2015","journal-title":"Rom. J. Morphol. Embryol."},{"key":"10.1016\/j.lfs.2023.122287_bb0030","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.toxicon.2017.10.016","article-title":"Exotoxins and endotoxins: inducers of inflammatory cytokines","volume":"149","author":"Cavaillon","year":"2018","journal-title":"Toxicon"},{"key":"10.1016\/j.lfs.2023.122287_bb0035","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2013.97","article-title":"Recognition of lipopolysaccharide pattern by TLR4 complexes","volume":"45","author":"Park","year":"2013","journal-title":"Exp. Mol. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.lfs.2023.122287_bb0040","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s12307-009-0022-y","article-title":"Cancer cells expressing toll-like receptors and the tumor microenvironment","volume":"2","author":"Sato","year":"2009","journal-title":"Cancer Microenviron."},{"key":"10.1016\/j.lfs.2023.122287_bb0045","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.3892\/etm.2014.2025","article-title":"Toll-like receptor 4 agonist, lipopolysaccharide, increases the expression levels of cytokines and chemokines in human peripheral blood mononuclear cells","volume":"8","author":"Pu","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.lfs.2023.122287_bb0050","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1158\/0008-5472.CAN-05-3948","article-title":"TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer","volume":"66","author":"Kelly","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2023.122287_bb0055","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1038\/onc.2009.289","article-title":"TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer","volume":"28","author":"Szajnik","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2023.122287_bb0060","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1182\/blood-2003-07-2427","article-title":"Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1\u03b1","volume":"103","author":"Blouin","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2023.122287_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010983","article-title":"Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1\u03b1 and dendritic cell maturation under normoxic conditions","volume":"5","author":"Spirig","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.lfs.2023.122287_bb0070","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/ijc.29519","article-title":"HIF-1 at the crossroads of hypoxia, inflammation, and cancer","volume":"138","author":"Balamurugan","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.lfs.2023.122287_bb0075","first-page":"5447","article-title":"A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation","volume":"12","author":"Semenza","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.lfs.2023.122287_bb0080","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/S0959-437X(98)80016-6","article-title":"Hypoxia-inducible factor 1: master regulator of O2 homeostasis","volume":"8","author":"Semenza","year":"1998","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"Suppl. 1","key":"10.1016\/j.lfs.2023.122287_bb0085","first-page":"S110","article-title":"HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism","volume":"21","author":"Haase","year":"2017","journal-title":"Hemodial. Int."},{"key":"10.1016\/j.lfs.2023.122287_bb0090","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","article-title":"Hypoxia-inducible factors in physiology and medicine","volume":"148","author":"Semenza","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2023.122287_bb0095","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-physiol-021115-105202","article-title":"Role of intestinal HIF-2\u03b1 in health and disease","volume":"78","author":"Ramakrishnan","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.lfs.2023.122287_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190074","article-title":"Knockdown of myeloid cell hypoxia-inducible factor-1alpha ameliorates the acute pathology in DSS-induced colitis","volume":"12","author":"Backer","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.lfs.2023.122287_bb0105","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.immuni.2013.11.020","article-title":"Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation","volume":"40","author":"Campbell","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.lfs.2023.122287_bb0110","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/mi.2015.67","article-title":"Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis","volume":"9","author":"Fluck","year":"2016","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0115","first-page":"47","article-title":"HIF-mediated innate immune responses: cell signaling and therapeutic implications","volume":"2","author":"Harris","year":"2014","journal-title":"Hypoxia (Auckl.)"},{"key":"10.1016\/j.lfs.2023.122287_bb0120","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.cell.2011.07.033","article-title":"Control of T(H)17\/T(reg) balance by hypoxia-inducible factor 1","volume":"146","author":"Dang","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2023.122287_bb0125","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/eji.201445064","article-title":"IL-17-producing CD4(+) T cells contribute to the loss of B-cell tolerance in experimental autoimmune myasthenia gravis","volume":"45","author":"Schaffert","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0130","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12883-015-0419-9","article-title":"Feasibility of up-regulating CD4(+)CD25(+) Tregs by IFN-gamma in myasthenia gravis patients","volume":"15","author":"Huang","year":"2015","journal-title":"BMC Neurol."},{"key":"10.1016\/j.lfs.2023.122287_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.803101","article-title":"Gut microbiota as regulators of Th17\/Treg balance in patients with myasthenia gravis","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0140","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/cam4.112","article-title":"BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I","volume":"2","author":"Ellinghaus","year":"2013","journal-title":"Cancer Med."},{"key":"10.1016\/j.lfs.2023.122287_bb0145","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1084\/jem.141.6.1365","article-title":"Experimental autoimmune myasthenia: a model of myasthenia gravis in rats and guinea pigs","volume":"141","author":"Lennon","year":"1975","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.lfs.2023.122287_bb0150","doi-asserted-by":"crossref","first-page":"A383","DOI":"10.1016\/j.autrev.2009.11.011","article-title":"Geoepidemiology of myasthenia gravis [corrected]","volume":"9","author":"Meyer","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.lfs.2023.122287_bb0155","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1073\/pnas.80.13.4089","article-title":"Anti-acetylcholine receptor antibodies directed against the alpha-bungarotoxin binding site induce a unique form of experimental myasthenia","volume":"80","author":"Gomez","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2023.122287_bb0160","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00415-015-7638-2","article-title":"Long-term outcome of 424 childhood-onset myasthenia gravis patients","volume":"262","author":"Gui","year":"2015","journal-title":"J. Neurol."},{"key":"10.1016\/j.lfs.2023.122287_bb0165","doi-asserted-by":"crossref","first-page":"e826","DOI":"10.1111\/j.1365-2567.2009.03089.x","article-title":"Disequilibrium of T helper type 1, 2 and 17 cells and regulatory T cells during the development of experimental autoimmune myasthenia gravis","volume":"128","author":"Mu","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.lfs.2023.122287_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107434","article-title":"Leflunomide ameliorates experimental autoimmune myasthenia gravis by regulating humoral and cellular immune responses","volume":"93","author":"Huang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2023.122287_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109693","article-title":"JAK2 inhibitor ameliorates the progression of experimental autoimmune myasthenia gravis and balances Th17\/Treg cells via regulating the JAK2\/STAT3-AKT\/mTOR signaling pathway","volume":"115","author":"Lu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2023.122287_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2020.108492","article-title":"Circulating Th1\/17 cells serve as a biomarker of disease severity and a target for early intervention in AChR-MG patients","volume":"218","author":"Ma","year":"2020","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0185","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nature11984","article-title":"Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1","volume":"496","author":"Wu","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2023.122287_bb0190","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/ni.2416","article-title":"Induction and molecular signature of pathogenic TH17 cells","volume":"13","author":"Lee","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0195","article-title":"Emerging role of hypoxia-inducible factor-1alpha in inflammatory autoimmune diseases: a comprehensive review","volume":"13","author":"Tang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0200","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.3389\/fimmu.2018.01667","article-title":"Hypoxia exacerbates inflammatory acute lung injury via the toll-like receptor 4 signaling pathway","volume":"9","author":"Wu","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0205","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/bfgp\/elt025","article-title":"Transcription factor interplay in T helper cell differentiation","volume":"12","author":"Evans","year":"2013","journal-title":"Brief. Funct. Genomics"},{"key":"10.1016\/j.lfs.2023.122287_bb0210","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.immuni.2008.05.009","article-title":"Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages","volume":"29","author":"Nurieva","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.lfs.2023.122287_bb0215","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s00415-018-8751-9","article-title":"Myasthenia gravis and infectious disease","volume":"265","author":"Gilhus","year":"2018","journal-title":"J. Neurol."},{"key":"10.1016\/j.lfs.2023.122287_bb0220","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1055\/s-0038-1660820","article-title":"Infection, immunodeficiency, and inflammatory diseases in autoimmune neurology","volume":"38","author":"Piquet","year":"2018","journal-title":"Semin. Neurol."},{"key":"10.1016\/j.lfs.2023.122287_bb0225","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3324\/haematol.2019.217430","article-title":"HIF-1alpha is over-expressed in leukemic cells from TP53-disrupted patients and is a promising therapeutic target in chronic lymphocytic leukemia","volume":"105","author":"Griggio","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.lfs.2023.122287_bb0230","first-page":"162","article-title":"Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: a one transcription factor (HIF-1) show?","volume":"1795","author":"Kaluz","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2023.122287_bb0235","doi-asserted-by":"crossref","first-page":"9361","DOI":"10.1128\/MCB.23.24.9361-9374.2003","article-title":"Differential roles of hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1) and HIF-2\u03b1 in hypoxic gene regulation","volume":"23","author":"Hu","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.lfs.2023.122287_bb0240","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.1091\/mbc.e06-05-0419","article-title":"The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1\u03b1 and HIF-2\u03b1","volume":"18","author":"Hu","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.lfs.2023.122287_bb0245","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1126\/science.1169956","article-title":"Regulation of hypoxia-inducible factor 2\u03b1 signaling by the stress-responsive deacetylase sirtuin 1","volume":"324","author":"Dioum","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.lfs.2023.122287_bb0250","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/cmi.2017.12","article-title":"IL-17-triggered downregulation of miR-497 results in high HIF-1alpha expression and consequent IL-1beta and IL-6 production by astrocytes in EAE mice","volume":"14","author":"Shan","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0255","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2023.122287_bb0260","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.omtn.2020.01.014","article-title":"Downregulation of hypoxia-inducible factor-1alpha by RNA interference alleviates the development of collagen-induced arthritis in rats","volume":"19","author":"Hu","year":"2020","journal-title":"Mol. Ther.\u2013Nucleic Acids"},{"key":"10.1016\/j.lfs.2023.122287_bb0265","first-page":"945","article-title":"Hypoxia inducible factor-1-alpha (HIF-1alpha) is related to both angiogenesis and inflammation in rheumatoid arthritis","volume":"27","author":"Brouwer","year":"2009","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.lfs.2023.122287_bb0270","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.molimm.2013.11.005","article-title":"Structural characterization of the main immunogenic region of the Torpedo acetylcholine receptor","volume":"58","author":"Morell","year":"2014","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0275","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fnagi.2014.00208","article-title":"The neuromuscular junction: aging at the crossroad between nerves and muscle","volume":"6","author":"Gonzalez-Freire","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.lfs.2023.122287_bb0280","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/1874609811104030209","article-title":"Motor unit and neuromuscular junction remodeling with aging","volume":"4","author":"Deschenes","year":"2011","journal-title":"Curr. Aging Sci."},{"key":"10.1016\/j.lfs.2023.122287_bb0285","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1128\/MCB.01036-12","article-title":"Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia","volume":"33","author":"Ibebunjo","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.lfs.2023.122287_bb0290","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/imr.12031","article-title":"T-cell subsets in the germinal center","volume":"252","author":"Ramiscal","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.lfs.2023.122287_bb0295","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.734282","article-title":"System-level scenarios for the elucidation of T cell-mediated germinal center B cell differentiation","volume":"12","author":"Verstegen","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0300","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3109\/08916934.2012.665524","article-title":"Germinal center B-cells","volume":"45","author":"Hamel","year":"2012","journal-title":"Autoimmunity"},{"key":"10.1016\/j.lfs.2023.122287_bb0305","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41577-019-0244-2","article-title":"B cell memory: building two walls of protection against pathogens","volume":"20","author":"Akkaya","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0310","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.990794","article-title":"Metabolic requirements of Th17 cells and of B cells: regulation and defects in health and in inflammatory diseases","volume":"13","author":"Bystrom","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0315","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4049\/jimmunol.0800167","article-title":"Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow","volume":"184","author":"Kojima","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0320","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41467-017-02683-x","article-title":"Hypoxia-inducible factor-1alpha is a critical transcription factor for IL-10-producing B cells in autoimmune disease","volume":"9","author":"Meng","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2023.122287_bb0325","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.molimm.2019.04.005","article-title":"Regulation of CD11b by HIF-1alpha and the STAT3 signaling pathway contributes to the immunosuppressive function of B cells in inflammatory bowel disease","volume":"111","author":"Qian","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0330","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/nyas.13591","article-title":"An imbalance between regulatory T cells and T helper 17 cells in acetylcholine receptor-positive myasthenia gravis patients","volume":"1413","author":"Villegas","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.lfs.2023.122287_bb0335","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.4049\/jimmunol.152.6.3152","article-title":"Major histocompatibility complex class II gene disruption prevents experimental autoimmune myasthenia gravis","volume":"152","author":"Kaul","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0340","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jaut.2014.06.003","article-title":"Experimental autoimmune myasthenia gravis (EAMG): from immunochemical characterization to therapeutic approaches","volume":"54","author":"Fuchs","year":"2014","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.lfs.2023.122287_bb0345","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1196\/annals.1405.023","article-title":"Strategies for treating autoimmunity: novel insights from experimental myasthenia gravis","volume":"1132","author":"Meriggioli","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.lfs.2023.122287_bb0350","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41590-018-0120-4","article-title":"Regulatory T cells in autoimmune disease","volume":"19","author":"Dominguez-Villar","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0355","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jid.2021.05.010","article-title":"Regulatory T cells and inflammatory mediators in autoimmune disease","volume":"142","author":"Gouirand","year":"2022","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.lfs.2023.122287_bb0360","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.4049\/jimmunol.180.4.2132","article-title":"Ex vivo generated regulatory T cells modulate experimental autoimmune myasthenia gravis","volume":"180","author":"Aricha","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0365","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/cei.13288","article-title":"The role of FOXP3(+) regulatory T cells in human autoimmune and inflammatory diseases","volume":"197","author":"Mohr","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0370","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.molimm.2018.11.015","article-title":"A role for Th1-like Th17 cells in the pathogenesis of inflammatory and autoimmune disorders","volume":"105","author":"Kamali","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0375","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/intimm\/dxw006","article-title":"CD4+ T-cell subsets in inflammatory diseases: beyond the Th1\/Th2 paradigm","volume":"28","author":"Hirahara","year":"2016","journal-title":"Int. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0380","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.20110278","article-title":"HIF1\u03b1-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells","volume":"208","author":"Shi","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.lfs.2023.122287_bb0385","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6978936","article-title":"The role of toll-like receptor 4 in infectious and noninfectious inflammation","volume":"2016","author":"Molteni","year":"2016","journal-title":"Mediators. Inflamm."},{"key":"10.1016\/j.lfs.2023.122287_bb0390","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.immuni.2015.02.001","article-title":"Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible factor-1\u03b1","volume":"42","author":"Shalova","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.lfs.2023.122287_bb0395","doi-asserted-by":"crossref","DOI":"10.1038\/emi.2017.21","article-title":"Nuclear translocation of HIF-1\u03b1 induced by influenza A (H1N1) infection is critical to the production of proinflammatory cytokines","volume":"6","author":"Guo","year":"2017","journal-title":"Emerg. Microbes. Infect."},{"key":"10.1016\/j.lfs.2023.122287_bb0400","doi-asserted-by":"crossref","first-page":"10581","DOI":"10.1038\/s41598-020-67396-6","article-title":"Extracellular glucose is crucially involved in the fate decision of LPS-stimulated RAW264.7 murine macrophage cells","volume":"10","author":"Aki","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2023.122287_bb0405","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.expneurol.2017.01.005","article-title":"Omega-3 fatty acids regulate NLRP3 inflammasome activation and prevent behavior deficits after traumatic brain injury","volume":"290","author":"Lin","year":"2017","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.lfs.2023.122287_bb0410","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1007\/s11064-013-1115-z","article-title":"Expression of the NLRP3 inflammasome in cerebral cortex after traumatic brain injury in a rat model","volume":"38","author":"Liu","year":"2013","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.lfs.2023.122287_bb0415","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9743280","article-title":"NLRP3 Inflammasome activation-mediated pyroptosis aggravates myocardial ischemia\/reperfusion injury in diabetic rats","volume":"2017","author":"Qiu","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2023.122287_bb0420","first-page":"3424","article-title":"HIF-1\u03b1 promotes NLRP3 inflammasome activation in bleomycin-induced acute lung injury","volume":"20","author":"Huang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.lfs.2023.122287_bb0425","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuroscience.2020.09.036","article-title":"Hypoxia inducible factor-1\u03b1 (HIF-1\u03b1) mediates NLRP3 inflammasome-dependent-pyroptotic and apoptotic cell death following ischemic stroke","volume":"448","author":"Jiang","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2023.122287_bb0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2021.101994","article-title":"HIF-1\u03b1 aggravated traumatic brain injury by NLRP3 inflammasome-mediated pyroptosis and activation of microglia","volume":"116","author":"Yuan","year":"2021","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.lfs.2023.122287_bb0435","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1002\/art.23074","article-title":"Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis","volume":"56","author":"Distler","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.lfs.2023.122287_bb0440","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1080\/15384101.2019.1670508","article-title":"HIF-1\u03b1 promotes the keloid development through the activation of TGF-\u03b2\/Smad and TLR4\/MyD88\/NF-\u03baB pathways","volume":"18","author":"Lei","year":"2019","journal-title":"Cell Cycle"},{"key":"10.1016\/j.lfs.2023.122287_bb0445","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3390\/cells8030285","article-title":"IL-6, IL-12, and IL-23 STAT-pathway genetic risk and responsiveness of lymphocytes in patients with multiple sclerosis","volume":"8","author":"von Essen","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2023.122287_bb0450","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.3389\/fimmu.2019.01535","article-title":"IL-6 mediated transcriptional programming of naive CD4+ T cells in early rheumatoid arthritis drives dysregulated effector function","volume":"10","author":"Ridgley","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2023.122287_bb0455","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.991188","article-title":"The metabolic plasticity of B cells","volume":"9","author":"Vivas-Garcia","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.lfs.2023.122287_bb0460","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/eji.200737973","article-title":"CCL2 recruitment of IL-6-producing CD11b+ monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity","volume":"38","author":"Bai","year":"2008","journal-title":"Eur. J. Immunol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523009220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523009220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:46:11Z","timestamp":1777423571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320523009220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":92,"alternative-id":["S0024320523009220"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2023.122287","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting HIF-1\u03b1 alleviates the inflammatory responses and rebuilds the CD4+ T cell subsets balance in the experimental autoimmune myasthenia gravis inflammation model via regulating cellular and humoral immunity","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2023.122287","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"122287"}}