{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T11:14:32Z","timestamp":1780658072714,"version":"3.54.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.lfs.2023.122392","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T11:57:58Z","timestamp":1703851078000},"page":"122392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Identification of SRSF10 as a promising prognostic biomarker with functional significance among SRSFs for glioma"],"prefix":"10.1016","volume":"338","author":[{"given":"Wenzhe","family":"An","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlan","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuijuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiyun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuexia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2023.122392_bb0005","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0140-6736(18)30990-5","article-title":"Primary brain tumours in adults","volume":"392","author":"Lapointe","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2023.122392_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215713","article-title":"Metabolism in the progression and metastasis of brain tumors","volume":"539","author":"Tyagi","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.lfs.2023.122392_bb0015","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization classification of tumors of the Central Nervous System: a summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.lfs.2023.122392_bb0020","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1001\/jama.2023.0023","article-title":"Glioblastoma and other primary brain malignancies in adults: a review","volume":"329","author":"Schaff","year":"2023","journal-title":"JAMA"},{"issue":"2023","key":"10.1016\/j.lfs.2023.122392_bb0025","article-title":"Isoliquiritigenin inhibits circ0030018 to suppress glioma tumorigenesis via the miR-1236\/HER2 signaling pathway","volume":"4","author":"Liu","year":"2020","journal-title":"MedComm"},{"key":"10.1016\/j.lfs.2023.122392_bb0030","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.tips.2019.12.003","article-title":"Immunotherapy for malignant glioma: current status and future directions","volume":"41","author":"Wang","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.lfs.2023.122392_bb0035","doi-asserted-by":"crossref","unstructured":"T. Li, X. Fu, J. Wang, W. Shang, X. Wang, L. Zhang, J. Li, Mechanism of NURP1 in temozolomide resistance in hypoxia-treated glioma cells via the KDM3A\/TFEB axis, Oncol. Res. 31 (n.d.) 345\u2013359. doi:10.32604\/or.2023.028724.","DOI":"10.32604\/or.2023.028724"},{"key":"10.1016\/j.lfs.2023.122392_bb0040","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature08909","article-title":"Expansion of the eukaryotic proteome by alternative splicing","volume":"463","author":"Nilsen","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2023.122392_bb0045","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-biochem-060614-034316","article-title":"Mechanisms and regulation of alternative pre-mRNA splicing","volume":"84","author":"Lee","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.lfs.2023.122392_bb0050","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41392-021-00486-7","article-title":"Alternative splicing and cancer: a systematic review","volume":"6","author":"Zhang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.lfs.2023.122392_bb0055","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.ymthe.2021.11.010","article-title":"Impacts and mechanisms of alternative mRNA splicing in cancer metabolism, immune response, and therapeutics","volume":"30","author":"Peng","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.lfs.2023.122392_bb0060","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.semcdb.2014.03.011","article-title":"Regulation of gene expression programmes by serine-arginine rich splicing factors","volume":"32","author":"\u00c4nk\u00f6","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.lfs.2023.122392_bb0065","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/wrna.1260","article-title":"THE RNAissance family: SR proteins as multifaceted regulators of gene expression","volume":"6","author":"Howard","year":"2015","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.lfs.2023.122392_bb0070","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41568-022-00541-7","article-title":"RNA splicing dysregulation and the hallmarks of cancer","volume":"23","author":"Bradley","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.lfs.2023.122392_bb0075","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1172\/JCI120279","article-title":"Splicing factor SRSF1 promotes gliomagenesis via oncogenic splice-switching of MYO1B","volume":"129","author":"Zhou","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2023.122392_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gpb.2020.10.005","article-title":"Chinese Glioma Genome Atlas (CGGA): a comprehensive resource with functional genomic data from Chinese glioma patients","volume":"19","author":"Zhao","year":"2021","journal-title":"Genom. Proteom. Bioinf."},{"key":"10.1016\/j.lfs.2023.122392_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.36","article-title":"Sangerbox: a comprehensive, interaction-friendly clinical bioinformatics analysis platform","volume":"1","author":"Shen","year":"2022","journal-title":"iMeta"},{"key":"10.1016\/j.lfs.2023.122392_bb0090","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neo.2017.05.002","article-title":"UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses","volume":"19","author":"Chandrashekar","year":"2017","journal-title":"Neoplasia"},{"key":"10.1016\/j.lfs.2023.122392_bb0095","doi-asserted-by":"crossref","first-page":"D900","DOI":"10.1093\/nar\/gky939","article-title":"CancerSEA: a cancer single-cell state atlas","volume":"47","author":"Yuan","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.lfs.2023.122392_bb0100","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2023.122392_bb0105","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1056\/NEJMoa1407279","article-title":"Glioma groups based on 1p\/19q, IDH, and TERT promoter mutations in tumors","volume":"372","author":"Eckel-Passow","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2023.122392_bb0110","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1038\/s41467-018-05373-4","article-title":"A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma","volume":"9","author":"Chen","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2023.122392_bb0115","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.cell.2019.06.024","article-title":"An integrative model of cellular states, plasticity and genetics for glioblastoma","volume":"178","author":"Neftel","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2023.122392_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104239","article-title":"Integrated single-cell transcriptomic analyses reveal that GPNMB-high macrophages promote PN-MES transition and impede T cell activation in GBM","volume":"83","author":"Xiong","year":"2022","journal-title":"eBioMedicine"},{"key":"10.1016\/j.lfs.2023.122392_bb0125","doi-asserted-by":"crossref","first-page":"11938","DOI":"10.7150\/thno.49451","article-title":"An immune cell infiltration-based immune score model predicts prognosis and chemotherapy effects in breast cancer","volume":"10","author":"Sui","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.lfs.2023.122392_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103315","article-title":"Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression","volume":"66","author":"Chen","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.lfs.2023.122392_bb0135","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/cas.15236","article-title":"Clinical characterization and immunosuppressive regulation of CD161 (KLRB1) in glioma through 916 samples","volume":"113","author":"Di","year":"2022","journal-title":"Cancer Sci."},{"issue":"2021","key":"10.1016\/j.lfs.2023.122392_bb0140","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.lfs.2023.122392_bb0145","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1038\/ncomms5581","article-title":"BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells","volume":"5","author":"Zhou","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2023.122392_bb0150","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrm.2017.27","article-title":"Alternative splicing as a regulator of development and tissue identity","volume":"18","author":"Baralle","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.lfs.2023.122392_bb0155","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1038\/onc.2013.533","article-title":"Hallmarks of alternative splicing in cancer","volume":"33","author":"Oltean","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2023.122392_bb0160","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1476","article-title":"Alternative-splicing defects in cancer: splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics","volume":"9","author":"Urbanski","year":"2018","journal-title":"Wiley Interdiscip. Rev. RNA."},{"key":"10.1016\/j.lfs.2023.122392_bb0165","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41420-021-00498-w","article-title":"SRSF1 promotes the inclusion of exon 3 of SRA1 and the invasion of hepatocellular carcinoma cells by interacting with exon 3 of SRA1pre-mRNA","volume":"7","author":"Lei","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2023.122392_bb0170","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1113","article-title":"Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer","volume":"12","author":"Pan","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.lfs.2023.122392_bb0175","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41571-021-00521-0","article-title":"The implications of IDH mutations for cancer development and therapy","volume":"18","author":"Pirozzi","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.lfs.2023.122392_bb0180","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00401-015-1424-1","article-title":"Oligodendroglioma: pathology, molecular mechanisms and markers","volume":"129","author":"Wesseling","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.lfs.2023.122392_bb0185","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nrneurol.2014.100","article-title":"MGMT testing--the challenges for biomarker-based glioma treatment","volume":"10","author":"Wick","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.lfs.2023.122392_bb0190","article-title":"Immunotherapy for Glioblastoma: current progress and challenges","volume":"12","author":"Yu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2023.122392_bb0195","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41392-022-01136-2","article-title":"Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response","volume":"7","author":"Wang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.lfs.2023.122392_bb0200","article-title":"Oncolytic virus Ad-TD-nsIL-12 inhibits glioma growth and reprograms the tumor immune microenvironment","volume":"122254","author":"Li","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2023.122392_bb0205","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.578877","article-title":"Immune checkpoint targeted therapy in glioma: status and hopes","volume":"11","author":"Qi","year":"2020","journal-title":"Front. Immunol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523010275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523010275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:15:20Z","timestamp":1758402920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320523010275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":41,"alternative-id":["S0024320523010275"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2023.122392","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of SRSF10 as a promising prognostic biomarker with functional significance among SRSFs for glioma","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2023.122392","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"122392"}}