{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T10:27:42Z","timestamp":1758450462594,"version":"3.44.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006182","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Esp\u00edrito Santo","doi-asserted-by":"publisher","award":["697\/2022","959\/2023"],"award-info":[{"award-number":["697\/2022","959\/2023"]}],"id":[{"id":"10.13039\/501100006182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["311868\/2022-3"],"award-info":[{"award-number":["311868\/2022-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.lfs.2023.122405","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T11:30:19Z","timestamp":1704195019000},"page":"122405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Testosterone modulates vasodilation in mesenteric arteries of hypertensive rats"],"prefix":"10.1016","volume":"338","author":[{"given":"Leticia Tinoco","family":"Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora Tacon da","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wender do Nascimento","family":"Rouver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger Lyrio dos","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2023.122405_bb0005","series-title":"Testosterone: From Basic to Clinical Aspects","first-page":"1","article-title":"The history of testosterone and the testes: from antiquity to modern times","author":"Nieschlag","year":"2017"},{"key":"10.1016\/j.lfs.2023.122405_bb0010","first-page":"342","article-title":"Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis","volume":"15","author":"Simpson","year":"1994","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.lfs.2023.122405_bb0015","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1210\/er.2010-0013","article-title":"The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders","volume":"32","author":"Miller","year":"2011","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.lfs.2023.122405_bb0020","first-page":"177","article-title":"Morphology of resistance arteries and comparison of effects of vasoconstrictors in mild essential hypertensive patients","volume":"16","author":"Schiffrin","year":"1993","journal-title":"Clin. Invest. Med."},{"key":"10.1016\/j.lfs.2023.122405_bb0025","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.steroids.2011.10.013","article-title":"Tissue physiology and pathology of aromatase","volume":"77","author":"Stocco","year":"2012","journal-title":"Steroids"},{"key":"10.1016\/j.lfs.2023.122405_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drugalcdep.2008.05.004","article-title":"Long-term psychiatric and medical consequences of anabolic\u2013androgenic steroid abuse: a looming public health concern?","volume":"98","author":"Kanayama","year":"2008","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.lfs.2023.122405_bb0035","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1521-0391.2013.12118.x","article-title":"The lifetime prevalence of anabolic-androgenic steroid use and dependence in Americans: current best estimates","volume":"23","author":"Pope","year":"2014","journal-title":"Am. J. Addict."},{"key":"10.1016\/j.lfs.2023.122405_bb0040","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1365-2362.2006.01667.x","article-title":"Impaired vasoreactivity in bodybuilders using androgenic anabolic steroids","volume":"36","author":"Lane","year":"2006","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.lfs.2023.122405_bb0045","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1016\/j.jacc.2020.03.060","article-title":"Summary of updated recommendations for primary prevention of cardiovascular disease in women","volume":"75","author":"Cho","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.lfs.2023.122405_bb0050","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0022-3565(25)05830-6","article-title":"The effect of various sterol derivatives on the blood pressure of the rat","volume":"69","author":"Grollman","year":"1940","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2023.122405_bb0055","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1161\/01.HYP.31.1.435","article-title":"Testosterone exacerbates hypertension and reduces pressure-natriuresis in male spontaneously hypertensive rats","volume":"31","author":"Reckelhoff","year":"1998","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.lfs.2023.122405_bb0060","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1253\/jcj.27.282","article-title":"Development of a strain of spontaneously hypertensive rats","volume":"27","author":"Okamoto","year":"1963","journal-title":"Jpn. Circ. J."},{"issue":"1","key":"10.1016\/j.lfs.2023.122405_bb0065","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1748-1716.1970.tb04773.x","article-title":"Background of increased flow resistance and vascular reactivity in spontaneously hypertensive rats","volume":"80","author":"Folkow","year":"1970","journal-title":"Acta Physiol. Scand."},{"issue":"2","key":"10.1016\/j.lfs.2023.122405_bb0070","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000158461","article-title":"Ultrastructural changes in mesenteric arteries from spontaneously hypertensive rats","volume":"20","author":"Lee","year":"1983","journal-title":"J. Vasc. Res."},{"issue":"3","key":"10.1016\/j.lfs.2023.122405_bb0075","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000158589","article-title":"Vascular changes at the prehypertensive phase in the mesenteric arteries from spontaneously hypertensive rats","volume":"22","author":"Lee","year":"1985","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.lfs.2023.122405_bb0080","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/01.RES.41.1.19","article-title":"Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats","volume":"41","author":"Mulvany","year":"1977","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.lfs.2023.122405_bb0085","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3181\/00379727-207-43802","article-title":"Changes in arterial smooth muscle contractility, contractile proteins, and arterial wall structure in spontaneous hypertension","volume":"207","author":"Packer","year":"1994","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.lfs.2023.122405_bb0090","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1476-5381.1988.tb10306.x","article-title":"Endothelium-dependent hyperpolarization of canine coronary smooth muscle","volume":"93","author":"Feletou","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2023.122405_bb0095","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/288373a0","article-title":"The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine","volume":"288","author":"Furchgott","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2023.122405_bb0100","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/320454a0","article-title":"Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor","volume":"320","author":"Gryglewski","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2023.122405_bb0105","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.1073\/pnas.84.24.9265","article-title":"Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide","volume":"84","author":"Ignarro","year":"1987","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.lfs.2023.122405_bb0110","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/263663a0","article-title":"An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation","volume":"263","author":"Moncada","year":"1976","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2023.122405_bb0115","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1161\/01.HYP.11.6.573","article-title":"Endothelium-dependent responses in carotid and renal arteries of normotensive and hypertensive rats","volume":"11","author":"L\u00fcscher","year":"1988","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2023.122405_bb0120","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1161\/01.HYP.21.6.929","article-title":"Vasodilation to acetylcholine in primary and secondary forms of human hypertension","volume":"21","author":"Taddei","year":"1993","journal-title":"Hypertension (Dallas, Tex.\u202f: 1979)"},{"key":"10.1016\/j.lfs.2023.122405_bb0125","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1016\/j.genm.2008.03.006","article-title":"Sex steroids and vascular responses in hypertension and aging","volume":"5","author":"Qiao","year":"2008","journal-title":"Gend. Med."},{"key":"10.1016\/j.lfs.2023.122405_bb0130","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1161\/01.HYP.37.5.1199","article-title":"Gender differences in the regulation of blood pressure","volume":"37","author":"Reckelhoff","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2023.122405_bb0135","first-page":"R1","article-title":"Reactive oxygen species: players in the cardiovascular effects of testosterone","volume":"310","author":"Tostes","year":"2016","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.lfs.2023.122405_bb0140","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.3892\/mmr.2016.5562","article-title":"Low-dose testosterone alleviates vascular damage caused by castration in male rats in puberty via modulation of the PI3K\/AKT signaling pathway","volume":"14","author":"Zhao","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.lfs.2023.122405_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2042-6410-3-1","article-title":"Alterations in vasomotor systems and mechanics of resistance-sized mesenteric arteries from SHR and WKY male rats following in vivo testosterone manipulation","volume":"3","author":"Toot","year":"2012","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.lfs.2023.122405_bb0150","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1093\/biolre\/iox043","article-title":"Hyperandrogenemia reduces endothelium-derived hyperpolarizing factor-mediated relaxation in mesenteric artery of female rats","volume":"96","author":"Mishra","year":"2017","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.lfs.2023.122405_bb0155","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1095\/biolreprod.115.130468","article-title":"Enalapril normalizes endothelium-derived hyperpolarizing factor-mediated relaxation in mesenteric artery of adult hypertensive rats prenatally exposed to testosterone1","volume":"92","author":"More","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.lfs.2023.122405_bb0160","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1210\/en.2009-1048","article-title":"Androgen receptor-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells: role of phosphatidylinositol 3-kinase\/akt pathway","volume":"151","author":"Yu","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2023.122405_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19336950.2023.2217637","article-title":"Cycling matters: sex hormone regulation of vascular potassium channels","volume":"17","author":"Baldwin","year":"2023","journal-title":"Channels"},{"issue":"1","key":"10.1016\/j.lfs.2023.122405_bb0170","doi-asserted-by":"crossref","first-page":"H115","DOI":"10.1152\/ajpheart.00046.2011","article-title":"Testosterone-induced relaxation of coronary arteries: activation of BKCa channels via the cGMP-dependent protein kinase","volume":"302","author":"Deenadayalu","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.lfs.2023.122405_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2019.105496","article-title":"Vascular mechanisms of testosterone: the non-genomic point of view","volume":"196","author":"Lorigo","year":"2020","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2023.122405_bb0180","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0014-2999(03)01453-5","article-title":"Mechanisms of vasorelaxation to testosterone in the rat aorta","volume":"465","author":"Tep-areenan","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2023.122405_bb0185","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1161\/01.HYP.34.6.1232","article-title":"Different mechanisms for testosterone-induced relaxation of aorta between normotensive and spontaneously hypertensive rats","volume":"34","author":"Honda","year":"1999","journal-title":"Hypertension (Dallas, Tex.\u202f: 1979)"},{"issue":"27","key":"10.1016\/j.lfs.2023.122405_bb0190","doi-asserted-by":"crossref","first-page":"11418","DOI":"10.1073\/pnas.0610467104","article-title":"The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted","volume":"104","author":"Bonnet","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2023.122405_bb0195","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1042\/CS20120700","article-title":"Testosterone and \u03b2-oestradiol prevent inward remodelling of rat small mesenteric arteries: role of NO and transglutaminase","volume":"124","author":"del Campo","year":"2013","journal-title":"Clin. Sci."},{"key":"10.1016\/j.lfs.2023.122405_bb0200","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0022-3565(25)12828-0","article-title":"Testosterone causes direct relaxation of rat thoracic aorta","volume":"277","author":"Costarella","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2023.122405_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137111","article-title":"Testosterone replacement therapy prevents alterations of coronary vascular reactivity caused by hormone deficiency induced by castration","volume":"10","author":"Rouver","year":"2015","journal-title":"PLoS One"},{"year":"2016","series-title":"Normativas Do CONCEA Para Produ\u00e7\u00e3o, Manuten\u00e7\u00e3o de Animais Em Atividades de Ensino Ou Pesquisa Cient\u00edfica: Lei, Decreto, Portarias, Resolu\u00e7\u00f5es","author":"Brasil","key":"10.1016\/j.lfs.2023.122405_bb0210"},{"key":"10.1016\/j.lfs.2023.122405_bb0215","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1590\/S0100-879X2001000700014","article-title":"Sex hormone modulation of serotonin-induced coronary vasodilation in isolated heart","volume":"34","author":"Moys\u00e9s","year":"2001","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.lfs.2023.122405_bb0220","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejogrb.2010.02.004","article-title":"Comparison of the effects of raloxifene and anastrozole on experimental endometriosis","volume":"150","author":"Altintas","year":"2010","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.lfs.2023.122405_bb0225","doi-asserted-by":"crossref","first-page":"F634","DOI":"10.1152\/ajprenal.00718.2010","article-title":"Inhibition of estradiol synthesis attenuates renal injury in male streptozotocin-induced diabetic rats","volume":"301","author":"Manigrasso","year":"2011","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.lfs.2023.122405_bb0230","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.3390\/ijerph16101726","article-title":"Finasteride-induced inhibition of 5\u03b1-reductase type 2 could lead to kidney damage\u2014animal, experimental study","volume":"16","author":"Baig","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.lfs.2023.122405_bb0235","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1210\/en.2004-0627","article-title":"Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5\u03b1-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia","volume":"145","author":"Gao","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2023.122405_bb0240","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/00000542-198907000-00015","article-title":"The contractile responses of isolated dog cerebral and extracerebral arteries to oxybarbiturates and thiobarbiturates","volume":"71","author":"Hatano","year":"1989","journal-title":"Anesthesiology"},{"key":"10.1016\/j.lfs.2023.122405_bb0245","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007074","article-title":"Cardiovascular and metabolic consequences of testosterone supplements in young and old male spontaneously hypertensive rats: implications for testosterone supplements in men","volume":"6","author":"Dalmasso","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.lfs.2023.122405_bb0250","doi-asserted-by":"crossref","first-page":"25","DOI":"10.33549\/physiolres.933907","article-title":"Differences in serum steroid hormones concentrations in Spontaneously Hypertensive Rats (SHR) \u2013 an animal model of Attention-Deficit\/Hyperactivity Disorder (ADHD)","volume":"68","author":"Koz\u0142owska","year":"2019","journal-title":"Physiol. Res."},{"issue":"3","key":"10.1016\/j.lfs.2023.122405_bb0255","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1081\/CEH-120003197","article-title":"Testosterone increased blood pressure and decreased renal tyrosine hydroxylase activity in SHR\/Y and Wistar-kyoto rats","volume":"24","author":"Sharma","year":"2002","journal-title":"Clin. Exp. Hypertens."},{"issue":"3","key":"10.1016\/j.lfs.2023.122405_bb0260","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1530\/JOE-21-0284","article-title":"O inibidor do mTOR melhora a hipertrofia mioc\u00e1rdica induzida pela testosterona em ratos hiperssivos","volume":"252","author":"Chen","year":"2022","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.lfs.2023.122405_bb0265","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3389\/fphys.2018.00490","article-title":"Detrimental effects of testosterone addition to estrogen therapy involve cytochrome P-450-induced 20-HETE synthesis in aorta of ovariectomized spontaneously hypertensive rat (SHR), a model of postmenopausal hypertension","volume":"9","author":"Costa","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lfs.2023.122405_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113717","article-title":"Sex hormone-like effects of icariin on T-cells immune modulation in spontaneously hypertensive rats","volume":"269","author":"Liu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.lfs.2023.122405_bb0275","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000158978","article-title":"Mesenteric arcade arteries contribute substantially to vascular resistance in conscious rats","volume":"30","author":"Christensen","year":"1993","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.lfs.2023.122405_bb0280","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mce.2017.08.016","article-title":"Intracrine androgen biosynthesis, metabolism and action revisited","volume":"465","author":"Schiffer","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.lfs.2023.122405_bb0285","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1530\/JME-20-0153","article-title":"Testosterone increases bradykinin-induced relaxation in the coronary bed of hypertensive rats","volume":"65","author":"Arapa-Diaz","year":"2020","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.lfs.2023.122405_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115108","article-title":"Cardiovascular risk factors and molecular routes underlying endothelial dysfunction: novel opportunities for primary prevention","volume":"202","author":"Benincasa","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2023.122405_bb0295","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1748-1716.2009.01964.x","article-title":"Endothelial dysfunction and vascular disease","volume":"196","author":"Vanhoutte","year":"2009","journal-title":"Acta Physiol."},{"key":"10.1016\/j.lfs.2023.122405_bb0300","first-page":"H511","article-title":"Estrogen reduces mouse cerebral artery tone through endothelial NOS- and cyclooxygenase-dependent mechanisms","volume":"279","author":"Geary","year":"2000","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.lfs.2023.122405_bb0305","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1006\/bbrc.1995.2297","article-title":"17-\u03b2-Estradiol stimulation of endothelial K+ channels","volume":"214","author":"Rusko","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2023.122405_bb0310","first-page":"C413","article-title":"Analysis of DHE-derived oxidation products by HPLC in the assessment of superoxide production and NADPH oxidase activity in vascular systems","volume":"292","author":"Fernandes","year":"2007","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.lfs.2023.122405_bb0315","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jchemneu.2010.07.006","article-title":"Effects of testosterone on orchiectomy-induced oxidative damage in the rat hippocampus","volume":"40","author":"Meydan","year":"2010","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.lfs.2023.122405_bb0320","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/sj.ijir.3901154","article-title":"Treatment of testosterone-induced gynecomastia with the aromatase inhibitor, anastrozole","volume":"16","author":"Rhoden","year":"2004","journal-title":"Int. J. Impot. Res."},{"key":"10.1016\/j.lfs.2023.122405_bb0325","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0022-3565(24)38195-9","article-title":"Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids","volume":"289","author":"Catella-Lawson","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2023.122405_bb0330","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0090-6980(02)00029-1","article-title":"Distinct functions of COX-1 and COX-2","volume":"68\u201369","author":"Morita","year":"2002","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.lfs.2023.122405_bb0335","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/384644a0","article-title":"Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents","volume":"384","author":"Kurumbail","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2023.122405_bb0340","doi-asserted-by":"crossref","first-page":"R233","DOI":"10.1152\/ajpregu.00338.2003","article-title":"Gender, sex hormones, and vascular tone","volume":"286","author":"Orshal","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.lfs.2023.122405_bb0345","doi-asserted-by":"crossref","first-page":"H2413","DOI":"10.1152\/ajpheart.2001.280.6.H2413","article-title":"Prologue: EDHF\u2014what is it?","volume":"280","author":"Campbell","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.lfs.2023.122405_bb0350","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/358352","article-title":"Enhanced protective effect of the combination of Uncaria and Semen Raphani on vascular endothelium in spontaneously hypertensive rats","volume":"2015","author":"Li","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523010408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320523010408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:14:10Z","timestamp":1758402850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320523010408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":70,"alternative-id":["S0024320523010408"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2023.122405","relation":{},"ISSN":["0024-3205"],"issn-type":[{"type":"print","value":"0024-3205"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Testosterone modulates vasodilation in mesenteric arteries of hypertensive rats","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2023.122405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"122405"}}