{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:43:51Z","timestamp":1791607431937,"version":"4.3.4"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005153","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.lfs.2024.122675","type":"journal-article","created":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T14:04:28Z","timestamp":1714313068000},"page":"122675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Quercetin attenuates inflammation in rosacea by directly targeting p65 and ICAM-1"],"prefix":"10.1016","volume":"347","author":[{"given":"Xin","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangfan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2024.122675_bb0005","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/j.jaad.2020.01.077","article-title":"Standard management options for rosacea: The 2019 update by the National Rosacea Society Expert Committee","volume":"82","author":"Thiboutot","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0010","first-page":"282","article-title":"Thyssen JP incidence and prevalence of rosacea: a systematic review and meta-analysis","volume":"179","author":"Gether","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0015","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.jaad.2013.04.043","article-title":"Rosacea: current state of epidemiology","volume":"69","author":"Tan","year":"2013","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0020","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jaad.2014.05.036","article-title":"Feldman SR the psychological impact of rosacea and the influence of current management options","volume":"71","author":"Moustafa","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0025","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/1346-8138.15339","article-title":"Relationship between rosacea and sleep","volume":"47","author":"Wang","year":"2020","journal-title":"J. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0030","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000444082","article-title":"Patients with Rosacea have increased risk of depression and anxiety disorders: a Danish Nationwide cohort study","volume":"232","author":"Egeberg","year":"2016","journal-title":"Dermatology"},{"key":"10.1016\/j.lfs.2024.122675_bb0035","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000506627","article-title":"Anxiety, depression, and suicidal ideation amongst patients with facial dermatoses (acne, Rosacea, perioral dermatitis, and folliculitis) in Lithuania","volume":"236","author":"Lukaviciute","year":"2020","journal-title":"Dermatology"},{"key":"10.1016\/j.lfs.2024.122675_bb0040","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/jdv.13748","article-title":"Feelings of stigmatization in patients with rosacea","volume":"31","author":"Halioua","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.lfs.2024.122675_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17091562","article-title":"Rosacea: molecular mechanisms and Management of a Chronic Cutaneous Inflammatory Condition","volume":"17","author":"Woo","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2024.122675_bb0050","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1001\/jamadermatol.2015.2230","article-title":"Genetic vs environmental factors that correlate with Rosacea: a cohort-based survey of twins","volume":"151","author":"Aldrich","year":"2015","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0055","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/jid.2015.53","article-title":"Assessment of the genetic basis of rosacea by genome-wide association study","volume":"135","author":"Chang","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0060","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s40257-019-00471-5","article-title":"Characterization and analysis of the skin microbiota in Rosacea: a case-control study","volume":"21","author":"Rainer","year":"2020","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0065","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s40257-020-00546-8","article-title":"Microbiota in Rosacea","volume":"21","author":"Kim","year":"2020","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0070","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nm1616","article-title":"Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea","volume":"13","author":"Yamasaki","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2024.122675_bb0075","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1038\/jid.2015.141","article-title":"Molecular and morphological characterization of inflammatory infiltrate in Rosacea reveals activation of Th1\/Th17 pathways","volume":"135","author":"Buhl","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0080","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/jidsymp.2011.7","article-title":"Clinical, cellular, and molecular aspects in the pathophysiology of rosacea","volume":"15","author":"Steinhoff","year":"2011","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"10.1016\/j.lfs.2024.122675_bb0085","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/jid.2010.351","article-title":"TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes","volume":"131","author":"Yamasaki","year":"2011","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0090","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1016\/j.jid.2021.02.745","article-title":"Antimicrobial peptide LL-37 drives Rosacea-like skin inflammation in an NLRP3-dependent manner","volume":"141","author":"Yoon","year":"2021","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0095","doi-asserted-by":"crossref","first-page":"e13560","DOI":"10.15252\/emmm.202013560","article-title":"A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea","volume":"13","author":"Deng","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.lfs.2024.122675_bb0100","article-title":"mTORC1-mediated angiogenesis is required for the development of Rosacea, front cell","volume":"9","author":"Peng","year":"2021","journal-title":"Dev. Biol."},{"key":"10.1016\/j.lfs.2024.122675_bb0105","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1111\/jdv.14349","article-title":"Swiss S1 guideline for the treatment of rosacea","volume":"31","author":"Anzengruber","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.lfs.2024.122675_bb0110","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.1132939","article-title":"The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease","volume":"313","author":"Lamb","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.lfs.2024.122675_bb0115","doi-asserted-by":"crossref","first-page":"105203","DOI":"10.1016\/j.phrs.2020.105203","article-title":"Integration of genetic variants and gene network for drug repurposing in colorectal cancer","volume":"161","author":"Irham","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2024.122675_bb0120","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/s13046-021-02135-x","article-title":"Differential gene expression-based connectivity mapping identified novel drug candidate and improved Temozolomide efficacy for glioblastoma","volume":"40","author":"Vengoji","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.lfs.2024.122675_bb0125","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1302\/2046-3758.98.BJR-2019-0301.R1","article-title":"Promising targets and drugs in rheumatoid arthritis: a module-based and cumulatively scoring approach","volume":"9","author":"Li","year":"2020","journal-title":"Bone Joint Res."},{"key":"10.1016\/j.lfs.2024.122675_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2020.583629","article-title":"Identification of molecular markers associated with the pathophysiology and treatment of lupus nephritis based on integrated transcriptome analysis","volume":"11","author":"Yao","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.lfs.2024.122675_bb0135","doi-asserted-by":"crossref","DOI":"10.1186\/1479-5876-12-153","article-title":"Drug-repurposing identified the combination of Trolox C and Cytisine for the treatment of type 2 diabetes","volume":"12","author":"Jin","year":"2014","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.lfs.2024.122675_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.938391","article-title":"Inhibition of HDAC6 with CAY10603 ameliorates diabetic kidney disease by suppressing NLRP3 Inflammasome","volume":"13","author":"Hou","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2024.122675_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.674871","article-title":"Keratinocyte-immune cell crosstalk in a STAT1-mediated pathway: novel insights into Rosacea pathogenesis","volume":"12","author":"Deng","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2024.122675_bb0150","doi-asserted-by":"crossref","first-page":"153527","DOI":"10.1016\/j.phymed.2021.153527","article-title":"Deciphering the synergistic network regulation of active components from SiNiSan against irritable bowel syndrome via a comprehensive strategy: combined effects of synephrine, paeoniflorin and naringin","volume":"86","author":"Cai","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2024.122675_bb0155","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2024.122675_bb0160","doi-asserted-by":"crossref","first-page":"D1197","DOI":"10.1093\/nar\/gkaa1063","article-title":"HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine","volume":"49","author":"Fang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.lfs.2024.122675_bb0165","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/exd.12745","article-title":"Recombinant erythroid differentiation regulator 1 inhibits both inflammation and angiogenesis in a mouse model of rosacea","volume":"24","author":"Kim","year":"2015","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0170","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00210-018-01604-z","article-title":"Topical application of phenolic compounds suppresses Propionibacterium acnes-induced inflammatory responses in mice with ear edema","volume":"392","author":"Dos Santos","year":"2019","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.lfs.2024.122675_bb0175","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/9780470559277.ch110180","article-title":"Target identification using drug affinity responsive target stability (DARTS)","volume":"3","author":"Lomenick","year":"2011","journal-title":"Curr. Protoc. Chem. Biol."},{"key":"10.1016\/j.lfs.2024.122675_bb0180","doi-asserted-by":"crossref","first-page":"114798","DOI":"10.1016\/j.bcp.2021.114798","article-title":"Drug affinity responsive target stability (DARTS) accelerated small molecules target discovery: principles and application","volume":"194","author":"Ren","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2024.122675_bb0185","article-title":"Integrated omics reveal the molecular characterization and pathogenic mechanism of rosacea","author":"Zhang","year":"2023","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0190","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"10.1016\/j.lfs.2024.122675_bb0195","doi-asserted-by":"crossref","first-page":"105971","DOI":"10.1016\/j.phrs.2021.105971","article-title":"Exploring metformin as a candidate drug for rosacea through network pharmacology and experimental validation","volume":"174","author":"Li","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2024.122675_bb0200","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/jidsymp.2011.9","article-title":"Homey B Rosacea: the cytokine and chemokine network","volume":"15","author":"Gerber","year":"2011","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"10.1016\/j.lfs.2024.122675_bb0205","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jid.2019.08.436","article-title":"Innate immune dysfunction in Rosacea promotes photosensitivity and vascular adhesion molecule expression","volume":"140","author":"Kulkarni","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0210","doi-asserted-by":"crossref","first-page":"21984","DOI":"10.1073\/pnas.0910040106","article-title":"Target identification using drug affinity responsive target stability (DARTS)","volume":"106","author":"Lomenick","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2024.122675_bb0215","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1468-3083.2010.03751.x","article-title":"Rosacea - global diversity and optimized outcome: proposed international consensus from the Rosacea international expert group","volume":"25","author":"Elewski","year":"2011","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.lfs.2024.122675_bb0220","doi-asserted-by":"crossref","first-page":"8825387","DOI":"10.1155\/2020\/8825387","article-title":"Li P quercetin: its main pharmacological activity and potential application in clinical medicine","volume":"2020","author":"Yang","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2024.122675_bb0225","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.ejmech.2018.06.053","article-title":"Therapeutic potential of quercetin as a cardiovascular agent","volume":"155","author":"Patel","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.lfs.2024.122675_bb0230","doi-asserted-by":"crossref","first-page":"108454","DOI":"10.1016\/j.jnutbio.2020.108454","article-title":"Quercetin alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities","volume":"84","author":"Yuan","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.lfs.2024.122675_bb0235","doi-asserted-by":"crossref","first-page":"114213","DOI":"10.1016\/j.jep.2021.114213","article-title":"Quercetin-mediated SIRT1 activation attenuates collagen-induced mice arthritis","volume":"279","author":"Shen","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.lfs.2024.122675_bb0240","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2019.09.024","article-title":"Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages","volume":"145","author":"Hu","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2024.122675_bb0245","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1021\/np300670w","article-title":"Quercetin-loaded microcapsules ameliorate experimental colitis in mice by anti-inflammatory and antioxidant mechanisms","volume":"76","author":"Guazelli","year":"2013","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.lfs.2024.122675_bb0250","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/exd.12685","article-title":"Modulation of HMGB1 translocation and RAGE\/NF\u03baB cascade by quercetin treatment mitigates atopic dermatitis in NC\/Nga transgenic mice","volume":"24","author":"Karuppagounder","year":"2015","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0255","doi-asserted-by":"crossref","first-page":"105676","DOI":"10.1016\/j.intimp.2019.105676","article-title":"Anti-inflammatory effects of quercetin in a mouse model of MC903-induced atopic dermatitis","volume":"74","author":"Hou","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2024.122675_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/nu8030167","article-title":"Quercetin, inflammation and immunity","volume":"8","author":"Li","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2024.122675_bb0265","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1166\/jbn.2021.3031","article-title":"Quercetin nanoparticle ameliorates lipopolysaccharide-triggered renal inflammatory impairment by regulation of Sirt1\/NF-KB pathway","volume":"17","author":"Lu","year":"2021","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.lfs.2024.122675_bb0270","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.jaad.2014.08.028","article-title":"Hata TR Rosacea: part I. Introduction, categorization, histology, pathogenesis, and risk factors","volume":"72","author":"Two","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0275","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016303","article-title":"The chemokine system in innate immunity","volume":"7","author":"Sokol","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.lfs.2024.122675_bb0280","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jaad.2005.10.009","article-title":"Videocapillaroscopic alterations in erythematotelangiectatic rosacea","volume":"54","author":"Rosina","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.lfs.2024.122675_bb0285","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/j.1600-0560.2006.00695.x","article-title":"Lymphangiogenesis and angiogenesis in non-phymatous rosacea","volume":"34","author":"Gomaa","year":"2007","journal-title":"J. Cutan. Pathol."},{"key":"10.1016\/j.lfs.2024.122675_bb0290","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity","volume":"18","author":"Karin","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.lfs.2024.122675_bb0295","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.lfs.2024.122675_bb0300","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ajo.2019.01.018","article-title":"Nuclear factor kappa-B is enriched in eyelid specimens of Rosacea: implications for pathogenesis and therapy","volume":"201","author":"Wladis","year":"2019","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.lfs.2024.122675_bb0305","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.iy.11.040193.004003","article-title":"Endothelial-leukocyte adhesion molecules","volume":"11","author":"Bevilacqua","year":"1993","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.lfs.2024.122675_bb0310","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nri2171","article-title":"Evolving functions of endothelial cells in inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nat. Rev. Immunol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524002650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524002650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T07:44:57Z","timestamp":1715240697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320524002650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":62,"alternative-id":["S0024320524002650"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2024.122675","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quercetin attenuates inflammation in rosacea by directly targeting p65 and ICAM-1","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2024.122675","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"122675"}}