{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:40:07Z","timestamp":1784868007364,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32272887"],"award-info":[{"award-number":["32272887"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LZ22C170003"],"award-info":[{"award-number":["LZ22C170003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.lfs.2024.122742","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T16:12:18Z","timestamp":1716567138000},"page":"122742","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Lipidomics and single-cell RNA sequencing reveal lipid and cell dynamics of porcine glycerol-injured skeletal muscle regeneration model"],"prefix":"10.1016","volume":"350","author":[{"given":"Ye","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziye","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyun","family":"Nong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tizhong","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"97","key":"10.1016\/j.lfs.2024.122742_bb0005","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1152\/japplphysiol.00368.2004","article-title":"Use of intramuscular triacylglycerol as a substrate source during exercise in humans","volume":"1985","author":"van Loon","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.lfs.2024.122742_bb0010","doi-asserted-by":"crossref","first-page":"E152","DOI":"10.1152\/ajpendo.00142.2017","article-title":"Intramuscular triglyceride synthesis: importance in muscle lipid partitioning in humans","volume":"314","author":"Bergman","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2024.122742_bb0015","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000100869","article-title":"Age-related changes in intramyocellular lipid in humans by in vivo H-MR spectroscopy","volume":"53","author":"Nakagawa","year":"2007","journal-title":"Gerontology"},{"key":"10.1016\/j.lfs.2024.122742_bb0020","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2337\/dc15-0995","article-title":"Reduced lower-limb muscle strength and volume in patients with type 2 diabetes in relation to neuropathy, intramuscular fat, and vitamin D levels","volume":"39","author":"Almurdhi","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.lfs.2024.122742_bb0025","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00256-011-1240-1","article-title":"Lower leg muscle involvement in Duchenne muscular dystrophy: an MR imaging and spectroscopy study","volume":"41","author":"Torriani","year":"2012","journal-title":"Skeletal Radiol."},{"key":"10.1016\/j.lfs.2024.122742_bb0030","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00441-018-2955-2","article-title":"Skeletal muscle fibrosis: an overview","volume":"375","author":"Mahdy","year":"2019","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.lfs.2024.122742_bb0035","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00441-018-2846-6","article-title":"Glycerol-induced injury as a new model of muscle regeneration","volume":"374","author":"Mahdy","year":"2018","journal-title":"Cell Tissue Res."},{"issue":"1","key":"10.1016\/j.lfs.2024.122742_bb0040","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/jcsm.12643","article-title":"Single-cell RNA sequencing and lipidomics reveal cell and lipid dynamics of fat infiltration in skeletal muscle","volume":"12","author":"Xu","year":"2021","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.lfs.2024.122742_bb0045","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.210110","article-title":"Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases","volume":"11","author":"Molina","year":"2021","journal-title":"Open Biol."},{"key":"10.1016\/j.lfs.2024.122742_bb0050","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tim.2011.11.002","article-title":"The pig: a model for human infectious diseases","volume":"20","author":"Meurens","year":"2012","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.lfs.2024.122742_bb0055","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s11248-016-9934-8","article-title":"The production of multi-transgenic pigs: update and perspectives for xenotransplantation","volume":"25","author":"Niemann","year":"2016","journal-title":"Transgenic Res."},{"key":"10.1016\/j.lfs.2024.122742_bb0065","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41538-023-00203-4","article-title":"Single-nucleus and bulk RNA sequencing reveal cellular and transcriptional mechanisms underlying lipid dynamics in high marbled pork","volume":"7","author":"Wang","year":"2023","journal-title":"NPJ Science of Food"},{"key":"10.1016\/j.lfs.2024.122742_bb0070","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12935-019-0986-8","article-title":"Overexpression of CENPF correlates with poor prognosis and tumor bone metastasis in breast cancer","volume":"19","author":"Sun","year":"2019","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.lfs.2024.122742_bb0075","doi-asserted-by":"crossref","first-page":"589","DOI":"10.7150\/jca.64017","article-title":"TOP2A promotes proliferation and metastasis of hepatocellular carcinoma regulated by miR-144-3p","volume":"13","author":"Wang","year":"2022","journal-title":"J. Cancer"},{"key":"10.1016\/j.lfs.2024.122742_bb0080","first-page":"54","article-title":"Proliferating SPP1\/MERTK-expressing macrophages in idiopathic pulmonary fibrosis","author":"Morse","year":"2019","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.lfs.2024.122742_bb0085","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1038\/s41467-020-15647-5","article-title":"Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis","volume":"11","author":"Tsukui","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2024.122742_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.595811","article-title":"Disparate interferon signaling and shared aberrant basaloid cells in single-cell profiling of idiopathic pulmonary fibrosis and systemic sclerosis-associated interstitial lung disease","volume":"12","author":"Valenzi","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2024.122742_bb0095","series-title":"Myosin Heavy Chain-Embryonic Regulates Skeletal Muscle Differentiation during Mammalian Development. Development (Cambridge, England)","first-page":"147","author":"Agarwal","year":"2020"},{"key":"10.1016\/j.lfs.2024.122742_bb0100","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.semcdb.2015.09.017","article-title":"PAX3 and PAX7 as upstream regulators of myogenesis","volume":"44","author":"Buckingham","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.lfs.2024.122742_bb0105","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0092-8674(00)00066-0","article-title":"Pax7 is required for the specification of myogenic satellite cells","volume":"102","author":"Seale","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2024.122742_bb0110","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.semcdb.2017.11.011","article-title":"Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis","volume":"72","author":"Zammit","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.lfs.2024.122742_bb0115","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.gene.2019.05.003","article-title":"Type III collagen (COL3A1): gene and protein structure, tissue distribution, and associated diseases","volume":"707","author":"Kuivaniemi","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.lfs.2024.122742_bb0120","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nature26138","article-title":"Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance","volume":"555","author":"Ghorpade","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2024.122742_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181880","article-title":"DPP4 gene variation affects GLP-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity","volume":"12","author":"B\u00f6hm","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2024.122742_bb0130","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41392-022-01008-9","article-title":"The role of CTHRC1 in promotion of cutaneous wound healing","volume":"7","author":"Duan","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.lfs.2024.122742_bb0135","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ebiom.2019.01.009","article-title":"Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-\u03b2 signaling","volume":"40","author":"Li","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.lfs.2024.122742_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12950-015-0109-9","article-title":"CXCL14 as an emerging immune and inflammatory modulator","volume":"13","author":"Lu","year":"2016","journal-title":"Journal of inflammation (London, England)"},{"key":"10.1016\/j.lfs.2024.122742_bb0145","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.autrev.2008.12.002","article-title":"CXCL10 and autoimmune diseases","volume":"8","author":"Lee","year":"2009","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.lfs.2024.122742_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166810","article-title":"FABP4 in LSECs promotes CXCL10-mediated macrophage recruitment and M1 polarization during NAFLD progression","volume":"1869","author":"Zhou","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.lfs.2024.122742_bb0155","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.plipres.2013.12.001","article-title":"Regulation of energy metabolism by long-chain fatty acids","volume":"53","author":"Nakamura","year":"2014","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.lfs.2024.122742_bb0160","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.scr.2018.08.010","article-title":"Odd skipped-related 1 (Osr1) identifies muscle-interstitial fibro-adipogenic progenitors (FAPs) activated by acute injury","volume":"32","author":"Stumm","year":"2018","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.lfs.2024.122742_bb0165","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/s41467-017-01120-3","article-title":"Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development","volume":"8","author":"Vallecillo-Garc\u00eda","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2024.122742_bb0170","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1113\/jphysiol.2002.023796","article-title":"Human skeletal muscle fatty acid and glycerol metabolism during rest, exercise and recovery","volume":"543","author":"van Hall","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.lfs.2024.122742_bb0175","doi-asserted-by":"crossref","DOI":"10.1172\/JCI148176","article-title":"Remodeling glycerophospholipids affects obesity-related insulin signaling in skeletal muscle","volume":"131","author":"Wolfgang","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2024.122742_bb0180","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/s43587-022-00309-6","article-title":"Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia","volume":"2","author":"Laurila","year":"2022","journal-title":"Nature Aging"},{"key":"10.1016\/j.lfs.2024.122742_bb0185","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1017\/S000711451200534X","article-title":"Adding MUFA to a dietary portfolio of cholesterol-lowering foods reduces apoAI fractional catabolic rate in subjects with dyslipidaemia","volume":"110","author":"Labont\u00e9","year":"2013","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.lfs.2024.122742_bb0190","article-title":"Fat infiltration in skeletal muscle: influential triggers and regulatory mechanism","volume":"27","author":"Wang","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.lfs.2024.122742_bb0195","first-page":"9","article-title":"Association analysis of single-cell RNA sequencing and proteomics reveals a vital role of Ca(2+) signaling in the determination of skeletal muscle development potential","author":"Qiu","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2024.122742_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2019.02.026","article-title":"High-dimensional single-cell cartography reveals novel skeletal muscle-resident cell populations","volume":"74","author":"Giordani","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.lfs.2024.122742_bb0205","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/s42003-021-02810-x","article-title":"Large-scale integration of single-cell transcriptomic data captures transitional progenitor states in mouse skeletal muscle regeneration","volume":"4","author":"McKellar","year":"2021","journal-title":"Communications Biology"},{"key":"10.1016\/j.lfs.2024.122742_bb0210","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/bs.ctdb.2017.08.003","article-title":"The muscle stem cell niche in health and disease","volume":"126","author":"Mashinchian","year":"2018","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.lfs.2024.122742_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.100993","article-title":"Temporal dynamics and heterogeneity of cell populations during skeletal muscle regeneration","volume":"23","author":"Oprescu","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.lfs.2024.122742_bb0220","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/s41467-022-29366-6","article-title":"Single-cell and spatial analysis reveal interaction of FAP(+) fibroblasts and SPP1(+) macrophages in colorectal cancer","volume":"13","author":"Qi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2024.122742_bb0225","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1038\/s41388-021-01827-0","article-title":"CTHRC1 promotes liver metastasis by reshaping infiltrated macrophages through physical interactions with TGF-\u03b2 receptors in colorectal cancer","volume":"40","author":"Zhang","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2024.122742_bb0230","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.ajpath.2012.11.004","article-title":"The involvement of collagen triple helix repeat containing 1 in muscular dystrophies","volume":"182","author":"Spector","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.lfs.2024.122742_bb0235","doi-asserted-by":"crossref","DOI":"10.1038\/srep23074","article-title":"Metabolic role of dipeptidyl peptidase 4 (DPP4) in primary human (pre)adipocytes","volume":"6","author":"Zille\u00dfen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2024.122742_bb0240","first-page":"364","article-title":"Identification of a mesenchymal progenitor cell hierarchy in adipose tissue","author":"Merrick","year":"2019","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.lfs.2024.122742_bb0245","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd5758","article-title":"Importance of the pig as a human biomedical model","volume":"13","author":"Lunney","year":"2021","journal-title":"Sci. Transl. Med."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524003321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524003321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T01:53:13Z","timestamp":1718675593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320524003321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":48,"alternative-id":["S0024320524003321"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2024.122742","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipidomics and single-cell RNA sequencing reveal lipid and cell dynamics of porcine glycerol-injured skeletal muscle regeneration model","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2024.122742","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122742"}}