{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:13:03Z","timestamp":1792883583235,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003489","name":"Henan University of Technology","doi-asserted-by":"publisher","award":["2020ZKCJ23"],"award-info":[{"award-number":["2020ZKCJ23"]}],"id":[{"id":"10.13039\/501100003489","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["2323000421165"],"award-info":[{"award-number":["2323000421165"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.lfs.2024.122767","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T06:32:56Z","timestamp":1717482776000},"page":"122767","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Activity and mechanism of action of antimicrobial peptide ACPs against Candida albicans"],"prefix":"10.1016","volume":"350","author":[{"given":"Kuiming","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiming","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.lfs.2024.122767_bb0005","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1021\/acs.chemrev.0c00199","article-title":"Antifungal drug resistance: molecular mechanisms in Candida albicans and beyond","volume":"121","author":"Lee","year":"2021","journal-title":"Chem. Rev."},{"issue":"2","key":"10.1016\/j.lfs.2024.122767_bb0010","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1371\/journal.pone.0172228","article-title":"Honokiol induces reactive oxygen species-mediated apoptosis in Candida albicans through mitochondrial dysfunction","volume":"12","author":"Sun","year":"2017","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.lfs.2024.122767_bb0015","article-title":"Interplay between Candida albicans and lactic acid bacteria in the gastrointestinal tract: impact on colonization resistance, microbial carriage, opportunistic infection, and host immunity","volume":"34","author":"Zeise","year":"2021","journal-title":"Clin. Mimrobiol. Rel."},{"issue":"4","key":"10.1016\/j.lfs.2024.122767_bb0020","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.3390\/ijms22042127","article-title":"Fructose induces fluconazole resistance in Candida albicans through activation of Mdr1 and Cdr1 transporters","volume":"22","author":"Suchodolski","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"36","key":"10.1016\/j.lfs.2024.122767_bb0025","doi-asserted-by":"crossref","first-page":"22473","DOI":"10.1073\/pnas.2003700117","article-title":"Fungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance","volume":"117","author":"Kowalski","year":"2020","journal-title":"P. Natl. Acad. Sci. USA."},{"issue":"4","key":"10.1016\/j.lfs.2024.122767_bb0030","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00458-19","article-title":"Combined antifungal resistance and biofilm tolerance: the global threat of Candida auris","volume":"4","author":"Kean","year":"2019","journal-title":"Msphere"},{"key":"10.1016\/j.lfs.2024.122767_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.hermed.2021.100495","article-title":"Antifungal activity of menthol alone and in combination on growth inhibition and biofilm formation of Candida albicans","volume":"29","author":"Norouzi","year":"2021","journal-title":"J. Herb. Med."},{"issue":"5","key":"10.1016\/j.lfs.2024.122767_bb0040","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.3390\/ijms23052771","article-title":"Hybrid nanoparticles and composite hydrogel systems for delivery of peptide antibiotics","volume":"23","author":"Iudin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.lfs.2024.122767_bb0045","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.3390\/molecules25122850","article-title":"Antimicrobial peptides as anticancer agents: functional properties and biological activities","volume":"25","author":"Tornesello","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.lfs.2024.122767_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.112303","article-title":"Multidrug resistance crisis during COVID-19 pandemic: role of anti-microbial peptides as next-generation therapeutics","volume":"211","author":"Sharma","year":"2022","journal-title":"Colloid. Surface. B."},{"key":"10.1016\/j.lfs.2024.122767_bb0055","doi-asserted-by":"crossref","first-page":"111682","DOI":"10.1016\/j.colsurfb.2021.111682","article-title":"Advances of peptides for antibacterial applications","volume":"202","author":"Yan","year":"2021","journal-title":"Colloids Surf. B."},{"key":"10.1016\/j.lfs.2024.122767_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.100954","article-title":"Antimicrobial peptides for combating drug-resistant bacterial infections","volume":"68","author":"Xuan","year":"2023","journal-title":"Drug. Resist. Update"},{"key":"10.1016\/j.lfs.2024.122767_bb0065","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mib.2019.03.004","article-title":"Toward computer-made artificial antibiotics","volume":"51","author":"Torres","year":"2019","journal-title":"Curr. Opin. Microbiol."},{"issue":"10","key":"10.1016\/j.lfs.2024.122767_bb0070","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1021\/acs.accounts.1c00040","article-title":"Peptides and antibiotic therapy: advances in design and delivery","volume":"54","author":"Schafer","year":"2021","journal-title":"Acc. Chem. Res."},{"issue":"1","key":"10.1016\/j.lfs.2024.122767_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/biom8010004","article-title":"Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo","volume":"8","author":"Kumar","year":"2018","journal-title":"Biomolecules"},{"key":"10.1016\/j.lfs.2024.122767_bb0080","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ijbiomac.2022.07.103","article-title":"In pursuit of next-generation therapeutics: antimicrobial peptides against superbugs, their sources, mechanism of action, nanotechnology-based delivery, and clinical applications","volume":"218","author":"Thakur","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.lfs.2024.122767_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115500","article-title":"Broad-spectrum hybrid antimicrobial peptides derived from PMAP-23 with potential LPS binding ability","volume":"210","author":"Lyu","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.lfs.2024.122767_bb0090","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/mmy\/myz105","article-title":"Fungal NOX is an essential factor for induction of TG2 in human hepatocytes","volume":"58","author":"Huang","year":"2020","journal-title":"Med. Mycol."},{"issue":"10","key":"10.1016\/j.lfs.2024.122767_bb0095","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.3390\/antibiotics11101451","article-title":"Recent progress in the discovery and design of antimicrobial peptides using traditional machine learning and deep learning","volume":"11","author":"Yan","year":"2022","journal-title":"Antibiotics-Basel"},{"key":"10.1016\/j.lfs.2024.122767_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.116072","article-title":"Antimicrobial peptides: An alternative to traditional antibiotics","volume":"265","author":"Ji","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.lfs.2024.122767_bb0105","article-title":"Studies on the in vitro mechanism and in vivo therapeutic effect of the antimicrobial peptide ACP5 against Trichophyton mentagrophytes","volume":"171177","author":"Zou","year":"2024","journal-title":"Peptides"},{"key":"10.1016\/j.lfs.2024.122767_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106355","article-title":"Rational design, synthesis, antifungal evaluation and docking studies of antifungal peptide CGA-N12 analogues based on the target CtKRE9","volume":"132","author":"Li","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.lfs.2024.122767_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115535","article-title":"Fatty acid modification of antimicrobial peptide CGA-N9 and the combats against Candida albicans infection","volume":"211","author":"Li","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"15","key":"10.1016\/j.lfs.2024.122767_bb0120","doi-asserted-by":"crossref","first-page":"7959","DOI":"10.3390\/ijms22157959","article-title":"Effects of lipidation on a proline-rich antibacterial peptide","volume":"22","author":"Armas","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.lfs.2024.122767_bb0125","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.3109\/13880209.2014.900808","article-title":"Possible mechanisms of the antifungal activity of fluconazole in combination with terbinafine against Candida albicans","volume":"52","author":"Khodavandi","year":"2014","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.lfs.2024.122767_bb0130","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1042\/BCJ20180801","article-title":"CGA-N9, an antimicrobial peptide derived from chromogranin a: direct cell penetration of and endocytosis by Candida tropicalis","volume":"476","author":"Li","year":"2019","journal-title":"Biochen. J."},{"issue":"3","key":"10.1016\/j.lfs.2024.122767_bb0135","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00301-22","article-title":"Extracellular vesicles regulate biofilm formation and yeast-to-hypha differentiation in Candida albicans","volume":"13","author":"Honorato","year":"2022","journal-title":"Mbio"},{"key":"10.1016\/j.lfs.2024.122767_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2015.12.003","article-title":"Prevention of Staphylococcus aureus biomaterial-associated infections using a polymer-lipid coating containing the antimicrobial peptide OP-145","volume":"222","author":"de Breij","year":"2016","journal-title":"J. Control. Release"},{"issue":"52","key":"10.1016\/j.lfs.2024.122767_bb0145","doi-asserted-by":"crossref","first-page":"26516","DOI":"10.1073\/pnas.1909585117","article-title":"The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection","volume":"116","author":"Mwangi","year":"2019","journal-title":"P. Natl. Acad. Sci. USA"},{"issue":"423","key":"10.1016\/j.lfs.2024.122767_bb0150","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1126\/scitranslmed.aan4044","article-title":"The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms","volume":"10","author":"de Breij","year":"2018","journal-title":"Sci. Transl. Med."},{"issue":"7","key":"10.1016\/j.lfs.2024.122767_bb0155","article-title":"Small-molecule morphogenesis modulators enhance the ability of 14-helical beta-peptides to prevent Candida albicans biofilm formation (vol 63, e02653-18, 2019)","volume":"64","author":"Lopez","year":"2020","journal-title":"Antimicrob. Agents. CH."},{"issue":"11","key":"10.1016\/j.lfs.2024.122767_bb0160","doi-asserted-by":"crossref","DOI":"10.1002\/psc.3497","article-title":"Activities of a broad-spectrum antimicrobial peptide analogue SAMP-A4-C8 and its combat against pneumonia in Staphylococcus aureus-infected mice","volume":"29","author":"Li","year":"2023","journal-title":"J. Pept. Sci."},{"issue":"24","key":"10.1016\/j.lfs.2024.122767_bb0165","doi-asserted-by":"crossref","first-page":"16879","DOI":"10.1021\/acs.jmedchem.2c01674","article-title":"Membrane-targeting neolignan-antimicrobial peptide mimic conjugates to combat methicillin-resistant Staphylococcus aureus (MRSA) infections","volume":"65","author":"Yang","year":"2022","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.lfs.2024.122767_bb0170","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s12866-022-02621-y","article-title":"The antimicrobial effect of a novel peptide LL-1 on Escherichia coli by increasing membrane permeability","volume":"22","author":"Zhou","year":"2022","journal-title":"BMC Microbiol."},{"issue":"3","key":"10.1016\/j.lfs.2024.122767_bb0175","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s10989-022-10387-0","article-title":"Influence of acetylation on the mechanism of action of antimicrobial peptide L163","volume":"28","author":"Li","year":"2022","journal-title":"Int. J. Pept. Res. Ther."},{"key":"10.1016\/j.lfs.2024.122767_bb0180","article-title":"A cecropin-4 derived peptide C18 inhibits Candida albicans by disturbing mitochondrial function","volume":"13","author":"Sun","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.lfs.2024.122767_bb0185","doi-asserted-by":"crossref","first-page":"e00516","DOI":"10.1016\/j.btre.2020.e00516","article-title":"Rhamnolipid exhibits anti-biofilm activity against the dermatophytic fungi Trichophyton rubrum and Trichophyton mentagrophytes","volume":"27","author":"Sen","year":"2020","journal-title":"Biotechnol. Reports"},{"key":"10.1016\/j.lfs.2024.122767_bb0190","series-title":"Evaluation of Antifungal Effects of Ethanolic and Aqueous Extracts of Zataria multiflora Herb in the Pathogenic Yeast Candida albicans Biofilm Inhibition","first-page":"4559","volume":"8(6)","author":"Ghasem Rahimi","year":"2014"},{"issue":"5","key":"10.1016\/j.lfs.2024.122767_bb0195","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1021\/bi900724x","article-title":"Effect of the hydrophobicity to net positive charge ratio on antibacterial and anti-endotoxin activities of structurally similar antimicrobial peptides","volume":"49","author":"Rosenfeld","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.lfs.2024.122767_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114693","article-title":"Multipurpose peptides: the venoms of amazonian stinging ants contain anthelmintic ponericins with diverse predatory and defensive activities","volume":"192","author":"Nixon","year":"2021","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.lfs.2024.122767_bb0205","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/femsre\/fux010","article-title":"Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria","volume":"41","author":"Hall","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"issue":"1","key":"10.1016\/j.lfs.2024.122767_bb0210","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41522-020-0114-5","article-title":"Transcriptional responses of Candida glabrata biofilm cells to fluconazole are modulated by the carbon source","volume":"6","author":"Alves","year":"2020","journal-title":"Npj. Biofilms. Microbi."},{"issue":"1","key":"10.1016\/j.lfs.2024.122767_bb0215","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/jac\/dkt322","article-title":"De novo generation of short antimicrobial peptides with enhanced stability and cell specificity","volume":"69","author":"Kim","year":"2014","journal-title":"J. Antimicrob. Chemoth."},{"issue":"23","key":"10.1016\/j.lfs.2024.122767_bb0220","doi-asserted-by":"crossref","first-page":"4290","DOI":"10.3390\/molecules24234290","article-title":"NMR study of the secondary structure and biopharmaceutical formulation of an active branched antimicrobial peptide","volume":"24","author":"Castiglia","year":"2019","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.lfs.2024.122767_bb0225","doi-asserted-by":"crossref","first-page":"7570","DOI":"10.1021\/acs.jmedchem.3c00460","article-title":"To fold or not to fold: Diastereomeric optimization of an \u03b1-helical antimicrobial peptide","volume":"66","author":"Personne","year":"2023","journal-title":"J. Med. Chem."},{"issue":"10","key":"10.1016\/j.lfs.2024.122767_bb0230","doi-asserted-by":"crossref","DOI":"10.1002\/psc.3352","article-title":"Effects of N-terminal modifications on the stability of antimicrobial peptide SAMP-A4 analogues against protease degradation","volume":"27","author":"Li","year":"2021","journal-title":"J. Pept. Sci."},{"key":"10.1016\/j.lfs.2024.122767_bb0235","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.colsurfb.2018.08.029","article-title":"Novel surfactant peptide for removal of biofilms","volume":"172","author":"Sun","year":"2018","journal-title":"Colloid. Surface. B."},{"issue":"2","key":"10.1016\/j.lfs.2024.122767_bb0240","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/08927014.2017.1280731","article-title":"Inhibitory effects of the essential oils -longipinene and linalool on biofilm formation and hyphal growth of Candida albicans","volume":"33","author":"Manoharan","year":"2017","journal-title":"Biofouling"},{"issue":"3","key":"10.1016\/j.lfs.2024.122767_bb0245","first-page":"1725","article-title":"Antifungal activity of rhizome coptidis and Alpinia galangal against Candida species","volume":"7","author":"Alireza Khodavandi","year":"2013","journal-title":"J. Pure Appl. Microbiol."},{"key":"10.1016\/j.lfs.2024.122767_bb0250","doi-asserted-by":"crossref","first-page":"00894","DOI":"10.3389\/fmicb.2017.00894","article-title":"Transcriptional responses of Candida albicans to antimicrobial peptide MAF-1A","volume":"8","author":"Wang","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.lfs.2024.122767_bb0255","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1042\/BCJ20190483","article-title":"The chromogranin a-derived antifungal peptide CGA-N9 induces apoptosis in Candida tropicalis","volume":"476","author":"Li","year":"2019","journal-title":"Biochem. J."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524003576?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524003576?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T01:54:54Z","timestamp":1718675694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320524003576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":51,"alternative-id":["S0024320524003576"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2024.122767","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activity and mechanism of action of antimicrobial peptide ACPs against Candida albicans","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2024.122767","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"122767"}}