{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T03:06:51Z","timestamp":1770347211058,"version":"3.49.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2019-1965"],"award-info":[{"award-number":["PICT 2019-1965"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 2022-2024-11220210100552CO"],"award-info":[{"award-number":["PIP 2022-2024-11220210100552CO"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.lfs.2024.122839","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T13:11:30Z","timestamp":1718284290000},"page":"122839","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Tauroursodeoxycholate prevents estradiol 17\u03b2-d-glucuronide-induced cholestasis and endocytosis of canalicular transporters by switching off pro-cholestatic signaling pathways"],"prefix":"10.1016","volume":"352","author":[{"given":"Anabela C.","family":"Medeot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea C.","family":"Boaglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gimena","family":"Salas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula M.","family":"Maidagan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisel S.","family":"Miszczuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismael R.","family":"Barosso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique J.","family":"S\u00e1nchez Pozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando A.","family":"Crocenzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo G.","family":"Roma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2024.122839_bb0005","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/cphy.c120027","volume":"3","author":"Boyer","year":"2013","journal-title":"Bile formation and secretion. Compr Physiol"},{"key":"10.1016\/j.lfs.2024.122839_bb0010","doi-asserted-by":"crossref","first-page":"7341","DOI":"10.3748\/wjg.v19.i42.7341","article-title":"Physiological and molecular biochemical mechanisms of bile formation","volume":"19","author":"Reshetnyak","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2024.122839_bb0015","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1124\/dmd.113.056358","article-title":"The role of canalicular ABC transporters in cholestasis","volume":"42","author":"Cuperus","year":"2014","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.lfs.2024.122839_bb0020","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1042\/CS20070227","article-title":"Hepatocellular transport in acquired cholestasis: new insights into functional, regulatory and therapeutic aspects","volume":"114","author":"Roma","year":"2008","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.lfs.2024.122839_bb0025","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1053\/jhep.2002.33327","article-title":"Altered localization and activity of canalicular Mrp2 in estradiol-17\u03b2-d-glucuronide-induced cholestasis","volume":"35","author":"Mottino","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2024.122839_bb0030","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.3748\/wjg.15.2049","article-title":"Intrahepatic cholestasis of pregnancy","volume":"15","author":"Geenes","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2024.122839_bb0035","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3109\/03602539709037580","article-title":"Cholestatic properties and hepatic transport of steroid glucuronides","volume":"29","author":"Vore","year":"1997","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.lfs.2024.122839_bb0040","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6679322","article-title":"Molecular pathogenesis of intrahepatic cholestasis of pregnancy","volume":"2021","author":"Xiao","year":"2021","journal-title":"Can. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2024.122839_bb0045","doi-asserted-by":"crossref","first-page":"G449","DOI":"10.1152\/ajpgi.00508.2002","article-title":"Estradiol-17\u03b2-d-glucuronide induces endocytic internalization of Bsep in rats","volume":"285","author":"Crocenzi","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2024.122839_bb0050","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1002\/hep.22532","article-title":"Ca2+-dependent protein kinase C isoforms are critical to estradiol-17\u03b2-d-glucuronide-induced cholestasis in the rat","volume":"48","author":"Crocenzi","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2024.122839_bb0055","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/hep.23846","article-title":"Phosphoinositide 3-kinase\/protein kinase B signaling pathway is involved in estradiol-17\u03b2-d-glucuronide-induced cholestasis: complementarity with classical protein kinase C","volume":"52","author":"Boaglio","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2024.122839_bb0060","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1042\/CS20110184","article-title":"Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications","volume":"121","author":"Roma","year":"2011","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.lfs.2024.122839_bb0065","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/164_2019_241","article-title":"UDCA, NorUDCA, and TUDCA in liver diseases: a review of their mechanisms of action and clinical applications","volume":"256","author":"Cabrera","year":"2019","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.lfs.2024.122839_bb0070","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/hep.1840040106","article-title":"Cholestasis induced by estradiol-17\u03b2-d-glucuronide: mechanisms and prevention by sodium taurocholate","volume":"4","author":"Adinolfi","year":"1984","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2024.122839_bb0075","first-page":"490","article-title":"Taurocholate and steroid glucuronides: mutual protection against cholestasis in the isolated perfused rat liver","volume":"237","author":"Durham","year":"1986","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2024.122839_bb0080","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/hep.1840110505","article-title":"Estradiol-17\u03b2-d-glucuronide (E-17G) cholestasis in perfused rat liver: fate of E-17G and choleretic responses to bile salts","volume":"11","author":"Utili","year":"1990","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2024.122839_bb0085","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3109\/00365529709011207","article-title":"Improvement of estradiol-17\u03b2-d-glucuronide-induced cholestasis by sodium tauroursodeoxycholate therapy in rats","volume":"32","author":"Kinbara","year":"1997","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.lfs.2024.122839_bb0090","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0168-8278(05)80045-5","article-title":"Estradiol-17\u03b2-d-glucuronide-induced cholestasis. Effects of ursodeoxycholate-3-O-glucuronide and 3,7-disulfate","volume":"17","author":"Sano","year":"1993","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2024.122839_bb0095","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/hep.1840140129","article-title":"Purification of hepatocyte couplets by centrifugal elutriation","volume":"14","author":"Wilton","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2024.122839_bb0100","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1021\/bp00009a007","article-title":"Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration","volume":"7","author":"Dunn","year":"1991","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.lfs.2024.122839_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050711","article-title":"Sequential activation of classic PKC and estrogen receptor alpha is involved in estradiol-17\u03b2-d-glucuronide-induced cholestasis","volume":"7","author":"Barosso","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.lfs.2024.122839_bb0110","doi-asserted-by":"crossref","first-page":"G863","DOI":"10.1152\/ajpgi.00457.2013","article-title":"Rab11, but not Rab4, facilitates cyclic AMP- and tauroursodeoxycholate-induced MRP2 translocation to the plasma membrane","volume":"307","author":"Park","year":"2014","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2024.122839_bb0115","doi-asserted-by":"crossref","first-page":"G385","DOI":"10.1152\/ajpgi.00430.2010","article-title":"cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinase","volume":"301","author":"Johnston","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2024.122839_bb0120","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.4049\/jimmunol.177.4.2441","article-title":"Identification of PP1alpha as a caspase-9 regulator in IL-2 deprivation-induced apoptosis","volume":"177","author":"Dessauge","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2024.122839_bb0125","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0016-5085(99)70076-4","article-title":"Involvement of p38MAPK in the regulation of proteolysis by liver cell hydration","volume":"116","author":"Haussinger","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2024.122839_bb0130","doi-asserted-by":"crossref","first-page":"G44","DOI":"10.1152\/ajpgi.00530.2001","article-title":"Role of PP2B in cAMP-induced dephosphorylation and translocation of NTCP","volume":"283","author":"Webster","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2024.122839_bb0135","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S0168-8278(99)80348-1","article-title":"Different pathways of canalicular secretion of sulfated and non-sulfated fluorescent bile acids: a study in isolated hepatocyte couplets and TR- rats","volume":"31","author":"Mills","year":"1999","journal-title":"J. Hepatol."},{"issue":"Pt 8","key":"10.1016\/j.lfs.2024.122839_bb0140","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1242\/jcs.111.8.1137","article-title":"Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2\/cMoat) to the apical domain in hepatocyte couplets","volume":"111","author":"Roelofsen","year":"1998","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.lfs.2024.122839_bb0145","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/hep.510280418","article-title":"Vasopressin-induced disruption of actin cytoskeletal organization and canalicular function in isolated rat hepatocyte couplets: possible involvement of protein kinase C","volume":"28","author":"Roma","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2024.122839_bb0150","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1258\/002367706777611460","article-title":"The isolated perfused rat liver: standardization of a time-honoured model","volume":"40","author":"Bessems","year":"2006","journal-title":"Lab. Anim"},{"key":"10.1016\/j.lfs.2024.122839_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049255","article-title":"ERK1\/2 and p38 MAPKs are complementarily involved in estradiol-17\u03b2-d-glucuronide-induced cholestasis: crosstalk with cPKC and PI3K","volume":"7","author":"Boaglio","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.lfs.2024.122839_bb0160","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1152\/ajplegacy.1970.219.3.809","article-title":"Mechanism of phenobarbital-induced hypercholeresis in the rat","volume":"219","author":"Berthelot","year":"1970","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.lfs.2024.122839_bb0165","doi-asserted-by":"crossref","first-page":"G1261","DOI":"10.1152\/ajpgi.2001.280.6.G1261","article-title":"Expression of multidrug resistance-associated protein 2 in small intestine from pregnant and postpartum rats","volume":"280","author":"Mottino","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2024.122839_bb0170","doi-asserted-by":"crossref","first-page":"G327","DOI":"10.1152\/ajpgi.00227.2004","article-title":"Role of microtubules in estradiol-17\u03b2-d-glucuronide-induced alteration of canalicular Mrp2 localization and activity","volume":"288","author":"Mottino","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2024.122839_bb0175","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0014-4827(73)90357-1","article-title":"Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion","volume":"82","author":"Seglen","year":"1973","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.lfs.2024.122839_bb0180","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1053\/jhep.2003.50170","article-title":"Rat hepatocyte aquaporin-8 water channels are down-regulated in extrahepatic cholestasis","volume":"37","author":"Carreras","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2024.122839_bb0185","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2024.122839_bb0190","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/S0960-9822(95)00277-6","article-title":"Protein kinase C is regulated in vivo by three functionally distinct phosphorylations","volume":"5","author":"Keranen","year":"1995","journal-title":"Curr. Biol."},{"key":"10.1016\/j.lfs.2024.122839_bb0195","doi-asserted-by":"crossref","first-page":"6247","DOI":"10.1128\/MCB.22.17.6247-6260.2002","article-title":"Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B","volume":"22","author":"Scheid","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.lfs.2024.122839_bb0200","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1053\/j.gastro.2005.06.019","article-title":"Efficacy and safety of ursodeoxycholic acid versus cholestyramine in intrahepatic cholestasis of pregnancy","volume":"129","author":"Kondrackiene","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2024.122839_bb0205","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.clnu.2017.06.015","article-title":"Transhepatic bile acid kinetics in pigs and humans","volume":"37","author":"Eggink","year":"2018","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.lfs.2024.122839_bb0210","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1053\/jhep.2001.24034","article-title":"Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver","volume":"33","author":"Beuers","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2024.122839_bb0215","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bcp.2019.06.009","article-title":"Anticholestatic mechanisms of ursodeoxycholic acid in lipopolysaccharide-induced cholestasis","volume":"168","author":"Razori","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2024.122839_bb0220","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/hep.26333","article-title":"Taurolithocholate-induced MRP2 retrieval involves MARCKS phosphorylation by protein kinase C\u03f5 in HUH-NTCP cells","volume":"58","author":"Schonhoff","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2024.122839_bb0225","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00204-015-1507-8","article-title":"EGFR participates downstream of ER\u03b1 in estradiol-17\u03b2-d-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets","volume":"90","author":"Barosso","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.lfs.2024.122839_bb0230","doi-asserted-by":"crossref","first-page":"17810","DOI":"10.1074\/jbc.M209898200","article-title":"Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets","volume":"278","author":"Beuers","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2024.122839_bb0235","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1007\/s00204-019-02514-6","article-title":"Sphingosine 1-phosphate receptor 2\/adenylyl cyclase\/protein kinase a pathway is involved in taurolithocholate-induced internalization of Abcc2 in rats","volume":"93","author":"Andermatten","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.lfs.2024.122839_bb0240","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/S0016-5085(03)00274-9","article-title":"Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis","volume":"124","author":"Haussinger","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2024.122839_bb0245","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.2174\/0929867325666171205153204","article-title":"Dynamic localization of hepatocellular transporters: role in biliary excretion and impairment in cholestasis","volume":"26","author":"Roma","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.lfs.2024.122839_bb0250","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1136\/gut.2007.140871","article-title":"Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-\/PKA-dependent mechanism in rat liver","volume":"57","author":"Wimmer","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2024.122839_bb0255","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1091\/mbc.e11-01-0047","article-title":"Prevention of estradiol-17\u03b2-d-glucuronide-induced canalicular transporter internalization by hormonal modulation of cAMP in rat hepatocytes","volume":"22","author":"Zucchetti","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.lfs.2024.122839_bb0260","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13529","article-title":"Mechanism of inhibition of taurolithocholate-induced retrieval of plasma membrane MRP2 by cyclic AMP and tauroursodeoxycholate","volume":"5","author":"Park","year":"2017","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.lfs.2024.122839_bb0265","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/382083a0","article-title":"Regulation by cAMP-dependent protein kinease of a G-protein-mediated phospholipase C","volume":"382","author":"Liu","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2024.122839_bb0270","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1159\/000430262","article-title":"Tauroursodeoxycholate protects rat hepatocytes from bile acid-induced apoptosis via \u03b21-integrin- and protein kinase a-dependent mechanisms","volume":"36","author":"Sommerfeld","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.lfs.2024.122839_bb0275","doi-asserted-by":"crossref","first-page":"12864","DOI":"10.1074\/jbc.M001492200","article-title":"Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1","volume":"276","author":"Kim","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2024.122839_bb0280","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/j.1365-2362.1993.tb00733.x","article-title":"Ursodeoxycholic acid improves ethinyl estradiol-induced cholestasis in the rat","volume":"23","author":"Jacquemin","year":"1993","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.lfs.2024.122839_bb0285","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1124\/mol.113.091090","article-title":"Differential roles of ubiquitination in the degradation mechanism of cell surface-resident bile salt export pump and multidrug resistance-associated protein 2","volume":"85","author":"Aida","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.lfs.2024.122839_bb0290","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1872-034X.2007.00209.x","article-title":"The role of radixin in altered localization of canalicular conjugate export pump Mrp2 in cholestatic rat liver","volume":"38","author":"Kojima","year":"2008","journal-title":"Hepatol. Res."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524004296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524004296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T13:30:01Z","timestamp":1721914201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320524004296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":58,"alternative-id":["S0024320524004296"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2024.122839","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tauroursodeoxycholate prevents estradiol 17\u03b2-d-glucuronide-induced cholestasis and endocytosis of canalicular transporters by switching off pro-cholestatic signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2024.122839","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"122839"}}