{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:16:46Z","timestamp":1777627006794,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21907017"],"award-info":[{"award-number":["21907017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672276"],"award-info":[{"award-number":["81672276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872613"],"award-info":[{"award-number":["81872613"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902348"],"award-info":[{"award-number":["81902348"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program Key Projects","doi-asserted-by":"publisher","award":["201803010038"],"award-info":[{"award-number":["201803010038"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.lfs.2024.122849","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T19:10:39Z","timestamp":1718651439000},"page":"122849","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["RP11-874\u00a0J12.4 promotes erlotinib resistance in non-small cell lung cancer via increasing AXL expression"],"prefix":"10.1016","volume":"351","author":[{"given":"Shaobo","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoliang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoxia","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nengzhi","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2024.122849_bb0005","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.lfs.2024.122849_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-24223-1_1","article-title":"Lung cancer statistics","volume":"893","author":"Torre","year":"2016","journal-title":"Lung Cancer and Personalized Medicine: Current Knowledge and Therapies"},{"key":"10.1016\/j.lfs.2024.122849_bb0015","series-title":"SEER Cancer Statistics Review, 1975-2018","author":"Howlader","year":"2021"},{"issue":"8","key":"10.1016\/j.lfs.2024.122849_bb0020","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/s41591-021-01450-2","article-title":"Toward personalized treatment approaches for non-small-cell lung cancer","volume":"27","author":"Wang","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2024.122849_bb0025","series-title":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) for Non-Small Cell Lung Cancer","author":"Ettinger","year":"2022"},{"key":"10.1016\/j.lfs.2024.122849_bb0030","first-page":"1040","article-title":"Therapy for stage IV non-small-cell lung cancer with driver alterations: ASCO and OH (CCO) joint guideline update","volume":"39","author":"Hanna","year":"2021"},{"issue":"16","key":"10.1016\/j.lfs.2024.122849_bb0035","doi-asserted-by":"crossref","first-page":"1370\u2212+","DOI":"10.1200\/JCO.18.02236","article-title":"Resistance mutations and efficacy of lorlatinib in advanced anaplastic lymphoma kinase-positive non-small-cell lung cancer","volume":"37","author":"Shaw","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.lfs.2024.122849_bb0040","unstructured":"Doebele R, Paz-Ares L, Farago A. Entrectinib in NTRK fusion-positive non-small cell lung cancer (NSCLC): integrated analysis of patients enrolled in three trials (STARTRK-2, STARTRK-1 and ALKA-372-001) [abstract]."},{"issue":"9","key":"10.1016\/j.lfs.2024.122849_bb0045","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1056\/NEJMoa2005653","article-title":"Efficacy of selpercatinib in RET fusion\u2013positive non\u2013small-cell lung cancer","volume":"383","author":"Drilon","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.lfs.2024.122849_bb0050","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1056\/NEJMoa2004407","article-title":"Tepotinib in non-small-cell lung cancer with exon 14 skipping mutations","volume":"383","author":"Paik","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.lfs.2024.122849_bb0055","first-page":"377","article-title":"Overcoming therapy resistance in EGFR-mutant lung cancer","volume":"2","author":"Passaro","year":"2021","journal-title":"Nat. Can."},{"issue":"1","key":"10.1016\/j.lfs.2024.122849_bb0060","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12943-019-1090-3","article-title":"AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications","volume":"18","author":"Zhu","year":"2019","journal-title":"Mol. Cancer"},{"issue":"12","key":"10.1016\/j.lfs.2024.122849_bb0065","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nrc3847","article-title":"The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer","volume":"14","author":"Graham","year":"2014","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.lfs.2024.122849_bb0070","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbcan.2018.10.003","article-title":"EMT: a mechanism for escape from EGFR-targeted therapy in lung cancer","volume":"1871","author":"Tulchinsky","year":"2019","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"1","key":"10.1016\/j.lfs.2024.122849_bb0075","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1158\/1078-0432.CCR-12-1558","article-title":"An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance","volume":"19","author":"Byers","year":"2013","journal-title":"Clin. Cancer Res."},{"issue":"11","key":"10.1016\/j.lfs.2024.122849_bb0080","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1158\/2159-8290.CD-22-0111","article-title":"AXL and error-prone DNA replication confer drug resistance and offer strategies to treat EGFR-mutant lung cancer","volume":"12","author":"Noronha","year":"2022","journal-title":"Cancer Discov."},{"issue":"7291","key":"10.1016\/j.lfs.2024.122849_bb0085","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08975","article-title":"Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis","volume":"464","author":"Gupta","year":"2010","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.lfs.2024.122849_bb0090","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1038\/s41588-018-0252-3","article-title":"Long noncoding RNA MALAT1 suppresses breast cancer metastasis","volume":"50","author":"Kim","year":"2018","journal-title":"Nat. Genet."},{"issue":"13","key":"10.1016\/j.lfs.2024.122849_bb0095","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.7150\/thno.26024","article-title":"Angio-LncRs: LncRNAs that regulate angiogenesis and vascular disease","volume":"8","author":"Yu","year":"2018","journal-title":"Theranostics"},{"issue":"25","key":"10.1016\/j.lfs.2024.122849_bb0100","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1038\/onc.2011.13","article-title":"Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a\/b in solid cancer","volume":"30","author":"Mudduluru","year":"2011","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.lfs.2024.122849_bb0105","doi-asserted-by":"crossref","first-page":"852\u2212+","DOI":"10.1038\/ng.2330","article-title":"Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer","volume":"44","author":"Zhang","year":"2012","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.lfs.2024.122849_bb0110","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1186\/s13046-021-02137-9","article-title":"M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way","volume":"40","author":"Li","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"W1","key":"10.1016\/j.lfs.2024.122849_bb0115","doi-asserted-by":"crossref","first-page":"W98","DOI":"10.1093\/nar\/gkx247","article-title":"GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses","volume":"45","author":"Tang","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"25","key":"10.1016\/j.lfs.2024.122849_bb0120","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1038\/onc.2011.13","article-title":"Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a\/b in solid cancer","volume":"30","author":"Mudduluru","year":"2011","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.lfs.2024.122849_bb0125","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S1470-2045(11)70184-X","article-title":"Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study","volume":"12","author":"Zhou","year":"2011","journal-title":"Lancet Oncol."},{"issue":"5","key":"10.1016\/j.lfs.2024.122849_bb0130","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.3892\/ol.2015.3654","article-title":"MicroRNA-34a-5p enhances sensitivity to chemotherapy by targeting AXL in hepatocellular carcinoma MHCC-97L cells","volume":"10","author":"Li","year":"2015","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.lfs.2024.122849_bb0135","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.canlet.2020.11.048","article-title":"LncRNAs in cancer: regulatory and therapeutic implications","volume":"501","author":"Nandwani","year":"2021","journal-title":"Cancer Lett."},{"issue":"7","key":"10.1016\/j.lfs.2024.122849_bb0140","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41568-021-00353-1","article-title":"Long noncoding RNAs in cancer metastasis","volume":"21","author":"Liu","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.lfs.2024.122849_bb0145","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","article-title":"Gene regulation by long non-coding RNAs and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.lfs.2024.122849_bb0150","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3727\/096504016X14648701447814","article-title":"Anexelekto (AXL) increases resistance to EGFR-TKI and activation of AKT and ERK1\/2 in non-small cell lung Cancer cells","volume":"24","author":"Tian","year":"2016","journal-title":"Oncol. Res."},{"issue":"2","key":"10.1016\/j.lfs.2024.122849_bb0155","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","article-title":"Gene regulation by long non-coding RNAs and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.lfs.2024.122849_bb0160","doi-asserted-by":"crossref","first-page":"951864","DOI":"10.3389\/fonc.2022.951864","article-title":"Non-coding RNA in cancer drug resistance: underlying mechanisms and clinical applications","volume":"12","author":"Zhou","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.lfs.2024.122849_bb0165","doi-asserted-by":"crossref","first-page":"114228","DOI":"10.1016\/j.bcp.2020.114228","article-title":"LncRNA regulation: new frontiers in epigenetic solutions to drug chemoresistance","volume":"189","author":"Zhou","year":"2021","journal-title":"Biochem. Pharmacol."},{"issue":"3\u20134","key":"10.1016\/j.lfs.2024.122849_bb0170","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41417-020-00214-3","article-title":"Mechanisms of drug resistance mediated by long non-coding RNAs in non-small-cell lung cancer","volume":"28","author":"La Montagna","year":"2021","journal-title":"Cancer Gene Ther."},{"issue":"5","key":"10.1016\/j.lfs.2024.122849_bb0175","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.181","article-title":"LncRNA HOTAIR regulates HIF-1\u03b1\/AXL signaling through inhibition of miR-217 in renal cell carcinoma","volume":"8","author":"Hong","year":"2017","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.lfs.2024.122849_bb0180","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s13075-022-02965-w","article-title":"Axl regulated survival\/proliferation network and its therapeutic intervention in mouse models of glomerulonephritis","volume":"24","author":"Zhen","year":"2022","journal-title":"Arthritis Res. Ther."},{"issue":"10","key":"10.1016\/j.lfs.2024.122849_bb0185","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1007\/s11427-013-4553-6","article-title":"Function of lncRNAs and approaches to lncRNA-protein interactions","volume":"56","author":"Zhu","year":"2013","journal-title":"Sci. China Life Sci."},{"issue":"6","key":"10.1016\/j.lfs.2024.122849_bb0190","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.lfs.2024.122849_bb0195","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s41420-022-01061-x","article-title":"The role of lncRNA-mediated ceRNA regulatory networks in pancreatic cancer","volume":"8","author":"Xu","year":"2022","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.lfs.2024.122849_bb0200","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s13046-023-02875-y","article-title":"Lnc AC016727.1\/BACH1\/HIF-1 \u03b1 signal loop promotes the progression of non-small cell lung cancer","volume":"42","author":"Zhang","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.lfs.2024.122849_bb0205","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13046-023-02726-w","article-title":"AXL in cancer: a modulator of drug resistance and therapeutic target","volume":"42","author":"Tang","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524004399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524004399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:47:20Z","timestamp":1777423640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320524004399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":41,"alternative-id":["S0024320524004399"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2024.122849","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RP11-874\u00a0J12.4 promotes erlotinib resistance in non-small cell lung cancer via increasing AXL expression","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2024.122849","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122849"}}