{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:51:28Z","timestamp":1788457888552,"version":"build-2803163510"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.lfs.2024.122909","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T09:26:38Z","timestamp":1720689998000},"page":"122909","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Beyond the lungs: Exploring diverse applications of bromhexine and ambroxol"],"prefix":"10.1016","volume":"353","author":[{"given":"Elham","family":"Ahmadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arya","family":"Afrooghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra Ebrahim","family":"Soltani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Elahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Shayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Amin Dabbagh","family":"Ohadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad-Reza","family":"Dehpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2024.122909_bb0005","series-title":"Textbook of Rabbit Medicine","first-page":"137","article-title":"Chapter 3 - therapeutics","author":"Varga","year":"2014"},{"issue":"1","key":"10.1016\/j.lfs.2024.122909_bb0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40248-017-0088-1","article-title":"A reappraisal of the mucoactive activity and clinical efficacy of bromhexine","volume":"12","author":"Zanasi","year":"2017","journal-title":"Multidiscip. Respir. Med."},{"issue":"5","key":"10.1016\/j.lfs.2024.122909_bb0015","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.pharma.2021.12.004","article-title":"Facile approaches for determination of Bromhexine hydrochloride and its active metabolite Ambroxol hydrochloride using eosin Y","volume":"80","author":"El-Sayed","year":"2022","journal-title":"Ann. Pharm. Fr."},{"key":"10.1016\/j.lfs.2024.122909_bb0020","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4693121","article-title":"Bromhexine hydrochloride prophylaxis of COVID-19 for medical personnel: a randomized open-label study","volume":"2022","author":"Mikhaylov","year":"2022","journal-title":"Interdiscip Perspect Infect Dis."},{"issue":"3","key":"10.1016\/j.lfs.2024.122909_bb0025","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00210-019-01737-9","article-title":"Neurorestorative effects of sub-chronic administration of ambroxol in rodent model of Parkinson\u2019s disease","volume":"393","author":"Mishra","year":"2020","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"9","key":"10.1016\/j.lfs.2024.122909_bb0030","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200749R","article-title":"Ambroxol, a mucolytic agent, boosts HO-1, suppresses NF-\u03baB, and decreases the susceptibility of the inflamed rat colon to apoptosis: a new treatment option for treating ulcerative colitis","volume":"36","author":"Cavalu","year":"2022","journal-title":"FASEB J."},{"issue":"14","key":"10.1016\/j.lfs.2024.122909_bb0035","first-page":"1141","article-title":"The antioxidative activity of the mucoregulatory agents: ambroxol, bromhexine and N-acetyl-L-cysteine","volume":"59","author":"Felix","year":"1996","journal-title":"A pulse radiolysis study. Life Sci."},{"issue":"6","key":"10.1016\/j.lfs.2024.122909_bb0040","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1159\/000518261","article-title":"Chronic respiratory diseases and neurodegenerative disorders: a primer for the practicing clinician","volume":"30","author":"Falsetti","year":"2021","journal-title":"Med. Princ. Pract."},{"issue":"5717","key":"10.1016\/j.lfs.2024.122909_bb0045","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1136\/bmj.3.5717.260","article-title":"Expectorant action of bromhexine in chronic obstructive bronchitis","volume":"3","author":"Hamilton","year":"1970","journal-title":"Br. Med. J."},{"issue":"5727","key":"10.1016\/j.lfs.2024.122909_bb0050","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/bmj.4.5727.117-a","article-title":"Bromhexine in chronic bronchitis","volume":"4","author":"Christensen","year":"1970","journal-title":"Br. Med. J."},{"key":"10.1016\/j.lfs.2024.122909_bb0055","first-page":"75","article-title":"Sputum fibre systems in exacerbations of longstanding pulmonary disease. A comparison of antibiotics and bromhexine (Bisolvan)","volume":"10","author":"Flavell Matts","year":"1973","journal-title":"Clin. Trials J."},{"key":"10.1016\/j.lfs.2024.122909_bb0060","first-page":"81","article-title":"Changes in the fibre system and viscosity of the sputum of bronchitis during treatment with bromhexine and guaiphenesin (Guaiacol glyceryl ether)","volume":"90","author":"B\u00fcrgi","year":"1974","journal-title":"Scand. J. Respir. Dis. Suppl."},{"issue":"1","key":"10.1016\/j.lfs.2024.122909_bb0065","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0007-0971(74)90004-7","article-title":"Bromhexine and mucociliary clearance in chronic bronchitis","volume":"68","author":"Thomson","year":"1974","journal-title":"Br. J. Dis. Chest"},{"issue":"3\u20134","key":"10.1016\/j.lfs.2024.122909_bb0070","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000195910","article-title":"Role of bromhexine in exacerbations of bronchiectasis. Double-blind randomized multicenter study versus placebo","volume":"58","author":"Olivieri","year":"1991","journal-title":"Respiration"},{"issue":"7630","key":"10.1016\/j.lfs.2024.122909_bb0075","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0140-6736(69)90702-8","article-title":"Effect of bromhexine on ventilatory capacity in patients with a variety of chest diseases","volume":"2","author":"Gent","year":"1969","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2024.122909_bb0080","first-page":"2127","article-title":"Results of administration of bisolvan fine granules for respiratory diseases in children","volume":"30","author":"Okamoto","year":"1981","journal-title":"New Drugs Clin Med."},{"issue":"3","key":"10.1016\/j.lfs.2024.122909_bb0085","first-page":"267","article-title":"Clinical effectiveness of a combination of bromhexine and amoxicillin in lower respiratory tract infection. A randomized controlled trial","volume":"45","author":"Roa","year":"1995","journal-title":"Arzneimittelforschung"},{"issue":"8","key":"10.1016\/j.lfs.2024.122909_bb0090","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/0002-9378(74)90271-3","article-title":"Fetal pulmonary surfactant induction by bromhexine metabolite 8","volume":"119","author":"Lorenz","year":"1974","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.lfs.2024.122909_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02091445","article-title":"Elektronenmikroskopische Befunde an der menschlichen Bronchialschleimhaut nach Behandlung mit Bisolvon","volume":"137","author":"Gieseking","year":"1968","journal-title":"Beitr. Klin. Erforsch. Tuberk. Lungenkr."},{"issue":"6","key":"10.1016\/j.lfs.2024.122909_bb0100","first-page":"705","article-title":"Experimental study of the possible influence of a fluidifying agent (bromhexine) on the penetration of erythromycine into bronchial secretions (author\u2019s transl)","volume":"34","author":"Bergogne-Berezin","year":"1979","journal-title":"Therapie"},{"issue":"4","key":"10.1016\/j.lfs.2024.122909_bb0105","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0891-5849(94)90130-9","article-title":"Antioxidant properties of Ambroxol","volume":"16","author":"Nowak","year":"1994","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2024.122909_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.imu.2021.100597","article-title":"Structural insights and inhibition mechanism of TMPRSS2 by experimentally known inhibitors Camostat mesylate, Nafamostat and Bromhexine hydrochloride to control SARS-coronavirus-2: a molecular modeling approach","volume":"24","author":"Sonawane","year":"2021","journal-title":"Informatics in Medicine Unlocked."},{"issue":"4","key":"10.1016\/j.lfs.2024.122909_bb0115","doi-asserted-by":"crossref","first-page":"209","DOI":"10.34172\/bi.2020.27","article-title":"Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: a randomized clinical trial","volume":"10","author":"Ansarin","year":"2020","journal-title":"Bioimpacts"},{"key":"10.1016\/j.lfs.2024.122909_bb0120","doi-asserted-by":"crossref","first-page":"1072629","DOI":"10.3389\/fcell.2023.1072629","article-title":"Neuropathic pain: mechanisms and therapeutic strategies","volume":"11","author":"Petroianu","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"7","key":"10.1016\/j.lfs.2024.122909_bb0125","doi-asserted-by":"crossref","first-page":"548","DOI":"10.2174\/1389200221666200711155632","article-title":"Comparison of Bromhexine and its active metabolite - Ambroxol as potential analgesics reducing Oxaliplatin-induced neuropathic pain - Pharmacodynamic and molecular docking studies","volume":"21","author":"Furga\u0142a-Wojas","year":"2020","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.lfs.2024.122909_bb0130","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.biopha.2018.07.039","article-title":"Time-shifted co-administration of sub-analgesic doses of ambroxol and pregabalin attenuates oxaliplatin-induced cold allodynia in mice","volume":"106","author":"Furga\u0142a","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2024.122909_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104949","article-title":"Role of 5-HT receptors in neuropathic pain: potential therapeutic implications","volume":"159","author":"Liu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2024.122909_bb0140","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.lfs.2018.02.002","article-title":"In vitro pharmacology of ambroxol: potential serotonergic sites of action","volume":"197","author":"Hull","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2024.122909_bb0145","author":"Hui","year":"2024"},{"issue":"2","key":"10.1016\/j.lfs.2024.122909_bb0150","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcad099","article-title":"Repurposing the mucolytic agent ambroxol for treatment of sub-acute and chronic ischaemic stroke","volume":"5","author":"Patzwaldt","year":"2023","journal-title":"Brain Commun."},{"issue":"5","key":"10.1016\/j.lfs.2024.122909_bb0155","doi-asserted-by":"crossref","first-page":"698","DOI":"10.2174\/1871527311312050015","article-title":"Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities","volume":"12","author":"Rodrigo","year":"2013","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.lfs.2024.122909_bb0160","series-title":"Intracranial Hemorrhage. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: William Thorell declares no relevant financial relationships with ineligible companies","author":"Tenny","year":"2024"},{"key":"10.1016\/j.lfs.2024.122909_bb0165","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7941716","article-title":"Ambroxol improves neuronal survival and reduces white matter damage through suppressing endoplasmic reticulum stress in microglia after intracerebral hemorrhage","volume":"2020","author":"Jiang","year":"2020","journal-title":"Biomed. Res. Int."},{"issue":"3","key":"10.1016\/j.lfs.2024.122909_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031851","article-title":"A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of Nanotherapeutics","volume":"23","author":"Lamptey","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2024.122909_bb0175","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/jnr.22754","article-title":"Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion","volume":"90","author":"R\u00f6hnert","year":"2012","journal-title":"J. Neurosci. Res."},{"issue":"8","key":"10.1016\/j.lfs.2024.122909_bb0180","first-page":"504","article-title":"Parkinson\u2019s disease and its management: part 1: disease entity, risk factors, pathophysiology, clinical presentation, and diagnosis","volume":"40","author":"DeMaagd","year":"2015","journal-title":"P t."},{"issue":"4","key":"10.1016\/j.lfs.2024.122909_bb0185","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/jamaneurol.2019.4611","article-title":"Ambroxol for the treatment of patients with Parkinson disease with and without Glucocerebrosidase gene mutations: a nonrandomized, noncontrolled trial","volume":"77","author":"Mullin","year":"2020","journal-title":"JAMA Neurology"},{"issue":"1","key":"10.1016\/j.lfs.2024.122909_bb0190","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/s41598-018-19479-8","article-title":"Effects of ambroxol on the autophagy-lysosome pathway and mitochondria in primary cortical neurons","volume":"8","author":"Magalhaes","year":"2018","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.lfs.2024.122909_bb0195","doi-asserted-by":"crossref","DOI":"10.1212\/NXG.0000000000000600","article-title":"Occurrence of amyotrophic lateral sclerosis in type 1 Gaucher disease","volume":"7","author":"Oliveira","year":"2021","journal-title":"Neurol Genet."},{"key":"10.1016\/j.lfs.2024.122909_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173446","article-title":"Drug repositioning in neurodegeneration: an overview of the use of ambroxol in neurodegenerative diseases","volume":"884","author":"Bouscary","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.lfs.2024.122909_bb0205","doi-asserted-by":"crossref","DOI":"10.1002\/syn.21967","article-title":"Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate","volume":"71","author":"Migdalska-Richards","year":"2017","journal-title":"Synapse"},{"issue":"2","key":"10.1016\/j.lfs.2024.122909_bb0210","doi-asserted-by":"crossref","DOI":"10.1136\/bmjno-2023-000535","article-title":"Ambroxol as a disease-modifying treatment to reduce the risk of cognitive impairment in GBA-associated Parkinson\u2019s disease: a multicentre, randomised, double-blind, placebo-controlled, phase II trial. The AMBITIOUS study protocol","volume":"5","author":"Colucci","year":"2023","journal-title":"BMJ Neurol Open"},{"issue":"6","key":"10.1016\/j.lfs.2024.122909_bb0215","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.19364","article-title":"Use of Ambroxol as therapy for Gaucher disease","volume":"6","author":"Zhan","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.lfs.2024.122909_bb0220","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3389\/fgene.2018.00597","article-title":"Infantile Neuroaxonal dystrophy: diagnosis and possible treatments","volume":"9","author":"Babin","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.lfs.2024.122909_bb0225","first-page":"12","article-title":"Exploring therapeutic strategies for infantile neuronal axonal dystrophy (INAD\/PARK14)","author":"Lin","year":"2023","journal-title":"Elife"},{"issue":"9","key":"10.1016\/j.lfs.2024.122909_bb0230","first-page":"778","article-title":"Cardiomyopathy: an overview","volume":"79","author":"Wexler","year":"2009","journal-title":"Am. Fam. Physician"},{"issue":"4","key":"10.1016\/j.lfs.2024.122909_bb0235","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s12012-022-09721-1","article-title":"Doxorubicin-induced cardiotoxicity: an overview on pre-clinical therapeutic approaches","volume":"22","author":"Sheibani","year":"2022","journal-title":"Cardiovasc. Toxicol."},{"issue":"5","key":"10.1016\/j.lfs.2024.122909_bb0240","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/0891-5849(95)00028-V","article-title":"Ambroxol inhibits doxorubicin-induced lipid peroxidation in heart of mice","volume":"19","author":"Nowak","year":"1995","journal-title":"Free Radic. Biol. Med."},{"issue":"10080","key":"10.1016\/j.lfs.2024.122909_bb0245","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.lfs.2024.122909_bb0250","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000138217","article-title":"Cytoprotective role of gastric surfactant in the ethanol-produced gastric mucosal injury of the rat","volume":"33","author":"Szelenyi","year":"1986","journal-title":"Pharmacology"},{"issue":"4","key":"10.1016\/j.lfs.2024.122909_bb0255","doi-asserted-by":"crossref","first-page":"221","DOI":"10.7555\/JBR.32.20180087","article-title":"Hepatic ischemia-reperfusion injury in liver transplant setting: mechanisms and protective strategies","volume":"33","author":"Rampes","year":"2019","journal-title":"J. Biomed. Res."},{"issue":"5","key":"10.1016\/j.lfs.2024.122909_bb0260","first-page":"381","article-title":"Could Ambroxol reduce cytokines in hepatic ischemia-reperfusion injury in rats?","volume":"123","author":"Gultekin","year":"2022","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.lfs.2024.122909_bb0265","article-title":"Immune-mediated hepatitis induced by immune checkpoint inhibitors: current updates and future perspectives","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2024.122909_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110890","article-title":"A synergistic effect of Ambroxol and Beta-glucosylceramide in alleviating immune-mediated hepatitis: a novel immunomodulatory non-immunosuppressive formulation for treatment of immune-mediated disorders","volume":"132","author":"Khoury","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.lfs.2024.122909_bb0275","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s40472-018-0183-z","article-title":"Hypothermic machine preservation of the liver: state of the art","volume":"5","author":"Schlegel","year":"2018","journal-title":"Curr. Transplant. Rep."},{"issue":"4","key":"10.1016\/j.lfs.2024.122909_bb0280","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/089419300416483","article-title":"Protective effects of ambroxol in hypothermic liver preservation: a transplant study","volume":"13","author":"Drews","year":"2000","journal-title":"J. Invest. Surg."},{"key":"10.1016\/j.lfs.2024.122909_bb0285","series-title":"LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD)","author":"Cisplatin.","year":"2012"},{"issue":"1","key":"10.1016\/j.lfs.2024.122909_bb0290","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1139\/cjpp-2018-0528","article-title":"Ambroxol attenuates cisplatin-induced hepatotoxicity and nephrotoxicity via inhibition of p-JNK\/p-ERK","volume":"97","author":"Bishr","year":"2019","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"4","key":"10.1016\/j.lfs.2024.122909_bb0295","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4062\/biomolther.2020.204","article-title":"Diabetic nephropathy - a review of risk factors, progression, mechanism, and dietary management","volume":"29","author":"Natesan","year":"2021","journal-title":"Biomol Ther (Seoul)."},{"issue":"4","key":"10.1016\/j.lfs.2024.122909_bb0300","first-page":"462","article-title":"The effect of bromhexine on experimentally induced diabetic nephropathy","volume":"64","author":"Luscombe","year":"1983","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.lfs.2024.122909_bb0305","doi-asserted-by":"crossref","first-page":"1185317","DOI":"10.3389\/fimmu.2023.1185317","article-title":"Oxidative stress and inflammation in diabetic nephropathy: role of polyphenols","volume":"14","author":"Jin","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.lfs.2024.122909_bb0310","first-page":"20","article-title":"Renal ischemia\/reperfusion injury; from pathophysiology to treatment","volume":"4","author":"Malek","year":"2015","journal-title":"J. Renal Inj. Prev."},{"issue":"8","key":"10.1016\/j.lfs.2024.122909_bb0315","first-page":"1037","article-title":"Does Ambroxol alleviate kidney ischemia-reperfusion injury in rats?","volume":"25","author":"G\u00fcltekin","year":"2022","journal-title":"Iran. J. Basic Med. Sci."},{"issue":"11","key":"10.1016\/j.lfs.2024.122909_bb0320","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.3390\/toxins2112490","article-title":"Mechanisms of Cisplatin nephrotoxicity","volume":"2","author":"Miller","year":"2010","journal-title":"Toxins (Basel)."},{"issue":"1","key":"10.1016\/j.lfs.2024.122909_bb0325","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/0886022X.2019.1702057","article-title":"Renal microvascular lesions in lupus nephritis","volume":"42","author":"Ding","year":"2020","journal-title":"Ren. Fail."},{"key":"10.1016\/j.lfs.2024.122909_bb0330","first-page":"286","article-title":"The effect of bromhexine on the kidney lesions in NZB-NZW-F1 mice","volume":"61","author":"Prause","year":"1986","journal-title":"Scand. J. Rheumatol. Suppl."},{"key":"10.1016\/j.lfs.2024.122909_bb0335","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2147\/JIR.S399284","article-title":"Oxidative stress contributes to inflammatory and cellular damage in systemic lupus erythematosus: cellular markers and molecular mechanism","volume":"16","author":"Yan","year":"2023","journal-title":"J. Inflamm. Res."},{"issue":"3","key":"10.1016\/j.lfs.2024.122909_bb0340","first-page":"199","article-title":"Mechanisms of hemorrhagic cystitis","volume":"2","author":"Haldar","year":"2014","journal-title":"Am J Clin Exp Urol."},{"key":"10.1016\/j.lfs.2024.122909_bb0345","first-page":"291","article-title":"Hemorrhagic cystitis: making rapid and shrewd clinical and surgical decisions for improving patient outcomes","volume":"15","author":"Jefferson","year":"2023","journal-title":"Res Rep Urol."},{"issue":"5","key":"10.1016\/j.lfs.2024.122909_bb0350","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s11255-019-02128-y","article-title":"Uroprotective effect of ambroxol in cyclophosphamide-induced cystitis in mice","volume":"51","author":"Barut","year":"2019","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.lfs.2024.122909_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109919","article-title":"Therapeutic potential of bromhexine for acute itch in mice: involvement of TMPRSS2 and kynurenine pathway","volume":"117","author":"Afrooghe","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.lfs.2024.122909_bb0360","doi-asserted-by":"crossref","first-page":"170","DOI":"10.7861\/clinmed.2021-0257","article-title":"Psoriasis: a brief overview","volume":"21","author":"Raharja","year":"2021","journal-title":"Clin. Med. (Lond.)"},{"key":"10.1016\/j.lfs.2024.122909_bb0365","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.intimp.2019.03.035","article-title":"Protective effects of ambroxol in psoriasis like skin inflammation: exploration of possible mechanisms","volume":"71","author":"Sunkari","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2024.122909_bb0370","author":"Golden","year":"2024"},{"issue":"1","key":"10.1016\/j.lfs.2024.122909_bb0375","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0002-9394(14)75902-1","article-title":"Influence of bromhexine on tear lysozome level in keratoconjunctivitis sicca","volume":"92","author":"Scharf","year":"1981","journal-title":"Am. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.lfs.2024.122909_bb0380","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1254\/jjp.39.241","article-title":"Effects of bromhexine on the secretions of saliva and tears","volume":"39","author":"Misawa","year":"1985","journal-title":"Jpn. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.lfs.2024.122909_bb0385","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s00417-020-05043-6","article-title":"Topical administration of ambroxol eye drops augments tear secretion in rabbits","volume":"259","author":"Yu","year":"2021","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"5","key":"10.1016\/j.lfs.2024.122909_bb0390","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF02153656","article-title":"Effect of bromhexine, ambroxol, and placebo on clinical and histopathological changes in \u201cSj\u00f6gren\u201d mice","volume":"223","author":"Prause","year":"1985","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"1","key":"10.1016\/j.lfs.2024.122909_bb0395","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/1873-3468.13560","article-title":"Bromhexine elevates REP2 expression to stimulate secretion from human primary conjunctiva fornix epithelial cells","volume":"594","author":"Wang","year":"2020","journal-title":"FEBS Lett."},{"issue":"9","key":"10.1016\/j.lfs.2024.122909_bb0400","doi-asserted-by":"crossref","first-page":"858","DOI":"10.2174\/1389200218666170719095344","article-title":"Role of nutrients and phyto-compounds in the modulation of antimicrobial resistance","volume":"18","author":"Harakeh","year":"2017","journal-title":"Curr. Drug Metab."},{"issue":"2","key":"10.1016\/j.lfs.2024.122909_bb0405","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms8020154","article-title":"Candida albicans antifungal resistance and tolerance in bloodstream infections: the triad yeast-host-antifungal","volume":"8","author":"Costa-de-Oliveira","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.lfs.2024.122909_bb0410","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fcimb.2017.00124","article-title":"Ambroxol hydrochloride combined with fluconazole reverses the resistance of Candida albicans to fluconazole","volume":"7","author":"Li","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"41","key":"10.1016\/j.lfs.2024.122909_bb0415","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.3748\/wjg.v17.i41.4545","article-title":"Pathophysiology and prevention of postoperative peritoneal adhesions","volume":"17","author":"Arung","year":"2011","journal-title":"World J. Gastroenterol."},{"issue":"4","key":"10.1016\/j.lfs.2024.122909_bb0420","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1080\/00015458.2017.1287395","article-title":"The preventive effect of ambroxol hydrochloride chitosan on postoperative intraperitoneal adhesion formation in a rat model","volume":"117","author":"Zhao","year":"2017","journal-title":"Acta Chir. Belg."},{"key":"10.1016\/j.lfs.2024.122909_bb0425","author":"Lanzotti","year":"2024"},{"issue":"5","key":"10.1016\/j.lfs.2024.122909_bb0430","first-page":"399","article-title":"The influence of ambroxol and capsaicin on the isolated rabbit bladder wall","volume":"62","author":"Drewa","year":"2005","journal-title":"Acta Pol. Pharm."},{"issue":"1","key":"10.1016\/j.lfs.2024.122909_bb0435","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41416-020-01126-7","article-title":"Insights into the role of sialylation in cancer progression and metastasis","volume":"124","author":"Dobie","year":"2021","journal-title":"Br. J. Cancer"},{"issue":"13","key":"10.1016\/j.lfs.2024.122909_bb0440","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1158\/0008-5472.CAN-22-3260","article-title":"Attenuation of sialylation augments antitumor immunity and improves response to immunotherapy in ovarian Cancer","volume":"83","author":"Cao","year":"2023","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.lfs.2024.122909_bb0445","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph20042994","article-title":"Preeclampsia: recent advances in predicting, preventing, and managing the maternal and fetal life-threatening condition","volume":"20","author":"Chang","year":"2023","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"4","key":"10.1016\/j.lfs.2024.122909_bb0450","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26040777","article-title":"A multi-objective approach for drug repurposing in preeclampsia","volume":"26","author":"Tejera","year":"2021","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.lfs.2024.122909_bb0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2018.12.005","article-title":"Oxidative stress: Normal pregnancy versus preeclampsia","volume":"1866","author":"Chiarello","year":"2020","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"5","key":"10.1016\/j.lfs.2024.122909_bb0460","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051775","article-title":"The role of NF\u03baB in healthy and Preeclamptic placenta: trophoblasts in the spotlight","volume":"21","author":"Armistead","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.lfs.2024.122909_bb0465","first-page":"971","article-title":"Clinical trial of bromhexine in Sj\u00f6gren\u2019s syndrome","volume":"13","author":"Avisar","year":"1981","journal-title":"Ann. Ophthalmol."},{"issue":"2","key":"10.1016\/j.lfs.2024.122909_bb0470","first-page":"124","article-title":"Primary sclerosing cholangitis and inflammatory bowel disease comorbidity: an update of the evidence","volume":"32","author":"Mertz","year":"2019","journal-title":"Ann. Gastroenterol."},{"issue":"6","key":"10.1016\/j.lfs.2024.122909_bb0475","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1007\/s10620-023-07862-z","article-title":"Cholestatic pruritus treatments in primary biliary cholangitis and primary Sclerosing cholangitis: a systematic literature review","volume":"68","author":"Smith","year":"2023","journal-title":"Dig. Dis. Sci."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524004995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524004995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T09:38:55Z","timestamp":1723541935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320524004995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":95,"alternative-id":["S0024320524004995"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2024.122909","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beyond the lungs: Exploring diverse applications of bromhexine and ambroxol","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2024.122909","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122909"}}