{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:35:09Z","timestamp":1793039709087,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.lfs.2024.122913","type":"journal-article","created":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T08:00:34Z","timestamp":1720944034000},"page":"122913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Deletion of vitamin D receptor exacerbated temporomandibular joint pathological changes under abnormal mechanical stimulation"],"prefix":"10.1016","volume":"353","author":[{"given":"Tianyi","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2046-8992","authenticated-orcid":false,"given":"Tong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2342-8096","authenticated-orcid":false,"given":"Baochao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7463-3762","authenticated-orcid":false,"given":"Yunzi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3910-3982","authenticated-orcid":false,"given":"Huang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2024.122913_bb0005","first-page":"29","article-title":"Gender difference in symptoms related to temporomandibular disorders in a population of 50-year-old subjects","volume":"17","author":"Johansson","year":"2003","journal-title":"J. Orofac. Pain"},{"issue":"8","key":"10.1016\/j.lfs.2024.122913_bb0010","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/joor.13472","article-title":"Impact of temporomandibular disorders on oral health-related quality of life: a systematic review and meta-analysis","volume":"50","author":"Qamar","year":"2023","journal-title":"J. Oral Rehabil."},{"issue":"2","key":"10.1016\/j.lfs.2024.122913_bb0015","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/ejo\/cjy034","article-title":"The impact of temporomandibular joint arthritis on functional disability and global health in patients with juvenile idiopathic arthritis","volume":"41","author":"Isola","year":"2019","journal-title":"Eur. J. Orthod."},{"issue":"2","key":"10.1016\/j.lfs.2024.122913_bb0020","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3892\/ijmm.2012.986","article-title":"Expression of muscle-specific integrins in masseter muscle fibers during malocclusion disease","volume":"30","author":"Cutroneo","year":"2012","journal-title":"Int. J. Mol. Med."},{"issue":"5","key":"10.1016\/j.lfs.2024.122913_bb0025","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1177\/0022034515574770","article-title":"Current understanding of pathogenesis and treatment of TMJ osteoarthritis","volume":"94","author":"Wang","year":"2015","journal-title":"J. Dent. Res."},{"issue":"4","key":"10.1016\/j.lfs.2024.122913_bb0030","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/odi.13623","article-title":"Overexpression of MMPs, cytokines, and RANKL\/OPG in temporomandibular joint osteoarthritis and their association with joint pain, mouth opening, and bone degeneration: a preliminary report","volume":"27","author":"Cafferata","year":"2021","journal-title":"Oral Dis."},{"issue":"10","key":"10.1016\/j.lfs.2024.122913_bb0035","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.archoralbio.2008.04.004","article-title":"Expression of proinflammatory cytokines in osteoarthritis of the temporomandibular joint","volume":"53","author":"Vernal","year":"2008","journal-title":"Arch. Oral Biol."},{"issue":"4","key":"10.1016\/j.lfs.2024.122913_bb0040","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.pain.2010.11.007","article-title":"Influence of headache frequency on clinical signs and symptoms of TMD in subjects with temple headache and TMD pain","volume":"152","author":"Anderson","year":"2011","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.lfs.2024.122913_bb0045","doi-asserted-by":"crossref","first-page":"6","DOI":"10.11607\/jop.1151","article-title":"Diagnostic criteria for temporomandibular disorders (DC\/TMD) for clinical and research applications: recommendations of the international RDC\/TMD consortium network* and orofacial pain special interest Groupdagger","volume":"28","author":"Schiffman","year":"2014","journal-title":"J. Oral Facial Pain Headache"},{"issue":"3","key":"10.1016\/j.lfs.2024.122913_bb0050","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1097\/SCS.0000000000009103","article-title":"Temporomandibular joint disk displacement: etiology, diagnosis, imaging, and therapeutic approaches","volume":"34","author":"Minervini","year":"2023","journal-title":"J. Craniofac. Surg."},{"key":"10.1016\/j.lfs.2024.122913_bb0055","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.coph.2015.04.001","article-title":"Physiological functions of vitamin D: what we have learned from global and conditional VDR knockout mouse studies","volume":"22","author":"Suda","year":"2015","journal-title":"Curr. Opin. Pharmacol."},{"issue":"5","key":"10.1016\/j.lfs.2024.122913_bb0060","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1172\/JCI45890","article-title":"Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D\u2013induced inhibition of bone mineralization","volume":"122","author":"Lieben","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.lfs.2024.122913_bb0065","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2024.122913_bb0070","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jsbmb.2013.11.003","article-title":"Is vitamin D deficiency a major global public health problem?","volume":"144","author":"Palacios","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"4","key":"10.1016\/j.lfs.2024.122913_bb0075","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.ecl.2017.07.002","article-title":"Global overview of vitamin D status","volume":"46","author":"van Schoor","year":"2017","journal-title":"Endocrinol. Metab. Clin. North Am."},{"issue":"2","key":"10.1016\/j.lfs.2024.122913_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/nu13020705","article-title":"Association of systemic sclerosis and periodontitis with vitamin D levels","volume":"13","author":"Isola","year":"2021","journal-title":"Nutrients"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2024.122913_bb0085","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mce.2011.05.012","article-title":"Genome-wide principles of gene regulation by the vitamin D receptor and its activating ligand","volume":"347","author":"Pike","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.lfs.2024.122913_bb0090","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jaut.2019.03.002","article-title":"Immunological effects of vitamin D and their relations to autoimmunity","volume":"100","author":"Yamamoto","year":"2019","journal-title":"J. Autoimmun."},{"issue":"27","key":"10.1016\/j.lfs.2024.122913_bb0095","doi-asserted-by":"crossref","first-page":"19450","DOI":"10.1074\/jbc.M113.467670","article-title":"Vitamin D receptor inhibits nuclear factor kappaB activation by interacting with IkappaB kinase beta protein","volume":"288","author":"Chen","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.lfs.2024.122913_bb0100","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.4049\/jimmunol.1102412","article-title":"Vitamin D inhibits monocyte\/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1","volume":"188","author":"Zhang","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2024.122913_bb0105","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.300","article-title":"1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes","volume":"7","author":"Gu","year":"2016","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.lfs.2024.122913_bb0110","doi-asserted-by":"crossref","first-page":"353","DOI":"10.7326\/0003-4819-125-5-199609010-00001","article-title":"Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham study","volume":"125","author":"McAlindon","year":"1996","journal-title":"Ann. Intern. Med."},{"issue":"5","key":"10.1016\/j.lfs.2024.122913_bb0115","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/art.24486","article-title":"Serum levels of vitamin D, sunlight exposure, and knee cartilage loss in older adults the tasmanian older adult Cohort Study","volume":"60","author":"Ding","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"11","key":"10.1016\/j.lfs.2024.122913_bb0120","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1007\/s11999-013-3269-z","article-title":"CORR insights(A (R)): does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial","volume":"471","author":"Felson","year":"2013","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"2","key":"10.1016\/j.lfs.2024.122913_bb0125","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.joca.2015.08.013","article-title":"Vitamin D prevents articular cartilage erosion by regulating collagen II turnover through TGF-beta1 in ovariectomized rats","volume":"24","author":"Li","year":"2016","journal-title":"Osteoarthr. Cartil."},{"issue":"2","key":"10.1016\/j.lfs.2024.122913_bb0130","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.bone.2013.04.015","article-title":"1,25(OH)2D deficiency induces temporomandibular joint osteoarthritis via secretion of senescence-associated inflammatory cytokines","volume":"55","author":"Shen","year":"2013","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.lfs.2024.122913_bb0135","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3109\/03009742.2011.617314","article-title":"Association of 25-hydroxyvitamin D with the incidence of knee and hip osteoarthritis: a 22-year follow-up study","volume":"41","author":"Konstari","year":"2012","journal-title":"Scand. J. Rheumatol."},{"issue":"5","key":"10.1016\/j.lfs.2024.122913_bb0140","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.bjoms.2020.08.101","article-title":"Relation of vitamin D and BsmI variant with temporomandibular diseases in the Turkish population","volume":"59","author":"Yildiz","year":"2021","journal-title":"Br. J. Oral Maxillofac. Surg."},{"issue":"25","key":"10.1016\/j.lfs.2024.122913_bb0145","doi-asserted-by":"crossref","first-page":"18172","DOI":"10.1074\/jbc.M112.407296","article-title":"Endoplasmic reticulum stress regulates rat mandibular cartilage thinning under compressive mechanical stress","volume":"288","author":"Li","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.lfs.2024.122913_bb0150","doi-asserted-by":"crossref","first-page":"68","DOI":"10.11607\/jop.1082","article-title":"Changes of temporomandibular joint and semaphorin 4D\/Plexin-B1 expression in a mouse model of incisor malocclusion","volume":"28","author":"Lu","year":"2014","journal-title":"J. Oral Facial Pain Headache"},{"issue":"3","key":"10.1016\/j.lfs.2024.122913_bb0155","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/odi.12112","article-title":"Cartilage degradation in temporomandibular joint induced by unilateral anterior crossbite prosthesis","volume":"20","author":"Wang","year":"2014","journal-title":"Oral Dis."},{"issue":"2","key":"10.1016\/j.lfs.2024.122913_bb0160","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00441-013-1754-z","article-title":"Morphological and cellular examinations of experimentally induced malocclusion in mice mandibular condyle","volume":"355","author":"Jung","year":"2014","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.lfs.2024.122913_bb0165","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/164146","article-title":"Superficial collagen fibril modulus and pericellular fixed charge density modulate chondrocyte volumetric behaviour in early osteoarthritis","volume":"2013","author":"Tanska","year":"2013","journal-title":"Comput. Math. Methods Med."},{"key":"10.1016\/j.lfs.2024.122913_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2022.105612","article-title":"Receptor-interacting protein 1 inhibition prevents mechanical stress-induced temporomandibular joint osteoarthritis by regulating apoptosis and later-stage necroptosis of chondrocytes","volume":"147","author":"Zhou","year":"2023","journal-title":"Arch. Oral Biol."},{"issue":"1","key":"10.1016\/j.lfs.2024.122913_bb0175","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/0022034510385237","article-title":"Expression of osteoclastogenesis inducers in a tissue model of periodontal ligament under compression","volume":"90","author":"Li","year":"2011","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.lfs.2024.122913_bb0180","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.bbrc.2016.12.139","article-title":"Nongenomic effects of 1 alpha,25-dihydroxyvitamin D-3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice","volume":"483","author":"Hirota","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.lfs.2024.122913_bb0185","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ng0897-391","article-title":"Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning","volume":"16","author":"Yoshizawa","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.lfs.2024.122913_bb0190","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bone.2017.06.022","article-title":"Vitamin D regulates osteocyte survival and perilacunar remodeling in human and murine bone","volume":"103","author":"Rolvien","year":"2017","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.lfs.2024.122913_bb0195","first-page":"192","article-title":"Class II malocclusion division 1: a new classification method by cephalometric analysis","volume":"13","author":"Perillo","year":"2012","journal-title":"Eur. J. Paediatr. Dent."},{"issue":"6","key":"10.1016\/j.lfs.2024.122913_bb0200","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/jbmr.3096","article-title":"VDR in osteoblast-lineage cells primarily mediates vitamin d treatment-induced increase in bone mass by suppressing bone resorption","volume":"32","author":"Nakamichi","year":"2017","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.lfs.2024.122913_bb0205","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1210\/en.2012-1542","article-title":"Vitamin D receptor in osteoblasts is a negative regulator of bone mass control","volume":"154","author":"Yamamoto","year":"2013","journal-title":"Endocrinology"},{"issue":"1\u20134","key":"10.1016\/j.lfs.2024.122913_bb0210","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3109\/03008209609029208","article-title":"Vitamin D regulation of metalloproteinase activity in matrix vesicles","volume":"35","author":"Dean","year":"1996","journal-title":"Connect. Tissue Res."},{"issue":"1\u20134","key":"10.1016\/j.lfs.2024.122913_bb0215","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000152916","article-title":"1,25-Dihydroxy vitamin D3 is an autocrine regulator of extracellular matrix turnover and growth factor release via ERp60-activated matrix vesicle matrix metalloproteinases","volume":"189","author":"Boyan","year":"2009","journal-title":"Cells Tissues Organs"},{"issue":"6","key":"10.1016\/j.lfs.2024.122913_bb0220","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1007\/s10753-015-0209-y","article-title":"Calcitriol suppressed inflammatory reactions in IL-1beta-stimulated human periodontal ligament cells","volume":"38","author":"Hosokawa","year":"2015","journal-title":"Inflammation"},{"issue":"9","key":"10.1016\/j.lfs.2024.122913_bb0225","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/joor.12304","article-title":"Installing and thereafter removing an aberrant prosthesis elicited opposite remodelling responses in growing mouse temporomandibular joints","volume":"42","author":"Zhang","year":"2015","journal-title":"J. Oral Rehabil."},{"issue":"3","key":"10.1016\/j.lfs.2024.122913_bb0230","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/odi.13274","article-title":"Effects of occlusion modification on the remodelling of degenerative mandibular condylar processes","volume":"26","author":"Zhou","year":"2020","journal-title":"Oral Dis."},{"issue":"4","key":"10.1016\/j.lfs.2024.122913_bb0235","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1177\/1535370214554533","article-title":"Tumor necrosis factor alpha promotes the proliferation of human nucleus pulposus cells via nuclear factor-kappaB, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase","volume":"240","author":"Wang","year":"2015","journal-title":"Exp. Biol. Med. (Maywood)"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524005034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524005034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T09:38:34Z","timestamp":1723541914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320524005034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":47,"alternative-id":["S0024320524005034"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2024.122913","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deletion of vitamin D receptor exacerbated temporomandibular joint pathological changes under abnormal mechanical stimulation","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2024.122913","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122913"}}