{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:16:38Z","timestamp":1777626998081,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2023-00301850"],"award-info":[{"award-number":["RS-2023-00301850"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2024-00413453"],"award-info":[{"award-number":["RS-2024-00413453"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00338402"],"award-info":[{"award-number":["RS-2024-00338402"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1A6C101A739"],"award-info":[{"award-number":["2022R1A6C101A739"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.lfs.2024.123042","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T20:10:27Z","timestamp":1725307827000},"page":"123042","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Blockade of forkhead box protein O1 signaling alleviates primary sclerosing cholangitis-induced sarcopenia in mice model"],"prefix":"10.1016","volume":"356","author":[{"given":"Dong-Hyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeongho","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Hyun","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2024.123042_bb0005","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nrgastro.2016.154","article-title":"Genetics of primary sclerosing cholangitis and pathophysiological implications","volume":"14","author":"Jiang","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2024.123042_bb0010","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1007\/s00424-018-2167-3","article-title":"Sarcopenia in a mice model of chronic liver disease: role of the ubiquitin-proteasome system and oxidative stress","volume":"470","author":"Campos","year":"2018","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.lfs.2024.123042_bb0015","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.dld.2023.08.037","article-title":"Myosteatosis independently predicts transplant-free survival in patients with primary sclerosing cholangitis","volume":"55","author":"Praktiknjo","year":"2023","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.lfs.2024.123042_bb0020","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nrrheum.2017.60","article-title":"Epidemiology of sarcopenia and insight into possible therapeutic targets","volume":"13","author":"Dennison","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.lfs.2024.123042_bb0025","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/jcp.29839","article-title":"Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor","volume":"236","author":"Abrigo","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.lfs.2024.123042_bb0030","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.coph.2021.11.003","article-title":"Emerging drugs for the treatment of primary sclerosing cholangitis","volume":"62","author":"Abbas","year":"2022","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.lfs.2024.123042_bb0035","doi-asserted-by":"crossref","first-page":"1289537","DOI":"10.3389\/fphys.2023.1289537","article-title":"Ubiquitin-proteasome pathway in skeletal muscle atrophy","volume":"14","author":"Pang","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lfs.2024.123042_bb0040","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s41467-020-20123-1","article-title":"Mechanisms of muscle atrophy and hypertrophy: implications in health and disease","volume":"12","author":"Sartori","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2024.123042_bb0045","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1065874","article-title":"Identification of ubiquitin ligases required for skeletal muscle atrophy","volume":"294","author":"Bodine","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.lfs.2024.123042_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21217922","article-title":"Sarcopenia induced by chronic liver disease in mice requires the expression of the bile acids membrane receptor TGR5","volume":"21","author":"Abrigo","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2024.123042_bb0055","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nrm3507","article-title":"FOXOs: signalling integrators for homeostasis maintenance","volume":"14","author":"Eijkelenboom","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.lfs.2024.123042_bb0060","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.2147\/DDDT.S305016","article-title":"Forkhead box protein O1: functional diversity and post-translational modification, a new therapeutic target?","volume":"15","author":"Zhang","year":"2021","journal-title":"Drug. Des. Devel. Ther."},{"key":"10.1016\/j.lfs.2024.123042_bb0065","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/j.ajpath.2022.09.003","article-title":"Forkhead box O signaling pathway in skeletal muscle atrophy","volume":"192","author":"Chen","year":"2022","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.lfs.2024.123042_bb0070","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101385RR","article-title":"FOXO1 cooperates with C\/EBP\u03b4 and ATF4 to regulate skeletal muscle atrophy transcriptional program during fasting","volume":"36","author":"Oyabu","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2024.123042_bb0075","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1172\/JCI32054","article-title":"A Foxo\/Notch pathway controls myogenic differentiation and fiber type specification","volume":"117","author":"Kitamura","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2024.123042_bb0080","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/ki.2012.84","article-title":"Transcription factor FoxO1, the dominant mediator of muscle wasting in chronic kidney disease, is inhibited by microRNA-486","volume":"82","author":"Xu","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2024.123042_bb0085","doi-asserted-by":"crossref","first-page":"135","DOI":"10.14283\/jfa.2022.30","article-title":"Challenges in the development of drugs for sarcopenia and frailty - report from the International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force","volume":"11","author":"Cesari","year":"2022","journal-title":"J. Frailty Aging"},{"key":"10.1016\/j.lfs.2024.123042_bb0090","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1124\/mol.110.065714","article-title":"Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db\/db mice","volume":"78","author":"Nagashima","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.lfs.2024.123042_bb0095","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/2211-5463.13547","article-title":"The FOXO1 inhibitor AS1842856 triggers apoptosis in glioblastoma multiforme and basal-like breast cancer cells","volume":"13","author":"Flores","year":"2023","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.lfs.2024.123042_bb0100","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1152\/japplphysiol.00347.2003","article-title":"Invited review: aging and sarcopenia","volume":"95","author":"Doherty","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.lfs.2024.123042_bb0105","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/hep.31652","article-title":"Bile acid profiles in primary sclerosing cholangitis and their ability to predict hepatic decompensation","volume":"74","author":"Mousa","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2024.123042_bb0110","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jcmgh.2023.08.013","article-title":"Hepatocyte FoxO1 deficiency protects from liver fibrosis via reducing inflammation and TGF-\u03b21-mediated HSC activation","volume":"17","author":"Pan","year":"2024","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2024.123042_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/CS20230934","article-title":"Bile salt signaling and bile salt-based therapies in cardiometabolic disease","volume":"138","author":"Groenen","year":"2024","journal-title":"Clin. Sci."},{"key":"10.1016\/j.lfs.2024.123042_bb0120","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41392-024-01811-6","article-title":"Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets","volume":"9","author":"Fleishman","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.lfs.2024.123042_bb0125","doi-asserted-by":"crossref","first-page":"e12462","DOI":"10.1111\/1755-5922.12462","article-title":"TGR5 activation induces cytoprotective changes in the heart and improves myocardial adaptability to physiologic, inotropic, and pressure-induced stress in mice","volume":"36","author":"Eblimit","year":"2018","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.lfs.2024.123042_bb0130","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1186\/s12967-019-02170-5","article-title":"FXR activation alleviates tacrolimus-induced post-transplant diabetes mellitus by regulating renal gluconeogenesis and glucose uptake","volume":"17","author":"Li","year":"2019","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.lfs.2024.123042_bb0135","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1210\/en.2004-0965","article-title":"Regulation of carbohydrate metabolism by the farnesoid X receptor","volume":"146","author":"Stayrook","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2024.123042_bb0140","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2337\/db23-0432","article-title":"Inhibitory regulation of FOXO1 in PPARd expression drives mitochondrial dysfunction and insulin resistance","volume":"73","author":"Park","year":"2024","journal-title":"Diabetes"},{"key":"10.1016\/j.lfs.2024.123042_bb0145","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s10142-024-01284-4","article-title":"Inhibition of FoxO1 alleviates polycystic ovarian syndrome by reducing inflammation and the immune response","volume":"24","author":"Huang","year":"2024","journal-title":"Funct. Integr. Genomics"},{"key":"10.1016\/j.lfs.2024.123042_bb0150","first-page":"1213","article-title":"Sarcopenia in chronic liver disease: a metabolic perspective","volume":"10","author":"Kumar","year":"2022","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.lfs.2024.123042_bb0155","article-title":"Body composition in chronic liver disease","volume":"25","author":"Nishikawa","year":"2024","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.lfs.2024.123042_bb0160","doi-asserted-by":"crossref","unstructured":"M. Milkiewicz,J. Kopyci\u0144ska,A. Kempi\u0144ska-Podhorodecka,T. Haas,D. P. Bogdanos,E. Elias andP. Milkiewicz, Ursodeoxycholic acid influences the expression of p27kip1 but not FoxO1 in patients with non-cirrhotic primary biliary cirrhosis, J Immunol Res 2014 (2014) 921285. doi:https:\/\/doi.org\/10.1155\/2014\/921285.","DOI":"10.1155\/2014\/921285"},{"key":"10.1016\/j.lfs.2024.123042_bb0165","doi-asserted-by":"crossref","unstructured":"Q. Pan,M. Gao,D. Kim,W. Ai,W. Yang,W. Jiang,W. Brashear,Y. Dai,S. Li,Y. Sun,Y. Qi andS. Guo, Hepatocyte FoxO1 deficiency protects from liver fibrosis via reducing inflammation and TGF-\u03b21-mediated HSC activation, Cell. Mol. Gastroenterol. Hepatol. 17 (2024) 41\u201358. doi:https:\/\/doi.org\/10.1016\/j.jcmgh.2023.08.013.","DOI":"10.1016\/j.jcmgh.2023.08.013"},{"key":"10.1016\/j.lfs.2024.123042_bb0170","doi-asserted-by":"crossref","unstructured":"O. S. I,W. Zhang,D. H. Wasserman,C. W. Liew,J. Liu,J. Paik,R. A. DePinho,D. B. Stolz,C. R. Kahn,M. W. Schwartz and T. G. Unterman, FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization, Nat. Commun. 6 (2015) 7079. doi:https:\/\/doi.org\/10.1038\/ncomms8079.","DOI":"10.1038\/ncomms8079"},{"key":"10.1016\/j.lfs.2024.123042_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbior.2022.100903","article-title":"Gaining insight into the role of FoxO1 in the progression of disuse-induced skeletal muscle atrophy","volume":"85","author":"Vilchinskaya","year":"2022","journal-title":"Adv. Biol. Regul."},{"key":"10.1016\/j.lfs.2024.123042_bb0180","article-title":"Insulin and LiCl synergistically rescue myogenic differentiation of FoxO1 over-expressed myoblasts","volume":"9","author":"Wu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2024.123042_bb0185","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1093\/emboj\/cdg116","article-title":"FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts","volume":"22","author":"Bois","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.lfs.2024.123042_bb0190","doi-asserted-by":"crossref","first-page":"10662","DOI":"10.18632\/oncotarget.12891","article-title":"FoxO1: a novel insight into its molecular mechanisms in the regulation of skeletal muscle differentiation and fiber type specification","volume":"8","author":"Xu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.lfs.2024.123042_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315039","article-title":"Inflammaging: implications in sarcopenia","volume":"23","author":"Antu\u00f1a","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2024.123042_bb0200","doi-asserted-by":"crossref","first-page":"1293146","DOI":"10.3389\/fendo.2024.1293146","article-title":"The causal association between circulating cytokines with the risk of frailty and sarcopenia under the perspective of geroscience","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.lfs.2024.123042_bb0205","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/s41419-023-06177-1","article-title":"FOXO family isoforms","volume":"14","author":"Santos","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2024.123042_bb0210","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/acel.12340","article-title":"The life-extending effect of dietary restriction requires Foxo3 in mice","volume":"14","author":"Shimokawa","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.lfs.2024.123042_bb0215","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1053\/j.gastro.2009.06.049","article-title":"FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation","volume":"137","author":"Zhou","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2024.123042_bb0220","first-page":"5329","article-title":"Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2","volume":"125","author":"Shi","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.lfs.2024.123042_bb0225","doi-asserted-by":"crossref","first-page":"E495","DOI":"10.1152\/ajpendo.00389.2016","article-title":"Forkhead box O3 plays a role in skeletal muscle atrophy through expression of E3 ubiquitin ligases MuRF-1 and atrogin-1 in Cushing\u2019s syndrome","volume":"312","author":"Kang","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2024.123042_bb0230","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.4161\/15384101.2014.965977","article-title":"Targeting FoxO1 with AS1842856 suppresses adipogenesis","volume":"13","author":"Zou","year":"2014","journal-title":"Cell Cycle (Georgetown, Tex.)"},{"key":"10.1016\/j.lfs.2024.123042_bb0235","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/nm.3695","article-title":"Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension","volume":"20","author":"Savai","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2024.123042_bb0240","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.cell.2017.09.045","article-title":"Selective inhibition of FOXO1 activator\/repressor balance modulates hepatic glucose handling","volume":"171","author":"Langlet","year":"2017","journal-title":"Cell"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524006325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524006325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:47:29Z","timestamp":1777423649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320524006325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":48,"alternative-id":["S0024320524006325"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2024.123042","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blockade of forkhead box protein O1 signaling alleviates primary sclerosing cholangitis-induced sarcopenia in mice model","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2024.123042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123042"}}