{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:14:58Z","timestamp":1776100498258,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"am","delay-in-days":317,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017987","name":"Korean-American Scientists and Engineers Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017987","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY003790"],"award-info":[{"award-number":["P30EY003790"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["F32EY035529"],"award-info":[{"award-number":["F32EY035529"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY029789 T32EY007145"],"award-info":[{"award-number":["EY029789 T32EY007145"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.lfs.2024.123058","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T20:18:39Z","timestamp":1726172319000},"page":"123058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Sex-dependent differential increase of specialized pro-resolving mediators in extracellular vesicles secreted by human primary conjunctival goblet cells during allergic inflammation"],"prefix":"10.1016","volume":"357","author":[{"given":"Changrim","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darlene A.","family":"Dartt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2024.123058_bb0005","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.lfs.2024.123058_bb0010","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/ACI.0000000000000098","article-title":"Conjunctival epithelial and goblet cell function in chronic inflammation and ocular allergic inflammation","volume":"14","author":"Dartt","year":"2014","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.lfs.2024.123058_bb0015","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.exer.2013.07.027","article-title":"Tear film mucins: front line defenders of the ocular surface; comparison with airway and gastrointestinal tract mucins","volume":"117","author":"Hodges","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.lfs.2024.123058_bb0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13223-020-0403-9","article-title":"A contemporary look at allergic conjunctivitis","volume":"16","author":"Dupuis","year":"2020","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"10.1016\/j.lfs.2024.123058_bb0025","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1167\/iovs.11-8748","article-title":"Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion","volume":"53","author":"Hayashi","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.lfs.2024.123058_bb0030","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.mam.2017.03.005","article-title":"Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors","volume":"58","author":"Chiang","year":"2017","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.lfs.2024.123058_bb0035","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.4049\/jimmunol.1000833","article-title":"Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation","volume":"186","author":"Dartt","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2024.123058_bb0040","doi-asserted-by":"crossref","DOI":"10.1038\/srep36124","article-title":"Lipoxin A(4) counter-regulates histamine-stimulated glycoconjugate secretion in conjunctival goblet cells","volume":"6","author":"Hodges","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2024.123058_bb0045","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/mi.2013.7","article-title":"Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion","volume":"6","author":"Li","year":"2013","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.lfs.2024.123058_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2017.03.001","article-title":"Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology","volume":"58","author":"Serhan","year":"2017","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.lfs.2024.123058_bb0055","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.lfs.2024.123058_bb0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","article-title":"Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.lfs.2024.123058_bb0065","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.lfs.2024.123058_bb0070","doi-asserted-by":"crossref","unstructured":"C. Thery, S. Amigorena, G. Raposo, A. Clayton, Isolation and characterization of exosomes from cell culture supernatants and biological fluids, Curr Protoc Cell Biol. Chapter 3 (2006) Unit 3 22. https:\/\/doi.org\/10.1002\/0471143030.cb0322s30.","DOI":"10.1002\/0471143030.cb0322s30"},{"key":"10.1016\/j.lfs.2024.123058_bb0075","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1350-9462(02)00038-1","article-title":"Regulation of mucin and fluid secretion by conjunctival epithelial cells","volume":"21","author":"Dartt","year":"2002","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.lfs.2024.123058_bb0080","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1167\/iovs.02-0550","article-title":"Isolation and characterization of cultured human conjunctival goblet cells","volume":"44","author":"Shatos","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.lfs.2024.123058_bb0085","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/601731","article-title":"An update on ocular surface epithelial stem cells: cornea and conjunctiva","volume":"2015","author":"Ramos","year":"2015","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.lfs.2024.123058_bb0090","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s00417-020-04725-5","article-title":"Assessment of goblet cell size and density in relation to epithelial cell (multi)layering on conjunctival impression cytology samples","volume":"258","author":"Doughty","year":"2020","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.lfs.2024.123058_bb0095","first-page":"1455","article-title":"Isolation, characterization, and propagation of rat conjunctival goblet cells in vitro","volume":"42","author":"Shatos","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.lfs.2024.123058_bb0100","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s10517-021-05309-x","article-title":"H1-receptor antagonist olopatadine inhibits MUC5AC secretion by conjunctival goblet cells","volume":"171","author":"He","year":"2021","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.lfs.2024.123058_bb0105","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1007\/s00018-018-2806-z","article-title":"Redox-dependent thiol modifications: implications for the release of extracellular vesicles","volume":"75","author":"Benedikter","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.lfs.2024.123058_bb0110","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","article-title":"Calcium signaling","volume":"131","author":"Clapham","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2024.123058_bb0115","article-title":"Biosynthesized multivalent lacritin peptides stimulate exosome production in human corneal epithelium","volume":"21","author":"Lee","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2024.123058_bb0120","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1046\/j.1525-1381.1999.99321.x","article-title":"Phospholipase A2 enzymes in eicosanoid generation","volume":"111","author":"Bingham","year":"1999","journal-title":"Proc. Assoc. Am. Physicians"},{"key":"10.1016\/j.lfs.2024.123058_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2022.101165","article-title":"Polyunsaturated fatty acids and fatty acid-derived lipid mediators: recent advances in the understanding of their biosynthesis, structures, and functions","volume":"86","author":"Dyall","year":"2022","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.lfs.2024.123058_bb0130","doi-asserted-by":"crossref","unstructured":"J.A. Welsh, D.C.I. Goberdhan, L. O'Driscoll, E.I. Buzas, C. Blenkiron, B. Bussolati, H. Cai, D. Di Vizio, T.A.P. Driedonks, U. Erdbrugger, J.M. Falcon-Perez, Q.L. Fu, A.F. Hill, M. Lenassi, S.K. Lim, M.G. Mahoney, S. Mohanty, A. Moller, R. Nieuwland, T. Ochiya, S. Sahoo, A.C. Torrecilhas, L. Zheng, A. Zijlstra, S. Abuelreich, R. Bagabas, P. Bergese, E.M. Bridges, M. Brucale, D. Burger, R.P. Carney, E. Cocucci, R. Crescitelli, E. Hanser, A.L. Harris, N.J. Haughey, A. Hendrix, A.R. Ivanov, T. Jovanovic-Talisman, N.A. Kruh-Garcia, V. Ku'ulei-Lyn Faustino, D. Kyburz, C. Lasser, K.M. Lennon, J. Lotvall, A.L. Maddox, E.S. Martens-Uzunova, R.R. Mizenko, L.A. Newman, A. Ridolfi, E. Rohde, T. Rojalin, A. Rowland, A. Saftics, U.S. Sandau, J.A. Saugstad, F. Shekari, S. Swift, D. Ter-Ovanesyan, J.P. Tosar, Z. Useckaite, F. Valle, Z. Varga, E. van der Pol, M.J.C. van Herwijnen, M.H.M. Wauben, A.M. Wehman, S. Williams, A. Zendrini, A.J. Zimmerman, M. Consortium, C. Thery, K.W. Witwer, Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches, J Extracell Vesicles. 13 (2024) e12404. https:\/\/doi.org\/10.1002\/jev2.12404.","DOI":"10.1002\/jev2.12404"},{"key":"10.1016\/j.lfs.2024.123058_bb0135","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1167\/iovs.64.12.38","article-title":"Isolation and characterization of human conjunctival mesenchymal stromal cells and their extracellular vesicles","volume":"64","author":"Garcia-Posadas","year":"2023","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.lfs.2024.123058_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23063136","article-title":"Extracellular vesicles secreted by corneal myofibroblasts promote corneal epithelial cell migration","volume":"23","author":"Yeung","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2024.123058_bb0145","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.plefa.2017.01.004","article-title":"Identification and profiling of specialized pro-resolving mediators in human tears by lipid mediator metabolomics","volume":"117","author":"English","year":"2017","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.lfs.2024.123058_bb0150","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cmet.2013.10.006","article-title":"Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases","volume":"19","author":"Spite","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2024.123058_bb0155","article-title":"Sex hormone-dependent lipid mediator formation in male and female mice during peritonitis","volume":"12","author":"Troisi","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2024.123058_bb0160","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1172\/JCI89429","article-title":"Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans","volume":"127","author":"Rathod","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2024.123058_bb0165","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1038\/s41433-022-02259-0","article-title":"Association between systemic omega-3 polyunsaturated fatty acid levels, and corneal nerve structure and function","volume":"37","author":"Britten-Jones","year":"2023","journal-title":"Eye (Lond.)"},{"key":"10.1016\/j.lfs.2024.123058_bb0170","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/opo.12365","article-title":"Omega-3 supplementation is neuroprotective to corneal nerves in dry eye disease: a pilot study","volume":"37","author":"Chinnery","year":"2017","journal-title":"Ophthalmic Physiol. Opt."},{"key":"10.1016\/j.lfs.2024.123058_bb0175","doi-asserted-by":"crossref","unstructured":"A. Olenik, I. Mahillo-Fernandez, N. Alejandre-Alba, G. Fernandez-Sanz, M.A. Perez, S. Luxan, S. Quintana, A. Martinez de Carneros Llorente, B. Garcia-Sandoval, I. Jimenez-Alfaro, Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction, Clin. Ophthalmol. 8 (2014) 831\u2013836. https:\/\/doi.org\/10.2147\/OPTH.S62470.","DOI":"10.2147\/OPTH.S62470"},{"key":"10.1016\/j.lfs.2024.123058_bb0180","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/ICO.0000000000001884","article-title":"Efficacy of omega-3 fatty acid supplementation for treatment of dry eye disease: a meta-analysis of randomized clinical trials","volume":"38","author":"Giannaccare","year":"2019","journal-title":"Cornea"},{"key":"10.1016\/j.lfs.2024.123058_bb0185","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2024.123058_bb0190","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.4049\/jimmunol.1003865","article-title":"Cutting edge: humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing","volume":"186","author":"Norling","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2024.123058_bb0195","doi-asserted-by":"crossref","DOI":"10.1038\/srep23978","article-title":"ExtraPEG: a polyethylene glycol-based method for enrichment of extracellular vesicles","volume":"6","author":"Rider","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2024.123058_bb4000","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 1(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524006489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524006489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T16:16:57Z","timestamp":1776097017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320524006489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":40,"alternative-id":["S0024320524006489"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2024.123058","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-dependent differential increase of specialized pro-resolving mediators in extracellular vesicles secreted by human primary conjunctival goblet cells during allergic inflammation","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2024.123058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123058"}}